Nothing Special   »   [go: up one dir, main page]

FI875202A - Steroider med en spiranring i 17-staellning, foerfarande foer framstaellning av dessa och anvaendning av dessa. - Google Patents

Steroider med en spiranring i 17-staellning, foerfarande foer framstaellning av dessa och anvaendning av dessa. Download PDF

Info

Publication number
FI875202A
FI875202A FI875202A FI875202A FI875202A FI 875202 A FI875202 A FI 875202A FI 875202 A FI875202 A FI 875202A FI 875202 A FI875202 A FI 875202A FI 875202 A FI875202 A FI 875202A
Authority
FI
Finland
Prior art keywords
dessa
steroider
spiranring
staellning
med
Prior art date
Application number
FI875202A
Other languages
English (en)
Other versions
FI875202A0 (fi
FI87078C (fi
FI87078B (fi
Inventor
Francois Nique
Lucien Nedelec
Daniel Philibert
Martine Moguilewsky
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI875202A0 publication Critical patent/FI875202A0/fi
Publication of FI875202A publication Critical patent/FI875202A/fi
Application granted granted Critical
Publication of FI87078B publication Critical patent/FI87078B/fi
Publication of FI87078C publication Critical patent/FI87078C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI875202A 1986-03-26 1987-11-25 Foerfarande foer framstaellning av terapeutiskt anvaendbara steroidderivat och mellanprodukter FI87078C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8604355 1986-03-26
FR8604355A FR2596395B1 (fr) 1986-03-26 1986-03-26 Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
FR8700096 1987-03-26
PCT/FR1987/000096 WO1987005908A1 (fr) 1986-03-26 1987-03-26 Steroides comportant un cycle spirannique en position 17, leur procede de preparation et leur utilisation

Publications (4)

Publication Number Publication Date
FI875202A0 FI875202A0 (fi) 1987-11-25
FI875202A true FI875202A (fi) 1987-11-25
FI87078B FI87078B (fi) 1992-08-14
FI87078C FI87078C (fi) 1992-11-25

Family

ID=9333576

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875202A FI87078C (fi) 1986-03-26 1987-11-25 Foerfarande foer framstaellning av terapeutiskt anvaendbara steroidderivat och mellanprodukter

Country Status (27)

Country Link
US (1) US4900725A (fi)
EP (1) EP0262188B1 (fi)
JP (2) JP2684180B2 (fi)
KR (1) KR880701244A (fi)
CN (1) CN1021445C (fi)
AU (1) AU604692B2 (fi)
CA (1) CA1299169C (fi)
DK (1) DK174211B1 (fi)
ES (1) ES2004268A6 (fi)
FI (1) FI87078C (fi)
FR (1) FR2596395B1 (fi)
GR (1) GR870471B (fi)
HU (1) HU198509B (fi)
IE (1) IE60143B1 (fi)
IL (1) IL82004A0 (fi)
MA (1) MA20918A1 (fi)
MX (1) MX5712A (fi)
NZ (1) NZ219776A (fi)
OA (1) OA08505A (fi)
PH (1) PH25612A (fi)
PT (1) PT84554B (fi)
SU (1) SU1715205A3 (fi)
TN (1) TNSN87042A1 (fi)
TR (1) TR23117A (fi)
WO (1) WO1987005908A1 (fi)
YU (1) YU53387A (fi)
ZA (1) ZA872130B (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0306846A3 (de) * 1987-09-11 1990-05-02 Dr. Karl Thomae GmbH Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
DE3921059A1 (de) * 1989-06-23 1991-01-10 Schering Ag 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel
FR2651233B1 (fr) * 1989-08-23 1991-12-13 Roussel Uclaf Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
FR2757399B1 (fr) * 1996-12-23 1999-12-17 Hoechst Marion Roussel Inc Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
WO1999061055A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
FR2789393B1 (fr) * 1999-02-05 2001-10-12 Centre Nat Rech Scient Lactol steroidique
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
GB0711948D0 (en) * 2007-06-20 2007-08-01 Bionature E A Ltd Neurosteriod compounds
CN104208718B (zh) 2009-02-20 2017-12-29 2-Bbb医疗股份有限公司 基于谷胱甘肽的药物递送系统
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
DE102009034362A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
JP5826750B2 (ja) * 2009-09-11 2015-12-02 バイオネイチャー イー．エイ． リミテッド． 炎症性疾患および自己免疫疾患へのステロイド化合物の使用
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
US9096641B2 (en) * 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509135A (en) * 1968-07-26 1970-04-28 Searle & Co 3-oxygenated 4'-5 - dihydrospiro(estra-4,9-diene-17,2'(3'h)-furans) and congeners
US3764596A (en) * 1971-06-22 1973-10-09 Sandoz Ag 17-dihydrofuranyl-substituted steroids
FR2496669A1 (fr) * 1980-12-23 1982-06-25 Roussel Uclaf Nouveaux derives steroides 3-ceto4 ou1-4 substitues en position 7, leur procede de preparation et leur application comme medicaments
FR2528434B1 (fr) * 1982-06-11 1985-07-19 Roussel Uclaf Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3410880A1 (de) * 1984-03-21 1985-10-03 Schering AG, Berlin und Bergkamen, 1000 Berlin 17-substituierte estradiene und estratriene

Also Published As

Publication number Publication date
HU198509B (en) 1989-10-30
MA20918A1 (fr) 1987-10-01
PH25612A (en) 1991-08-08
DK618287D0 (da) 1987-11-25
AU604692B2 (en) 1991-01-03
AU7167487A (en) 1987-10-20
YU53387A (en) 1988-08-31
KR880701244A (ko) 1988-07-26
CA1299169C (fr) 1992-04-21
FI875202A0 (fi) 1987-11-25
FR2596395A1 (fr) 1987-10-02
EP0262188A1 (fr) 1988-04-06
SU1715205A3 (ru) 1992-02-23
MX5712A (es) 1993-11-01
JPS63502902A (ja) 1988-10-27
IE60143B1 (en) 1994-06-01
JP2652007B2 (ja) 1997-09-10
JP2684180B2 (ja) 1997-12-03
NZ219776A (en) 1990-03-27
FR2596395B1 (fr) 1989-05-26
TR23117A (tr) 1989-04-03
DK174211B1 (da) 2002-09-23
JPH08311094A (ja) 1996-11-26
US4900725A (en) 1990-02-13
DK618287A (da) 1988-01-22
GR870471B (en) 1987-07-30
WO1987005908A1 (fr) 1987-10-08
PT84554B (pt) 1989-11-10
ES2004268A6 (es) 1988-12-16
IL82004A0 (en) 1987-10-20
EP0262188B1 (fr) 1990-11-14
OA08505A (fr) 1988-07-29
ZA872130B (en) 1988-05-25
PT84554A (fr) 1987-04-01
FI87078C (fi) 1992-11-25
CN87103193A (zh) 1988-01-13
HUT46037A (en) 1988-09-28
CN1021445C (zh) 1993-06-30
TNSN87042A1 (fr) 1990-01-01
IE870772L (en) 1987-09-26
FI87078B (fi) 1992-08-14

Similar Documents

Publication Publication Date Title
FI875202A (fi) Steroider med en spiranring i 17-staellning, foerfarande foer framstaellning av dessa och anvaendning av dessa.
ATE102193T1 (de) Thiazolidinedionederivate.
NL300034I2 (nl) Gesubstitueerde thiahzolidinedionderivaten.
IL61834A0 (en) Sulphonamidophenylcarboxylic acids and derivatives thereof,process for the preparation thereof and pharmaceutical compositions containing the same
FI820281L (fi) Foerfarande foer framstaellning av 2-penemkompositioner med forfarandet framstaellda nya 2-penemkompositioner och dessa inehaollande farmaceutiska blandningar
FI874570A (fi) Antibakteriska medel -ii.
FI904850A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 24-homo-D-vitamiinijohdannaisten valmistamiseksi
FI860369A0 (fi) Imidazolderivat, deras framstaellning och anvaendning samt dessa derivat innehaollande farmaceutiska kompositioner.
SE8403801L (sv) Nya bensotiazepiner med kardiovaskuler anvendbarhet, forfarande for framstellning derav och farmaceutiska kompositioner som innehaller dem
KR930016402A (ko) 항-hiv 활성을 갖는 이미다졸 유도체
DE3673688D1 (de) Succinimide derivate, herstellung und anwendung.
FI934675A (fi) Nya 2-sackarinylmetylarylkarboxylater som aer anvaendbara som proteolytiska enzyminhibitorer och kompositioner och anvaendning av dessa
FI912903A (fi) Nya n-benzyl-n1-fenyl- och fenylalkyl -tiourea-foereningar.
SE7608306L (sv) Nya 5-fluoropyrimidin-4-on-derivat
BR9202830A (pt) Preparacao de combinacao farmaceutica,processo para sua fabricacao,uso e processo de tratamento ou prevencao de hipertensao
DE3688161D1 (de) Gegebenenfalls etherifizierte oder esterifizierte in stellung 2 substituierte 4-oh-chinolincarbonsaeurederivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
DE68906827D1 (de) Phenothiazinderivate, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES2023760A6 (es) Procedimiento para la preparacion de derivados benzotiazinicos.
JPS56131551A (en) Tyrosine derivative and medicinal use
ATE36536T1 (de) Phosphoroimidate.
FI870098A (fi) Nya pregnanderivat, foerfaranden foer deras framstaellning och farmaceutiska preparat, vilka innehaoller desamma.
DE58909745D1 (de) Tetrahydro-4-phenylimino-3-thiophenessigsäuren
ES2083961T3 (es) Acidos 3-anilino-2-hidroxicarbonil-4-tiofenoaceticos.

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: ROUSSEL UCLAF SOCIETE ANONYME