Nothing Special   »   [go: up one dir, main page]

ES2498091T3 - Procedimiento para producir nanopartículas - Google Patents

Procedimiento para producir nanopartículas Download PDF

Info

Publication number
ES2498091T3
ES2498091T3 ES09739571.9T ES09739571T ES2498091T3 ES 2498091 T3 ES2498091 T3 ES 2498091T3 ES 09739571 T ES09739571 T ES 09739571T ES 2498091 T3 ES2498091 T3 ES 2498091T3
Authority
ES
Spain
Prior art keywords
nanoparticles
procedure
biodegradable polymer
produce nanoparticles
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09739571.9T
Other languages
English (en)
Inventor
Aravind Chakrapani
Manmohan Singh
Derek T. O'hagan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2498091T3 publication Critical patent/ES2498091T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/14—Powdering or granulating by precipitation from solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/16—Biodegradable polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

Método de formación de nanopartículas que comprende poner en contacto un primer líquido que comprende un polímero biodegradable disuelto en un disolvente orgánico con un segundo líquido que comprende un disolvente acuoso que comprende un tampón, que es miscible con el disolvente orgánico, al tiempo que es un no disolvente para el polímero biodegradable, en condiciones de agitación suave sin remover de manera que se forman nanopartículas, con lo que el rendimiento del proceso, en base a la cantidad de polímero biodegradable que se recupera en forma de nanopartículas, es del 90% o más y con lo que el valor D(v, 0,5) para las nanopartículas es inferior a 200 nm.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
imagen11
imagen12
imagen13
imagen14
imagen15
imagen16
imagen17
imagen18
imagen19
imagen20
imagen21
imagen22
imagen23
imagen24
imagen25
imagen26
imagen27
imagen28
imagen29
imagen30

Claims (1)

  1. imagen1
ES09739571.9T 2008-04-28 2009-04-28 Procedimiento para producir nanopartículas Active ES2498091T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4842808P 2008-04-28 2008-04-28
US48428P 2008-04-28
PCT/US2009/041932 WO2009134769A1 (en) 2008-04-28 2009-04-28 Nanoparticles for use in pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2498091T3 true ES2498091T3 (es) 2014-09-24

Family

ID=40792578

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09739571.9T Active ES2498091T3 (es) 2008-04-28 2009-04-28 Procedimiento para producir nanopartículas

Country Status (6)

Country Link
US (1) US9393295B2 (es)
EP (1) EP2282771B1 (es)
JP (2) JP2011518885A (es)
CA (1) CA2722765C (es)
ES (1) ES2498091T3 (es)
WO (1) WO2009134769A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100160368A1 (en) * 2008-08-18 2010-06-24 Gregory Jefferson J Methods of Treating Dermatological Disorders and Inducing Interferon Biosynthesis With Shorter Durations of Imiquimod Therapy
SI2378876T1 (sl) 2008-12-19 2019-05-31 Medicis Pharmaceutical Corporation Formulacije z nižjo dozirno jakostjo imikvimoda in kratki odmerni režimi za zdravljenje aktinične keratoze
ES2653313T3 (es) * 2009-07-13 2018-02-06 Medicis Pharmaceutical Corporation Formulaciones de imiquimod con concentración de dosificación menor y regímenes de dosificación cortos para el tratamiento de verrugas genitales y perianales
US8994811B2 (en) * 2010-01-27 2015-03-31 National University Corporation Hokkaido University Diffraction microscopy
WO2012164480A1 (en) * 2011-05-30 2012-12-06 National Institute Of Immunology A vaccine composition capable of inducing memory antibody response from single point immunization
JPWO2012169518A1 (ja) * 2011-06-07 2015-02-23 ホソカワミクロン株式会社 液状組成物及びそれを用いた化粧料並びに育毛剤
US20130122106A1 (en) * 2011-10-19 2013-05-16 Aphios Corporation Dosage form, and methods of making and using the same, to produce immunization in animals and humans
CA2871786C (en) * 2012-04-24 2021-11-16 Ohio State Innovation Foundation Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome
KR101732760B1 (ko) * 2013-10-10 2017-05-24 주식회사 엘지화학 폴리락트산 입자의 제조방법
US10280199B2 (en) 2014-02-07 2019-05-07 Phibro Animal Health Corporation Coronavirus proteins and antigens
US10117886B2 (en) * 2014-05-30 2018-11-06 Hao Cheng Hyaluronidase and a low density second PEG layer on the surface of therapeutic-encapsulated nanoparticles to enhance nanoparticle diffusion and circulation
EP3454893A4 (en) * 2016-05-11 2020-01-01 Phibro Animal Health Corporation COMPOSITION WITH ANTIGENS AND A MUCUTINE ADJUVAN AND METHOD FOR USE
US10279031B2 (en) 2016-05-11 2019-05-07 Phibro Animal Health Corporation Composition comprising antigens and a mucosal adjuvant and a method for using
WO2018009672A1 (en) 2016-07-06 2018-01-11 University Of Maryland, College Park Polyphosphazene polyelectrolytes and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0829246B2 (ja) 1986-10-01 1996-03-27 三菱製紙株式会社 マイクロカプセルの製造方法
FR2608988B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
FR2634397B2 (fr) * 1986-12-31 1991-04-19 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
DE69630514D1 (de) * 1995-01-05 2003-12-04 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
GB9514285D0 (en) 1995-07-13 1995-09-13 Univ Nottingham Polymeric lamellar substrate particles for drug delivery
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
US6884435B1 (en) * 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
JP4601168B2 (ja) 1998-07-29 2010-12-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 吸着表面を有する微小粒子、それを作製する方法、およびその使用
EP1322292B1 (en) * 2000-09-28 2007-01-03 Novartis Vaccines and Diagnostics, Inc. Microparticle compositions and methods for the manufacture thereof
ATE320792T1 (de) 2000-09-28 2006-04-15 Chiron Corp Mikropartikel zur verabreichung von heterologen nukleinsäure
WO2004065578A2 (en) * 2003-01-14 2004-08-05 Chiron Corporation Microparticles comprising polynucleotide adsorbed on the surface of or entrapped within the microparticles
US9393215B2 (en) * 2005-12-02 2016-07-19 Novartis Ag Nanoparticles for use in immunogenic compositions
US8431160B2 (en) * 2006-02-24 2013-04-30 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
CA2702305C (en) * 2007-03-30 2015-07-21 Bind Biosciences, Inc. Cancer cell targeting using nanoparticles

Also Published As

Publication number Publication date
CA2722765A1 (en) 2009-11-05
EP2282771A1 (en) 2011-02-16
WO2009134769A1 (en) 2009-11-05
CA2722765C (en) 2016-10-04
JP2015057444A (ja) 2015-03-26
US9393295B2 (en) 2016-07-19
US20110038900A1 (en) 2011-02-17
JP2011518885A (ja) 2011-06-30
EP2282771B1 (en) 2014-06-25

Similar Documents

Publication Publication Date Title
ES2498091T3 (es) Procedimiento para producir nanopartículas
BR112014009433A2 (pt) processo de transformação adaptava com base em previsão em tela e aparelho usando o processo
BRPI0923266A8 (pt) método para recuperação avançada de petróleo
EA201070793A1 (ru) Нанодисперсия
CL2011001992A1 (es) Proceso para producir 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina que comprende la etapa de precipitar el solvato isopropanol bromhidrato del compuesto a partir de un solvente con mas de 65% (v/v) de isopropanol; proceso de purificacion; y el intermediario solvato isopropanol bromhidrato del compuesto.
CL2008000156A1 (es) Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel.
AR088697A1 (es) Procesos basados en membranas para reducir al menos una impureza y para elaborar un concentrado que comprende al menos un componente natural a partir de una mezcla de aceites de acidos grasos no marinos, y composiciones resultantes
AR074022A1 (es) Proceso de seleccion de formulacion de color con pantalla de visualizacion
ES2525879T3 (es) Procedimiento, aparato y sistema para la limpieza basada en dos disolventes de componentes de precisión
DE602007013896D1 (de) Phasentrennverfahren unter verwendung eines teilfluorierten fluorkohlenwasserstoffs
CL2009001081A1 (es) Procedimiento para producir un vehiculo en forma de particulas que comprende disolver polibutilcianoacrilado en un disolvente organico para formar una solucion polimerica, anadir una solucion acuosa, mezclar y obtener el vehiculo en forma de particulas; composicion farmaceutica que comprende dicho vehiculo.
EP1688798A3 (en) Aqueous based residue removers comprising fluoride
CL2011000557A1 (es) Un proceso de alta recuperacion para la remocion de sulfato a partir de una fuente de agua; y un proceso de alta recuperacion para la remocion de sulfato y cot a partir de una fuente de agua
BR112015018716A2 (pt) técnicas para autenticar um dispositivo para encaixe sem fio
AR070689A1 (es) Un procedimiento para el revestimiento de superficies metalicas con una composicion lubricante que contiene ceras
AR074637A1 (es) Formas de sal de adicion acida de r-(+)-n-propargil-1-aminoindano (es decir , base de rasagilina), un compuesto de formula (1), procesos para prepararlos y aislarlos y usos de los mismos
AR087198A1 (es) Composiciones de prolamina a base de agua, metodos para fabricar composiciones de prolamina a base de agua, y sus aplicaciones
PH12019501406A1 (en) Chemically amplified positive type photoresist composition and pattern forming method using the same
EP2922003A3 (en) Extracting method, recommending method, information processing apparatus and method for decision support on road repair method
EP3246663A3 (en) Sharing safety driving metrics for navigable segments
EP4296340A3 (en) Solvent application in bottle wash using amidine based formulas
BR112018015647A2 (pt) composição aquosa de revestimento de componente único, película de polímero, embalagem, método para formação de película polimérica, e, uso de uma composição.
ES2621366T3 (es) Utilización de múltiples soplados de barra de estiramiento contrario y/o elemento de levantamiento de base
DOP2007000025A (es) Sistema y metodo para la separación de soluto de una solucion acuosa
AR102853A1 (es) Purificación de gelatina