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ES488388A1 - Procedimiento de preparacion de derivados hidroxilados del tiazol - Google Patents

Procedimiento de preparacion de derivados hidroxilados del tiazol

Info

Publication number
ES488388A1
ES488388A1 ES488388A ES488388A ES488388A1 ES 488388 A1 ES488388 A1 ES 488388A1 ES 488388 A ES488388 A ES 488388A ES 488388 A ES488388 A ES 488388A ES 488388 A1 ES488388 A1 ES 488388A1
Authority
ES
Spain
Prior art keywords
thiazole derivatives
preparation
image
carbon atoms
thiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488388A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES488388A1 publication Critical patent/ES488388A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento de preparación de derivados hidroxilados del tiazol, en forma de racematos o de isómeros ópticamente activos, que responde a la fórmula **fórmula ** en la cual n es 1 o 2 y Ar es un radical fenilo que puede llevar uno o varios sustituyentes escogidos del grupo constituido por átomos de halógeno , CF3, radicales fenilo, alcohilo y cicloalcohilo, radicales alcohilo rectos o ramificados que tienen de 1 a 4 átomos de carbono, radicales cicloalcohilo que tienen de 3 a 6 átomos de carbono, así como sus sales de adición de ácidos farmacéuticamente aceptables, procedimiento caracterizado porque se hace reaccionar una tiourea de fórmula II **fórmula ** y una cetona apropiada de fórmula (III) X-CH2-CO-CH2O-Ar en la cual X es un halógeno , preferentemente cloro o bromo, o cualquier otro grupo nucleófugo.
ES488388A 1979-02-12 1980-02-08 Procedimiento de preparacion de derivados hidroxilados del tiazol Expired ES488388A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7903431A FR2448544A1 (fr) 1979-02-12 1979-02-12 Derives de thiazole et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ES488388A1 true ES488388A1 (es) 1980-10-01

Family

ID=9221832

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488388A Expired ES488388A1 (es) 1979-02-12 1980-02-08 Procedimiento de preparacion de derivados hidroxilados del tiazol

Country Status (17)

Country Link
US (1) US4282225A (es)
EP (1) EP0015798B1 (es)
JP (1) JPS55111492A (es)
AT (1) ATE772T1 (es)
AU (1) AU5536180A (es)
CA (1) CA1117942A (es)
DE (1) DE3060236D1 (es)
DK (1) DK58380A (es)
ES (1) ES488388A1 (es)
FR (1) FR2448544A1 (es)
GR (1) GR74116B (es)
IE (1) IE49387B1 (es)
IL (1) IL59358A (es)
NO (1) NO800326L (es)
NZ (1) NZ192844A (es)
PT (1) PT70818A (es)
ZA (1) ZA80742B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719346A (en) * 1952-06-14 1955-10-04 Caciagli Armando Molding apparatus having vibrating means
FR2479831A1 (fr) * 1980-04-08 1981-10-09 Synthelabo Derives de thiazole, leur preparation et leur application en therapeutique
WO2014013284A1 (en) 2012-07-17 2014-01-23 Italmatch Chemicals S.P.A. Pvc flame retardant compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2853872A (en) * 1955-03-14 1958-09-30 E J Lavino & Co Refractory brick
US4059588A (en) * 1965-07-19 1977-11-22 Ici Australia Limited Process for preparing 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
CH513918A (de) * 1968-07-31 1971-10-15 Sandoz Ag Verfahren zur Herstellung von 2-n-Alkyl-3-phenyl-6,7-dihydro-5H-thiazolo(3,2-a)pyrimidinen bzw. 2-n-Alkyl-3-phenyl-5,6-dihydroimidazo(2,1-b)thiazolen
US3671533A (en) * 1970-01-26 1972-06-20 Sandoz Ag 2,3,5,6-TETRAHYDROIMIDAZO{8 2,1-b{9 THIAZOLES
BE797547A (fr) * 1973-03-29 1973-10-01 Ici Ltd Composes, compositions et procedes antibacteriens

Also Published As

Publication number Publication date
PT70818A (fr) 1980-03-01
NO800326L (no) 1980-08-13
DE3060236D1 (en) 1982-04-29
IL59358A0 (en) 1980-05-30
ZA80742B (en) 1981-02-25
EP0015798B1 (fr) 1982-03-24
GR74116B (es) 1984-06-06
EP0015798A1 (fr) 1980-09-17
IE800245L (en) 1980-08-12
IE49387B1 (en) 1985-10-02
DK58380A (da) 1980-08-13
FR2448544A1 (fr) 1980-09-05
JPS55111492A (en) 1980-08-28
AU5536180A (en) 1980-08-21
IL59358A (en) 1982-09-30
ATE772T1 (de) 1982-04-15
NZ192844A (en) 1981-07-13
FR2448544B1 (es) 1982-11-12
CA1117942A (en) 1982-02-09
US4282225A (en) 1981-08-04

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