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ES476305A1 - Un procedimiento para la preparacion de nuevos derivados aminicos - Google Patents

Un procedimiento para la preparacion de nuevos derivados aminicos

Info

Publication number
ES476305A1
ES476305A1 ES476305A ES476305A ES476305A1 ES 476305 A1 ES476305 A1 ES 476305A1 ES 476305 A ES476305 A ES 476305A ES 476305 A ES476305 A ES 476305A ES 476305 A1 ES476305 A1 ES 476305A1
Authority
ES
Spain
Prior art keywords
zero
lower alkyl
group
furan
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES476305A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES476305A1 publication Critical patent/ES476305A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1.Un procedimiento para la preparación de nuevos derivados amínicos de fórmula general (I): **Fórmula-01** y sus sales fisiológicamente aceptables, N-óxidos, hidratos y bioprecursores de los mismos; en cuya fórmula y representa =O, =S, =CHNO2 ó =NR3, donde R3 representa hidrógeno, nitro, ciano, alquilo inferior, arilo, (alquil inferior)sulfonilo o arilsulfonilo; R1 y R2, que pueden ser iguales o diferentes, representan cada uno de ellos hidrógeno, alquilo inferior, cicloalquilo, alquenilo inferior, aralquilo, hidroxi, trifluoralquilo inferior, alquilo inferior sustituido con hidroxi, alcoxi inferior, amino, alquilamino inferior o dialquilamino inferior o bien R1 y R2 junto con el átomo de nitrógeno al que están enlazados forman un anillo heterocíclico de 5 a 7 miembros que puede contener otros hereroátomos o el grupo **Fórmula-02**, donde R4 representa hidrógeno o alquilo inferior; Q representa un anillo de furano o tiofeno cuya incorporación al resto de la molécula se realiza a través de enlaces en las posiciones 2 y 5 o un anillo de benceno cuya incorporación al resto de la molécula se realiza a través de enlaces en las posiciones 1 y 3 o 1 y 4; X representa -CH2-, -O- ó -S-; n representa 0, 1 ó 2; m representa 2, 3 ó 4; Alq representa un grupo alquilo de cadena lineal de 1 a 3 átomos de carbono; (con la excepción de que n no es O cuando X es oxígeno y Q es un sistema cíclico de furano o tiofeno); q representa 2, 3 ó 4 o adicionalmente puede representar 0 ó 1 cuando E es un grupo -CH2-; p representa 0, 1 ó 2; E representa -CH2-, -O- ó -S- y Z representa un anillo aromático monocíclico, carbocíclico o heterocíclico de 5 ó 6 miembros que puede estar opcionalmente sustituido con uno o más grupos.
ES476305A 1977-12-23 1978-12-22 Un procedimiento para la preparacion de nuevos derivados aminicos Expired ES476305A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5371677 1977-12-23
GB7844778 1978-11-16

Publications (1)

Publication Number Publication Date
ES476305A1 true ES476305A1 (es) 1980-05-16

Family

ID=26267325

Family Applications (1)

Application Number Title Priority Date Filing Date
ES476305A Expired ES476305A1 (es) 1977-12-23 1978-12-22 Un procedimiento para la preparacion de nuevos derivados aminicos

Country Status (11)

Country Link
US (3) US4233302A (es)
EP (1) EP0002930B1 (es)
JP (1) JPS54109963A (es)
AU (1) AU525927B2 (es)
DE (1) DE2862355D1 (es)
DK (1) DK581278A (es)
ES (1) ES476305A1 (es)
FI (1) FI783917A (es)
IE (1) IE47701B1 (es)
IT (1) IT1109339B (es)
NZ (1) NZ189253A (es)

Families Citing this family (51)

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US4238487A (en) * 1979-10-31 1980-12-09 Merck & Co., Inc. Aminoalkyl benzofuran derivatives
YU53681A (en) * 1980-03-08 1983-12-31 Smith Kline French Lab Process for obtaining 5-dimethylamino-methyl-2-furane methanol
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
JPS57102852A (en) * 1980-12-19 1982-06-26 Shionogi & Co Ltd Dicarboxylic acid diamide
US4374378A (en) * 1981-01-28 1983-02-15 The United States Of America As Represented By The United States National Aeronautics And Space Administration Scanning seismic intrusion detection method and apparatus
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US4503051A (en) * 1981-05-18 1985-03-05 Bristol-Myers Company Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
US4539316A (en) * 1981-05-18 1985-09-03 Bristol-Myers Company Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US4546188A (en) * 1981-05-18 1985-10-08 Bristol-Myers Company Substituted 1,2-diaminocyclobutene-3,4-diones
US4607105A (en) * 1981-05-18 1986-08-19 Bristol-Myers Company 3-cyclobutene-1,2-dione intermediates
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
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US4597902A (en) * 1981-05-20 1986-07-01 A. H. Robins Company, Incorporated N-(arylthioalkyl)-N'-(aminoalkyl)ureas
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WO1983002113A1 (en) * 1981-12-17 1983-06-23 Yuki, Hiroshi Propenylamine derivatives and drug containing same
US4478821A (en) * 1982-01-26 1984-10-23 The Gillette Company Inhibition of body odor
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
IT1190793B (it) * 1982-04-27 1988-02-24 Magis Farmaceutici Composti attivi nel trattamento dell'ulcera e sintomi allergici della pelle
DE3238867A1 (de) * 1982-10-20 1984-04-26 Ludwig Heumann & Co GmbH, 8500 Nürnberg Heterocyclische verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS5988458A (ja) * 1982-11-12 1984-05-22 Toyama Chem Co Ltd アミン誘導体およびその塩
CA1254212A (en) * 1982-11-12 1989-05-16 Shiro Hirai Amine derivatives, salts thereof, process for preparing the same and an anti-ulcer agent containing the same
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
ES521588A0 (es) * 1983-03-30 1984-08-16 Ferrer Int Procedimiento de obtencion de nuevas n-ciano-formamidinas.
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JPH0639466B2 (ja) * 1987-08-03 1994-05-25 杏林製薬株式会社 ウレア誘導体
US4918086A (en) * 1987-08-07 1990-04-17 Ciba-Geigy Corporation 1-nitro-2,2-diaminoethylene derivatives
JPH01131172A (ja) * 1987-08-28 1989-05-24 Toyama Chem Co Ltd アミン誘導体およびその塩、それらの製造法、並びにそれらを含有する抗潰瘍剤
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Also Published As

Publication number Publication date
JPS54109963A (en) 1979-08-29
DK581278A (da) 1979-08-09
US4304780A (en) 1981-12-08
IE782542L (en) 1979-06-23
DE2862355D1 (en) 1984-01-19
NZ189253A (en) 1981-07-13
JPH0220639B2 (es) 1990-05-10
FI783917A (fi) 1979-06-24
IE47701B1 (en) 1984-05-30
US4279911A (en) 1981-07-21
US4233302A (en) 1980-11-11
IT7852447A0 (it) 1978-12-22
EP0002930A1 (en) 1979-07-11
EP0002930B1 (en) 1983-12-14
AU4273578A (en) 1979-06-28
IT1109339B (it) 1985-12-16
AU525927B2 (en) 1982-12-09

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202