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FR2258175A1 - Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity - Google Patents

Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity

Info

Publication number
FR2258175A1
FR2258175A1 FR7402195A FR7402195A FR2258175A1 FR 2258175 A1 FR2258175 A1 FR 2258175A1 FR 7402195 A FR7402195 A FR 7402195A FR 7402195 A FR7402195 A FR 7402195A FR 2258175 A1 FR2258175 A1 FR 2258175A1
Authority
FR
France
Prior art keywords
liquid
heterosides
esp
those
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7402195A
Other languages
French (fr)
Other versions
FR2258175B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7402195A priority Critical patent/FR2258175A1/en
Priority to DE19742436479 priority patent/DE2436479A1/en
Publication of FR2258175A1 publication Critical patent/FR2258175A1/en
Application granted granted Critical
Publication of FR2258175B1 publication Critical patent/FR2258175B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

Steroid heterosides (I), esp. those from Ruscus aculeatus, are purified by extracting an organic phase contg. at least one solvent for (I) with an aq. phase of pH >=13, (I) being present in one or other of these phases, then decanting and recovering (I) from the organic phase. (I) have venotonic activity and are hydrolysed to prosapogenins and genins. The pref. 2% ethanolic soln. has significant activity in the carragheenin oedema test and is used in treating varicose and prevaricose states. Prodts. are practically 100% pure so have defined and consistent activity. Overall yield is 50-80%.
FR7402195A 1974-01-23 1974-01-23 Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity Granted FR2258175A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7402195A FR2258175A1 (en) 1974-01-23 1974-01-23 Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity
DE19742436479 DE2436479A1 (en) 1974-01-23 1974-07-29 METHOD OF CLEANING UP STEROID HETEROSIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7402195A FR2258175A1 (en) 1974-01-23 1974-01-23 Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity

Publications (2)

Publication Number Publication Date
FR2258175A1 true FR2258175A1 (en) 1975-08-18
FR2258175B1 FR2258175B1 (en) 1978-08-11

Family

ID=9133854

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7402195A Granted FR2258175A1 (en) 1974-01-23 1974-01-23 Purifying steroid heterosides by liquid-liquid extraction - esp. those from Ruscus aculeatus to give a prod. of predictable activity

Country Status (2)

Country Link
DE (1) DE2436479A1 (en)
FR (1) FR2258175A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062529A1 (en) * 1998-06-04 1999-12-09 Pierre Fabre Dermo-Cosmetique Pharmaceutical or cosmetic composition and method for cosmetic treatment of angiogenic disorders
EP1338283A1 (en) * 2002-02-26 2003-08-27 Pierre Fabre Dermo-Cosmetique Use of neoruscine to treat alopecia

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19709924C2 (en) * 1997-03-11 2001-09-13 Skf Gmbh Device for supporting conical rotating bodies in machines for machining or testing the rotating surfaces

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062529A1 (en) * 1998-06-04 1999-12-09 Pierre Fabre Dermo-Cosmetique Pharmaceutical or cosmetic composition and method for cosmetic treatment of angiogenic disorders
FR2779348A1 (en) * 1998-06-04 1999-12-10 Fabre Pierre Dermo Cosmetique NOVEL PHARMACEUTICAL OR COSMETIC COMPOSITION, IN PARTICULAR HAIR AND PROCESS FOR THE COSMETIC TREATMENT OF CONDITIONS RELATING TO ANGIOGENIC DISORDERS
EP1338283A1 (en) * 2002-02-26 2003-08-27 Pierre Fabre Dermo-Cosmetique Use of neoruscine to treat alopecia
FR2836383A1 (en) * 2002-02-26 2003-08-29 Fabre Pierre Dermo Cosmetique USE OF NEORUSCIN FOR THE PREPARATION OF A HAIR COMPOSITION FOR THE TREATMENT OF ALOPECIA

Also Published As

Publication number Publication date
DE2436479A1 (en) 1975-07-24
FR2258175B1 (en) 1978-08-11

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Legal Events

Date Code Title Description
ST Notification of lapse