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ES427164A1 - Spinal anesthesia using small amounts of tetrodotoxin or desoxytetrodotoxin - Google Patents

Spinal anesthesia using small amounts of tetrodotoxin or desoxytetrodotoxin

Info

Publication number
ES427164A1
ES427164A1 ES427164A ES427164A ES427164A1 ES 427164 A1 ES427164 A1 ES 427164A1 ES 427164 A ES427164 A ES 427164A ES 427164 A ES427164 A ES 427164A ES 427164 A1 ES427164 A1 ES 427164A1
Authority
ES
Spain
Prior art keywords
desoxytetrodotoxin
tetrodotoxin
small amounts
spinal anesthesia
micrograms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES427164A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra USA Inc
Original Assignee
Astra Pharmaceutical Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharmaceutical Products Inc filed Critical Astra Pharmaceutical Products Inc
Publication of ES427164A1 publication Critical patent/ES427164A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Vertebrates can be anesthetized regionally by a subarachnoid administration of tetrodotoxin or desoxytetrodotoxin. The amount of tetrodotoxin which should be administered in a preferred embodiment ranges between 1 and 12 micrograms, whereas the amount of desoxytetrodotoxin ranges between 10 and 120 micrograms.
ES427164A 1973-08-14 1974-06-11 Spinal anesthesia using small amounts of tetrodotoxin or desoxytetrodotoxin Expired ES427164A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US388147A US3898339A (en) 1973-08-14 1973-08-14 Spinal anesthesia using small amounts of tetrodotoxin or desoxytetrodotoxin

Publications (1)

Publication Number Publication Date
ES427164A1 true ES427164A1 (en) 1976-10-01

Family

ID=23532901

Family Applications (1)

Application Number Title Priority Date Filing Date
ES427164A Expired ES427164A1 (en) 1973-08-14 1974-06-11 Spinal anesthesia using small amounts of tetrodotoxin or desoxytetrodotoxin

Country Status (14)

Country Link
US (1) US3898339A (en)
JP (1) JPS5048112A (en)
AT (1) AT335616B (en)
BE (1) BE816214A (en)
CA (1) CA1027863A (en)
DD (1) DD115035A5 (en)
DE (1) DE2427732A1 (en)
ES (1) ES427164A1 (en)
FR (1) FR2240735B1 (en)
GB (1) GB1453343A (en)
IE (1) IE39410B1 (en)
LU (1) LU70304A1 (en)
NL (1) NL7407853A (en)
ZA (1) ZA743765B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69529156T2 (en) * 1994-03-17 2003-09-25 Nanning Maple Leaf Pharmaceutical Co., Ltd. USE OF AMINO-HYDROGENATED CHINAZOLINE COMPOUNDS AND THEIR DERIVATIVES FOR BODYING IN DRUG ADDICTION
CN1051706C (en) * 1994-03-17 2000-04-26 南宁枫叶药业有限公司 Amino hydrogenated quinazoline oxazoline compound and derivant thereof are guarded against the new purposes of falling drug dependence
US5585398A (en) * 1994-07-15 1996-12-17 Ernst; Amy A. Topical anesthetic comprising lidocaine, adrenaline, and tetracaine, and its method of use
US5550049A (en) 1994-11-10 1996-08-27 Merck & Co., Inc Process for identifying para cation channel modulators
WO1998043619A2 (en) * 1997-04-02 1998-10-08 The Regents Of The University Of California Method of local anesthesia
CN1236773C (en) * 2000-11-22 2006-01-18 南宁枫叶药业有限公司 Preparation for analgesia and anesthesia or curing drug dependence
AU2005287580A1 (en) * 2004-09-22 2006-03-30 Wex Medical Limited Tetrodotoxin and its derivatives for the treatment of peripheral-nervously derived neuropathic pain
EP1931349A4 (en) * 2005-08-25 2009-08-05 Wex Pharmaceuticals Inc Use of sodium channel blockers for the management of musculoskeletal pain
US9018222B2 (en) 2006-03-27 2015-04-28 Wex Medical Limited Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy

Also Published As

Publication number Publication date
BE816214A (en) 1974-12-12
AU6993474A (en) 1975-12-11
FR2240735B1 (en) 1978-07-28
LU70304A1 (en) 1976-04-13
CA1027863A (en) 1978-03-14
IE39410L (en) 1975-02-14
JPS5048112A (en) 1975-04-30
US3898339A (en) 1975-08-05
GB1453343A (en) 1976-10-20
NL7407853A (en) 1975-02-18
DE2427732A1 (en) 1975-02-27
FR2240735A1 (en) 1975-03-14
DD115035A5 (en) 1975-09-12
ZA743765B (en) 1975-06-25
AT335616B (en) 1977-03-25
ATA484974A (en) 1976-07-15
IE39410B1 (en) 1978-09-27

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