FI954852A - 1,5-Benzodiazepine derivatives with CCK and / or gastrin antagonist activity - Google Patents

1,5-Benzodiazepine derivatives with CCK and / or gastrin antagonist activity Download PDF

Info

Publication number: FI954852A
Authority: FI; Finland
Prior art keywords: cck; antagonist activity; benzodiazepine derivatives; gastrin antagonist; gastrin
Prior art date: 1993-04-15

Application number

FI954852A

Other languages

Finnish (fi)

Swedish (sv)

Other versions

FI954852A0 (en

Inventor

Harry Finch

Pritom Shah

Robin Arthur Ellis Carr

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-15

Filing date

1995-10-12

Publication date

1995-10-12

1993-04-15 Priority claimed from GB939307833A external-priority patent/GB9307833D0/en

1994-03-29 Priority claimed from GB9406037A external-priority patent/GB9406037D0/en

1995-10-12 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

1995-10-12 Publication of FI954852A publication Critical patent/FI954852A/en

1995-10-12 Publication of FI954852A0 publication Critical patent/FI954852A0/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Crystallography & Structural Chemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

FI954852A 1993-04-15 1995-10-12 1,5-bentzodiazepine derivatives with CCK and / or gastrin antagonistic activity FI954852A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939307833A GB9307833D0 (en)	1993-04-15	1993-04-15	Modulators of cholecystokinin and gastrin
GB9406037A GB9406037D0 (en)	1994-03-29	1994-03-29	1,5 Benzodiazepine derivatives
PCT/EP1994/001130 WO1994024151A1 (en)	1993-04-15	1994-04-13	1,5 benzodiazepine derivatives having cck and/or gastrin antagonistic activity

Publications (2)

Publication Number	Publication Date
FI954852A true FI954852A (en)	1995-10-12
FI954852A0 FI954852A0 (en)	1995-10-12

Family

ID=26302765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI954852A FI954852A0 (en)	1993-04-15	1995-10-12	1,5-bentzodiazepine derivatives with CCK and / or gastrin antagonistic activity

Country Status (14)

Country	Link
EP (1)	EP0694040A1 (en)
JP (1)	JPH08508743A (en)
CN (1)	CN1120845A (en)
AU (1)	AU688316B2 (en)
CA (1)	CA2158972A1 (en)
CZ (1)	CZ267695A3 (en)
FI (1)	FI954852A0 (en)
HU (1)	HUT74091A (en)
NO (1)	NO954091L (en)
NZ (1)	NZ265271A (en)
OA (1)	OA10236A (en)
PL (1)	PL311083A1 (en)
SK (1)	SK125495A3 (en)
WO (1)	WO1994024151A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1073089C (en) *	1993-12-28	2001-10-17	盐野义制药株式会社	Novel benzodizaepine derivative
DE69724644T4 (en) *	1996-12-10	2006-08-10	Zeria Pharmaceutical Co., Ltd.	1,5-benzodiazepine derivatives
US6444849B1 (en)	1997-06-25	2002-09-03	Mitsubishi Chemical Corporation	Amide derivatives
JP2000026434A (en)	1998-06-05	2000-01-25	Zeria Pharmaceut Co Ltd	New 1,5-benzodiazepine derivative
EP1142868A4 (en) *	1998-12-22	2004-09-29	Mitsubishi Chem Corp	Amide derivatives
GB201414116D0 (en)	2014-08-08	2014-09-24	Trio Medicines Ltd	Benzodiazepine derivatives
GB201513979D0 (en)	2015-08-07	2015-09-23	Trio Medicines Ltd	Synthesis of benzodiazepine derivatives
EP4041722A4 (en)	2019-10-07	2023-12-13	Kallyope, Inc.	Gpr119 agonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (en) *	1988-12-29	1994-01-21	Roussel Uclaf	NOVEL 2,4-DIOXO 2,3,4,5-TETRAHYDRO 1H-1,5-BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2659653B1 (en) *	1990-03-13	1992-05-22	Rhone Poulenc Sante	DERIVATIVES OF UREA, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
US5206234A (en) *	1990-10-22	1993-04-27	Merck & Co., Inc.	Benzolactam analogs as antagonists of cck
GB9201180D0 (en) *	1992-01-21	1992-03-11	Glaxo Group Ltd	Chemical compounds

1994
- 1994-04-13 AU AU65675/94A patent/AU688316B2/en not_active Ceased
- 1994-04-13 CN CN94191771A patent/CN1120845A/en active Pending
- 1994-04-13 HU HU9502977A patent/HUT74091A/en unknown
- 1994-04-13 JP JP6522733A patent/JPH08508743A/en active Pending
- 1994-04-13 EP EP94913579A patent/EP0694040A1/en not_active Withdrawn
- 1994-04-13 NZ NZ265271A patent/NZ265271A/en unknown
- 1994-04-13 SK SK1254-95A patent/SK125495A3/en unknown
- 1994-04-13 WO PCT/EP1994/001130 patent/WO1994024151A1/en not_active Application Discontinuation
- 1994-04-13 CA CA002158972A patent/CA2158972A1/en not_active Abandoned
- 1994-04-13 PL PL94311083A patent/PL311083A1/en unknown
- 1994-04-13 CZ CZ952676A patent/CZ267695A3/en unknown
1995
- 1995-10-12 FI FI954852A patent/FI954852A0/en unknown
- 1995-10-13 NO NO954091A patent/NO954091L/en unknown
- 1995-10-21 OA OA60721A patent/OA10236A/en unknown

Also Published As

Publication number	Publication date
WO1994024151A1 (en)	1994-10-27
JPH08508743A (en)	1996-09-17
CA2158972A1 (en)	1994-10-27
NO954091D0 (en)	1995-10-13
CZ267695A3 (en)	1996-04-17
SK125495A3 (en)	1996-06-05
CN1120845A (en)	1996-04-17
OA10236A (en)	1997-10-07
NZ265271A (en)	1997-06-24
HUT74091A (en)	1996-11-28
HU9502977D0 (en)	1995-12-28
AU688316B2 (en)	1998-03-12
EP0694040A1 (en)	1996-01-31
PL311083A1 (en)	1996-02-05
FI954852A0 (en)	1995-10-12
NO954091L (en)	1995-12-13
AU6567594A (en)	1994-11-08

Publication	Publication Date	Title
FI954853A (en)	1995-10-12	1,5-Benzodiazepine derivatives with CCK antagonist or agonist activity
ZA954315B (en)	1996-11-26	Gastrin and cck antagonists
HUP9802678A3 (en)	1999-12-28	Bicyclic amino derivatives and pgd2 antagonist containing the same
LV11526A (en)	1996-10-20	Benzodiazepines with antiarrhythmic agents
EP0636892A3 (en)	1996-03-06	Electrostatic voltmeter.
AU3461293A (en)	1993-09-13	Benzodiazepine derivatives, as CCK and gastrin antagonists
DE69413405D1 (en)	1998-10-22	1,5-BENZODIAZEPINE DERIVATIVES USED AS CCK OR GASTRINE ANTAGONISTS
AP9801289A0 (en)	1998-09-30	Proc ss fo prep ring ,4-di ydroxypy-ridine and 2,4-dihydroxy-3-nitropyridine
DE69401247D1 (en)	1997-02-06	HINGE ARRANGEMENT
FI954852A (en)	1995-10-12	1,5-Benzodiazepine derivatives with CCK and / or gastrin antagonist activity
EP0662964A1 (en)	1995-07-19	Heterocyclic amines having colmodulin antagonist properties.
DE69416082D1 (en)	1999-03-04	Hinge set
NO912772D0 (en)	1991-07-15	PYRAZOLIDINON CCK, GASTRIN ANTAGONISTS AND PHARMACEUTICAL FORMS THEREOF.
DE69531586D1 (en)	2003-10-02	Immunosuppressive cyclolignan derivatives
NO933444D0 (en)	1993-09-27	LINE ARRANGEMENT
AU7228994A (en)	1995-02-20	1,5-benzodiazepine derivatives useful as cck or gastrin antagonists
GB9502503D0 (en)	1995-03-29	Gastrin and CCK antagonists
FR2710560B1 (en)	1995-12-08	Multiple reduction airbrush.
FR2690753B3 (en)	1994-07-22	PRINTER TESTER.
KR950006628U (en)	1995-03-21	Inclined hinge
GB9312311D0 (en)	1993-07-28	New benzodiazepine derivatives
FI1022U1 (en)	1993-11-17	Sits Foer roddbaotar
KR950020747U (en)	1995-07-26	Stamper Plating Ring
FI99004C (en)	1997-09-25	Gangway with several uses