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FI935444A0 - Tioesterderivat av 3'-O-propargyltrifluortymidin, foerfarande foer framstaellning av desamma och deras anvaendning som anticancermedel - Google Patents

Tioesterderivat av 3'-O-propargyltrifluortymidin, foerfarande foer framstaellning av desamma och deras anvaendning som anticancermedel

Info

Publication number
FI935444A0
FI935444A0 FI935444A FI935444A FI935444A0 FI 935444 A0 FI935444 A0 FI 935444A0 FI 935444 A FI935444 A FI 935444A FI 935444 A FI935444 A FI 935444A FI 935444 A0 FI935444 A0 FI 935444A0
Authority
FI
Finland
Prior art keywords
trifluorothymidine
propargyl
thioester derivatives
thioester
derivatives
Prior art date
Application number
FI935444A
Other languages
English (en)
Other versions
FI935444A (fi
Inventor
Nobuyuki Fukazawa
Nobuya Kawauchi
Hiroki Ishibashi
Shizuo Shimada
Daiji Iwata
Nobuo Takebayashi
Hajime Edatsugi
Takeshi Sobajima
Osamu Yano
Original Assignee
Mitsui Toatsu Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals filed Critical Mitsui Toatsu Chemicals
Publication of FI935444A0 publication Critical patent/FI935444A0/fi
Publication of FI935444A publication Critical patent/FI935444A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI935444A 1992-12-07 1993-12-03 3'-O-propargyyli-trifluoritymidiinin tioesterijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö syövänvastaisena aineena FI935444A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP32633292 1992-12-07
JP17971693 1993-07-21

Publications (2)

Publication Number Publication Date
FI935444A0 true FI935444A0 (fi) 1993-12-03
FI935444A FI935444A (fi) 1994-06-08

Family

ID=26499485

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935444A FI935444A (fi) 1992-12-07 1993-12-03 3'-O-propargyyli-trifluoritymidiinin tioesterijohdannaiset, menetelmä niiden valmistamiseksi ja niiden käyttö syövänvastaisena aineena

Country Status (5)

Country Link
EP (1) EP0601520A1 (fi)
KR (1) KR940014390A (fi)
CN (1) CN1094409A (fi)
FI (1) FI935444A (fi)
NO (1) NO934399L (fi)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548712B2 (en) * 1983-05-23 1986-01-02 Taiho Pharmaceutical Co., Ltd. 2:-deoxy-5-substituted uridine derivatives
JP2522926B2 (ja) * 1987-01-20 1996-08-07 大鵬薬品工業株式会社 ２′−デオキシ−５−トリフルオロメチルウリジン誘導体の製造方法
JP2631223B2 (ja) * 1988-04-12 1997-07-16 大鵬薬品工業株式会社 ５−置換−２´−デオキシウリジン類
KR950004900B1 (ko) * 1991-06-07 1995-05-15 미쯔이 도오아쯔 가가쿠 가부시기가이샤 트리플루오로티미딘 유도체, 그 제조 방법 및 그것을 유효 성분으로 하는 제암제

Also Published As

Publication number Publication date
EP0601520A1 (en) 1994-06-15
NO934399L (no) 1994-06-08
KR940014390A (ko) 1994-07-18
FI935444A (fi) 1994-06-08
NO934399D0 (no) 1993-12-03
CN1094409A (zh) 1994-11-02

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Legal Events

Date Code Title Description
FD Application lapsed