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ES471964A1 - Un procedimiento para la preparacion de un tiofeno - Google Patents

Un procedimiento para la preparacion de un tiofeno

Info

Publication number
ES471964A1
ES471964A1 ES471964A ES471964A ES471964A1 ES 471964 A1 ES471964 A1 ES 471964A1 ES 471964 A ES471964 A ES 471964A ES 471964 A ES471964 A ES 471964A ES 471964 A1 ES471964 A1 ES 471964A1
Authority
ES
Spain
Prior art keywords
preparation
alpha
substituted
thien
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471964A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES471964A1 publication Critical patent/ES471964A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para la preparación de tiofenos 3- sustituidos que implica la ciclación de un nuevo intermediario y evita el uso de los costosos materiales de partida empleados anteriormente, los tiofenos son útiles para la preparación de penicilinas y cefalosporinas. El procedimiento se dirige a la preparación de un tiofeno de fórmula (I) **fórmula** donde R1 representa un grupo ácido carboxílico o un éster o amida del mismo o un grupo nitrilo, R2 representa un grupo adecuado para uso momo alfa sustituyente en la cadena lateral de una penicilina o cefalosporina, cuyo procedimiento consiste en tratar un compuesto de fórmula **fórmula** donde X representa halógeno o hidroxilo opcionalmente funcionalizado e Y representa halógeno, hidroxilo o alcoxi, con una fuente de azufre nucleófilo, en condiciones básicas.
ES471964A 1977-07-23 1978-07-21 Un procedimiento para la preparacion de un tiofeno Expired ES471964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3100877 1977-07-23

Publications (1)

Publication Number Publication Date
ES471964A1 true ES471964A1 (es) 1980-01-16

Family

ID=10316543

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471964A Expired ES471964A1 (es) 1977-07-23 1978-07-21 Un procedimiento para la preparacion de un tiofeno

Country Status (10)

Country Link
US (2) US4252976A (es)
EP (2) EP0023726B1 (es)
JP (1) JPS5424867A (es)
DK (1) DK323978A (es)
ES (1) ES471964A1 (es)
FI (1) FI782300A (es)
IE (1) IE47135B1 (es)
IL (1) IL55144A0 (es)
IT (1) IT1105934B (es)
ZA (1) ZA784101B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3163354D1 (en) * 1980-04-11 1984-06-07 Beecham Group Plc Process for the preparation of 3-substituted thiophenes
ES8204729A1 (es) * 1981-08-11 1982-05-16 Madaus Cerafarm Lab Procedimiento para la preparacion de acidos de 2-(3'-tienil)propionicos 5'-sustituidos
DE3544079C2 (de) * 1985-12-13 1998-07-30 Bosch Gmbh Robert Verfahren zur Verarbeitung von Interrupt-Signalen
AT392497B (de) 1989-06-02 1991-04-10 Voest Alpine Maschinenbau Gleitstuhl, gleitplatte bzw. rippenplatte fuer schienenweichen oder -kreuzungen
DE3919029A1 (de) * 1989-06-10 1990-12-13 Hoechst Ag Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester
WO1993009112A1 (en) * 1991-11-06 1993-05-13 Ciba-Geigy Ag A process for the production of cyclic sulfonium salts
DE202008004595U1 (de) 2008-04-02 2008-07-17 Wastec B.V. Müllbehälter mit einer elektronischen Dateneinrichtung

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2381882A (en) * 1945-08-14 Ester
US2183929A (en) * 1939-12-19 Chx c ch
US2093519A (en) * 1935-04-25 1937-09-21 Ig Farbenindustrie Ag Process for the manufacture of condensation products of crotonaldehyde
FR990943A (fr) * 1948-07-20 1951-09-27 Bataafsche Petroleum Procédé de préparation des acides 2, 4-pentadiénoiques
US2540071A (en) * 1949-01-21 1951-01-30 Rohm & Haas Allylic rearrangement
US2662914A (en) * 1950-04-22 1953-12-15 Eastman Kodak Co Alpha, alpha-vitamin a diacid and synthesis of isoprenic polyenes
US3360527A (en) * 1966-05-03 1967-12-26 Bristol Banyu Res Inst Ltd Vinylpenicillins
DE1667997A1 (de) * 1967-01-13 1971-07-22 Tenneco Chem Fungicide Mittel und diese enthaltendes Saatgut
US3801608A (en) * 1972-07-17 1974-04-02 Zoecon Corp Novel 2,4-diolefinic 2,2-diesters and cyanoesters
SU527431A1 (ru) * 1974-10-22 1976-09-05 Иркутский институт органической химии СО АН СССР Способ получени тиофена и тиоацетальдегида
JPS51122061A (en) * 1975-03-20 1976-10-25 Seitetsu Kagaku Co Ltd Process for preparation of thiophene and its derivatives

Also Published As

Publication number Publication date
IT1105934B (it) 1985-11-11
EP0000633B1 (en) 1981-11-04
US4282373A (en) 1981-08-04
ZA784101B (en) 1979-07-25
IE47135B1 (en) 1983-12-28
IT7850415A0 (it) 1978-07-21
FI782300A (fi) 1979-01-24
JPS5424867A (en) 1979-02-24
US4252976A (en) 1981-02-24
EP0023726A1 (en) 1981-02-11
IL55144A0 (en) 1978-09-29
DK323978A (da) 1979-01-24
IE781469L (en) 1979-01-23
EP0000633A2 (en) 1979-02-07
EP0023726B1 (en) 1982-05-19
EP0000633A3 (en) 1979-06-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202