FI913142A0 - Migraenfoerhindrande alkoxipyrimidinderivat. - Google Patents

Migraenfoerhindrande alkoxipyrimidinderivat.

Info

Publication number: FI913142A0
Authority: FI; Finland
Prior art keywords: migraenfoerhindrande; alkoxipyrimidinderivat; indolylalkyl; piperazines; pyrimidinyl
Prior art date: 1990-06-29

Application number

FI913142A

Other languages

English (en)

Other versions

FI101224B1 (fi

FI101224B (fi

FI913142A (fi

Inventor

David W Smith

Frank D Yocca

Joseph P Yevich

Ronald J Mattson

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-29

Filing date

1991-06-27

Publication date

1991-06-27

1991-06-27 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1991-06-27 Publication of FI913142A0 publication Critical patent/FI913142A0/fi

1991-12-30 Publication of FI913142A publication Critical patent/FI913142A/fi

1998-05-15 Application granted granted Critical

1998-05-15 Publication of FI101224B1 publication Critical patent/FI101224B1/fi

1998-05-15 Publication of FI101224B publication Critical patent/FI101224B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Luminescent Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

FI913142A 1990-06-29 1991-06-27 Menetelmä terapeuttisesti käyttökelpoisten alkoksipyrimidiinijohdannai sten valmistamiseksi FI101224B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US54612290A	1990-06-29	1990-06-29
US54612290		1990-06-29
US68020891A	1991-04-04	1991-04-04
US68020891		1991-04-04
SG15595A SG15595G (en)	1990-06-29	1995-01-30	Antimigraine alkoxypyrimidine derivatives
SG15595		1995-01-30

Publications (4)

Publication Number	Publication Date
FI913142A0 true FI913142A0 (fi)	1991-06-27
FI913142A FI913142A (fi)	1991-12-30
FI101224B1 FI101224B1 (fi)	1998-05-15
FI101224B FI101224B (fi)	1998-05-15

Family

ID=27356028

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI913142A FI101224B (fi)	1990-06-29	1991-06-27	Menetelmä terapeuttisesti käyttökelpoisten alkoksipyrimidiinijohdannai sten valmistamiseksi

Country Status (15)

Country	Link
US (1)	US5300506A (fi)
EP (1)	EP0464558B1 (fi)
JP (1)	JPH04230378A (fi)
AT (1)	ATE116312T1 (fi)
AU (1)	AU643038B2 (fi)
CA (1)	CA2043709C (fi)
CY (1)	CY1831A (fi)
DE (1)	DE69106237T2 (fi)
DK (1)	DK0464558T3 (fi)
ES (1)	ES2066278T3 (fi)
FI (1)	FI101224B (fi)
HK (1)	HK51995A (fi)
IE (1)	IE66687B1 (fi)
PT (1)	PT98115B (fi)
SG (1)	SG15595G (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5077293A (en) *	1990-06-29	1991-12-31	Bristol-Myers Squibb Co.	1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
CA2084531A1 (en) *	1991-12-19	1993-06-20	David W. Smith	Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9211277D0 (en)	1992-05-28	1992-07-15	Glaxo Group Inc	Pharmaceutical compositions
GB9226610D0 (en) *	1992-12-21	1993-02-17	Smithkline Beecham Plc	Compounds
US5521188A (en) *	1993-09-16	1996-05-28	Bristol-Myers Squibb Company	Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
CA2130078A1 (en) *	1993-09-16	1995-03-17	Jonas A. Gylys	Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines
US5468768A (en) *	1994-01-06	1995-11-21	Bristol-Myers Squibb Company	Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) *	1994-06-21	1996-10-16	Vita Invest Sa	Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
US5550239A (en) *	1994-11-08	1996-08-27	Bristol-Myers Squibb Company	Process for large-scale production of indolyl alkyl pyrimidinyl piperazine compounds
GB9423682D0 (en) *	1994-11-23	1995-01-11	Merck Sharp & Dohme	Therapeutic agents
GB9501865D0 (en) *	1995-01-31	1995-03-22	Merck Sharp & Dohme	Therapeutic agents
US5618816A (en) *	1995-03-02	1997-04-08	Bristol-Myers Squibb Company	Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
AU6386196A (en) *	1995-06-19	1997-01-15	Eli Lilly And Company	Process for parallel synthesis of a non-peptide library
CA2228286A1 (en) *	1995-08-07	1997-02-20	Merck Sharp & Dohme Limited	Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives
JPH09124643A (ja) *	1995-08-14	1997-05-13	Bristol Myers Squibb Co	抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
AR004229A1 (es) *	1995-11-06	1998-11-04	Wyeth Corp	Derivados indolalquilo de benzodioxanmetilamina y su uso para preparar medicamentos
GB9609374D0 (en) *	1996-05-03	1996-07-10	Merck Sharp & Dohme	Therapeutic agents
US7189753B1 (en)	1997-11-06	2007-03-13	Cady Roger K	Preemptive prophylaxis of migraine
FR2799463B1 (fr) *	1999-10-12	2004-04-16	Adir	Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
WO2002079153A1 (en) *	2001-03-28	2002-10-10	Biocatalytics, Inc.	Method for producing tryptamine derivatives
US6800637B2 (en)	2002-09-12	2004-10-05	Wyeth	Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
EP1632491A1 (en) *	2004-08-30	2006-03-08	Laboratorios Del Dr. Esteve, S.A.	Substituted indole compounds and their use as 5-HT6 receptor modulators
JP2009515834A (ja) *	2006-08-29	2009-04-16	テバファーマシューティカルインダストリーズリミティド	５−フェニル−１−トリチル−１ｈ−テトラゾールの合成のための方法
EP2036888A1 (en) *	2007-09-17	2009-03-18	Laboratorios del Dr. Esteve S.A.	Naphthyl-substituted sulfonamides
EA201001425A1 (ru) *	2008-03-14	2011-06-30	Мерк Патент Гмбх	Азаиндольные соединения для лечения заболеваний центральной нервной системы
US20090281114A1 (en) *	2008-05-08	2009-11-12	Fabre-Kramer Pharmaceuticals, Inc.	Indolylalkyl derivatives of pyrimidinylpiperazine and metabolites thereof for treatment of anxiety, depression, and sexual dysfunction
US9598401B2 (en)	2013-07-29	2017-03-21	Sunshine Lake Pharma Co., Ltd.	Substituted heteroaryl compounds and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (fi) *	1959-09-25	1900-01-01
GB1189064A (en) *	1967-05-01	1970-04-22	Sterling Drug Inc	Indole Derivatives
NL7103002A (fi) *	1970-03-06	1971-09-08
IT1170387B (it) *	1982-06-07	1987-06-03	Glaxo Group Ltd	Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
GB2162522B (en) *	1984-08-01	1988-02-24	Glaxo Group Ltd	An indole derivative
GB8601959D0 (en) *	1986-01-28	1986-03-05	Glaxo Group Ltd	Indole derivatives
US4954502A (en) *	1988-06-10	1990-09-04	Bristol-Myers Squibb Company	1-indolyalkyl-4-(substituted-pyridinyl)piperazines
FR2635104B1 (fr) *	1988-08-03	1992-04-30	Synthelabo	Derives d'indolone, leur preparation et leur application en therapeutique
US5077293A (en) *	1990-06-29	1991-12-31	Bristol-Myers Squibb Co.	1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines

1991
- 1991-05-31 CA CA002043709A patent/CA2043709C/en not_active Expired - Fee Related
- 1991-06-24 EP EP91110376A patent/EP0464558B1/en not_active Expired - Lifetime
- 1991-06-24 DK DK91110376.0T patent/DK0464558T3/da active
- 1991-06-24 ES ES91110376T patent/ES2066278T3/es not_active Expired - Lifetime
- 1991-06-24 AT AT91110376T patent/ATE116312T1/de not_active IP Right Cessation
- 1991-06-24 DE DE69106237T patent/DE69106237T2/de not_active Expired - Fee Related
- 1991-06-27 FI FI913142A patent/FI101224B/fi active
- 1991-06-27 PT PT98115A patent/PT98115B/pt not_active IP Right Cessation
- 1991-06-27 AU AU79416/91A patent/AU643038B2/en not_active Ceased
- 1991-06-28 JP JP3183911A patent/JPH04230378A/ja active Pending
- 1991-06-28 IE IE228091A patent/IE66687B1/en not_active IP Right Cessation
1992
- 1992-10-13 US US07/960,063 patent/US5300506A/en not_active Expired - Lifetime
1995
- 1995-01-30 SG SG15595A patent/SG15595G/en unknown
- 1995-04-06 HK HK51995A patent/HK51995A/xx not_active IP Right Cessation
- 1995-12-01 CY CY183195A patent/CY1831A/xx unknown

Also Published As

Publication number	Publication date
PT98115A (pt)	1992-03-31
CY1831A (en)	1995-12-01
EP0464558B1 (en)	1994-12-28
ES2066278T3 (es)	1995-03-01
ATE116312T1 (de)	1995-01-15
FI101224B1 (fi)	1998-05-15
IE66687B1 (en)	1996-01-24
US5300506A (en)	1994-04-05
DK0464558T3 (da)	1995-03-13
DE69106237T2 (de)	1995-05-11
PT98115B (pt)	1998-12-31
FI101224B (fi)	1998-05-15
AU7941691A (en)	1992-01-02
HK51995A (en)	1995-04-13
SG15595G (en)	1995-06-16
CA2043709C (en)	2002-01-22
CA2043709A1 (en)	1991-12-30
EP0464558A1 (en)	1992-01-08
DE69106237D1 (de)	1995-02-09
AU643038B2 (en)	1993-11-04
JPH04230378A (ja)	1992-08-19
FI913142A (fi)	1991-12-30
IE912280A1 (en)	1992-01-01

Publication	Publication Date	Title
FI913142A (fi)	1991-12-30	Migraenfoerhindrande alkoxipyrimidinderivat.
MY103352A (en)	1993-06-30	Piperazinyl-heterocyclic compounds
DE69433802D1 (de)	2004-06-24	Therapeutisch wirksame linksdrehende und rechtsdrehende 1-((4-Chlorphenyl)phenylmethyl) Piperazine
DK0646115T3 (da)	2003-04-22	Heterocykliske/cykliske aminderivater
NO930615D0 (no)	1993-02-22	Hypoglykemiske hydroksyurinstoffderivater
DE69623899D1 (de)	2002-10-31	Behandlung von Tinnitus mit neuroprotektiven Wirkstoffen
EP0276543A3 (en)	1989-08-30	Use of buspirone for the improvement of short term memory
FI911980A (fi)	1991-10-25	N-(3-fluor-2-fosfonylmetoxipropyl) -derivat av heterocykliska purin- och pyrimidinbaser, deras framstaellning och anvaendning.
FI950909A (fi)	1995-09-02	Rasvahappojohdannaisia
ATE133663T1 (de)	1996-02-15	Antiglancoma-zusammensetzungen enthaltend 3- arylcarbonyl-1-aminoalkyl-1h-indol
DE59107445D1 (de)	1996-04-04	Kombination von Arbeitsgerät und höhenverstellbare Versorgungseinheit
ATE116316T1 (de)	1995-01-15	Antipsychotische 4-(1,2- benzisoazolyl)piperidinderivate.
FI935780A (fi)	1994-06-23	HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
MY103210A (en)	1993-05-29	Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds.
DK0492841T3 (da)	1995-09-18	Anti-herpes-castanosperminestere
HK1005016A1 (en)	1998-12-18	Use of buspirone in sleep apneas
NO971261L (no)	1997-05-05	Kinoksalin-derivater nyttige innen terapi
ATE70181T1 (de)	1991-12-15	Verwendung von oxochinazolinderivaten bei der behandlung von hyperurikaemie.
DK0661058T3 (da)	2004-04-05	Anvendelse af bradykininantagonister til behandling af virussygdomme
ITMI911483A1 (it)	1992-11-30	Procedimento e macchina per la lavorazione del binario
DE69107214D1 (de)	1995-03-16	Laser und verstärker.
BR7000829U (pt)	1991-11-19	Cadeira enfileiravel e empilhavel