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ES8106156A1 - Un procedimiento para la preparacion de derivados de oxadia-zolotriazona - Google Patents

Un procedimiento para la preparacion de derivados de oxadia-zolotriazona

Info

Publication number
ES8106156A1
ES8106156A1 ES490617A ES490617A ES8106156A1 ES 8106156 A1 ES8106156 A1 ES 8106156A1 ES 490617 A ES490617 A ES 490617A ES 490617 A ES490617 A ES 490617A ES 8106156 A1 ES8106156 A1 ES 8106156A1
Authority
ES
Spain
Prior art keywords
oxadiazolotriazine
derivatives
formula
oxadiazolotriazine derivatives
vasodilators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490617A
Other languages
English (en)
Other versions
ES490617A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8106156A1 publication Critical patent/ES8106156A1/es
Publication of ES490617A0 publication Critical patent/ES490617A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/98—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE OXADIAZOLOTRIACINA DE FORMULA GENERAL (I), DONDE R ELEVADO A 1 ES UN ATOMO DE HIDROGENO, R CUADRADO UN GRUPO DE FORMULA (II), R CUBO UN GRUPO DE DIALAMINO, R ELEVADO A 4 UN GRUPO DE ALQUILO, ALOALQUILO, ALCOXIALQUILO, ARILOAXIALQUILO, ARALQUILOXIALQUILO, ARALQUILO, ACILOXICARBONIALQUILO O ARILO. SE INTRODUCE UN GRUPO DE FORMULA (II) EN EL GRUPO AMINICO DE FORMULA GENERAL (III) Y SE HACE REACCIONAR CON UN DERIVADO DE ACIDO ACTIVADO A TEMPERATURAS DE 0 A 70 GC Y EN PRESENCIA DE UN DISOLVENTE INERTE. SE PUEDE CONVERTIR EL COMPUESTO DE FORMULA (I) OBTENIDO EN UNA SAL. SE UTILIZA EN EL TRATAMIENTO DE HIPERTENSION VASCULAR-CONDICIONADA Y COMO VASODILATADORES PARA CASOS DE TRASTORNOS DEL SUMINISTRO SANGUINEO PERIFERICO. *FORMULA*
ES490617A 1978-07-31 1980-04-16 Un procedimiento para la preparacion de derivados de oxadia-zolotriazona Granted ES490617A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH818478 1978-07-31
CH450579 1979-05-15

Publications (2)

Publication Number Publication Date
ES8106156A1 true ES8106156A1 (es) 1981-07-16
ES490617A0 ES490617A0 (es) 1981-07-16

Family

ID=25695645

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490617A Granted ES490617A0 (es) 1978-07-31 1980-04-16 Un procedimiento para la preparacion de derivados de oxadia-zolotriazona

Country Status (18)

Country Link
US (2) US4276417A (es)
EP (1) EP0007643B1 (es)
AR (1) AR226822A1 (es)
AU (1) AU529907B2 (es)
CA (1) CA1104134A (es)
DE (1) DE2966658D1 (es)
DK (1) DK158471C (es)
ES (1) ES490617A0 (es)
FI (1) FI792311A (es)
GR (1) GR72919B (es)
HU (1) HU179986B (es)
IE (1) IE48672B1 (es)
IL (1) IL57885A (es)
MC (1) MC1278A1 (es)
NO (1) NO792510L (es)
NZ (1) NZ190915A (es)
PH (1) PH14560A (es)
PT (1) PT70003A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148826C (da) * 1980-12-19 1986-03-24 Hoffmann La Roche Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade
CH649291A5 (de) * 1982-03-16 1985-05-15 Hoffmann La Roche Dicarbamate.
RU2450004C2 (ru) * 2006-08-04 2012-05-10 Мерц Фарма Гмбх Унд Ко. Кгаа Замещенные пиразолопиримидины, способ их получения и их применение в качестве лекарственного средства

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620637U (de) 1951-01-18 1951-03-08 Porenit Werke Dr Adolph K G Mauerstein aus gips, zementgebundenem material o. dgl.
GB1025902A (en) 1962-02-08 1966-04-14 Upjohn Co N-alkenylmelamine 5-oxides and pharmaceutical compositions containing them
GB1053113A (es) 1963-04-19
US3270018A (en) 1964-02-13 1966-08-30 Upjohn Co 1, 3, 5-triazine ethers
US3270014A (en) * 1965-07-01 1966-08-30 Upjohn Co 1, 2-dihydro-1-hydroxy-1, 3, 5-triazines
US3354159A (en) 1965-12-02 1967-11-21 Upjohn Co Pyrimido-1, 3, 5-triazinols
US3475430A (en) * 1966-01-07 1969-10-28 Upjohn Co 1,2-dihydro-1,3,5-triazine ethers
US3576805A (en) * 1969-05-22 1971-04-27 American Cyanamid Co N**2,n**4,n**6-trisubstituted melamines
US3642720A (en) * 1970-04-30 1972-02-15 Ciba Geigy Corp Triazine based polybenzimidazole
CH638216A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-deriate.
CH638215A5 (de) * 1977-02-04 1983-09-15 Hoffmann La Roche Oxadiazolopyrimidin-derivate.

Also Published As

Publication number Publication date
AU529907B2 (en) 1983-06-23
GR72919B (es) 1984-01-11
MC1278A1 (fr) 1980-05-23
CA1104134A (en) 1981-06-30
HU179986B (en) 1983-01-28
IE791438L (en) 1980-01-31
US4336380A (en) 1982-06-22
PT70003A (en) 1979-08-01
NO792510L (no) 1980-02-01
AR226822A1 (es) 1982-08-31
EP0007643A1 (de) 1980-02-06
IE48672B1 (en) 1985-04-17
EP0007643B1 (de) 1984-02-15
ES490617A0 (es) 1981-07-16
FI792311A (fi) 1980-02-01
US4276417A (en) 1981-06-30
DK158471C (da) 1990-10-08
AU4917079A (en) 1980-02-07
DK158471B (da) 1990-05-21
PH14560A (en) 1981-09-24
NZ190915A (en) 1984-07-31
IL57885A0 (en) 1979-11-30
IL57885A (en) 1982-08-31
DK322679A (da) 1980-02-01
DE2966658D1 (de) 1984-03-22

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506