Nothing Special   »   [go: up one dir, main page]

FI911152A0 - Amplifikationsfoerfaranden av nukleinsyrasekvens. - Google Patents

Amplifikationsfoerfaranden av nukleinsyrasekvens.

Info

Publication number
FI911152A0
FI911152A0 FI911152A FI911152A FI911152A0 FI 911152 A0 FI911152 A0 FI 911152A0 FI 911152 A FI911152 A FI 911152A FI 911152 A FI911152 A FI 911152A FI 911152 A0 FI911152 A0 FI 911152A0
Authority
FI
Finland
Prior art keywords
nucleic acid
copies
disclosed
methods
sequence
Prior art date
Application number
FI911152A
Other languages
English (en)
Inventor
Daniel Louis Kacian
Timothy J Fultz
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of FI911152A0 publication Critical patent/FI911152A0/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/706Specific hybridization probes for hepatitis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
FI911152A 1989-07-11 1991-03-07 Amplifikationsfoerfaranden av nukleinsyrasekvens. FI911152A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37950189A 1989-07-11 1989-07-11
PCT/US1990/003907 WO1991001384A1 (en) 1989-07-11 1990-07-10 Nucleic acid sequence amplification methods utilizing a transcription complex

Publications (1)

Publication Number Publication Date
FI911152A0 true FI911152A0 (fi) 1991-03-07

Family

ID=23497522

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911152A FI911152A0 (fi) 1989-07-11 1991-03-07 Amplifikationsfoerfaranden av nukleinsyrasekvens.

Country Status (15)

Country Link
US (1) US5480784A (fi)
EP (3) EP0731174B1 (fi)
JP (4) JP3241717B2 (fi)
KR (1) KR100242252B1 (fi)
AT (2) ATE141956T1 (fi)
AU (2) AU650622B2 (fi)
DE (2) DE69028257T2 (fi)
DK (1) DK0408295T3 (fi)
ES (1) ES2091225T3 (fi)
FI (1) FI911152A0 (fi)
GR (1) GR3021704T3 (fi)
IE (1) IE902539A1 (fi)
NO (1) NO910902D0 (fi)
PT (1) PT94662A (fi)
WO (1) WO1991001384A1 (fi)

Families Citing this family (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817797A (en) * 1988-06-01 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services Sequencing DNA; a modification of the polymerase chain reaction
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US5780219A (en) * 1989-07-11 1998-07-14 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to human hepatitis B virus
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
ZA918965B (en) * 1990-11-13 1992-08-26 Siska Diagnostics Inc Nucleic acid amplification by two-enzyme,self-sustained sequence replication
AU9165091A (en) 1990-12-31 1992-08-17 Promega Corporation Nucleic acid amplification with dna-dependent rna polymerase activity of rna replicases
DE4106473C2 (de) * 1991-03-01 1994-03-10 Boehringer Mannheim Gmbh Verfahren zur Herstellung in vitro replizierbarer Nukleinsäuren
WO1993005184A1 (en) * 1991-09-10 1993-03-18 Love Jack D Dna/rna target and signal amplification
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US6100099A (en) 1994-09-06 2000-08-08 Abbott Laboratories Test strip having a diagonal array of capture spots
US6093538A (en) * 1992-05-06 2000-07-25 Gen-Probe Incorporated Nucleic acid probes to ureaplasma
WO1993022461A1 (en) * 1992-05-06 1993-11-11 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
JPH07506254A (ja) * 1992-05-06 1995-07-13 ジェン−プローブ・インコーポレイテッド ヒトb型肝炎ウイルスに対する核酸増幅オリゴヌクレオチドおよびプローブ
CA2137563C (en) * 1992-06-08 2005-06-28 Thomas B. Ryder Preparation of nucleic acid from mononuclear cells
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
JP4372837B2 (ja) * 1992-08-04 2009-11-25 ジェン−プローブ・インコーポレイテッド 核酸配列増幅
DE4238699A1 (de) * 1992-11-17 1994-05-19 Boehringer Mannheim Gmbh Einfaches Nukleinsäurevermehrungsverfahren
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
CA2159103C (en) * 1993-03-26 2002-03-12 Sherrol H. Mcdonough Detection of human immunodeficiency virus type 1
AU689789B2 (en) * 1993-07-23 1998-04-09 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
FR2708288B1 (fr) 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
US5459037A (en) * 1993-11-12 1995-10-17 The Scripps Research Institute Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations
DE69431240T2 (de) * 1993-12-01 2003-04-17 Toyo Boseki K.K., Osaka Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme
KR100230718B1 (ko) * 1994-03-16 1999-11-15 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 등온 가닥 변위 핵산 증폭법
ATE209258T1 (de) * 1994-07-15 2001-12-15 Akzo Nobel Nv Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
EP0709466B1 (en) * 1994-10-28 2006-09-27 Gen-Probe Incorporated Compositions and methods for the simultaneous detection and quantification of multiple specific nucleic acid sequences
DE4441602A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verbessertes Transkriptionsverfahren
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
EP0914462A4 (en) * 1996-03-18 2002-05-22 Molecular Biology Resources Amplification of target nucleic acid sequences
CA2255624C (en) 1996-05-22 2007-09-04 Gen-Probe Incorporated Compositions and methods for the detection of mycobacterium kansasii
US6489097B2 (en) 1996-06-28 2002-12-03 Chugai Seiyaku Kabushiki Kaisha Method for the detection of telomerase activity
JPH1028585A (ja) * 1996-07-16 1998-02-03 Toyobo Co Ltd 耐熱性リボヌクレアーゼhを用いる核酸増幅法
JP4211948B2 (ja) 1996-08-02 2009-01-21 ベーイーオー・メリュー 標的核酸配列の増幅方法
AU735416B2 (en) * 1996-11-06 2001-07-05 Sequenom, Inc. Dna diagnostics based on mass spectrometry
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
US6849400B1 (en) 1997-07-23 2005-02-01 Gen-Probe Incorporated Methods for detecting and measuring spliced nucleic acids
WO1999005161A1 (en) 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
AU736503B2 (en) 1997-08-08 2001-07-26 Biomerieux Nucleic acid sequences that can be used as primers and probes in the amplification and detection of all subtypes of HIV-1
JP2002505071A (ja) 1997-11-04 2002-02-19 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
JP3736617B2 (ja) * 1997-12-12 2006-01-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞型の決定方法
US20040002079A1 (en) * 1998-02-11 2004-01-01 Gunn Robert B. Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness
AU748847B2 (en) 1998-02-27 2002-06-13 Pamgene B.V. Method for the non-specific amplification of nucleic acid
EP1614475B1 (en) 1998-05-01 2007-05-30 Gen-Probe Incorporated Device for agitating the fluid contents of a container
JP2002521037A (ja) * 1998-07-23 2002-07-16 ジェン−プローブ・インコーポレーテッド スプライシングされた核酸を検出および測定する方法
AU759915B2 (en) * 1998-07-31 2003-05-01 Gen-Probe Incorporated Reversible inhibiting probes
US20030049657A1 (en) * 1998-11-13 2003-03-13 Cherry Joshua L. Use of primers containing non-replicatable residues for improved cycle-sequencing of nucleic acids
EP1238100B1 (en) * 1999-07-23 2005-09-07 Gen-Probe Incorporated Polynucleotide amplification method
GB9917816D0 (en) * 1999-07-29 1999-09-29 Cytocell Ltd Chemically modified probes used to regulate nucleic acid amplification assays
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
DK1431303T3 (en) 1999-09-13 2014-02-17 Nugen Technologies Inc A composition for isothermal linear amplification of polynucleotide sequences
US6582938B1 (en) 2001-05-11 2003-06-24 Affymetrix, Inc. Amplification of nucleic acids
AU2001254670A1 (en) * 2000-03-02 2001-09-12 Akzo Nobel N.V. Detection of hepatitis b virus rna
CA2405450C (en) 2000-03-31 2011-08-16 Merck & Co., Inc. Dermacentor variabilis gaba-gated chloride channels
US6534292B1 (en) * 2000-05-08 2003-03-18 Genencor International, Inc. Methods for forming recombined nucleic acids
DE60141087D1 (de) 2000-06-26 2010-03-04 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
DE60045932D1 (de) 2000-09-01 2011-06-16 Gen Probe Inc HIV-1-Sequenzverstärkung zur Erkennung von Sequenzen in Zusammenhang mit Wirkstoffresistenz-Mutationen
CA2423729A1 (en) 2000-10-06 2002-04-11 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
ATE475720T1 (de) 2000-12-13 2010-08-15 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US6770752B2 (en) 2001-01-09 2004-08-03 Becton, Dickinson And Company Sequences for detection of HIV-1
KR20030088035A (ko) * 2001-03-07 2003-11-15 바이오메리욱스 비.브이. 전사 기초한 증폭을 이용하는 dna의 증폭 및 검출 방법
US6946251B2 (en) * 2001-03-09 2005-09-20 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences using RNA-DNA composite primers
CA2439074A1 (en) * 2001-03-09 2002-09-19 Nugen Technologies, Inc. Methods and compositions for amplification of rna sequences
WO2002097394A2 (en) * 2001-05-31 2002-12-05 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
US7074558B2 (en) * 2001-06-07 2006-07-11 Pbi Technology, Inc. Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products
TWI335938B (en) * 2001-08-15 2011-01-11 Rna replication and amplification
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
WO2003048308A2 (en) 2001-11-30 2003-06-12 Applera Corporation Thermus brockianus nucleic acid polymerases
JP2005511043A (ja) 2001-11-30 2005-04-28 アプレラ コーポレイション Thermusthermophilus核酸ポリメラーゼ
KR100446621B1 (ko) * 2001-12-18 2004-09-07 삼성전자주식회사 다중 중합효소 연쇄반응에 의한 mody3유전자의 증폭을 위한 프라이머 세트
AU2003208959A1 (en) * 2002-01-30 2003-09-02 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
DE60323067D1 (de) * 2002-03-11 2008-10-02 Nugen Technologies Inc Verfahren zur erzeugung doppelsträngiger dna mit einem 3'-einzelstranganteil und verwendungen dieser komplexe zur rekombination
CA2477670A1 (en) * 2002-03-15 2003-09-25 Arcturus Bioscience, Inc. Improved nucleic acid amplification
EP1573056A4 (en) * 2002-05-17 2007-11-28 Nugen Technologies Inc METHODS FOR FRAGMENTATION, LABELING AND IMMOBILIZATION OF NUCLEIC ACIDS
EP1513958B1 (en) * 2002-06-14 2011-08-10 Gen-Probe Incorporated Compositions for detecting hepatitis b virus
US7074561B2 (en) 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
US6852494B2 (en) * 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
EP1613778B1 (en) 2003-04-14 2014-11-26 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
US7381811B2 (en) 2003-05-19 2008-06-03 Gen-Probe Incorporated Compositions and methods for detecting Trichomonas vaginalis in a sample
US20050176125A1 (en) * 2003-12-23 2005-08-11 Rosetta Inpharmatics Llc Alternatively spliced isoform of CDC25A phosphatase and methods of use
CA2552007A1 (en) 2003-12-29 2005-07-21 Nugen Technologies, Inc. Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
JP5009787B2 (ja) 2004-05-07 2012-08-22 ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド Erg遺伝子を単独でまたは前立腺癌中で過剰発現もしくは過少発現される他の遺伝子と組み合わせて用いる、前立腺癌を診断または治療する方法
US20050266469A1 (en) * 2004-05-25 2005-12-01 Raymond Christopher K Alternatively spliced isoforms of checkpoint kinase 1 (CHK1)
EP1758981A4 (en) 2004-05-28 2013-01-16 Wafergen Inc DEVICES AND METHOD FOR MULTIPLEX ANALYZES
US7150969B2 (en) * 2004-06-04 2006-12-19 Rosetta Inpharmatics Llc Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
US20050277121A1 (en) 2004-06-11 2005-12-15 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
JP4658660B2 (ja) 2005-03-30 2011-03-23 株式会社日立ハイテクノロジーズ 核酸検出法
US8124335B2 (en) 2005-05-06 2012-02-28 Gen-Probe Incorporated Compositions and assays to detect influenza virus A and B nucleic acids
NZ603604A (en) 2005-05-09 2014-02-28 Theranos Inc Point-of-care fluidic systems and uses thereof
CN101175852B (zh) 2005-05-13 2013-02-13 和光纯药工业株式会社 堪萨斯分枝杆菌检测用的引物和探针、以及使用它们检测堪萨斯分枝杆菌的方法
US7550264B2 (en) 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
EP2612870A1 (en) 2005-09-12 2013-07-10 The Regents of the University of Michigan Recurrent gene fusions in prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US20100035331A1 (en) 2006-02-15 2010-02-11 Tosoh Corporation Method for extracting of nucleic acid from biological material
ATE553220T1 (de) 2006-03-13 2012-04-15 Wako Pure Chem Ind Ltd Verfahren zur erkennung eines mutierten gens
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
EP2011871A4 (en) 2006-05-02 2010-01-27 Wako Pure Chem Ind Ltd PRIMER AND PROBE FOR THE DETECTION OF MYCOBACTERIUM INTRACELLULARE AND METHOD FOR THE DETECTION OF MYCOBACTERIUM INTRACELLULARE USING THE PRIMER AND THE PROBE
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
ES2358296T3 (es) 2006-06-06 2011-05-09 Gen-Probe Incorporated Oligonucleótidos marcados y uso de los mismos en métodos de amplificación de ácidos nucleicos.
EP2038429B1 (en) * 2006-06-30 2013-08-21 Nugen Technologies, Inc. Methods for fragmentation and labeling of nucleic acids
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US8048626B2 (en) 2006-07-28 2011-11-01 California Institute Of Technology Multiplex Q-PCR arrays
WO2008021290A2 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP1921156A1 (en) * 2006-11-10 2008-05-14 bioMerieux B.V. Improved multiplex nucleic acid amplification using blocked primers
EP2479273A3 (en) 2006-12-18 2012-10-10 Wako Pure Chemical Industries, Ltd. Primer and probe for detection of mycobacterium avium and method for detection of mycobacterium avium using the same
WO2008080029A2 (en) 2006-12-21 2008-07-03 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
CN101605911A (zh) * 2007-01-17 2009-12-16 梅里第安生物科学公司 有效用于核酸的环-介导的等温扩增(lamp)的稳定试剂和试剂盒
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
JP4340298B2 (ja) 2007-03-01 2009-10-07 株式会社日立ハイテクノロジーズ 核酸回収方法及び核酸回収装置
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
JP2009000044A (ja) 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
JP2009000063A (ja) 2007-06-22 2009-01-08 Tosoh Corp 改良されたノロウイルスrna検出方法
WO2009009432A2 (en) 2007-07-06 2009-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
JP5433572B2 (ja) 2007-07-06 2014-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Mipol1−etv1遺伝子再編成
EP3756767B1 (en) 2007-10-02 2024-05-01 Labrador Diagnostics LLC Modular point-of-care devices and uses thereof
EP2202305A4 (en) 2007-10-04 2011-01-19 Tosoh Corp PRIMER FOR RRNA AMPLIFICATION OF A BACTERIUM OF THE GENUS LEGIONELLA, PROOF PROCEDURE AND DETECTION KIT
JP5299986B2 (ja) * 2007-11-01 2013-09-25 国立大学法人山口大学 核酸の定量方法
EP3434785A1 (en) 2007-12-21 2019-01-30 bioMerieux SA Detection of methicillin-resistant staphylococcus aureus
EP2546344A3 (en) 2008-02-08 2013-04-03 Wako Pure Chemical Industries, Ltd. Primer and probe for detecting chlamydophilia caviae, as well as chlamydophilia caviae detection method using the same
US20090203531A1 (en) * 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
CA2719247C (en) * 2008-03-25 2017-03-21 The Regents Of The University Of Michigan Ikki inhibitor therapies and screening methods, and related ikki diagnostics
AU2009246363B2 (en) 2008-05-13 2013-10-24 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
EP2291553A4 (en) 2008-05-28 2011-12-14 Genomedx Biosciences Inc SYSTEMS AND METHODS FOR THE EXPRESSION-BASED DISTINCTION OF DIFFERENT CLINICAL ILLICIT STADIAS IN PROSTATE CANCER
ES2650066T3 (es) 2008-05-28 2018-01-16 Wako Pure Chemical Industries, Ltd. Cebador y sonda para la detección de Mycobacterium intracellulare, y método para la detección de Mycobacterium intracellulare empleando el cebador o la sonda
EP2297358A2 (en) 2008-05-30 2011-03-23 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
EP2326957B1 (en) * 2008-09-03 2013-06-12 Abbott Molecular Inc. Assays and kits for determining hiv-1 tropism
EP2331703A2 (en) * 2008-09-12 2011-06-15 Promega Corporation Assessing expression of endogenous and exogenous genes
JP5428272B2 (ja) 2008-10-06 2014-02-26 東ソー株式会社 サバイビンmRNAの測定方法
WO2010078374A1 (en) 2008-12-30 2010-07-08 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
AU2010203517B2 (en) 2009-01-09 2012-08-16 The Regents Of The University Of Michigan Recurrent gene fusions in cancer
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
AU2010264468B2 (en) 2009-06-23 2015-01-22 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from Mollicutes
US8512955B2 (en) 2009-07-01 2013-08-20 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
US8999675B2 (en) 2009-08-31 2015-04-07 Gen-Probe Incorporated Dengue virus assay
JP5800817B2 (ja) 2009-09-17 2015-10-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌における再発性遺伝子融合
ES2533536T3 (es) 2009-11-19 2015-04-10 Solis Biodyne Oü Composiciones para aumentar la estabilidad y actividad de polipéptidos, y métodos relacionados
CA2896129C (en) 2010-01-22 2015-12-29 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
US9458513B2 (en) 2010-03-23 2016-10-04 Wako Pure Chemical Industries, Ltd. Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same
EP3587593B1 (en) 2010-04-21 2023-09-27 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acids
CN103118692A (zh) 2010-04-26 2013-05-22 Atyr医药公司 与半胱氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
AU2011248614B2 (en) 2010-04-27 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases
AU2011248489B2 (en) 2010-04-28 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases
WO2011139854A2 (en) 2010-04-29 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
EP2563383B1 (en) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
JP6008840B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ, インコーポレイテッド フェニルアラニルαtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8981045B2 (en) 2010-05-03 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
AU2011248355B2 (en) 2010-05-03 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ, インコーポレイテッド p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8945541B2 (en) 2010-05-14 2015-02-03 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011153277A2 (en) 2010-06-01 2011-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
EP2588629B1 (en) 2010-06-30 2017-05-17 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
CN103109187B (zh) 2010-07-07 2015-03-25 密执安大学评议会 乳腺癌的诊断和治疗
WO2012021247A2 (en) 2010-07-12 2012-02-16 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases
WO2012009373A2 (en) 2010-07-12 2012-01-19 Gen-Probe Incorporated Compositions and assays to detect swine h1n1 influenza a virus, seasonal h1 influenza a virus and seasonal h3 influenza a virus nucleic acids
BR112013001647A2 (pt) 2010-07-23 2016-05-24 Beckman Coulter Inc sistema e método contendo unidades analíticas
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
EP3438289A1 (en) 2010-10-04 2019-02-06 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
CA2818486C (en) 2010-11-19 2018-09-11 The Regents Of The University Of Michigan Ncrna and uses thereof
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
KR101909764B1 (ko) 2011-01-21 2018-12-10 테라노스, 인코포레이티드 샘플 사용 최대화를 위한 시스템 및 방법
WO2012112558A1 (en) 2011-02-14 2012-08-23 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
EP3272886B1 (en) 2011-04-25 2019-09-25 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
EA027558B1 (ru) 2011-05-19 2017-08-31 Эйджена Байосайенс, Инк. Способ обнаружения мультиплексных нуклеиновых кислот
EP3620533B1 (en) 2011-09-06 2023-01-18 Gen-Probe Incorporated Closed nucleic acid structures
EP2753714B1 (en) 2011-09-06 2017-04-12 Gen-Probe Incorporated Circularized templates for sequencing
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
TWI624543B (zh) 2011-09-25 2018-05-21 賽瑞諾斯有限公司 用於多重分析的系統和方法
FR2981088B1 (fr) 2011-10-06 2013-11-29 Biomerieux Sa Arn polymerases mutees
SG11201401628WA (en) 2011-10-19 2014-05-29 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
WO2013067413A1 (en) 2011-11-04 2013-05-10 Gen-Probe Incorporated Molecular assay reagents and methods
JP2014533100A (ja) 2011-11-04 2014-12-11 オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf 結腸直腸癌の分析のための方法およびバイオマーカー
WO2013070748A1 (en) 2011-11-07 2013-05-16 Beckman Coulter, Inc. Magnetic damping for specimen transport system
EP2776844B1 (en) 2011-11-07 2020-09-30 Beckman Coulter, Inc. Specimen container detection
JP6190380B2 (ja) 2011-11-07 2017-08-30 ベックマン コールター, インコーポレイテッド 等分機システムおよびワークフロー
JP6165755B2 (ja) 2011-11-07 2017-07-19 ベックマン コールター, インコーポレイテッド ロボットアーム
BR112014010955A2 (pt) 2011-11-07 2017-06-06 Beckman Coulter Inc sistema e método para processar amostras
CN104105969B (zh) 2011-11-07 2016-10-12 贝克曼考尔特公司 离心机系统和工作流程
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
WO2013096460A1 (en) 2011-12-20 2013-06-27 The Regents Of The University Of Michigan Pseudogenes and uses thereof
WO2013096799A1 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
WO2013096838A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
CA2858284A1 (en) 2011-12-23 2013-06-27 Biomerieux Detection of meca variant strains of methicillin-resistant staphylococcus aureus
WO2013101935A1 (en) 2011-12-27 2013-07-04 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
JP2015503923A (ja) 2012-01-09 2015-02-05 オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf 結腸直腸癌の解析のための方法およびバイオマーカー
CN104093890B (zh) 2012-01-26 2016-04-20 纽亘技术公司 用于靶向核酸序列富集和高效文库产生的组合物和方法
AU2013221317B2 (en) 2012-02-16 2017-07-06 Pangu Biopharma Limited Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases
US9506117B2 (en) 2012-02-21 2016-11-29 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
AU2013229151A1 (en) 2012-03-06 2014-09-25 Aarhus University Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
US9732387B2 (en) 2012-04-03 2017-08-15 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and Crohn's disease
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
CA2877094A1 (en) 2012-06-18 2013-12-27 Nugen Technologies, Inc. Compositions and methods for negative selection of non-desired nucleic acid sequences
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
EP4219765B1 (en) 2012-08-16 2024-12-18 Veracyte SD, Inc. Prostate cancer prognosis using biomarkers
KR20150055002A (ko) 2012-09-11 2015-05-20 테라노스, 인코포레이티드 생물학적 서명을 이용한 정보 관리 시스템 및 방법
JP6242336B2 (ja) 2012-09-28 2017-12-06 株式会社Bna Bnaクランプ法
EP2904120B1 (en) 2012-10-04 2018-01-10 The Board of Trustees of The Leland Stanford Junior University Methods and reagents for detection, quantitation, and serotyping of dengue viruses
EP2909341A2 (en) 2012-10-18 2015-08-26 Oslo Universitetssykehus HF Biomarkers for cervical cancer
CA2892822C (en) 2012-11-27 2023-08-08 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
AU2014216060A1 (en) 2013-02-18 2015-08-20 Theranos Ip Company, Llc Systems and methods for collecting and transmitting assay results
CN105378108A (zh) 2013-03-13 2016-03-02 雅培分子公司 用于分离核酸的系统和方法
US9701999B2 (en) 2013-03-14 2017-07-11 Abbott Molecular, Inc. Multiplex methylation-specific amplification systems and methods
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CA2905429A1 (en) 2013-03-14 2014-10-02 Abbott Molecular Inc. Minimizing errors using uracil-dna-n-glycosylase
WO2014151511A2 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
WO2014150910A1 (en) 2013-03-15 2014-09-25 Ibis Biosciences, Inc. Dna sequences to assess contamination in dna sequencing
US9340817B2 (en) 2013-03-27 2016-05-17 Sample6 Technologies, Inc. Methods of making recombinant phage, compositions and articles of manufacture of same for bacterial detection
EP3457138A3 (en) 2013-04-30 2019-06-19 Université de Montréal Novel biomarkers for acute myeloid leukemia
EP2991647B1 (en) 2013-05-02 2019-04-24 The Regents Of The University Of Michigan Deuterated amlexanox with improved metabolic stability
AU2014281406A1 (en) 2013-06-19 2016-01-21 Sample6 Technologies, Inc. Phage-based bacterial detection assay
US10392670B2 (en) 2013-07-25 2019-08-27 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ, インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
KR20240025725A (ko) 2013-12-11 2024-02-27 아큐라젠 홀딩스 리미티드 희귀 서열 변이를 검출하기 위한 조성물 및 방법
WO2017062863A1 (en) 2015-10-09 2017-04-13 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
WO2015112949A2 (en) * 2014-01-27 2015-07-30 ArcherDX, Inc. Isothermal methods and related compositions for preparing nucleic acids
US9745614B2 (en) 2014-02-28 2017-08-29 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
WO2015188178A1 (en) 2014-06-06 2015-12-10 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
CN107208091A (zh) 2014-11-11 2017-09-26 雅培分子公司 杂交探针和方法
JP6620160B2 (ja) 2015-02-20 2019-12-11 タカラ バイオ ユーエスエー, インコーポレイテッド 単一細胞の迅速かつ正確な分注、視覚化及び解析のための方法
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
EP3283512A4 (en) 2015-04-17 2018-10-03 Distributed Bio Inc Method for mass humanization of non-human antibodies
CA2983224A1 (en) 2015-04-24 2016-10-27 Agena Bioscience, Inc. Multiplexed method for the identification and quantitation of minor alleles and polymorphisms
CA2983227A1 (en) 2015-04-24 2016-10-27 Agena Bioscience, Inc. Multiplex methods for detection and quantification of minor variants
WO2016172632A2 (en) 2015-04-24 2016-10-27 Atila Biosystems, Inc Amplification with primers of limited nucleotide composition
CN108026593A (zh) * 2015-05-18 2018-05-11 卡琳缪恩股份有限公司 区分hiv-1与慢病毒载体的方法
CA2990000A1 (en) 2015-06-19 2016-12-22 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
CN115927547A (zh) 2015-12-03 2023-04-07 安可济控股有限公司 用于形成连接产物的方法和组合物
EP3407974A4 (en) 2016-01-29 2019-08-28 The Regents Of The University Of Michigan Amlexanox Analogs
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017201102A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
US11460405B2 (en) 2016-07-21 2022-10-04 Takara Bio Usa, Inc. Multi-Z imaging and dispensing with multi-well devices
JP6966052B2 (ja) 2016-08-15 2021-11-10 アキュラーゲン ホールディングス リミテッド 稀な配列変異体を検出するための組成物および方法
AU2017315425B2 (en) 2016-08-24 2023-11-09 The Regents Of The University Of Michigan Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
AU2017328953B2 (en) 2016-09-15 2023-09-14 Archerdx, Llc Methods of nucleic acid sample preparation for analysis of cell-free DNA
CA3037185A1 (en) 2016-09-15 2018-03-22 ArcherDX, Inc. Methods of nucleic acid sample preparation
JP6767833B2 (ja) 2016-09-29 2020-10-14 日本特殊陶業株式会社 加熱装置
CN110736695A (zh) 2016-09-30 2020-01-31 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
WO2018127786A1 (en) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions and methods for determining a treatment course of action
WO2018132916A1 (en) 2017-01-20 2018-07-26 Genomedx Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
CA3055925A1 (en) 2017-03-09 2018-09-13 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
AU2018240553B2 (en) 2017-03-24 2023-03-02 Gen-Probe Incorporated Cover assembly and related methods of use
US11078542B2 (en) 2017-05-12 2021-08-03 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
EP3668996A4 (en) 2017-08-18 2021-04-21 Sera Prognostics, Inc. PREGNANCY CLOCK PROTEIN TO PREDICT THE EXPECTED DATE AND TIME OF BIRTH
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
CN112601823A (zh) 2018-06-12 2021-04-02 安可济控股有限公司 用于形成连接产物的方法和组合物
EP3841223A1 (en) 2018-08-08 2021-06-30 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3937780A4 (en) 2019-03-14 2022-12-07 InSilixa, Inc. METHODS AND SYSTEMS FOR TIME RESOLVED FLUORESCENCE-BASED DETECTION
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
WO2021046270A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
WO2021252574A1 (en) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Nucleic acid biomarkers for placental dysfunction
US20240271186A1 (en) 2021-08-03 2024-08-15 Wageningen Universiteit Argonaute-based nucleic acid detection system
WO2023021330A1 (en) 2021-08-16 2023-02-23 University Of Oslo Compositions and methods for determining a treatment course of action
WO2023140731A1 (en) 2022-01-20 2023-07-27 Wageningen Universiteit Thermostable rna polymerase
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
EP4493716A1 (en) 2022-03-15 2025-01-22 Diagenode S.A. Detection of methylation status of a dna sample

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA559709A (en) * 1958-07-01 International Standard Electric Corporation Travelling wave tubes
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DK171161B1 (da) * 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
US5075211A (en) * 1986-03-26 1991-12-24 Genetic Systems Corporation Synthetic antigen for the detection of AIDS-related disease
CA1338457C (en) * 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
IE72468B1 (en) * 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
WO1990001068A1 (en) * 1988-07-22 1990-02-08 Life Technologies, Inc. Sequence specific assay for the detection of a nucleic acid molecule
AU4829690A (en) * 1988-12-16 1990-07-10 Siska Diagnostics, Inc. Self-sustained, sequence replication system
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences

Also Published As

Publication number Publication date
AU6166390A (en) 1991-02-22
EP0731174A2 (en) 1996-09-11
ATE282716T1 (de) 2004-12-15
EP0731175A3 (en) 2004-05-26
EP0731175A2 (en) 1996-09-11
DE69034177D1 (de) 2004-12-23
IE902539A1 (en) 1991-02-27
EP0731174A3 (en) 1998-03-25
DE69028257D1 (de) 1996-10-02
JP3445131B2 (ja) 2003-09-08
DE69028257T2 (de) 1997-01-09
DE69034177T2 (de) 2005-10-27
JP2000350592A (ja) 2000-12-19
NO910902D0 (no) 1991-03-07
US5480784A (en) 1996-01-02
ES2091225T3 (es) 1996-11-01
DK0408295T3 (da) 1996-09-16
JP3350511B2 (ja) 2002-11-25
ATE141956T1 (de) 1996-09-15
KR920701478A (ko) 1992-08-11
EP0408295B1 (en) 1996-08-28
JPH1146778A (ja) 1999-02-23
EP0408295A3 (en) 1991-08-28
JP2002355099A (ja) 2002-12-10
AU677418B2 (en) 1997-04-24
AU7415694A (en) 1994-11-24
WO1991001384A1 (en) 1991-02-07
EP0408295A2 (en) 1991-01-16
GR3021704T3 (en) 1997-02-28
JPH04500759A (ja) 1992-02-13
JP3241717B2 (ja) 2001-12-25
PT94662A (pt) 1991-03-20
AU650622B2 (en) 1994-06-30
EP0731174B1 (en) 2004-11-17
KR100242252B1 (ko) 2000-03-02

Similar Documents

Publication Publication Date Title
FI911152A0 (fi) Amplifikationsfoerfaranden av nukleinsyrasekvens.
CA2020958A1 (en) Nucleic acid sequence amplification methods
ES2104611T3 (es) Procedimiento de amplificacion mejorado de acidos nucleicos.
TW360712B (en) Nucleic acid sequence amplification method, composition and kit
ATE106948T1 (de) Verfahren zur amplifizierung von nukleinsäuren.
WO1993016094A3 (en) Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
ATE236269T1 (de) Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
CA2141430A1 (en) Nucleic acid sequence amplification
DE69940623D1 (de) Prozess zur Synthetisierung von Nukleinsäure
FI961283A (fi) Tehokkaan nukleiinihapposekvensoinnin menetelmiä ja koostumuksia
ATE87932T1 (de) Alpha-oligonukleotide.
ATE242261T1 (de) Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen
Kacian et al. Kits for nucleic acid sequence amplification methods
DK0463043T3 (da) Fremgangsmåde til stabilisering af hybridiseringen af komplementære polynukleotidsekvenser
DE68925844D1 (de) Verfahren zur Markierung einer Nucleinsäure-Sonde und Reagenzienkit zur Ausführung dieses Verfahrens
JPS57182650A (en) Detection method for gene by oligoliponucleotide
SCHALLER I. DNA-Dependent Processes