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ES413260A1 - Nn * 11 chikan 33 pirorijiniru * chiobenzuamidono seiho - Google Patents

Nn * 11 chikan 33 pirorijiniru * chiobenzuamidono seiho

Info

Publication number
ES413260A1
ES413260A1 ES413260A ES413260A ES413260A1 ES 413260 A1 ES413260 A1 ES 413260A1 ES 413260 A ES413260 A ES 413260A ES 413260 A ES413260 A ES 413260A ES 413260 A1 ES413260 A1 ES 413260A1
Authority
ES
Spain
Prior art keywords
formula
phenyl
lower alcohol
substituted
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES413260A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES413260A1 publication Critical patent/ES413260A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Method of preparing N- (1-substituted-3-pyrrolidinyl) benzamides having the following structural formula: **(See formula)** where R is cycloalkyl phenyl and phenyl-lower alcohol, R1 is hydrogen, lower alcohol of 1 to 8 carbon atoms and phenyl, R2 is halogen, lower alcohol, lower alkoxy, amino, nitro, monoalkoxylamino, dialcoylamino, mercaptomethyl, acetamido, sulfamoyl, cyano, hydroxyl, benzyloxy and trifluoromethyl, n is an integer from zero to three inclusive, as well as its optical isomers and its pharmaceutically acceptable acid addition salts, characterized in that 3-amino pyrrolidine is mixed and reacted substituted of the formula: **(See formula)** wherein R and R1 are as defined above, with a substituted benzoyl chloride of the formula: **(See formula)** wherein R2 and n are as defined above, provided that R2 is not primary amino or acetamido, to obtain the compound of formula I above. (Machine-translation by Google Translate, not legally binding)
ES413260A 1972-04-03 1973-04-02 Nn * 11 chikan 33 pirorijiniru * chiobenzuamidono seiho Expired ES413260A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24084072A 1972-04-03 1972-04-03
US34041773A 1973-03-12 1973-03-12

Publications (1)

Publication Number Publication Date
ES413260A1 true ES413260A1 (en) 1976-05-16

Family

ID=26933765

Family Applications (1)

Application Number Title Priority Date Filing Date
ES413260A Expired ES413260A1 (en) 1972-04-03 1973-04-02 Nn * 11 chikan 33 pirorijiniru * chiobenzuamidono seiho

Country Status (9)

Country Link
JP (4) JPS5620312B2 (en)
CA (1) CA999003A (en)
CH (1) CH580582A5 (en)
DK (1) DK138491B (en)
ES (1) ES413260A1 (en)
NL (1) NL178318C (en)
NO (1) NO142077C (en)
PH (1) PH15259A (en)
SE (3) SE402102B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8362003B2 (en) 2002-11-27 2013-01-29 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA732296B (en) * 1972-04-03 1974-11-27 Robins Co Inc A H Method for controlling emesis with n-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
JPS5423113Y2 (en) * 1974-10-08 1979-08-09
JPS5925784B2 (en) * 1975-12-17 1984-06-21 山之内製薬株式会社 Synquina carbon amide
JPS5232815U (en) * 1975-08-28 1977-03-08
JPS5925785B2 (en) * 1976-01-01 1984-06-21 山之内製薬株式会社 Novel carboxylic acid amide derivative
JPS5522699A (en) * 1979-08-10 1980-02-18 Yamanouchi Pharmaceut Co Ltd Novel 3-amino-1-benzylpyrrolidine derivative
JPS6316492U (en) * 1986-07-18 1988-02-03
WO1995029891A1 (en) * 1994-04-28 1995-11-09 Yamanouchi Pharmaceutical Co., Ltd. N-(3-pyrrolidinyl)benzamide derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8362003B2 (en) 2002-11-27 2013-01-29 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
US8729063B2 (en) 2002-11-27 2014-05-20 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors

Also Published As

Publication number Publication date
DK138491B (en) 1978-09-18
SE7711953L (en) 1977-10-24
CH580582A5 (en) 1976-10-15
NL178318B (en) 1985-10-01
CA999003A (en) 1976-10-26
DE2316644B2 (en) 1977-04-28
JPS4913165A (en) 1974-02-05
PH15259A (en) 1982-11-02
JPS5527905B2 (en) 1980-07-24
SE402102B (en) 1978-06-19
SE431868B (en) 1984-03-05
JPS5620312B2 (en) 1981-05-13
NO142077B (en) 1980-03-17
DK138491C (en) 1979-04-09
NL7304557A (en) 1973-10-05
NO142077C (en) 1980-06-25
NL178318C (en) 1986-03-03
DE2316644A1 (en) 1973-10-18
SE8302193D0 (en) 1983-04-19
SE8302193L (en) 1983-04-19
JPS5069067A (en) 1975-06-09
SE431869B (en) 1984-03-05
JPS5069066A (en) 1975-06-09
JPS5182261A (en) 1976-07-19

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