ES483711A1 - Procedimiento para la preparacion de nuevos 4-hidroxi-2h-(1)benzotieno(2,3-c)-1,2-tiazin-3-carboxamido-1,1-dioxidos - Google Patents
Procedimiento para la preparacion de nuevos 4-hidroxi-2h-(1)benzotieno(2,3-c)-1,2-tiazin-3-carboxamido-1,1-dioxidosInfo
- Publication number
- ES483711A1 ES483711A1 ES483711A ES483711A ES483711A1 ES 483711 A1 ES483711 A1 ES 483711A1 ES 483711 A ES483711 A ES 483711A ES 483711 A ES483711 A ES 483711A ES 483711 A1 ES483711 A1 ES 483711A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- hydroxy
- benzothieno
- preparation
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- XUMRBOGFWPGLEU-UHFFFAOYSA-N 4-hydroxy-1,1-dioxo-2h-[1]benzothiolo[2,3-e]thiazine-3-carboxamide Chemical class S1C2=CC=CC=C2C2=C1C(O)=C(C(=O)N)NS2(=O)=O XUMRBOGFWPGLEU-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
Procedimiento para la preparación de nuevos 4-hidroxi- 2H[1]benzotieno[2,3-e]-1,2-tiazin-3-carboxamido-1,1-dióxidos de la fórmula general **(Fórmula)** en la que R1 significa un átomo de hidrógeno o de halógeno o un grupo alcohilo con 1 a 3 átomos de carbono, R2 significa un átomo de hidrógeno o un grupo alcohilo con 1 a 3 átomos de carbono, y R3 significa un radical hidrocarbonado aromático con 6 a 10 átomos de carbono o un radical heteroaromático con 2 a 9 átomos de carbono que contiene 1 ó 2 átomos de nitrógeno y/o un átomo de oxígeno o de azufre, pudiendo estar sustituidos los radicales aromáticos antes mencionados con 1 ó 2 radicales alochilo de 1 a 6 átomos de carbono, con un átomo de halógeno, con un grupo hidroxi, trifluorometilo o halógenofenilo o con un grupo alcoxi con 1-3 átomos de carbono, y de sus sales fisiológicamente compatibles con bases orgánicas o inorgánicas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782838377 DE2838377A1 (de) | 1978-09-02 | 1978-09-02 | Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES483711A1 true ES483711A1 (es) | 1980-04-16 |
Family
ID=6048562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES483711A Expired ES483711A1 (es) | 1978-09-02 | 1979-08-29 | Procedimiento para la preparacion de nuevos 4-hidroxi-2h-(1)benzotieno(2,3-c)-1,2-tiazin-3-carboxamido-1,1-dioxidos |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4259336A (es) |
| EP (1) | EP0009142A1 (es) |
| JP (1) | JPS5535086A (es) |
| AU (1) | AU5046679A (es) |
| DE (1) | DE2838377A1 (es) |
| DK (1) | DK365879A (es) |
| ES (1) | ES483711A1 (es) |
| FI (1) | FI792721A (es) |
| GR (1) | GR69999B (es) |
| IL (1) | IL58155A0 (es) |
| NO (1) | NO792828L (es) |
| PT (1) | PT70134A (es) |
| YU (1) | YU212279A (es) |
| ZA (1) | ZA794618B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5811280A (en) * | 1979-06-13 | 1980-12-18 | F. Hoffmann-La Roche Ag | Thiazine derivatives |
| GR80576B (en) * | 1983-10-17 | 1984-11-29 | Fujisawa Pharmaceutical Co | Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same |
| US4683306A (en) * | 1984-07-13 | 1987-07-28 | Yuhan Corporation Co., Ltd. | Process for the preparation of 3,4-dihydro-2-substituted-2H-1,2-thiazine-carboxylic acid 1,1-dioxide derivatives |
| JP2690742B2 (ja) * | 1987-03-30 | 1997-12-17 | 第一製薬株式会社 | 複素環アミン誘導体 |
| US4914101A (en) * | 1987-06-10 | 1990-04-03 | Pfizer Inc. | 3,4-Dihydro-2-alkyl-3-oxo-n-aryl-2H-(1)benzo-thieno(3,2-e)-1,2-thiazine-4-carboxamide-1,1-dioxides |
| EP1384723A1 (de) * | 2002-07-26 | 2004-01-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Neue 4-Hydroxy-2H-thieno[2,3-e]-1,2-thiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47877A (en) * | 1974-08-26 | 1978-10-31 | Sparamedica Ag | Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them |
| DE2539112C2 (de) * | 1975-09-03 | 1983-12-15 | Dr. Karl Thomae Gmbh, 7950 Biberach | 4-Hydroxy-2H-naphtho[2,1-e]-1,2-thiazin-3-carboxamid-1,1-dioxide, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE2452946A1 (de) * | 1974-11-08 | 1976-05-13 | Merck Patent Gmbh | Pyrazolidinone und verfahren zu ihrer herstellung |
| SU623520A3 (ru) * | 1976-09-07 | 1978-09-05 | Ф.Гоффанн-Ля Рош И Ко Аг, (Фирма) | Способ получени производных тиенотиазина |
| DE2704485A1 (de) * | 1977-02-03 | 1978-08-10 | Thomae Gmbh Dr K | Neue 2,5-dihydro-1,2-thiazino eckige klammer auf 5,6-b eckige klammer zu indol-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
-
1978
- 1978-09-02 DE DE19782838377 patent/DE2838377A1/de not_active Withdrawn
-
1979
- 1979-08-16 GR GR59843A patent/GR69999B/el unknown
- 1979-08-27 EP EP79103150A patent/EP0009142A1/de not_active Withdrawn
- 1979-08-29 ES ES483711A patent/ES483711A1/es not_active Expired
- 1979-08-30 YU YU02122/79A patent/YU212279A/xx unknown
- 1979-08-31 PT PT70134A patent/PT70134A/pt unknown
- 1979-08-31 FI FI792721A patent/FI792721A/fi not_active Application Discontinuation
- 1979-08-31 JP JP11053079A patent/JPS5535086A/ja active Pending
- 1979-08-31 AU AU50466/79A patent/AU5046679A/en not_active Abandoned
- 1979-08-31 IL IL58155A patent/IL58155A0/xx unknown
- 1979-08-31 NO NO792828A patent/NO792828L/no unknown
- 1979-08-31 ZA ZA00794618A patent/ZA794618B/xx unknown
- 1979-08-31 DK DK365879A patent/DK365879A/da not_active Application Discontinuation
- 1979-10-22 US US06/086,743 patent/US4259336A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE2838377A1 (de) | 1980-03-20 |
| DK365879A (da) | 1980-03-03 |
| JPS5535086A (en) | 1980-03-11 |
| IL58155A0 (en) | 1979-12-30 |
| GR69999B (es) | 1982-07-23 |
| ZA794618B (en) | 1981-05-27 |
| YU212279A (en) | 1983-01-21 |
| AU5046679A (en) | 1980-03-13 |
| FI792721A (fi) | 1980-03-03 |
| US4259336A (en) | 1981-03-31 |
| NO792828L (no) | 1980-03-04 |
| PT70134A (de) | 1979-09-01 |
| EP0009142A1 (de) | 1980-04-02 |
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