ES8302712A1 - Imidazobenzodiazepines - Google Patents
ImidazobenzodiazepinesInfo
- Publication number
- ES8302712A1 ES8302712A1 ES509284A ES509284A ES8302712A1 ES 8302712 A1 ES8302712 A1 ES 8302712A1 ES 509284 A ES509284 A ES 509284A ES 509284 A ES509284 A ES 509284A ES 8302712 A1 ES8302712 A1 ES 8302712A1
- Authority
- ES
- Spain
- Prior art keywords
- piperazin
- image
- alkyl
- radical
- alk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KLNFAMGHSZQYHR-UHFFFAOYSA-N imidazo[4,5-i][1,2]benzodiazepine Chemical class C1=CC=NN=C2C3=NC=NC3=CC=C21 KLNFAMGHSZQYHR-UHFFFAOYSA-N 0.000 title 1
- -1 4-phenyl-piperazin-1-yl Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KZKRRZFCAYOXQE-UHFFFAOYSA-N 1$l^{2}-azinane Chemical compound C1CC[N]CC1 KZKRRZFCAYOXQE-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the general formula (I), < IMAGE > (in which R1 represents a hydrogen atom, a halogen atom, a nitro radical or a trifluoromethyl radical, R2 represents a hydrogen atom or a halogen atom and R3 and R4, together with the nitrogen atom to which they are attached, represent a 4-alkyl- piperazin-1-yl, 4-cycloalkyl-alkyl- piperazin-1-yl, 4-phenyl-piperazin-1-yl or piperidino radical) as well as their addition salts with mineral or organic acids, are prepared by reacting a compound of formula (II), < IMAGE > with an amine of formula III, < IMAGE > (in which alk and alk' represent alkyl radicals containing from 1 to 3 carbon atoms) in the presence of an organic solvent followed, if desired by salt formation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8106171A FR2502621B1 (en) | 1981-03-27 | 1981-03-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES509284A0 ES509284A0 (en) | 1983-01-16 |
| ES8302712A1 true ES8302712A1 (en) | 1983-01-16 |
Family
ID=9256708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509284A Expired ES8302712A1 (en) | 1981-03-27 | 1982-02-03 | Imidazobenzodiazepines |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS57169483A (en) |
| AU (1) | AU549222B2 (en) |
| CA (1) | CA1175823A (en) |
| CH (1) | CH651565A5 (en) |
| DE (1) | DE3211243A1 (en) |
| DK (1) | DK153404C (en) |
| ES (1) | ES8302712A1 (en) |
| FI (1) | FI71152C (en) |
| FR (1) | FR2502621B1 (en) |
| GB (1) | GB2095674B (en) |
| HU (1) | HU185092B (en) |
| IT (1) | IT1147917B (en) |
| MA (1) | MA19416A1 (en) |
| NL (1) | NL193246C (en) |
| PT (1) | PT74669B (en) |
| SE (2) | SE448731B (en) |
| ZA (1) | ZA821141B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3872090A (en) * | 1972-07-12 | 1975-03-18 | Boehringer Sohn Ingelheim | 3-(amino-methylene)-5-phenyl-1,4-benzodiazepin-2-ones |
| IL48888A (en) * | 1975-02-15 | 1979-03-12 | Roussel Uclaf | 2-aminomethylene-1,2-dihydro-6-phenyl-1h-imidazo(1,2-a)(1,4) benzodiazepin-1-ones, process for their preparation andpharmaceutical compositions incorporating them |
-
1981
- 1981-03-27 FR FR8106171A patent/FR2502621B1/fr not_active Expired
-
1982
- 1982-01-19 SE SE8200271A patent/SE448731B/en not_active IP Right Cessation
- 1982-01-19 SE SE8200271D patent/SE8200271L/en not_active Application Discontinuation
- 1982-02-03 ES ES509284A patent/ES8302712A1/en not_active Expired
- 1982-02-22 ZA ZA821141A patent/ZA821141B/en unknown
- 1982-02-26 AU AU80947/82A patent/AU549222B2/en not_active Expired
- 1982-03-18 MA MA19621A patent/MA19416A1/en unknown
- 1982-03-19 IT IT48036/82A patent/IT1147917B/en active
- 1982-03-23 NL NL8201208A patent/NL193246C/en not_active IP Right Cessation
- 1982-03-24 JP JP57045728A patent/JPS57169483A/en active Pending
- 1982-03-25 FI FI821058A patent/FI71152C/en not_active IP Right Cessation
- 1982-03-26 PT PT74669A patent/PT74669B/en unknown
- 1982-03-26 GB GB8208933A patent/GB2095674B/en not_active Expired
- 1982-03-26 DK DK138682A patent/DK153404C/en not_active IP Right Cessation
- 1982-03-26 CA CA000399537A patent/CA1175823A/en not_active Expired
- 1982-03-26 HU HU82939A patent/HU185092B/en not_active IP Right Cessation
- 1982-03-26 CH CH1896/82A patent/CH651565A5/en not_active IP Right Cessation
- 1982-03-26 DE DE19823211243 patent/DE3211243A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IT8248036A0 (en) | 1982-03-19 |
| NL193246B (en) | 1998-12-01 |
| FR2502621B1 (en) | 1983-10-28 |
| ES509284A0 (en) | 1983-01-16 |
| ZA821141B (en) | 1983-01-26 |
| SE8200271L (en) | 1982-09-28 |
| DE3211243C2 (en) | 1993-05-19 |
| NL8201208A (en) | 1982-10-18 |
| SE448731B (en) | 1987-03-16 |
| CH651565A5 (en) | 1985-09-30 |
| DK153404B (en) | 1988-07-11 |
| PT74669A (en) | 1982-04-01 |
| MA19416A1 (en) | 1982-10-01 |
| FR2502621A1 (en) | 1982-10-01 |
| DK138682A (en) | 1982-09-28 |
| AU549222B2 (en) | 1986-01-23 |
| FI71152B (en) | 1986-08-14 |
| FI71152C (en) | 1986-11-24 |
| AU8094782A (en) | 1982-09-30 |
| GB2095674A (en) | 1982-10-06 |
| NL193246C (en) | 1999-04-02 |
| FI821058A0 (en) | 1982-03-25 |
| IT1147917B (en) | 1986-11-26 |
| GB2095674B (en) | 1984-10-10 |
| HU185092B (en) | 1984-11-28 |
| FI821058L (en) | 1982-09-28 |
| PT74669B (en) | 1985-01-08 |
| DE3211243A1 (en) | 1982-10-07 |
| JPS57169483A (en) | 1982-10-19 |
| DK153404C (en) | 1988-11-21 |
| CA1175823A (en) | 1984-10-09 |
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