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ES8502116A1 - Un compuesto de pirazolpiridina. - Google Patents

Un compuesto de pirazolpiridina.

Info

Publication number
ES8502116A1
ES8502116A1 ES522325A ES522325A ES8502116A1 ES 8502116 A1 ES8502116 A1 ES 8502116A1 ES 522325 A ES522325 A ES 522325A ES 522325 A ES522325 A ES 522325A ES 8502116 A1 ES8502116 A1 ES 8502116A1
Authority
ES
Spain
Prior art keywords
compound
alkyl
formula
pirazolpiridina
pyrazolpyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522325A
Other languages
English (en)
Other versions
ES522325A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zeneca Inc
Original Assignee
ICI Americas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838301676A external-priority patent/GB8301676D0/en
Application filed by ICI Americas Inc filed Critical ICI Americas Inc
Publication of ES522325A0 publication Critical patent/ES522325A0/es
Publication of ES8502116A1 publication Critical patent/ES8502116A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C07C53/21—Acids containing three or more carbon atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PIRAZOLPIRIDINA.CONSISTE EN CICLIZAR INTERNAMENTE UN COMPUESTO DE FORMULA (II) A TEMPERATURA ENTRE 150 Y 250JC, EN PRESENCIA DE UN PROMOTOR DE LA REACCION COMO ZNCL2, PURO O EN PRESENCIA DE UN SOLVENTE CON ALTO PUNTO DE EBULLICION COMO XILENO O CLOROBENCENO, PARA DAR COMPUESTOS DE FORMULA (I), DONDE R ES H O ALQUILO; R ES H; D ES OXIGENO O NR; R ES H, ALQUILO, CICLOALQUILO, ALQUENILO Y OTROS; Y R Y R SON H, ALQUILO, ARILO Y OTROS.TIENEN APLICACIONES FARMACEUTICAS COMO DEPRESORES DEL SISTEMA NERVIOSO.
ES522325A 1982-05-12 1983-05-12 Un compuesto de pirazolpiridina. Expired ES8502116A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8213700 1982-05-12
GB838301676A GB8301676D0 (en) 1983-01-21 1983-01-21 Nitrogen containing heterocycles

Publications (2)

Publication Number Publication Date
ES522325A0 ES522325A0 (es) 1984-12-16
ES8502116A1 true ES8502116A1 (es) 1984-12-16

Family

ID=26282806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522325A Expired ES8502116A1 (es) 1982-05-12 1983-05-12 Un compuesto de pirazolpiridina.

Country Status (17)

Country Link
US (2) US4511568A (es)
EP (1) EP0094175B1 (es)
KR (1) KR840004750A (es)
AU (1) AU1425983A (es)
DD (1) DD210456A5 (es)
DE (1) DE3367217D1 (es)
DK (1) DK211783A (es)
ES (1) ES8502116A1 (es)
FI (1) FI831646A7 (es)
GB (1) GB8310266D0 (es)
GR (1) GR78856B (es)
IL (1) IL68571A0 (es)
IN (1) IN159825B (es)
NO (1) NO831678L (es)
NZ (1) NZ204203A (es)
PT (1) PT76678B (es)
ZW (1) ZW10983A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8329531D0 (en) * 1983-11-04 1983-12-07 Ici America Inc Pyrazolopyridine cycloalkanones
DE3520390A1 (de) * 1984-07-07 1986-02-06 Bayer Ag, 5090 Leverkusen Imidazo-pyrrolo-pyridin-derivate
GB8421116D0 (en) * 1984-08-20 1984-09-26 Ici America Inc Alkynyl derivatives
GB8425104D0 (en) * 1984-10-04 1984-11-07 Ici America Inc Amide derivatives
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
DE19944332A1 (de) 1999-09-16 2001-03-22 Dresden Arzneimittel Antikonvulsiv und anxiolytisch wirkende 4-Amino-1-aryl-1,5-dihydro-pyrrol-2-one und Verfahren zu deren Herstellung
US20030220646A1 (en) * 2002-05-23 2003-11-27 Thelen Sarah L. Method and apparatus for reducing femoral fractures
CN104592128A (zh) * 2005-12-20 2015-05-06 阿斯利康(瑞典)有限公司 作为gabaa受体调节剂的取代的噌啉衍生物及其合成方法
US7465795B2 (en) * 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
TW200911760A (en) * 2007-06-19 2009-03-16 Astrazeneca Ab Compounds and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1186063A (en) * 1966-03-14 1970-04-02 American Home Prod Benzonaphthyridine Derivatives
BE787249A (fr) * 1971-08-05 1973-02-05 Squibb & Sons Inc Derives amino d'acides pyrazolopyridine carboxyliques, leurs esters et les sels de ces composes, ainsi que leurs procedes de preparation
US3850940A (en) * 1972-11-24 1974-11-26 Squibb & Sons Inc Intermediate pyrazolopyridine carbonitriles
US4051236A (en) * 1973-02-15 1977-09-27 E. R. Squibb & Sons, Inc. Inhibition of blood platelet aggregation
US4038281A (en) * 1975-10-16 1977-07-26 E. R. Squibb & Sons, Inc. Certain 2,7-dihydro-4H-pyrazolo[3,4-b]pyridine-5-ketones
US4018779A (en) * 1976-03-25 1977-04-19 E. R. Squibb & Sons, Inc. Derivatives of 10,11-dihydrobenzo[4,5]cyclohepta[1,2-b]-pyrazolo[4,3-e]pyridine-5(1H)ones
US4072681A (en) * 1977-03-02 1978-02-07 E. R. Squibb & Sons, Inc. 3,7-Dihydro- and 1,7-dihydro-4H-pyrazolo[4',3':5,6]pyrido[4,3-d]pyrimidin-4-ones
US4329349A (en) * 1979-07-25 1982-05-11 Sandoz, Inc. 6-C1-4 Alkyl-7-phenyl or substituted phenyl-1,6-naphthyridine-5(6H)-ones
US4364948A (en) * 1981-09-28 1982-12-21 Ici Americas Inc. Pyrazolo[3,4-b]pyridine compounds

Also Published As

Publication number Publication date
ZW10983A1 (en) 1984-12-05
IL68571A0 (en) 1983-09-30
EP0094175A1 (en) 1983-11-16
AU1425983A (en) 1983-11-17
DE3367217D1 (en) 1986-12-04
FI831646L (fi) 1983-11-13
FI831646A7 (fi) 1983-11-13
PT76678A (en) 1983-06-01
US4645838A (en) 1987-02-24
DD210456A5 (de) 1984-06-13
KR840004750A (ko) 1984-10-24
US4511568A (en) 1985-04-16
FI831646A0 (fi) 1983-05-11
ES522325A0 (es) 1984-12-16
PT76678B (en) 1986-01-14
NZ204203A (en) 1986-01-24
IN159825B (es) 1987-06-06
DK211783D0 (da) 1983-05-11
NO831678L (no) 1983-11-14
EP0094175B1 (en) 1986-10-29
GB8310266D0 (en) 1983-05-18
DK211783A (da) 1983-11-13
GR78856B (es) 1984-10-02

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