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ES2113857T3 - Composiciones osteoinductoras. - Google Patents

Composiciones osteoinductoras.

Info

Publication number
ES2113857T3
ES2113857T3 ES90905830T ES90905830T ES2113857T3 ES 2113857 T3 ES2113857 T3 ES 2113857T3 ES 90905830 T ES90905830 T ES 90905830T ES 90905830 T ES90905830 T ES 90905830T ES 2113857 T3 ES2113857 T3 ES 2113857T3
Authority
ES
Spain
Prior art keywords
bmp
osteoinductive compositions
proteins
osteoinductive
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90905830T
Other languages
English (en)
Inventor
Elizabeth A Wang
John M Wozney
Vicki A Rosen
Anthony J Celeste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/370,547 external-priority patent/US5106748A/en
Priority claimed from US07/438,919 external-priority patent/US5141905A/en
Priority claimed from US07/490,033 external-priority patent/US5187076A/en
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of ES2113857T3 publication Critical patent/ES2113857T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

SE PUBLICAN LAS PROTEINAS PURIFICADAS BMP-5, BMP-6 Y BMP-7 Y LOS PROCEDIMIENTOS PARA PRODUCIRLAS. SE PUEDEN UTILIZAR DICHAS PROTEINAS EN LOS TRATAMIENTOS DE LOS DEFECTOS OSEOS Y/O DE LOS CARTILAGOS Y EN LA CURACION DE HERIDAS Y REPARACION DE LOS TEJIDOS RELACIONADOS.
ES90905830T 1989-03-28 1990-03-27 Composiciones osteoinductoras. Expired - Lifetime ES2113857T3 (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US32961089A 1989-03-28 1989-03-28
US34755989A 1989-05-04 1989-05-04
US37054989A 1989-06-23 1989-06-23
US37054489A 1989-06-23 1989-06-23
US07/370,547 US5106748A (en) 1986-07-01 1989-06-23 Dna sequences encoding 5 proteins
US43740989A 1989-11-15 1989-11-15
US07/438,919 US5141905A (en) 1986-07-01 1989-11-17 Dna sequences encoding bmp-7 proteins
US07/490,033 US5187076A (en) 1986-07-01 1990-03-07 DNA sequences encoding BMP-6 proteins
PCT/US1990/001630 WO1990011366A1 (en) 1989-03-28 1990-03-27 Osteoinductive compositions

Publications (1)

Publication Number Publication Date
ES2113857T3 true ES2113857T3 (es) 1998-05-16

Family

ID=27575396

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90905830T Expired - Lifetime ES2113857T3 (es) 1989-03-28 1990-03-27 Composiciones osteoinductoras.

Country Status (8)

Country Link
EP (1) EP0429570B1 (es)
KR (1) KR100214740B1 (es)
AT (1) ATE162223T1 (es)
CA (1) CA2030518C (es)
DE (1) DE69031939T2 (es)
DK (1) DK0429570T3 (es)
ES (1) ES2113857T3 (es)
WO (1) WO1990011366A1 (es)

Families Citing this family (79)

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US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
DE01201546T1 (de) * 1988-04-08 2004-07-08 Stryker Corp., Kalamazoo Osteogene Einrichtungen
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
ES2168091T3 (es) * 1990-05-16 2002-06-01 Genetics Inst Proteinas de induccion osea y cartilaginosa.
WO1992005199A1 (en) * 1990-09-26 1992-04-02 Genetics Institute, Inc. Bmp-5 derivatives
ES2120964T3 (es) * 1990-10-18 1998-11-16 Stryker Corp Peptidos osteogenicos.
WO1992007004A1 (en) * 1990-10-18 1992-04-30 Creative Biomolecules, Inc. Osteogenic protein
US6399569B1 (en) * 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
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DK0592562T3 (da) * 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
DE69231567T2 (de) * 1991-08-30 2001-06-28 Creative Biomolecules, Inc. Screeningverfahren von morphogenischen Proteinen
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
IT1259042B (it) * 1992-01-27 1996-03-11 Mini Ricerca Scient Tecnolog Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante
US5610021A (en) * 1992-02-21 1997-03-11 Creative Biomolecules, Inc. Compositions and methods for identification and use of soluble complex forms of osteogenic proteins
DK0653942T3 (da) * 1992-07-31 2003-10-20 Curis Inc Morphogen-induceret nerve-regenerering og -reparation
US6333168B1 (en) * 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US6764994B1 (en) 1993-08-10 2004-07-20 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Growth/differential factor of the TGF-B family
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
DE4420157B4 (de) * 1993-08-10 2013-04-25 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Neuer Wachstums/Differenzierungsfaktor der TGF-β-Familie
ATE378407T1 (de) * 1994-04-29 2007-11-15 Curis Inc Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen
US5906827A (en) † 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
JP4388602B2 (ja) 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
PT980252E (pt) 1997-05-05 2005-01-31 Curis Inc Terapias para insuficiencia renal aguda
CA2291514C (en) 1997-05-30 2011-07-12 Creative Biomolecules, Inc. Methods for evaluating tissue morphogenesis and activity
US6649631B1 (en) 1997-10-23 2003-11-18 The Board Of Regents Of The University Of Texas System Compositions and methods for treating bone deficit conditions
JPH11313675A (ja) 1998-04-30 1999-11-16 Hoechst Marion Roussel Kk ヒトｂｍｐ−７プロモーターおよびこれを用いた骨関連物質の探索法
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6838436B1 (en) 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6462019B1 (en) 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
DE69927512T2 (de) 1998-10-06 2006-07-06 Stryker Corp., Kalamazoo Verwendung von op-1 zur herstellung einer pharmazeutischen zusammensetzung zur reparatur von nicht-gelenksknorpeldefekten eines säugers
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
EP1223990B1 (en) 1999-10-15 2004-07-28 Genetics Institute, LLC Formulations of hyaluronic acid for delivery of osteogenic proteins
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
ES2247423T5 (es) 2001-11-19 2015-12-30 Scil Technology Gmbh Método de producción de un dispositivo recubierto homogéneamente que tiene propiedades osteoinductoras y osteoconductoras
US7491691B2 (en) 2002-05-03 2009-02-17 Sindrey Dennis R Connective tissue stimulating peptides
EP1539261B1 (en) 2002-09-10 2006-04-12 Scil Technology GmbH Metal implant coated under reduced oxygen concentration with osteoinductive protein
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PT1675608E (pt) 2003-09-12 2007-05-31 Etex Corp Barras sólidas e pastas de fosfato de cálcio injectável para a libertação de proteínas osteogénicas.
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JP5201987B2 (ja) 2004-05-25 2013-06-05 ストライカー コーポレイション 軟骨欠損を処置するための、形態形成タンパク質の使用
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US7910552B2 (en) 2005-05-27 2011-03-22 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
US9011930B2 (en) 2006-05-01 2015-04-21 Zycal Bioceuticals Healthcare Company, Inc. Nutritional supplement and use thereof
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AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
CN102026619A (zh) 2008-04-14 2011-04-20 先进科技及再生医学有限责任公司 液体缓冲的gdf-5制剂
AU2008353306B2 (en) 2008-05-16 2011-09-01 Industry Foundation Of Chonnam National University An synthetic peptide containing bone forming peptide 1(BFP 1) for stimulating osteoblast differentiation, and pharmaceutical composition comprising the synthetic peptide
US8025872B2 (en) 2008-05-16 2011-09-27 Industry Foundation Of Chonnam National University Osteogenic synthetic peptides, pharmaceutical compositions comprising the same, and medium containing the same
EP2303911B1 (en) * 2008-06-20 2012-08-15 Industry Foundation Of Chonnam National University A synthetic peptide consisting of bone forming peptide 2(bfp 2) for stimulating osteoblast differentiation, and pharmaceutical composition comprising the synthetic peptide
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
EP2311482A1 (en) * 2009-10-12 2011-04-20 Industry Foundation Of Chonnam National University Osteogenic synthetic BMP-7 peptides, pharmaceutical compositions cell culture medium containing same
HUE036240T2 (hu) 2010-08-18 2018-06-28 Samumed Llc Diketonok és hidroxiketonok mint kateninszignálút-aktivátorok
US9216181B2 (en) 2011-06-08 2015-12-22 Southwest Research Institute BMP-2 upregulating compounds for healing bone tissue and screening methods for selecting such compounds
DK2968249T3 (en) 2013-02-22 2019-03-04 Samumed Llc GAMMA DIKETONS AS WNT / BETA-CATENIN SIGNAL ROAD ACTIVATORS
MX368248B (es) 2014-08-20 2019-09-25 Samumed Llc Gamma-dicetonas para tratamiento y prevencion de piel envejecida y arrugas.
CN109082453B (zh) * 2018-08-28 2022-10-21 南京赛尔健生物技术有限公司 一种多肽作为流感疫苗佐剂提高流感疫苗免疫效果的用途
CN109182430B (zh) * 2018-08-28 2022-10-21 南京赛尔健生物技术有限公司 一种流感疫苗免疫佐剂

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US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
JPH03503649A (ja) * 1988-04-08 1991-08-15 ジェネティックス・インスティテュート・インコーポレイテッド 硬骨および軟骨誘導組成物
DE01201546T1 (de) * 1988-04-08 2004-07-08 Stryker Corp., Kalamazoo Osteogene Einrichtungen
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices

Also Published As

Publication number Publication date
EP0429570B1 (en) 1998-01-14
ATE162223T1 (de) 1998-01-15
EP0429570A1 (en) 1991-06-05
CA2030518C (en) 2000-03-21
DE69031939D1 (de) 1998-02-19
DE69031939T2 (de) 1998-09-10
WO1990011366A1 (en) 1990-10-04
KR920700291A (ko) 1992-02-19
DK0429570T3 (da) 1998-04-27
CA2030518A1 (en) 1990-09-29
KR100214740B1 (ko) 1999-08-02

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