ES263335A1 - Phenylcyclopropyl amides - Google Patents
Phenylcyclopropyl amidesInfo
- Publication number
- ES263335A1 ES263335A1 ES0263335A ES263335A ES263335A1 ES 263335 A1 ES263335 A1 ES 263335A1 ES 0263335 A ES0263335 A ES 0263335A ES 263335 A ES263335 A ES 263335A ES 263335 A1 ES263335 A1 ES 263335A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- amino
- nitrogen
- substituted
- mercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of general formula: <FORM:0961313/C1/1> wherein R is hydrogen, lower (1-8C) alkyl, lower alkenyl, phenyl-lower alkyl, nuclear substituted phenyl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, hydroxy-lower alkyl, halo-lower alkyl, dicyclic hydroxy methyl, mono- or di-amino-lower alkyl, (halophenoxy)-lower alkyl, (mercapto)-(amino)-substituted lower alkyl, (alkyl-mercapto)-(amino)-substituted lower alkyl, (hydroxy)-(amino)-substituted lower alkyl, o -carboxy-(amino)-lower alkyl, a nitrogen-containing heterocyclyl group, an o -(nitrogen-containing heterocyclyl)-(amino)-lower alkyl group, or an o -(nitrogen-containing heterocyclyl)-lower alkyl group trans isomers are preferred: and the process of reacting a compound of formula: <FORM:0961313/C1/2> with a compound of formula: <FORM:0961313/C1/3> in the presence of dicyclohexylcarbodiimide to yield a product of formula: <FORM:0961313/C1/4> wherein R1 is mono- or di-amino-lower alkyl, (mercapto)-(amino), substituted lower alkyl, (alkyl-mercapto)-(amino)-substituted lower alkyl, (hydroxy)-(amino)-substituted lower alkyl, an o -carboxy-(amino)-lower alkyl group, a nitrogen-containing heterocyclyl group, or an o -(nitrogen-containing-heterocyclyl) - (amino) - lower alkyl group. Other processes exemplified use as starting material acid halides which are reacted with the phenylcyclopropylamine N-(trans-2-phenylcyclopropyl)-2-piperidino-acetamide is prepared by reacting the chloroacetamide with piperidine. Pharmaceutical compositions are mentioned which comprise compounds I together with suitable carriers for administration to humans and animals. Oral administration and solid (tablets, capsules) and liquid carriers are mentioned. The compounds inhibit monoamine oxidase and are used in depression, angina pectoris and arthritis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1114260A | 1960-02-26 | 1960-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES263335A1 true ES263335A1 (en) | 1961-04-16 |
Family
ID=21749061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0263335A Expired ES263335A1 (en) | 1960-02-26 | 1960-12-17 | Phenylcyclopropyl amides |
Country Status (5)
| Country | Link |
|---|---|
| DE (1) | DE1234728B (en) |
| DK (1) | DK110096C (en) |
| ES (1) | ES263335A1 (en) |
| FR (1) | FR1445453A (en) |
| GB (1) | GB961313A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954778A (en) * | 1970-03-03 | 1976-05-04 | Zambon S.P.A. | Aminoacetyl derivatives of 2,3-diphenyl cyclopropyl amine |
| US3954777A (en) * | 1970-03-03 | 1976-05-04 | Zambon S.P.A. | Aminopropionyl derivatives of 2,3-diphenyl cyclopropylamine |
-
1960
- 1960-12-14 GB GB4308160A patent/GB961313A/en not_active Expired
- 1960-12-17 ES ES0263335A patent/ES263335A1/en not_active Expired
-
1961
- 1961-02-10 DK DK56461A patent/DK110096C/en active
- 1961-02-23 FR FR853691A patent/FR1445453A/en not_active Expired
-
1962
- 1962-03-17 DE DEL41511A patent/DE1234728B/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK110096C (en) | 1968-11-04 |
| GB961313A (en) | 1964-06-17 |
| FR1445453A (en) | 1966-07-15 |
| DE1234728B (en) | 1967-02-23 |
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