ES544127A0 - Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos - Google Patents

Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos

Info

Publication number: ES544127A0
Authority: ES; Spain
Prior art keywords: alcanoicos; benzaze; acides; ona; amino
Prior art date: 1983-02-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES544127A

Other languages

English (en)

Other versions

ES8702363A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Ciba Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-02-10

Filing date

1985-06-13

Publication date

1987-01-01

1985-06-13 Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG

1987-01-01 Publication of ES544127A0 publication Critical patent/ES544127A0/es

1987-01-01 Publication of ES8702363A1 publication Critical patent/ES8702363A1/es

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

ES544127A 1983-02-10 1985-06-13 Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos Expired ES8702363A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/465,695 US4473575A (en)	1982-07-19	1983-02-10	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids

Publications (2)

Publication Number	Publication Date
ES544127A0 true ES544127A0 (es)	1987-01-01
ES8702363A1 ES8702363A1 (es)	1987-01-01

Family

ID=23848805

Family Applications (10)

Application Number	Title	Priority Date	Filing Date
ES529595A Expired ES8707216A1 (es)	1983-02-10	1984-02-09	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES529594A Expired ES8609261A1 (es)	1983-02-10	1984-02-09	Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos
ES544127A Expired ES8702363A1 (es)	1983-02-10	1985-06-13	Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES544260A Expired ES8609265A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544258A Expired ES8609264A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544259A Expired ES8700239A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544256A Expired ES8705409A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
ES529595A Expired ES8707216A1 (es)	1983-02-10	1984-02-09	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoicos
ES529594A Expired ES8609261A1 (es)	1983-02-10	1984-02-09	Procedimiento para preparar nuevos acidos 3-amino-1-benzazepin-2-ona-1-alcanoicos

Family Applications After (7)

Application Number	Title	Priority Date	Filing Date
ES544260A Expired ES8609265A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544258A Expired ES8609264A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544255A Expired ES8609262A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544259A Expired ES8700239A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544256A Expired ES8705409A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544257A Expired ES8609263A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico
ES544254A Expired ES8703859A1 (es)	1983-02-10	1985-06-17	Procedimiento para preparar nuevos acidos 3-(5-aminopentil)-amino-1-benzazepin-2-ona-1-alcanoico

Country Status (24)

Country	Link
US (1)	US4473575A (es)
EP (2)	EP0119955B1 (es)
JP (2)	JPS59172473A (es)
KR (1)	KR900009023B1 (es)
AR (8)	AR242564A1 (es)
AT (2)	ATE50989T1 (es)
AU (1)	AU574061B2 (es)
CA (2)	CA1225397A (es)
CY (1)	CY1674A (es)
DD (1)	DD218359A5 (es)
DE (2)	DE3481612D1 (es)
DK (2)	DK171257B1 (es)
ES (10)	ES8707216A1 (es)
FI (1)	FI77857C (es)
GR (1)	GR79809B (es)
HK (1)	HK97592A (es)
HU (1)	HU192394B (es)
IE (1)	IE56858B1 (es)
IL (1)	IL70881A (es)
NO (1)	NO166232C (es)
NZ (1)	NZ207091A (es)
PT (1)	PT78075B (es)
SG (1)	SG94992G (es)
ZA (1)	ZA84958B (es)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) *	1983-02-10	1986-03-11	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4537885A (en) *	1983-02-10	1985-08-27	Ciba Geigy Corporation	Certain benzazocinone and benzazoninone derivatives
US4600534A (en) *	1984-02-06	1986-07-15	Ciba-Geigy Corporation	Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
EP0166357A3 (en) *	1984-06-26	1988-10-26	Merck & Co. Inc.	Benzofused lactams and pharmaceutical compositions containing them
DE3586445T2 (de) *	1984-06-26	1993-01-14	Merck & Co Inc	Kondensierte benzo-laktam-verbindungen und deren pharmazeutische zusammensetzungen.
US4692522A (en) *	1985-04-01	1987-09-08	Merck & Co., Inc.	Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) *	1985-06-13	1988-11-15	Ciba-Geigy Corporation	Novel sulfonic acid esters and their preparation
DE3767514D1 (de) *	1986-03-11	1991-02-28	Thompson Barry Antony	Fuettern von vieh mit polymeren.
AT399717B (de) *	1986-05-28	1995-07-25	Ciba Geigy Ag	Verfahren zur herstellung von (2,5-dihydro-2-oxo- 5-phenyl-3-furanyl)aminen
GR870819B (en) *	1986-05-28	1987-09-25	Ciba Geigy Ag	Preparation method of (2,5 dihydro -2 -oxo-5 - phenyl -3 - furanyl) amines and their utilization for preparing ace - inhibitors
US5028704A (en) *	1986-05-28	1991-07-02	Ciba-Geigy Corporation	(2,5-dihydro 5-phenyl-2-oxo-3-furanyl)amines, methods of manufacture, and use thereof in the production of angiotensin converting enzyme inhibitors
US4918187A (en) *	1986-05-28	1990-04-17	Ciba-Geigy Corporation	[2,5-Dihydro 5-phenyl-2-oxo-3-furanyl]amines
US4962105A (en)	1987-10-19	1990-10-09	Ciba-Geigy Corporation	Potentiation of antihypertensive effect of ace inhibitors
JPH07116224B2 (ja) *	1987-12-29	1995-12-13	吉富製薬株式会社	ベンゾラクタム化合物
GB9100028D0 (en) *	1991-01-02	1991-02-20	Ici Plc	Compounds
US5428031A (en) *	1991-12-03	1995-06-27	Merck & Co., Inc.	Methods of treating cardiac arrhythmia
US5552397A (en) *	1992-05-18	1996-09-03	E. R. Squibb & Sons, Inc.	Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5646276A (en) *	1992-05-13	1997-07-08	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
RU2124503C1 (ru)	1992-05-18	1999-01-10	И.Р.Сквибб энд Санз, Инк.	Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
GB9212308D0 (en) *	1992-06-10	1992-07-22	Ici Plc	Therapeutic compositions
GB9311948D0 (en) *	1993-06-10	1993-07-28	Zeneca Ltd	Substituted nitrogen heterocycles
DK0730581T3 (da) *	1993-11-22	2001-11-26	Merck & Co Inc	3-acylaminobezazepiner
AU692300B2 (en) *	1993-11-22	1998-06-04	Merck & Co., Inc.	2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1, 4-benzodiazepines
US5801168A (en) *	1994-06-09	1998-09-01	Zeneca Limited	Substituted nitrogen heterocycles
US5587375A (en) *	1995-02-17	1996-12-24	Bristol-Myers Squibb Company	Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) *	1995-05-17	1999-03-02	Bristol-Myers Squibb	Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5635504A (en) *	1995-06-07	1997-06-03	Bristol-Myers Squibb Co.	Diazepine containing dual action inhibitors
DE69626981T2 (de) *	1995-06-07	2003-12-18	Merck & Co., Inc.	N-(2-oxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepin-3-yl)-3-amide
US5631251A (en) *	1995-06-07	1997-05-20	Merck & Co., Inc.	5-cyclopropyl-1,4 benzodiazepine-2-ones
US5700797A (en) *	1995-06-07	1997-12-23	Merck & Co, Inc.	N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5691331A (en) *	1995-06-07	1997-11-25	Merck & Co., Inc.	N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5726171A (en) *	1995-06-07	1998-03-10	Merck & Co Inc	N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5650408A (en) *	1995-06-07	1997-07-22	Karanewsky; Donald S.	Thiazolo benzazepine containing dual action inhibitors
US6211235B1 (en)	1996-11-22	2001-04-03	Elan Pharmaceuticals, Inc.	Compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6191166B1 (en) *	1997-11-21	2001-02-20	Elan Pharmaceuticals, Inc.	Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis
US6683075B1 (en)	1996-12-23	2004-01-27	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en)	1996-12-23	2003-10-21	Athena Neurosciences, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP2002241368A (ja) *	1997-02-18	2002-08-28	Shionogi & Co Ltd	新規ベンゾラクタム誘導体およびそれを含有する医薬組成物
WO1998041510A1 (fr) *	1997-03-14	1998-09-24	Shionogi & Co., Ltd.	Nouveaux derives du benzolactame et compositions medicamenteuses les contenant
US6509331B1 (en)	1998-06-22	2003-01-21	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en)	1998-06-22	2003-04-22	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en)	1998-06-22	2003-03-04	Elan Pharmaceuticals, Inc.	Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) *	1998-06-22	2004-08-10	Elan Pharmaceuticals, Inc.	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en)	1998-06-22	2003-05-27	Elan Pharmaceutials, Inc.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
WO2001035964A1 (en) *	1999-11-18	2001-05-25	Antexpharma, Inc.	Substituted 1-benzazepines and derivatives thereof
US7795468B2 (en) *	2001-01-19	2010-09-14	Chevron U.S.A. Inc.	Functionalized higher diamondoids
AU2002348276A1 (en) *	2001-11-16	2003-06-10	Bristol-Myers Squibb Company	Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20050192265A1 (en) *	2003-03-20	2005-09-01	Thompson Richard C.	Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
US20050203168A1 (en) *	2004-03-11	2005-09-15	The Regents Of The University Of Michigan	Angiotensin converting enzyme inhibitor use for treatment and prevention of gastrointestinal disorders
US8080579B2 (en) *	2005-10-03	2011-12-20	The Regents Of The University Of Michigan	Compositions and methods for treatment of inflammatory bowel disease
US7592461B2 (en)	2005-12-21	2009-09-22	Bristol-Myers Squibb Company	Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US20070238770A1 (en) *	2006-04-05	2007-10-11	Bristol-Myers Squibb Company	Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
EP2089355A2 (en)	2006-11-01	2009-08-19	Brystol-Myers Squibb Company	Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
WO2008057857A1 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
EP2527360B1 (en)	2007-06-04	2015-10-28	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7828840B2 (en) *	2007-11-15	2010-11-09	Med Institute, Inc.	Medical devices and methods for local delivery of angiotensin II type 2 receptor antagonists
AU2009256157B2 (en)	2008-06-04	2014-12-18	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011525537A (ja)	2008-06-24	2011-09-22	ブリストル−マイヤーズスクイブカンパニー	グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性のシクロペンタチオフェン調節剤およびその使用
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
KR102272746B1 (ko)	2013-06-05	2021-07-08	보슈 헬스 아일랜드 리미티드	구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
WO2015027021A1 (en)	2013-08-22	2015-02-26	Bristol-Myers Squibb Company	Imide and acylurea derivatives as modulators of the glucocorticoid receptor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3330823A (en) *	1964-12-16	1967-07-11	Squibb & Sons Inc	N-amino-loweralkylene-benzo-lactams
US3395150A (en) *	1965-02-26	1968-07-30	Squibb & Sons Inc	Benzothiazepine carboxamides and derivatives thereof
GB1305278A (es) *	1970-03-12	1973-01-31
JPS5129522B2 (es) *	1972-07-13	1976-08-26
JPS5520970B2 (es) *	1972-07-15	1980-06-06
FR2358151A1 (fr) *	1976-03-31	1978-02-10	Roussel Uclaf	Nouvelles benzazepines et leurs sels, procede de preparation et application a titre de medicaments
IL58849A (en) *	1978-12-11	1983-03-31	Merck & Co Inc	Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4377515A (en) *	1979-10-01	1983-03-22	Merck & Co., Inc.	Long lasting agonists and antagonists of LH-RH
GR74635B (es) *	1980-08-18	1984-06-29	Merck & Co Inc
US4409146A (en) *	1980-10-06	1983-10-11	Merck & Co., Inc.	Substituted caprolactam derivatives as antihypertensives
IN156096B (es) *	1981-03-19	1985-05-11	Usv Pharma Corp
US4415496A (en) *	1981-03-23	1983-11-15	Merck & Co., Inc.	Bicyclic lactams
ZA825779B (en) *	1981-08-11	1984-04-25	Ciba Geigy Ag	Benzazepins-2-ones
GB2103614B (en) *	1981-08-11	1984-11-21	Ciba Geigy Ag	Benzazepin-2-ones
US4410520A (en) *	1981-11-09	1983-10-18	Ciba-Geigy Corporation	3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) *	1982-07-19	1984-09-25	Ciba-Geigy Corporation	3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
EP0107095B1 (en) *	1982-09-30	1987-09-09	Merck & Co. Inc.	1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

1983
- 1983-02-10 US US06/465,695 patent/US4473575A/en not_active Expired - Lifetime
1984
- 1984-02-06 AT AT84810071T patent/ATE50989T1/de active
- 1984-02-06 EP EP84810072A patent/EP0119955B1/de not_active Expired
- 1984-02-06 EP EP84810071A patent/EP0119954B1/de not_active Expired - Lifetime
- 1984-02-06 AT AT84810072T patent/ATE48598T1/de active
- 1984-02-06 DE DE8484810071T patent/DE3481612D1/de not_active Expired - Lifetime
- 1984-02-06 DE DE8484810072T patent/DE3480705D1/de not_active Expired - Lifetime
- 1984-02-07 IL IL70881A patent/IL70881A/xx not_active IP Right Cessation
- 1984-02-08 GR GR73754A patent/GR79809B/el unknown
- 1984-02-08 PT PT78075A patent/PT78075B/pt not_active IP Right Cessation
- 1984-02-08 CA CA000446971A patent/CA1225397A/en not_active Expired
- 1984-02-08 CA CA000446970A patent/CA1218993A/en not_active Expired
- 1984-02-08 FI FI840513A patent/FI77857C/fi not_active IP Right Cessation
- 1984-02-09 HU HU84523A patent/HU192394B/hu not_active IP Right Cessation
- 1984-02-09 ES ES529595A patent/ES8707216A1/es not_active Expired
- 1984-02-09 NO NO840487A patent/NO166232C/no unknown
- 1984-02-09 JP JP59020905A patent/JPS59172473A/ja active Granted
- 1984-02-09 AU AU24430/84A patent/AU574061B2/en not_active Ceased
- 1984-02-09 DD DD84259979A patent/DD218359A5/de not_active IP Right Cessation
- 1984-02-09 IE IE302/84A patent/IE56858B1/en not_active IP Right Cessation
- 1984-02-09 DK DK058284A patent/DK171257B1/da not_active IP Right Cessation
- 1984-02-09 ES ES529594A patent/ES8609261A1/es not_active Expired
- 1984-02-09 NZ NZ207091A patent/NZ207091A/en unknown
- 1984-02-09 ZA ZA84958A patent/ZA84958B/xx unknown
- 1984-02-09 DK DK58184A patent/DK58184A/da not_active Application Discontinuation
- 1984-02-10 KR KR1019840000630A patent/KR900009023B1/ko not_active IP Right Cessation
- 1984-02-10 AR AR84295689A patent/AR242564A1/es active
- 1984-02-10 JP JP59022031A patent/JPS59172475A/ja active Granted
1985
- 1985-06-13 ES ES544127A patent/ES8702363A1/es not_active Expired
- 1985-06-17 ES ES544260A patent/ES8609265A1/es not_active Expired
- 1985-06-17 ES ES544258A patent/ES8609264A1/es not_active Expired
- 1985-06-17 ES ES544255A patent/ES8609262A1/es not_active Expired
- 1985-06-17 ES ES544259A patent/ES8700239A1/es not_active Expired
- 1985-06-17 ES ES544256A patent/ES8705409A1/es not_active Expired
- 1985-06-17 ES ES544257A patent/ES8609263A1/es not_active Expired
- 1985-06-17 ES ES544254A patent/ES8703859A1/es not_active Expired
1986
- 1986-08-15 AR AR86304922A patent/AR243165A1/es active
- 1986-08-15 AR AR86304924A patent/AR243163A1/es active
- 1986-08-15 AR AR86304925A patent/AR243162A1/es active
- 1986-08-15 AR AR86304921A patent/AR242191A1/es active
- 1986-08-15 AR AR86304920A patent/AR242190A1/es active
- 1986-08-15 AR AR86304923A patent/AR243164A1/es active
- 1986-08-15 AR AR86304926A patent/AR243161A1/es active
1992
- 1992-09-21 SG SG949/92A patent/SG94992G/en unknown
- 1992-12-03 HK HK975/92A patent/HK97592A/xx not_active IP Right Cessation
1993
- 1993-10-10 CY CY1674A patent/CY1674A/xx unknown

Also Published As

Publication number	Publication date
ES529594A0 (es)	1986-07-16
EP0119954B1 (de)	1990-03-14
AU574061B2 (en)	1988-06-30
JPS59172475A (ja)	1984-09-29
ES544256A0 (es)	1987-05-01
AR243165A1 (es)	1993-07-30
ATE50989T1 (de)	1990-03-15
KR900009023B1 (ko)	1990-12-17
IL70881A (en)	1987-10-30
ES544260A0 (es)	1986-09-01
EP0119955B1 (de)	1989-12-13
FI77857C (fi)	1989-05-10
EP0119954A2 (de)	1984-09-26
AU2443084A (en)	1984-08-16
IL70881A0 (en)	1984-05-31
DD218359A5 (de)	1985-02-06
ZA84958B (en)	1984-09-26
AR242190A1 (es)	1993-03-31
EP0119955A2 (de)	1984-09-26
ES544254A0 (es)	1987-03-01
PT78075A (en)	1984-03-01
ES8609265A1 (es)	1986-09-01
NZ207091A (en)	1985-11-08
ES8705409A1 (es)	1987-05-01
CY1674A (en)	1993-10-10
US4473575A (en)	1984-09-25
FI840513A0 (fi)	1984-02-08
ES8703859A1 (es)	1987-03-01
CA1218993A (en)	1987-03-10
NO166232B (no)	1991-03-11
ES8700239A1 (es)	1986-10-16
CA1225397A (en)	1987-08-11
HK97592A (en)	1992-12-11
ES8609263A1 (es)	1986-09-01
EP0119955A3 (en)	1986-06-11
KR840007722A (ko)	1984-12-10
DK58284D0 (da)	1984-02-09
DK58284A (da)	1984-08-11
JPS59172473A (ja)	1984-09-29
ES544257A0 (es)	1986-09-01
ES544259A0 (es)	1986-10-16
ES8609262A1 (es)	1986-09-01
ES544258A0 (es)	1986-09-01
AR242191A1 (es)	1993-03-31
JPH0421665B2 (es)	1992-04-13
ES529595A0 (es)	1987-07-16
ES544255A0 (es)	1986-09-01
FI840513A (fi)	1984-08-11
AR242564A1 (es)	1993-04-30
EP0119954A3 (en)	1986-06-11
PT78075B (en)	1986-06-11
NO166232C (no)	1991-06-19
DE3481612D1 (de)	1990-04-19
HU192394B (en)	1987-06-29
GR79809B (es)	1984-10-31
DK58184D0 (da)	1984-02-09
DK171257B1 (da)	1996-08-12
NO840487L (no)	1984-08-13
AR243161A1 (es)	1993-07-30
DK58184A (da)	1984-08-11
ES8609264A1 (es)	1986-09-01
FI77857B (fi)	1989-01-31
IE840302L (en)	1984-08-10
ES8707216A1 (es)	1987-07-16
DE3480705D1 (de)	1990-01-18
AR243162A1 (es)	1993-07-30
SG94992G (en)	1992-12-04
ES8702363A1 (es)	1987-01-01
JPH0460108B2 (es)	1992-09-25
ES8609261A1 (es)	1986-07-16
AR243163A1 (es)	1993-07-30
IE56858B1 (en)	1992-01-01
ATE48598T1 (de)	1989-12-15
AR243164A1 (es)	1993-07-30

Publication	Publication Date	Title
ES544127A0 (es)	1987-01-01	Procedimiento para preparar nuevos acidos 3-amino-1-benzaze-pin-2-ona-1-alcanoicos
ES536469A0 (es)	1985-06-01	Procedimiento para preparar nuevas 1-bencil-aminoalquil-pirrolidinonas
MX7035E (es)	1987-03-06	Procedimiento para preparar 3-isoxazolidinona
ES557240A0 (es)	1987-05-16	Procedimiento para preparar nuevos 2-arilimidazoles
ES550692A0 (es)	1987-05-01	Procedimiento para preparar nuevas somatostatinas
ES537440A0 (es)	1985-12-16	Un procedimiento para preparar 1-amino-4-nitro-acridinonas sustituidas
ES530461A0 (es)	1985-07-16	Procedimiento para preparar nuevos azoles
ES543085A0 (es)	1986-01-01	Procedimiento para preparar nuevos 2-fenil-imidazoles.
AR230995A1 (es)	1984-08-31	Procedimiento para producir n-fosfono-metilglicina
ES551439A0 (es)	1987-06-01	Procedimiento para preparar 4h-1-benzopiran-4-onas
ES550241A0 (es)	1987-02-16	Procedimiento para preparar nuevos derivados imidazo
ES550240A0 (es)	1987-02-16	Procedimiento para preparar nuevos derivados imidazo
AR240816A1 (es)	1991-02-28	Procedimiento para producir nuevos derivados de la cumarina
ES544118A0 (es)	1986-01-16	Procedimiento para preparar nuevos bencimidazoles
ES549152A0 (es)	1987-05-01	Procedimiento para preparar nuevas homoproporgilaminas.
BR8307683A (pt)	1984-12-11	Turbociclone para separar suspensoes
ES549804A0 (es)	1987-05-01	Procedimiento para preparar nuevos derivados imidazo
ES523497A0 (es)	1984-10-01	Procedimiento para preparar n-fosfonometilglicina.
ES548236A0 (es)	1986-05-16	Procedimiento para preparar adenosinas n6 sustituidas
ES548235A0 (es)	1987-04-16	Procedimiento para preparar n6-benzopirano- y benzotiopira- no-adenosinas
ES539501A0 (es)	1986-01-01	Procedimiento para preparar nuevas n-(naftilalquil)-hidroxi-laminas
ES518959A0 (es)	1984-03-01	Procedimiento para preparar fenilureas.
MX157884A (es)	1988-12-19	Procedimiento para preparar 2-halogenoacetanilidas n-substituidas
ES557313A0 (es)	1988-01-01	Procedimiento para preparar derivados de fenilpirazina
ES531586A0 (es)	1984-12-01	Procedimiento para preparar difenilazometinas

Legal Events

Date	Code	Title	Description
1997-05-01	FD1A	Patent lapsed	Effective date: 19970401