Nothing Special   »   [go: up one dir, main page]

ES488535A0 - Procedimiento para preparar derivados de di fosfonatos. - Google Patents

Procedimiento para preparar derivados de di fosfonatos.

Info

Publication number
ES488535A0
ES488535A0 ES488535A ES488535A ES488535A0 ES 488535 A0 ES488535 A0 ES 488535A0 ES 488535 A ES488535 A ES 488535A ES 488535 A ES488535 A ES 488535A ES 488535 A0 ES488535 A0 ES 488535A0
Authority
ES
Spain
Prior art keywords
phosphonates
procedure
preparing derivatives
derivatives
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES488535A
Other languages
English (en)
Other versions
ES8105338A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symphar SA
Original Assignee
Symphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7904992A external-priority patent/GB2043073B/en
Application filed by Symphar SA filed Critical Symphar SA
Priority to ES498991A priority Critical patent/ES8201592A1/es
Publication of ES488535A0 publication Critical patent/ES488535A0/es
Publication of ES8105338A1 publication Critical patent/ES8105338A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3882Arylalkanephosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES488535A 1979-02-13 1980-02-13 Procedimiento para preparar derivados de di fosfonatos. Expired ES8105338A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES498991A ES8201592A1 (es) 1979-09-25 1981-01-30 Procedimiento para preparar derivados de gem-difosfonato

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7904992A GB2043073B (en) 1979-02-13 1979-02-13 Mono-and diphosphonate compounds
GB7933157A GB2043072B (en) 1979-02-13 1979-09-25 Diphosphonate compounds

Publications (2)

Publication Number Publication Date
ES488535A0 true ES488535A0 (es) 1981-05-16
ES8105338A1 ES8105338A1 (es) 1981-05-16

Family

ID=26270548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488535A Expired ES8105338A1 (es) 1979-02-13 1980-02-13 Procedimiento para preparar derivados de di fosfonatos.

Country Status (7)

Country Link
US (2) US4309364A (es)
EP (1) EP0015370B1 (es)
AU (1) AU536326B2 (es)
CA (1) CA1148561A (es)
DE (1) DE3061551D1 (es)
ES (1) ES8105338A1 (es)
GB (1) GB2043072B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds
DE3007764A1 (de) * 1980-02-29 1981-10-15 Boehringer Mannheim Gmbh Verfahren und reagens zur bestimmung der beta -lipoproteine
EP0084822B1 (de) 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
EP0085321B1 (de) * 1982-01-27 1986-08-27 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
IT1195993B (it) * 1984-01-12 1988-11-03 Gentili Ist Spa Forme farmaceutiche a base di difosfonati
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
DE3425812A1 (de) * 1984-07-13 1986-01-16 Deutsches Krebsforschungszentrum, 6900 Heidelberg Neue 1-hydroxy-1,1-diphosphonsaeureverbindungen, verfahren zu ihrer herstellung und pharmakologische zubereitungen, insbesondere zur behandlung von knochentumoren
HU190579B (en) * 1984-07-18 1986-09-29 Nitrokemia Ipartelepek,Hu Plant growth regulating compositions comprising etherified hydroxy-alkyl-phosphonic acid-derivatives as active substance
CH664158A5 (fr) * 1984-07-18 1988-02-15 Symphar Sa Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant.
ATE60711T1 (de) * 1986-12-20 1991-02-15 Boehringer Mannheim Gmbh Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
US4822780A (en) * 1987-07-08 1989-04-18 Otsuka Pharmaceutical Factory, Inc. Carboxamide compounds
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
CH675422A5 (es) * 1988-03-31 1990-09-28 Symphar Sa
FI89364C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
CA2067974A1 (en) * 1991-05-13 1992-11-14 Scott A. Biller Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
WO1992022559A1 (en) * 1991-06-19 1992-12-23 The Upjohn Company Dialkyl (dialkoxyphosphinyl)methyl phosphates as anti-inflammatory agents
US5213154A (en) * 1992-08-17 1993-05-25 Gas Research Institute Liquid desiccant regeneration system
WO1994020508A1 (en) 1993-03-08 1994-09-15 Eisai Co., Ltd. Phosphonic acid derivatives
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
FR2827289B1 (fr) * 2001-07-16 2004-07-23 Univ Paris 13 Nouveau derive d'acide diphosphonique, son application en therapeutique et procede de preparation
WO2003070179A2 (en) * 2002-02-19 2003-08-28 Ilex Products, Inc. Phosphonate-phosphate and diphosphonate apolipoprotein e modulators
EP1504013A4 (en) * 2002-05-11 2006-05-03 Ilex Products Inc USE OF HYDROXYPHOSPHONATES AND PHOSPHONOPHOSPHATES AS MODULATORS OF APOLIPOPROTEIN E
US8314081B2 (en) 2009-10-26 2012-11-20 Warner Chilcott Company, Llc Bisphosphonate compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848475A (en) * 1953-04-20 1958-08-19 Ciba Ltd Substituted methylene bis
FR1394386A (fr) * 1963-04-09 1965-04-02 Monsanto Co Nouveaux acides organo-méthylène diphosphoniques, leurs sels et esters
DE1302557B (es) * 1963-04-09 1971-08-26
US3471406A (en) * 1965-09-07 1969-10-07 Plains Chem Dev Co Detergent compositions containing methane tri and tetra phosphonic acid compounds
US3463835A (en) * 1965-10-05 1969-08-26 Plains Chem Dev Co Aromatic polyphosphonic acids,salts and esters
FR8441M (es) * 1968-04-01 1971-07-15
GB1508772A (en) * 1975-04-04 1978-04-26 Shell Int Research Biologically active compositions
US4067971A (en) * 1976-05-13 1978-01-10 The Procter & Gamble Company Therapeutic composition
US4237165A (en) * 1976-06-04 1980-12-02 Science Union Et Cie Treatment of carbohydrate metabolism disorders
US4137309A (en) * 1976-10-14 1979-01-30 The Procter & Gamble Company Therapeutic treatment
US4113862A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Carboxy phosphonate pharmaceutical composition
US4113861A (en) * 1977-05-02 1978-09-12 The Procter & Gamble Company Phosphonate pharmaceutical composition
GB2043072B (en) * 1979-02-13 1983-11-23 Symphar Sa Diphosphonate compounds

Also Published As

Publication number Publication date
DE3061551D1 (en) 1983-02-17
AU5495180A (en) 1980-08-21
CA1148561A (en) 1983-06-21
US4371527A (en) 1983-02-01
EP0015370B1 (en) 1983-01-12
EP0015370A1 (en) 1980-09-17
AU536326B2 (en) 1984-05-03
US4309364A (en) 1982-01-05
GB2043072A (en) 1980-10-01
ES8105338A1 (es) 1981-05-16
GB2043072B (en) 1983-11-23

Similar Documents

Publication Publication Date Title
ES488535A0 (es) Procedimiento para preparar derivados de di fosfonatos.
ES497884A0 (es) Procedimiento para preparar derivados de 2-amino-4-hidroxi- quinazolina
AR226847A1 (es) Procedimiento para preparar derivados de 1-benzimidazol
ES508618A0 (es) Procedimiento para la preparacion de derivados de la quino- lina.
ES488635A0 (es) Procedimiento para preparar derivados de pirimidina
ES517332A0 (es) Procedimiento para preparar derivados de feniltiadiazinona.
ES494119A0 (es) Procedimiento para preparar derivados de 3-aminoproxiarilo
ES487584A0 (es) Procedimiento para preparar nuevos derivados de pleuromuti- lin
ES488772A0 (es) Procedimiento para preparar derivados de pirimidona
ES495267A0 (es) Procedimiento para la obtencion de derivados de triazo- lil-a-fluorpinacolilo,acilados de efecto fungicida
ES508031A0 (es) Procedimiento para preparar derivados de dihidropiridina.
ES493555A0 (es) Procedimiento para preparar derivados fluorados de metil-be ta-alanina.
ES522786A0 (es) Procedimiento para preparar derivados de piperacina.
ES494291A0 (es) Procedimiento para la preparacion de derivados diazoicos.
AR226119A1 (es) Procedimiento para preparar derivados de 4-sulfamoilfenil-3-sustituido-2-fenil-imino-4-tiazolina
ES490061A0 (es) Procedimiento para preparar nuevos derivados de (piridil-2)-2-tetrahidrotiofeno
ES492394A0 (es) Procedimiento para preparar derivados de pirimidina
MX6971E (es) Procedimiento para preparar derivados de tetrahidroquinolina
ES509744A0 (es) Procedimiento para preparar derivados sustituidos de tetrahidropirimidinona.
ES494211A0 (es) Procedimiento para la preparacion de nuevos derivados de 10-halogen-e-homo-eburnanos.
ES494480A0 (es) Procedimiento para preparar nuevos derivados de cefalospori-na
ES515568A0 (es) Procedimiento para preparar derivados de fenantreno.
ES515767A0 (es) Procedimiento para preparar derivados de indano.
ES504681A0 (es) Procedimiento para preparar derivados de 11- hidroxi-13 oxa-prostaglandina.
ES492692A0 (es) Procedimiento para preparar derivados de benoimidazol