FI902333A0 - Menetelmä oksoftalatsinyylietikkahapon ja sen analogien valmistamiseksi - Google Patents

Menetelmä oksoftalatsinyylietikkahapon ja sen analogien valmistamiseksi

Info

Publication number: FI902333A0
Authority: FI; Finland
Prior art keywords: analogues; preparation; oxophthalazinylacetic; acid; oxophthalazinylacetic acid
Prior art date: 1989-05-11

Application number

FI902333A

Other languages

English (en)

Swedish (sv)

Other versions

FI93959C (fi

FI93959B (fi

Inventor

Banavara Lakshmana Mylari

William James Zembrowski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-11

Filing date

1990-05-10

Publication date

1990-05-10

1990-05-10 Application filed by Pfizer filed Critical Pfizer

1990-05-10 Publication of FI902333A0 publication Critical patent/FI902333A0/fi

1995-03-15 Application granted granted Critical

1995-03-15 Publication of FI93959B publication Critical patent/FI93959B/fi

1995-06-26 Publication of FI93959C publication Critical patent/FI93959C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

FI902333A 1989-05-11 1990-05-10 Menetelmä oksoftalatsinyylietikkahapon ja sen analogien valmistamiseksi FI93959C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35099789		1989-05-11
US07/350,997 US4954629A (en)	1989-05-11	1989-05-11	Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Publications (3)

Publication Number	Publication Date
FI902333A0 true FI902333A0 (fi)	1990-05-10
FI93959B FI93959B (fi)	1995-03-15
FI93959C FI93959C (fi)	1995-06-26

Family

ID=23379152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI902333A FI93959C (fi)	1989-05-11	1990-05-10	Menetelmä oksoftalatsinyylietikkahapon ja sen analogien valmistamiseksi

Country Status (30)

Country	Link
US (1)	US4954629A (fi)
EP (1)	EP0397350B1 (fi)
JP (1)	JPH035479A (fi)
KR (1)	KR920006419B1 (fi)
CN (1)	CN1025855C (fi)
AR (1)	AR246968A1 (fi)
AT (1)	ATE103913T1 (fi)
AU (2)	AU618898B2 (fi)
BG (1)	BG50609A3 (fi)
CA (1)	CA2016504C (fi)
CZ (1)	CZ281213B6 (fi)
DD (1)	DD294257A5 (fi)
DE (1)	DE69007846T2 (fi)
DK (1)	DK0397350T3 (fi)
EG (1)	EG19082A (fi)
ES (1)	ES2063265T3 (fi)
FI (1)	FI93959C (fi)
HU (1)	HU212304B (fi)
IE (1)	IE62591B1 (fi)
IL (3)	IL94301A (fi)
MX (2)	MX167455B (fi)
NO (1)	NO177708C (fi)
NZ (1)	NZ233597A (fi)
PH (1)	PH26567A (fi)
PL (1)	PL164427B1 (fi)
PT (1)	PT93985B (fi)
RO (1)	RO107256B1 (fi)
RU (1)	RU2014333C1 (fi)
YU (1)	YU91290A (fi)
ZA (1)	ZA903565B (fi)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4996204A (en) *	1989-05-11	1991-02-26	Pfizer Inc.	Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
IL124236A (en) *	1997-05-05	2003-01-12	Pfizer	Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) *	1998-08-21	2000-07-05	Pfizer Products Inc.	Polymorph of zopolrestat monohydrate
US8916563B2 (en) *	2010-07-16	2014-12-23	The Trustees Of Columbia University In The City Of New York	Aldose reductase inhibitors and uses thereof
JP5934206B2 (ja) *	2010-07-16	2016-06-15	ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク	アルドース還元酵素阻害剤および同使用方法
CN102558184B (zh) *	2011-12-30	2014-07-16	西南大学	酞嗪类衍生物的合成方法
CN102702108A (zh) *	2012-06-27	2012-10-03	上海大学	1,2-二氢酞嗪类化合物及其合成方法
CN102863393A (zh) *	2012-09-26	2013-01-09	上海大学	1,2-二氢酞嗪类化合物及其合成方法
EP3757107B1 (en)	2016-06-21	2023-10-25	The Trustees of Columbia University in the City of New York	4-oxo-3,4-dihydrothieno[3,4-d]pyridazine compounds as aldose reductase inhibitors and methods of use thereof
SI3658142T1 (sl)	2017-07-28	2024-09-30	Applied Therapeutics, Inc.,	Sestavki in postopki za zdravljenje galaktozemije
SG11202110590PA (en)	2019-04-01	2021-10-28	Applied Therapeutics Inc	Inhibitors of aldose reductase
JP2022531466A (ja)	2019-05-07	2022-07-06	ユニバーシティオブマイアミ	遺伝性ニューロパチーおよび関連障害の処置および検出

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3337859A1 (de) *	1983-01-21	1984-07-26	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von benzthiazolen
DE3684410D1 (de) *	1985-11-07	1992-04-23	Pfizer	Heterocyclische oxophthalazinylessigsaeure.
CA1299178C (en) *	1985-11-07	1992-04-21	Banavara Lakshmana Mylari	Heterocyclic oxophtalazinyl acetic acids
JPH0676391B2 (ja) *	1987-06-09	1994-09-28	フアイザー・インコーポレイテツド	ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (en) *	1987-12-21	1990-08-16	Pfizer Inc.	Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) *	1988-01-19	1989-07-27	Pfizer Inc.	1h-indazole-3-acetic acids as aldose reductase inhibitors
US4996204A (en) *	1989-05-11	1991-02-26	Pfizer Inc.	Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

1989
- 1989-05-11 US US07/350,997 patent/US4954629A/en not_active Expired - Lifetime
1990
- 1990-04-25 ES ES90304441T patent/ES2063265T3/es not_active Expired - Lifetime
- 1990-04-25 DK DK90304441.0T patent/DK0397350T3/da active
- 1990-04-25 EP EP90304441A patent/EP0397350B1/en not_active Expired - Lifetime
- 1990-04-25 AT AT90304441T patent/ATE103913T1/de not_active IP Right Cessation
- 1990-04-25 DE DE69007846T patent/DE69007846T2/de not_active Expired - Fee Related
- 1990-05-02 RO RO144965A patent/RO107256B1/ro unknown
- 1990-05-04 IE IE162690A patent/IE62591B1/en not_active IP Right Cessation
- 1990-05-06 IL IL9430190A patent/IL94301A/en not_active IP Right Cessation
- 1990-05-06 IL IL114271A patent/IL114271A/en not_active IP Right Cessation
- 1990-05-08 NZ NZ233597A patent/NZ233597A/en unknown
- 1990-05-08 CZ CS902278A patent/CZ281213B6/cs not_active IP Right Cessation
- 1990-05-09 PT PT93985A patent/PT93985B/pt not_active IP Right Cessation
- 1990-05-09 PL PL90285113A patent/PL164427B1/pl unknown
- 1990-05-10 ZA ZA903565A patent/ZA903565B/xx unknown
- 1990-05-10 YU YU91290A patent/YU91290A/sh unknown
- 1990-05-10 BG BG091982A patent/BG50609A3/xx unknown
- 1990-05-10 DD DD90340590A patent/DD294257A5/de not_active IP Right Cessation
- 1990-05-10 HU HU902995A patent/HU212304B/hu not_active IP Right Cessation
- 1990-05-10 NO NO902071A patent/NO177708C/no not_active IP Right Cessation
- 1990-05-10 KR KR1019900006579A patent/KR920006419B1/ko not_active IP Right Cessation
- 1990-05-10 FI FI902333A patent/FI93959C/fi not_active IP Right Cessation
- 1990-05-10 EG EG27690A patent/EG19082A/xx active
- 1990-05-10 AR AR90316824A patent/AR246968A1/es active
- 1990-05-10 CN CN90102797A patent/CN1025855C/zh not_active Expired - Fee Related
- 1990-05-10 RU SU904743977A patent/RU2014333C1/ru active
- 1990-05-10 AU AU54906/90A patent/AU618898B2/en not_active Ceased
- 1990-05-10 CA CA002016504A patent/CA2016504C/en not_active Expired - Fee Related
- 1990-05-11 JP JP2122862A patent/JPH035479A/ja active Granted
- 1990-05-11 MX MX020672A patent/MX167455B/es unknown
- 1990-05-11 PH PH40512A patent/PH26567A/en unknown
1991
- 1991-10-28 AU AU86806/91A patent/AU626225B2/en not_active Ceased
1992
- 1992-12-31 MX MX9207687A patent/MX9207687A/es not_active IP Right Cessation
1995
- 1995-06-22 IL IL11427195A patent/IL114271A0/xx unknown

Also Published As

Publication number	Publication date
IL94301A0 (en)	1991-03-10
EG19082A (en)	1994-07-30
ES2063265T3 (es)	1995-01-01
NO177708C (no)	1995-11-08
KR900018114A (ko)	1990-12-20
FI93959C (fi)	1995-06-26
HU212304B (en)	1996-05-28
KR920006419B1 (ko)	1992-08-06
CZ227890A3 (en)	1996-04-17
NZ233597A (en)	1992-02-25
ATE103913T1 (de)	1994-04-15
NO902071D0 (no)	1990-05-10
DE69007846T2 (de)	1994-07-28
PT93985A (pt)	1991-01-08
CN1047499A (zh)	1990-12-05
PL164427B1 (pl)	1994-07-29
AR246968A1 (es)	1994-10-31
DK0397350T3 (da)	1994-05-09
EP0397350B1 (en)	1994-04-06
AU618898B2 (en)	1992-01-09
PT93985B (pt)	1996-11-29
IE62591B1 (en)	1995-02-08
HUT54690A (en)	1991-03-28
PL285113A1 (en)	1991-07-15
FI93959B (fi)	1995-03-15
JPH035479A (ja)	1991-01-11
CA2016504A1 (en)	1990-11-11
NO902071L (no)	1990-11-12
BG50609A3 (en)	1992-09-15
AU5490690A (en)	1990-11-15
MX167455B (es)	1993-03-23
IL114271A (en)	1998-04-05
CA2016504C (en)	1999-07-27
IL114271A0 (en)	1995-10-31
PH26567A (en)	1992-08-19
YU91290A (sh)	1992-09-07
EP0397350A1 (en)	1990-11-14
CN1025855C (zh)	1994-09-07
US4954629A (en)	1990-09-04
NO177708B (no)	1995-07-31
MX9207687A (es)	1994-06-30
AU8680691A (en)	1992-01-02
JPH0573753B2 (fi)	1993-10-15
DD294257A5 (de)	1991-09-26
RU2014333C1 (ru)	1994-06-15
HU902995D0 (en)	1990-09-28
DE69007846D1 (de)	1994-05-11
IE901626L (en)	1990-11-11
RO107256B1 (ro)	1993-10-30
AU626225B2 (en)	1992-07-23
ZA903565B (en)	1991-12-24
CZ281213B6 (cs)	1996-07-17
IL94301A (en)	1996-01-19

Publication	Publication Date	Title
PT87754A (pt)	1988-07-01	Process for the preparation of new amino acid derivatives
DE69031814D1 (de)	1998-01-29	Verfahren zur Herstellung von Polyoxyalkylenderivaten
BR8706496A (pt)	1988-07-12	Processo para preparacao de compostos e utilizacao
PT90637A (pt)	1989-11-30	Processo de preparacao de polianidridos
PT84790B (pt)	1989-12-29	Processo de preparacao de derivados de amino-tiazol e de amino-oxazole e de composicoes farmaceuticas contendo-os
FI891074A0 (fi)	1989-03-07	Menetelmä syklisten sulfaattien valmistamiseksi
BR8905349A (pt)	1990-05-22	Processo para a preparacao de uma cicloalcanona e/ou um cicloalcanol
PT87153A (pt)	1988-05-01	Process for the preparation of acid ribofuranuronic derivatives
BR8802843A (pt)	1989-01-03	Processo para a preparacao de alcanotriois e alcanopoliois
FI902333A0 (fi)	1990-05-10	Menetelmä oksoftalatsinyylietikkahapon ja sen analogien valmistamiseksi
FI935791A (fi)	1994-06-26	Menetelmä polyhydroksikarboksyylihapon valmistamiseksi
DE69027569D1 (de)	1996-08-01	Verfahren zur Herstellung von Enynderivaten
FI91961C (fi)	1994-09-12	Menetelmä (S)- -etyyli-2-okso-1-pyrrolidiiniasetamidin valmistamiseksi
FI885692A0 (fi)	1988-12-08	Karboksimetyylisulfoetyyliselluloosa ja menetelmä sen valmistamiseksi
FI880301A (fi)	1988-07-27	Aminomuovihartsi ja menetelmä sen valmistamiseksi
BR8807384A (pt)	1990-03-20	Processo para a preparacao de anidridos oxi-diftalicos
IT8947842A0 (it)	1989-04-12	Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
ZA866809B (en)	1987-04-29	Process for the preparation of optically active alpha-phenoxy-propionic acid and its derivatives
ZA891534B (en)	1989-11-29	Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
FI890477A (fi)	1989-08-06	Menetelmä terapeuttisesti käyttökelpoisen 2,5-diamino-6-fluoriheksaanihapon ja sen suolojen valmistamiseksi
PT86776A (pt)	1988-03-01	Process for the preparation of piperazinecarboxylic acid and pharmaceutical compositions containing it
PT84184A (pt)	1987-02-01	Process for the preparation of 8 alpha-acylaminoergolines and of pharmaceutical compositions containing them
IT8919339A0 (it)	1989-02-07	Procedimento per la preparazione di acido n fosfonometiliminodiacetico e di cloruri di acidi.
BR8905815A (pt)	1990-06-12	Processo para preparacao de cetoximossilanos
IT8621734A0 (it)	1986-09-17	Processo per la preparazione dell'alfa-n-[(ipoxatin-9-il)pentilossicarbonil-]arginina

Legal Events

Date	Code	Title	Description
1995-02-16	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: PFIZER INC.