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ES8105152A1 - Un metodo para la preparacion de un anticuerpo monoclonico, de fijacion de complemento - Google Patents

Un metodo para la preparacion de un anticuerpo monoclonico, de fijacion de complemento

Info

Publication number
ES8105152A1
ES8105152A1 ES490944A ES490944A ES8105152A1 ES 8105152 A1 ES8105152 A1 ES 8105152A1 ES 490944 A ES490944 A ES 490944A ES 490944 A ES490944 A ES 490944A ES 8105152 A1 ES8105152 A1 ES 8105152A1
Authority
ES
Spain
Prior art keywords
antibody
diagnostic
cell line
monoclonal
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490944A
Other languages
English (en)
Other versions
ES490944A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21871750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8105152(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of ES490944A0 publication Critical patent/ES490944A0/es
Publication of ES8105152A1 publication Critical patent/ES8105152A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE UN ANTICUERPO MONOCLONICO DE FIJACION DE COMPLEMENTO. CONSTA DE LAS SIGUIENTES ETAPAS: 1. INMUNIZAR RATONES CON CELULAS T HUMANAS PURIFICADAS POSITIVAS A ROSETRE E. 2. SEPARAR LOS BAZOS DE DICHOS RATONES Y CONFECCIONAR UNA SUSPENSION DE CELULAS DE BAZO. 3. FUSIONAR DICHAS CELULAS DE BAZO CON CELULAS DE MIELOMA DE RATON EN PRESENCIA DE UN PROMOTOR DE FUSION. 4. DILUIR Y CULTIVAR LAS CELULAS FUSIONADAS EN POCILLOS SEPARADOS EN UN MEDIO QUE NO SOPORTARA LAS CELULAS DE MIELOMA SIN FUSIONAR. 5. EVALUAR EL SOBRENADANTE EN CADA POCILLO QUE CONTIENE UN HIBRIDOMA EN CUANTO A LA PRESENCIA DEL ANTICUERPO PARA LAS CELULAS T. 6. SELECCIONAR Y CLONAR UN HIBRIDOMA PRODUCTOR DE ANTICUERPO QUE FIJA UN COMPLEMENTO Y REACCIONA CON TODAS LAS CELULAS T PERIFERICAS HUMANAS NORMALES, PERO NO CON LAS B PERIFERICAS HUMANAS NORMALES, LAS CELULAS NULAS O LOS MACROFAGOS.
ES490944A 1979-04-26 1980-04-25 Un metodo para la preparacion de un anticuerpo monoclonico, de fijacion de complemento Expired ES8105152A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/033,669 US4361549A (en) 1979-04-26 1979-04-26 Complement-fixing monoclonal antibody to human T cells, and methods of preparing same

Publications (2)

Publication Number Publication Date
ES490944A0 ES490944A0 (es) 1981-05-16
ES8105152A1 true ES8105152A1 (es) 1981-05-16

Family

ID=21871750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490944A Expired ES8105152A1 (es) 1979-04-26 1980-04-25 Un metodo para la preparacion de un anticuerpo monoclonico, de fijacion de complemento

Country Status (22)

Country Link
US (1) US4361549A (es)
EP (1) EP0018795B2 (es)
JP (2) JPS55145617A (es)
AT (1) ATE14023T1 (es)
AU (1) AU544791B2 (es)
CA (1) CA1182406A (es)
DE (2) DE3070803D1 (es)
DK (1) DK154769C (es)
ES (1) ES8105152A1 (es)
FI (1) FI75183C (es)
HK (1) HK23886A (es)
IE (1) IE50422B1 (es)
IL (1) IL59917A (es)
MY (1) MY8600514A (es)
NL (1) NL930131I2 (es)
NO (1) NO159221C (es)
NZ (1) NZ193469A (es)
PH (1) PH16642A (es)
PT (1) PT71147B (es)
SG (1) SG6686G (es)
YU (1) YU48442B (es)
ZA (1) ZA802525B (es)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
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YU48442B (sh) 1998-07-10
DE18795T1 (de) 1984-07-19
CA1182406A (en) 1985-02-12
NL930131I1 (nl) 1993-11-01
PT71147A (en) 1980-05-01
AU5775780A (en) 1980-10-30
IE50422B1 (en) 1986-04-16
NO159221B (no) 1988-08-29
ZA802525B (en) 1981-12-30
ATE14023T1 (de) 1985-07-15
ES490944A0 (es) 1981-05-16
PT71147B (en) 1981-08-11
IE800840L (en) 1980-10-24
US4361549A (en) 1982-11-30
PH16642A (en) 1983-12-06
NO159221C (no) 1988-12-07
EP0018795B1 (en) 1985-06-26
AU544791B2 (en) 1985-06-13
NO801214L (no) 1980-10-27
IL59917A (en) 1983-12-30
EP0018795B2 (en) 1999-04-07
FI75183C (fi) 1988-05-09
DE3070803D1 (en) 1985-08-01
HK23886A (en) 1986-04-11
DK180380A (da) 1980-10-27
EP0018795A2 (en) 1980-11-12
JPS6362520B2 (es) 1988-12-02
NZ193469A (en) 1984-07-06
YU114680A (en) 1984-02-29
NL930131I2 (nl) 1998-07-01
DK154769B (da) 1988-12-19
IL59917A0 (en) 1980-06-30
FI75183B (fi) 1988-01-29
MY8600514A (en) 1986-12-31
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JPH0159868B2 (es) 1989-12-20
FI801342A (fi) 1980-10-27
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DK154769C (da) 1989-06-19

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