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ES406047A1 - Procedimiento para la produccion de agentes coronaries en capsulas de gelatine rompibles por mordedura - Google Patents

Procedimiento para la produccion de agentes coronaries en capsulas de gelatine rompibles por mordedura

Info

Publication number
ES406047A1
ES406047A1 ES406047A ES406047A ES406047A1 ES 406047 A1 ES406047 A1 ES 406047A1 ES 406047 A ES406047 A ES 406047A ES 406047 A ES406047 A ES 406047A ES 406047 A1 ES406047 A1 ES 406047A1
Authority
ES
Spain
Prior art keywords
weight
gelatin capsules
procedure
parts
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES406047A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25761638&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES406047(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19722209526 external-priority patent/DE2209526C3/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES406047A1 publication Critical patent/ES406047A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00—Special receptacle or package
    • Y10S206/828—Medicinal content

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedimiento para la producción de agentes coronarios en cápsulas de gelatina rompibles por mordedura, conteniendo 4-(2''-nitrofenil)-2,6-dimetil-3,5-dicarbometoxi-1,4- dihidropiridina y un polialquilenglicol, de administración per os; caracterizado porque en una primera etapa, se prepara un agente coronario de rápida actuación perlingualmente resorbible, mezclando, bajo luz amarilla de sodio, en secuencia arbitraria, (a) 1 parte en peso de 4- (2''nitro-fenil)-2,6-dimetil-3,5-dicarbometoxi-1,4-dihidropiridina, (b) 6 a 50 preferentemente 15 a 35, partes en peso de polialquilenglicol con 2-3 átomos de carbono en los restos alquileno y con un peso molecular medio de 200 a 600, © 1 a 10 partes en peso de alcoholes inferiores con 1 a 3 grupos hidroxilo, especialmente glicerina ; (d) 1 a 10 partes en peso de agua, y, en caso dado, ulteriores agentes auxiliares de formulación usuales, y en una segunda etapa, la solución así obtenida se llena en cápsulas de gelatina que contienen un colorante que absorbe la luz con longitud de onda de 280 a 420 nm, especialmente el colorante para alimentos Gelborange-S (color index 15 985) y agentes opaquizantes, especialmente dióxido de titanio, formándose estas cápsulas de gelatina de dos bandas de gelatina por el procedimiento de "rotary-die" , primeramente en dos medios cuencos que después se sueldan con excepción de una pequeña abertura para el llenado de la solución de sustancia activa y que, después de llenar con la solución, se sellan totalmente por soldadura.
ES406047A 1971-08-24 1972-08-23 Procedimiento para la produccion de agentes coronaries en capsulas de gelatine rompibles por mordedura Expired ES406047A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2142316 1971-08-24
DE19722209526 DE2209526C3 (de) 1972-02-29 1972-02-29 Coronartherapeutlkum in Form von Gelatine-BeiBkapseln

Publications (1)

Publication Number Publication Date
ES406047A1 true ES406047A1 (es) 1981-08-16

Family

ID=25761638

Family Applications (1)

Application Number Title Priority Date Filing Date
ES406047A Expired ES406047A1 (es) 1971-08-24 1972-08-23 Procedimiento para la produccion de agentes coronaries en capsulas de gelatine rompibles por mordedura

Country Status (25)

Country Link
US (1) US3784684A (es)
JP (2) JPS5434048B2 (es)
KR (1) KR780000433B1 (es)
BE (1) BE787951A (es)
BG (1) BG27728A3 (es)
CA (1) CA981582A (es)
CY (1) CY918A (es)
DD (1) DD99729A5 (es)
DK (1) DK130628B (es)
EG (1) EG10633A (es)
ES (1) ES406047A1 (es)
FI (1) FI53922C (es)
FR (1) FR2150848B1 (es)
GB (1) GB1362627A (es)
HK (1) HK44877A (es)
IE (1) IE36891B1 (es)
IL (1) IL40165A (es)
KE (1) KE2756A (es)
LU (1) LU65929A1 (es)
MY (1) MY7800003A (es)
NL (1) NL176836C (es)
NO (1) NO138167C (es)
RO (1) RO88521B (es)
SG (1) SG34877G (es)
SU (1) SU432703A3 (es)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
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ZA725808B (en) * 1971-08-24 1973-05-30 Bayer Ag A coronary agent in special form and processes for its manufacture
SU432703A3 (es) * 1971-08-24 1974-06-15 Фридрих Боссерт, Вульф Фатер, Курт Бауер
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Also Published As

Publication number Publication date
US3784684A (en) 1974-01-08
NL176836C (nl) 1985-06-17
CA981582A (en) 1976-01-13
FI53922C (fi) 1979-09-07
IL40165A0 (en) 1972-10-29
IE36891B1 (en) 1977-03-16
SG34877G (en) 1987-04-03
NO138167B (no) 1978-04-10
JPS5434048B2 (es) 1979-10-24
DD99729A5 (es) 1973-08-20
BE787951A (fr) 1973-02-26
IE36891L (en) 1973-02-24
EG10633A (en) 1976-08-31
FR2150848B1 (es) 1976-04-16
CY918A (en) 1977-12-23
MY7800003A (en) 1978-12-31
JPS53121921A (en) 1978-10-24
KE2756A (en) 1977-10-14
DK130628B (da) 1975-03-17
GB1362627A (en) 1974-08-07
IL40165A (en) 1975-03-13
NO138167C (no) 1978-07-26
RO88521B (ro) 1987-05-01
SU432703A3 (es) 1974-06-15
NL176836B (nl) 1985-01-16
HK44877A (en) 1977-09-09
NL7211565A (es) 1973-02-27
LU65929A1 (es) 1973-01-15
KR780000433B1 (en) 1978-10-14
JPS4828621A (es) 1973-04-16
RO88521A (ro) 1987-04-30
DK130628C (es) 1975-08-25
FI53922B (fi) 1978-05-31
FR2150848A1 (es) 1973-04-13
BG27728A3 (en) 1979-12-12

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