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ES8107214A1 - Procedimiento de preparacion de nuevos derivados de tetrahi-dropiridin-4-il-indol - Google Patents

Procedimiento de preparacion de nuevos derivados de tetrahi-dropiridin-4-il-indol

Info

Publication number
ES8107214A1
ES8107214A1 ES493311A ES493311A ES8107214A1 ES 8107214 A1 ES8107214 A1 ES 8107214A1 ES 493311 A ES493311 A ES 493311A ES 493311 A ES493311 A ES 493311A ES 8107214 A1 ES8107214 A1 ES 8107214A1
Authority
ES
Spain
Prior art keywords
carbon atoms
preparation
hydrogen
alkyl
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493311A
Other languages
English (en)
Other versions
ES493311A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES493311A0 publication Critical patent/ES493311A0/es
Publication of ES8107214A1 publication Critical patent/ES8107214A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE TETRAHIDROPIRIDIN-4-IL-INDOL. CONSISTE EN HACER REACCIONAR EL COMPUESTO DE FORMULA GENERAL (I) CON CLORHIDRATO DE 4-PIPERIDONA EN MEDIO ALCALINO O EN MEDIO ACIDO. SE OBTIENE EL COMPUESTO (II), QUE SE AISLA Y, SI SE DESEA, SE SALIFICA; R REPRESENTA UN RADICAL METILTIO, AMINO O TRIFLUOROMETILO, Y R2 REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL ALCOHILO CON 1 A 3 ATOMOS DE CARBONO. LA REACCION SE EFECTUA EN POTASA METANOLICA 2N. *FORMULA*
ES493311A 1979-07-13 1980-07-11 Procedimiento de preparacion de nuevos derivados de tetrahi-dropiridin-4-il-indol Expired ES8107214A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7918217A FR2460947A1 (fr) 1979-07-13 1979-07-13 Nouveau derives n-substitues du tetrahydropyridinyl-indole, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (2)

Publication Number Publication Date
ES493311A0 ES493311A0 (es) 1981-08-16
ES8107214A1 true ES8107214A1 (es) 1981-08-16

Family

ID=9227845

Family Applications (2)

Application Number Title Priority Date Filing Date
ES493308A Granted ES493308A0 (es) 1979-07-13 1980-07-11 Procedimiento de preparacion de nuevos derivados n-sustitui-dos de tetrahidropiridinil-indol
ES493311A Expired ES8107214A1 (es) 1979-07-13 1980-07-11 Procedimiento de preparacion de nuevos derivados de tetrahi-dropiridin-4-il-indol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES493308A Granted ES493308A0 (es) 1979-07-13 1980-07-11 Procedimiento de preparacion de nuevos derivados n-sustitui-dos de tetrahidropiridinil-indol

Country Status (16)

Country Link
US (1) US4324790A (es)
EP (1) EP0022705B1 (es)
JP (2) JPS5615282A (es)
AT (1) ATE2954T1 (es)
AU (1) AU535197B2 (es)
BE (1) BE884279A (es)
CA (1) CA1145752A (es)
DE (1) DE3062614D1 (es)
DK (1) DK152048C (es)
ES (2) ES493308A0 (es)
FR (1) FR2460947A1 (es)
HU (1) HU184792B (es)
IE (1) IE50067B1 (es)
PT (1) PT71549B (es)
SU (1) SU936813A3 (es)
ZA (2) ZA803789B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2533924A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
US5214059A (en) * 1989-07-03 1993-05-25 Hoechst-Roussel Pharmaceuticals Incorporated 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
ZA200709038B (en) * 2005-04-13 2009-01-28 Neuraxon Inc Substituted indole compounds having nos inhibitory activity
CN101466709B (zh) * 2006-04-13 2013-03-20 轴突公司 具有nos抑制活性的1,5和3,6-取代的吲哚化合物
EP2219449A4 (en) * 2007-11-16 2010-10-27 Univ Arizona State METHOD FOR THE TREATMENT OF EXPOSURE TO DAMAGING
MX2010005343A (es) * 2007-11-16 2010-08-09 Neuraxon Inc Compuestos indola 3, 5-sustituidos que tienen actividad inhibidora de la re-absorcion y el reciclo de nos y norepinefrina.
JP2011503120A (ja) * 2007-11-16 2011-01-27 ニューラクソン，インコーポレーテッド 内臓痛を治療するためのインドール化合物および方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2193584B1 (es) * 1972-07-28 1975-08-08 Roussel Uclaf
DE2322470A1 (de) 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
SU639243A1 (ru) * 1976-12-27 1979-11-25 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср 1-/4-(4-Фторфенил)-4-оксибутил/ -4- (индолил-31)-1,2,3,6-тетрагидропиридин или его соли, обладающие психотропными свойствами
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels

Also Published As

Publication number Publication date
JPS6348872B2 (es) 1988-09-30
PT71549A (fr) 1980-08-01
EP0022705B1 (fr) 1983-04-06
JPS6351154B2 (es) 1988-10-13
DK300180A (da) 1981-01-14
ES493311A0 (es) 1981-08-16
DK152048C (da) 1988-10-10
FR2460947B1 (es) 1981-07-10
ZA803789B (en) 1981-06-24
IE50067B1 (en) 1986-02-05
FR2460947A1 (fr) 1981-01-30
ES8107213A1 (es) 1981-08-16
DK152048B (da) 1988-01-25
IE801456L (en) 1981-01-13
US4324790A (en) 1982-04-13
ATE2954T1 (de) 1983-04-15
ES493308A0 (es) 1981-08-16
HU184792B (en) 1984-10-29
ZA803793B (en) 1981-06-24
DE3062614D1 (en) 1983-05-11
EP0022705A1 (fr) 1981-01-21
JPS5615282A (en) 1981-02-14
AU535197B2 (en) 1984-03-08
AU6035980A (en) 1981-01-15
JPS5615283A (en) 1981-02-14
PT71549B (fr) 1981-12-14
SU936813A3 (ru) 1982-06-15
CA1145752A (fr) 1983-05-03
BE884279A (fr) 1981-01-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401