FI882358A - Cykliska antikoagulationspeptider. - Google Patents

Cykliska antikoagulationspeptider. Download PDF

Info

Publication number: FI882358A
Authority: FI; Finland
Prior art keywords: cyclic; anticoagulationspeptider; chem; formula; relates
Prior art date: 1987-05-21

Application number

FI882358A

Other languages

English (en)

Other versions

FI89063B (fi

FI882358A0 (fi

FI89063C (fi

Inventor

John L Krstenansky

Simon J T Mao

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-21

Filing date

1988-05-19

Publication date

1988-11-22

1988-05-19 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1988-05-19 Publication of FI882358A0 publication Critical patent/FI882358A0/fi

1988-11-22 Publication of FI882358A publication Critical patent/FI882358A/fi

1993-04-30 Publication of FI89063B publication Critical patent/FI89063B/fi

1993-08-10 Application granted granted Critical

1993-08-10 Publication of FI89063C publication Critical patent/FI89063C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Public Health (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)

FI882358A 1987-05-21 1988-05-19 Foerfarande foer framstaellning av peptidderivat av hirudin som hindrar koagulationen i blod FI89063C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5316987A	1987-05-21	1987-05-21
US5316987		1987-05-21

Publications (4)

Publication Number	Publication Date
FI882358A0 FI882358A0 (fi)	1988-05-19
FI882358A true FI882358A (fi)	1988-11-22
FI89063B FI89063B (fi)	1993-04-30
FI89063C FI89063C (fi)	1993-08-10

Family

ID=21982364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI882358A FI89063C (fi)	1987-05-21	1988-05-19	Foerfarande foer framstaellning av peptidderivat av hirudin som hindrar koagulationen i blod

Country Status (17)

Country	Link
EP (1)	EP0291982B1 (fi)
JP (1)	JP2858249B2 (fi)
KR (1)	KR970010926B1 (fi)
CN (1)	CN88103015A (fi)
AT (1)	ATE91490T1 (fi)
AU (1)	AU613627B2 (fi)
CA (1)	CA1340646C (fi)
DE (1)	DE3882279T2 (fi)
DK (1)	DK278488A (fi)
ES (1)	ES2058176T3 (fi)
FI (1)	FI89063C (fi)
HU (1)	HU198513B (fi)
IL (1)	IL86438A (fi)
NO (1)	NO882238L (fi)
NZ (1)	NZ224678A (fi)
PT (1)	PT87536B (fi)
ZA (1)	ZA883443B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5192745A (en) *	1987-05-21	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
US5236898A (en) *	1987-05-21	1993-08-17	Merrell Dow Pharmaceuticals Inc.	Cyclic anticoagulant peptides
NZ228995A (en) *	1988-05-10	1992-03-26	Merrell Dow Pharma	Hirudin peptide derivatives and pharmaceutical compositions
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
ZA907743B (en) *	1989-10-03	1991-07-31	Merrell Dow Pharma	Radiolabeled anticoagulant peptides
US5192747A (en) *	1989-10-03	1993-03-09	Merrell Dow Pharmaceuticals Inc.	Anticoagulant peptides
CA2035917C (en) *	1990-02-13	2001-10-02	John L. Krstenansky	Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
FR2667071A1 (fr) *	1990-09-26	1992-03-27	Adir	Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
SE9103489L (sv) *	1991-11-26	1993-02-22	Flaekt Ab	Saett att reglera stroempulsmatningen till en elektrostatisk stoftavskiljare
GB9303275D0 (en) *	1993-02-18	1993-04-07	Ciba Geigy Ag	Pharmaceutical compositions
JPH08502661A (ja) *	1993-08-04	1996-03-26	チバ−ガイギーアクチェンゲゼルシャフト	高分子量デスルファトヒルジン
US6057314A (en) *	1995-12-21	2000-05-02	Biochem Pharma Inc.	Low molecular weight bicyclic thrombin inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3445532A1 (de) *	1984-12-13	1986-06-19	Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn	Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten

1988
- 1988-05-16 ZA ZA883443A patent/ZA883443B/xx unknown
- 1988-05-16 CA CA000566916A patent/CA1340646C/en not_active Expired - Fee Related
- 1988-05-17 AU AU16342/88A patent/AU613627B2/en not_active Ceased
- 1988-05-18 NZ NZ224678A patent/NZ224678A/xx unknown
- 1988-05-19 KR KR1019880005870A patent/KR970010926B1/ko not_active IP Right Cessation
- 1988-05-19 AT AT88108048T patent/ATE91490T1/de not_active IP Right Cessation
- 1988-05-19 PT PT87536A patent/PT87536B/pt not_active IP Right Cessation
- 1988-05-19 DE DE88108048T patent/DE3882279T2/de not_active Expired - Fee Related
- 1988-05-19 IL IL86438A patent/IL86438A/xx unknown
- 1988-05-19 FI FI882358A patent/FI89063C/fi not_active IP Right Cessation
- 1988-05-19 EP EP88108048A patent/EP0291982B1/en not_active Expired - Lifetime
- 1988-05-19 ES ES88108048T patent/ES2058176T3/es not_active Expired - Lifetime
- 1988-05-20 JP JP63122188A patent/JP2858249B2/ja not_active Expired - Fee Related
- 1988-05-20 HU HU882616A patent/HU198513B/hu not_active IP Right Cessation
- 1988-05-20 DK DK278488A patent/DK278488A/da not_active Application Discontinuation
- 1988-05-20 NO NO882238A patent/NO882238L/no unknown
- 1988-05-21 CN CN198888103015A patent/CN88103015A/zh active Pending

Also Published As

Publication number	Publication date
HUT46933A (en)	1988-12-28
ZA883443B (en)	1988-11-16
FI89063B (fi)	1993-04-30
IL86438A0 (en)	1988-11-15
PT87536B (pt)	1992-09-30
DE3882279D1 (de)	1993-08-19
CN88103015A (zh)	1988-12-21
JP2858249B2 (ja)	1999-02-17
NO882238L (no)	1988-11-22
IL86438A (en)	1992-11-15
ES2058176T3 (es)	1994-11-01
HU198513B (en)	1989-10-30
FI882358A0 (fi)	1988-05-19
EP0291982B1 (en)	1993-07-14
PT87536A (pt)	1989-05-31
NO882238D0 (no)	1988-05-20
DK278488A (da)	1988-11-22
DE3882279T2 (de)	1993-10-28
DK278488D0 (da)	1988-05-20
ATE91490T1 (de)	1993-07-15
KR880013976A (ko)	1988-12-22
CA1340646C (en)	1999-07-13
JPS63303996A (ja)	1988-12-12
AU1634288A (en)	1988-11-24
NZ224678A (en)	1990-08-28
EP0291982A3 (en)	1990-07-11
KR970010926B1 (ko)	1997-07-02
EP0291982A2 (en)	1988-11-23
FI89063C (fi)	1993-08-10
AU613627B2 (en)	1991-08-08

Publication	Publication Date	Title
FI882358A0 (fi)	1988-05-19	Cykliska antikoagulationspeptider.
FI882359A (fi)	1988-11-22	Cykliska antikoagulationspeptider. pi path slues6208 s880524 mlues6205 m881102
DE68916850D1 (de)	1994-08-25	Antikoagulierende Peptid-Alkohole.
FI904852A0 (fi)	1990-10-02	Antikoagulantpeptider.
DK614489D0 (da)	1989-12-06	Peptidderivater

Legal Events

Date	Code	Title	Description
1993-04-01	BB	Publication of examined application
1994-12-13	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: MERRELL DOW PHARMACEUTICALS INC.