ES329462A1 - A procedure for the preparation of bencenosulfonilureas (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of bencenosulfonilureas (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES329462A1 ES329462A1 ES0329462A ES329462A ES329462A1 ES 329462 A1 ES329462 A1 ES 329462A1 ES 0329462 A ES0329462 A ES 0329462A ES 329462 A ES329462 A ES 329462A ES 329462 A1 ES329462 A1 ES 329462A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- formula
- salts
- ethers
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
A process for the preparation of benzenesulfonylureas of the formula ** (See formula) ** in which they mean: R lower alkyl, preferably methyl, or lower alkenyl. X halogen, preferably chloro, lower alkyl, preferably methyl, or lower alkoxy, preferably methoxy, in position 4 or 5 with respect to the carbonamide group. R cyclohexyl, methylcyclohexyl or ethylcyclohexyl, methyl and ethyl being preferably in position 4 with respect to the amino group of the cyclohexyl moiety, endomethylenecyclohexenylmethyl or endomethylenecyclohexylmethyl, or their salts, characterized in that a) benzenesulfonyl isocyanates, benzenesulfonylcarbamic acid esters, benzenesulfonylthiocarbamic acid esters, benzenesulfonylcarbamic acid halides or substituted benzenesulfonylureas in para position with the group ** (See formula) ** they are reacted with amines substituted with R 1 or optionally with their salts, b) benzenesulfonamides of the formula ** (See formula) ** or optionally their salts are reacted with isocyanates, carbamic acid esters, thiocarbamic acid esters, carbamic acid halides or ureas, all of which are substituted with R 1, c) correspondingly substituted benzenesulfonyl halides are reacted with ureas, isoureas ethers, isothioureas ethers or parabanic acids, all substituted with R1, and the benzenesulfonyl isurene ethers, benzene ethers, sulfonyl isothiourea or benzenesulfonylparaban acids, obtained therefrom or otherwise, they hydrolyze, d) in correspondingly substituted benzenesulfonylthioureas, the sulfur atom is permuted by an oxygen atom, e) corresponding benzenesulfenyl or benzenesulfinyl ureas are oxidized or f) in benzenesulfonylureas of the formula ** (See formula) ** the rest is introduced by acylation ** (See formula) ** optionally by phases and the products of the reaction are optionally treated with alkaline agents for the formation of salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF46721A DE1301812B (en) | 1965-07-27 | 1965-07-27 | Process for the preparation of benzenesulfonylureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES329462A1 true ES329462A1 (en) | 1967-12-01 |
Family
ID=7101195
Family Applications (15)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0329462A Expired ES329462A1 (en) | 1965-07-27 | 1966-07-23 | A procedure for the preparation of bencenosulfonilureas (Machine-translation by Google Translate, not legally binding) |
| ES344045A Expired ES344045A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344044A Expired ES344044A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344048A Expired ES344048A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344046A Expired ES344046A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344049A Expired ES344049A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344047A Expired ES344047A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355481A Expired ES355481A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355475A Expired ES355475A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355479A Expired ES355479A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355474A Expired ES355474A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355478A Expired ES355478A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355476A Expired ES355476A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355480A Expired ES355480A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355477A Expired ES355477A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
Family Applications After (14)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES344045A Expired ES344045A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344044A Expired ES344044A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344048A Expired ES344048A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344046A Expired ES344046A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344049A Expired ES344049A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES344047A Expired ES344047A1 (en) | 1965-07-27 | 1967-08-11 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355481A Expired ES355481A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355475A Expired ES355475A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355479A Expired ES355479A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355474A Expired ES355474A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355478A Expired ES355478A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355476A Expired ES355476A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355480A Expired ES355480A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
| ES355477A Expired ES355477A1 (en) | 1965-07-27 | 1968-06-26 | Benzenesulphonyl-ureas and process for their manufacture |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS526985B1 (en) |
| AT (11) | AT278032B (en) |
| BE (2) | BE684654A (en) |
| BR (2) | BR6681115D0 (en) |
| CH (1) | CH478103A (en) |
| CY (2) | CY534A (en) |
| DE (1) | DE1301812B (en) |
| DK (2) | DK117419B (en) |
| ES (15) | ES329462A1 (en) |
| FI (1) | FI45959C (en) |
| FR (1) | FR5943M (en) |
| GB (2) | GB1153272A (en) |
| IL (2) | IL26016A (en) |
| IN (3) | IN139503B (en) |
| IS (2) | IS756B6 (en) |
| IT (2) | IT1043760B (en) |
| LU (2) | LU51616A1 (en) |
| MC (1) | MC601A1 (en) |
| MY (2) | MY7000086A (en) |
| NL (1) | NL6610580A (en) |
| NO (2) | NO121834B (en) |
| SE (1) | SE328566B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670901A1 (en) * | 1967-08-09 | 1971-03-18 | Hoechst Ag | Process for the preparation of benzenesulfonylureas |
| DE3833439A1 (en) * | 1988-10-01 | 1991-09-12 | Hoechst Ag | METHOD FOR MICRONIZING GLIBENCLAMIDE |
-
1965
- 1965-07-27 DE DEF46721A patent/DE1301812B/en active Pending
-
1966
- 1966-04-25 NO NO162726A patent/NO121834B/no unknown
- 1966-06-22 IL IL26016A patent/IL26016A/en unknown
- 1966-07-08 BR BR181115/66A patent/BR6681115D0/en unknown
- 1966-07-13 DK DK364466AA patent/DK117419B/en unknown
- 1966-07-14 IT IT15327/66A patent/IT1043760B/en active
- 1966-07-14 FI FI661889A patent/FI45959C/en active
- 1966-07-21 IL IL26194A patent/IL26194A/en unknown
- 1966-07-22 LU LU51616D patent/LU51616A1/xx unknown
- 1966-07-22 LU LU51617D patent/LU51617A1/xx unknown
- 1966-07-22 IS IS1581A patent/IS756B6/en unknown
- 1966-07-23 ES ES0329462A patent/ES329462A1/en not_active Expired
- 1966-07-25 GB GB33285/66A patent/GB1153272A/en not_active Expired
- 1966-07-25 AT AT824368A patent/AT278032B/en not_active IP Right Cessation
- 1966-07-25 AT AT711268A patent/AT274842B/en active
- 1966-07-25 AT AT710868A patent/AT274838B/en active
- 1966-07-25 AT AT711168A patent/AT274841B/en active
- 1966-07-25 GB GB33416/66A patent/GB1149391A/en not_active Expired
- 1966-07-25 AT AT708266A patent/AT275541B/en active
- 1966-07-25 AT AT711068A patent/AT274840B/en active
- 1966-07-25 AT AT08242/68A patent/AT278031B/en not_active IP Right Cessation
- 1966-07-25 AT AT08244/68A patent/AT279638B/de not_active IP Right Cessation
- 1966-07-25 AT AT710968A patent/AT274839B/en active
- 1966-07-25 AT AT708166A patent/AT274830B/en active
- 1966-07-26 DK DK388766AA patent/DK123652B/en unknown
- 1966-07-26 NO NO164067A patent/NO123569B/no unknown
- 1966-07-26 SE SE10158/66A patent/SE328566B/xx unknown
- 1966-07-26 IS IS1582A patent/IS822B6/en unknown
- 1966-07-26 IT IT17340/66A patent/IT1043761B/en active
- 1966-07-26 MC MC636A patent/MC601A1/en unknown
- 1966-07-27 JP JP41049301A patent/JPS526985B1/ja active Pending
- 1966-07-27 BE BE684654D patent/BE684654A/xx not_active IP Right Cessation
- 1966-07-27 NL NL6610580A patent/NL6610580A/xx unknown
- 1966-07-27 CH CH1086166A patent/CH478103A/en not_active IP Right Cessation
- 1966-07-27 BR BR181609/66A patent/BR6681609D0/en unknown
- 1966-07-27 BE BE684652D patent/BE684652A/xx not_active IP Right Cessation
- 1966-08-31 AT AT08241/68A patent/AT279637B/en not_active IP Right Cessation
- 1966-10-26 FR FR81659A patent/FR5943M/fr not_active Expired
-
1967
- 1967-08-11 ES ES344045A patent/ES344045A1/en not_active Expired
- 1967-08-11 ES ES344044A patent/ES344044A1/en not_active Expired
- 1967-08-11 ES ES344048A patent/ES344048A1/en not_active Expired
- 1967-08-11 ES ES344046A patent/ES344046A1/en not_active Expired
- 1967-08-11 ES ES344049A patent/ES344049A1/en not_active Expired
- 1967-08-11 ES ES344047A patent/ES344047A1/en not_active Expired
-
1968
- 1968-06-26 ES ES355481A patent/ES355481A1/en not_active Expired
- 1968-06-26 ES ES355475A patent/ES355475A1/en not_active Expired
- 1968-06-26 ES ES355479A patent/ES355479A1/en not_active Expired
- 1968-06-26 ES ES355474A patent/ES355474A1/en not_active Expired
- 1968-06-26 ES ES355478A patent/ES355478A1/en not_active Expired
- 1968-06-26 ES ES355476A patent/ES355476A1/en not_active Expired
- 1968-06-26 ES ES355480A patent/ES355480A1/en not_active Expired
- 1968-06-26 ES ES355477A patent/ES355477A1/en not_active Expired
-
1970
- 1970-04-07 CY CY53470A patent/CY534A/en unknown
- 1970-05-22 CY CY54070A patent/CY540A/en unknown
- 1970-12-31 MY MY197086A patent/MY7000086A/en unknown
- 1970-12-31 MY MY1970111A patent/MY7000111A/en unknown
-
1974
- 1974-08-24 IN IN1914/CAL/74A patent/IN139503B/en unknown
- 1974-08-24 IN IN1917/CAL/74A patent/IN139506B/en unknown
- 1974-08-24 IN IN1912/CAL/74A patent/IN139501B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1127050A (en) | Substituted phenylcarbamates and herbicidal preparations thereof | |
| DE3887919D1 (en) | Means for preserving wood and wood-based materials. | |
| ES457806A1 (en) | A PROCEDURE FOR THE PREPARATION OF PHENYL UREAS. | |
| ES329462A1 (en) | A procedure for the preparation of bencenosulfonilureas (Machine-translation by Google Translate, not legally binding) | |
| GB1407856A (en) | Anti-inflammatory thiazole compositions and methods for using same | |
| GB1020819A (en) | N-substituted tetrahydrothiazine dioxides and process for preparing them | |
| KR840007564A (en) | Method for preparing substituted benzylcycloalkenylurea derivatives | |
| KR840004081A (en) | Method for preparing sulfonyl urea | |
| ES376816A1 (en) | N - (4-(beta-<2-methoxy-5-chloro-benzamido>-ethyl) - benzenesulfonyl)-n'-cyclopentyl-urea and process for its manufacture | |
| GB1472127A (en) | Phenyl-thiadiazolyl-thiourea | |
| KR850004578A (en) | Method for preparing a novel 1,4-naphthoquinone derivative | |
| GB1182694A (en) | Benzenesulfonyl Ureas and process for their manufacture | |
| ES312479A1 (en) | A process for the preparation of N- (4- (beta-phenoxyacetamidoethyl) -benenosulfonil) -n'-ciclohexilurea. (Machine-translation by Google Translate, not legally binding) | |
| GB1127672A (en) | Benzenesulphonyl-ureas and process for their manufacture | |
| GB1185395A (en) | Benzenesulphonyl-Ureas and process for preparing them | |
| ES312477A1 (en) | Procedure for the preparation of N- (4 (beta-4-chloro-benzamidoethyl) -benenosulfonil) -n'-ciclohexilurea. (Machine-translation by Google Translate, not legally binding) | |
| ES312471A1 (en) | Procedure for the preparation of N-4- (beta-benzamidoethyl) -benenosulfonil n'-ciclohexilurea. (Machine-translation by Google Translate, not legally binding) | |
| ES310736A1 (en) | Benzenesulfonyl ureas | |
| GB1002650A (en) | New azido-benzenesulphonyl ureas, a process for their manufacture and pharmaceutical preparations containing them | |
| GB808071A (en) | Manufacture of new sulphonyl-ureas | |
| GB953097A (en) | New benzenesulphonyl ureas and process for their manufacture | |
| ATE22880T1 (en) | PROCESS FOR THE PRODUCTION OF PHENYLETHANOLAMINES. | |
| KR830004241A (en) | Method for preparing sulfonyl urea | |
| GB1012623A (en) | 1-chloro-n-sulphonyl-formamidines and process for their manufacture | |
| CH613448A5 (en) | Process for the preparation of novel 1-(N-(p-fluorobenzoylpropyl)-4-piperidyl)ureas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19870926 |