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ES406134A1 - Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES406134A1
ES406134A1 ES406134A ES406134A ES406134A1 ES 406134 A1 ES406134 A1 ES 406134A1 ES 406134 A ES406134 A ES 406134A ES 406134 A ES406134 A ES 406134A ES 406134 A1 ES406134 A1 ES 406134A1
Authority
ES
Spain
Prior art keywords
carbon atoms
radical
alcohol
signifies hydrogen
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406134A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of ES406134A1 publication Critical patent/ES406134A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedure for the preparation of 3,4-dihydro-2H-isoquinoline-1-thiones of the general formula **(See formula)** in which R1 and R2 each signify the same or different alcohol radicals, each with 1 to 6 carbon atoms or R1 signifies a phenylalkyl radical with 7 or 8 carbon atoms or a phenyl radical and at the same time R2 signifies hydrogen, a alcoholic or alcoholic radical with 1 to 6 carbon atoms, a carbon atom being able to be replaced by an oxygen or sulfur atom or it means a phenyl radical, being able to form R1 and R2 also, together with the carbon atom in position 4, a ring 5- or 6-membered saturated carbocyclic, R3 signifies hydrogen or an alkoxy group with 1 to 4 carbon atoms, and R4 signifies hydrogen or together with R3 the 6,7-oxymethylene group, and R5 signifies hydrogen or an alcohol radical with 1 to 4 6 carbon atoms, preferably with 1-4 carbon atoms, characterized in that a) it is subjected to cyclization by treatment with acid catalysts to compounds of the general formulas **(See formula)** wherein R1 to R5 have the above meanings and Y means an optionally substituted amino group, an O-alcohol or S-alcohol radical or an S-phenyl radical; or b) in compounds of the general formula III **(See formula)** the oxygen atom is replaced by sulfur in a manner known per se. (Machine-translation by Google Translate, not legally binding)
ES406134A 1971-09-01 1972-08-26 Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding) Expired ES406134A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2143745A DE2143745A1 (en) 1971-09-01 1971-09-01 3,4-DIHYDRO-2H-ISOCHINOLIN-1-THIONE AND THE METHOD FOR MANUFACTURING IT

Publications (1)

Publication Number Publication Date
ES406134A1 true ES406134A1 (en) 1975-08-01

Family

ID=5818354

Family Applications (1)

Application Number Title Priority Date Filing Date
ES406134A Expired ES406134A1 (en) 1971-09-01 1972-08-26 Procedure for the preparation of 3-dihydro-2H-isoquinolein-1-tionas. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
JP (1) JPS4834885A (en)
AU (1) AU4610472A (en)
BE (1) BE788321A (en)
CA (1) CA972755A (en)
DD (1) DD102148A5 (en)
DE (1) DE2143745A1 (en)
ES (1) ES406134A1 (en)
FR (1) FR2151044A1 (en)
IL (1) IL40250A0 (en)
NL (1) NL7211627A (en)
ZA (1) ZA725997B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89997A0 (en) * 1988-04-25 1989-12-15 Lilly Co Eli Propanamine derivatives
US5177075A (en) * 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
ATE117553T1 (en) * 1988-08-19 1995-02-15 Warner Lambert Co SUBSTITUTED DIHYDROISOCINOLINONES AND RELATED COMPOUNDS AS AMPLIFIERS OF THE LETHAL EFFECTS OF RADIATION AND CERTAIN CHEMOTHERAPEUTICS; SELECTED COMPOUNDS, ANALOGUES AND METHODS.
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
CA2444531A1 (en) 2001-05-08 2002-11-14 Kudos Pharmaceuticals Limited Isoquinolinone derivatives as parp inhibitors
ATE491703T1 (en) 2002-04-30 2011-01-15 Kudos Pharm Ltd PHTHALAZINONE DERIVATIVES
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
CA2699038A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
WO2009050469A1 (en) 2007-10-17 2009-04-23 Kudos Pharmaceuticals Limited 4- [3- (4-cyclopropanecarbonyl-piperazine-i-carbonyl) -4 -fluoro-benzyl] -2h-phthalaz in-1-one
UY31603A1 (en) 2008-01-23 2009-08-31 DERIVATIVES OF FTALAZINONA
CN102238945B (en) 2008-10-07 2014-10-29 阿斯利康(英国)有限公司 Pharmaceutical formulation 514

Also Published As

Publication number Publication date
BE788321A (en) 1973-03-01
FR2151044A1 (en) 1973-04-13
DE2143745A1 (en) 1973-03-08
JPS4834885A (en) 1973-05-22
AU4610472A (en) 1974-03-07
CA972755A (en) 1975-08-12
IL40250A0 (en) 1972-10-29
ZA725997B (en) 1973-07-25
DD102148A5 (en) 1973-12-05
NL7211627A (en) 1973-03-05

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