ES2195943T3 - Compuestos heteroaromaticos biciclicos y triciclicos. - Google Patents
Compuestos heteroaromaticos biciclicos y triciclicos.Info
- Publication number
- ES2195943T3 ES2195943T3 ES00977138T ES00977138T ES2195943T3 ES 2195943 T3 ES2195943 T3 ES 2195943T3 ES 00977138 T ES00977138 T ES 00977138T ES 00977138 T ES00977138 T ES 00977138T ES 2195943 T3 ES2195943 T3 ES 2195943T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- compounds
- triciclic
- bicycle
- heteroaromatic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de fórmula **fórmula** o una sal farmacéuticamente aceptable del mismo, en la que: X representa N o CR1, en la que R1 es hidrógeno, halógeno, hidroxi, ciano, nitro, amino, alquilo C1-C6, alcoxi C1-C6, trifluorometilo, trifluorometoxi, mono- o dialquil(C1-C6)amino o aminoalquilo C1-C6; X1 representa N, CH o alquilo C1-C6; Y y Z son independientemente hidrógeno, halógeno, hidroxi, ciano, nitro, amino, alquilo C1-C6, alcoxi C1-C6, trifluorometilo, trifluorometoxi, mono- o dialquil(C1-C6)amino o aminoalquilo C1-C6; o Y y Z forman juntos un anillo de arileno o un anillo de cicloalquileno C3-C8, cada uno de los cuales está sustituido opcionalmente con hasta cuatro grupos R2 seleccionados independientemente en cada caso entre halógeno, hidroxi, ciano, nitro, amino, alquilo C1- C6, alcoxi C1-C6, trifluorometilo, trifluorometoxi, mono- o dialquil(C1-C6)amino y aminoalquilo C1-C6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16505499P | 1999-11-12 | 1999-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2195943T3 true ES2195943T3 (es) | 2003-12-16 |
Family
ID=22597230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00977138T Expired - Lifetime ES2195943T3 (es) | 1999-11-12 | 2000-11-10 | Compuestos heteroaromaticos biciclicos y triciclicos. |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US6511987B1 (es) |
| EP (1) | EP1228069B1 (es) |
| JP (1) | JP2003513975A (es) |
| KR (1) | KR20020050262A (es) |
| CN (1) | CN1390217A (es) |
| AT (1) | ATE236158T1 (es) |
| AU (1) | AU1481701A (es) |
| BR (1) | BR0015420A (es) |
| CA (1) | CA2388593A1 (es) |
| DE (1) | DE60001983T2 (es) |
| ES (1) | ES2195943T3 (es) |
| IL (1) | IL149550A0 (es) |
| MX (1) | MXPA02004735A (es) |
| NO (1) | NO20022185D0 (es) |
| WO (1) | WO2001034603A2 (es) |
| ZA (1) | ZA200203653B (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1228069B1 (en) | 1999-11-12 | 2003-04-02 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
| US6833377B2 (en) | 2001-02-05 | 2004-12-21 | Gevys Pharmaceuticals Ltd. | Composition and method for potentiating drugs |
| FR2823752B1 (fr) * | 2001-04-18 | 2004-10-22 | Servier Lab | Nouveaux derives de pyrimidin-4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6686352B2 (en) * | 2001-05-18 | 2004-02-03 | Hoffmann-La Roche Inc. | Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives |
| US6921762B2 (en) | 2001-11-16 | 2005-07-26 | Amgen Inc. | Substituted indolizine-like compounds and methods of use |
| WO2004060313A2 (en) | 2002-12-30 | 2004-07-22 | Celgene Corporation | Fluoroalkoxy-substituted 1, 3-dihydro-isoindolyl compounds and their pharmaceutical uses |
| WO2005025563A1 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders |
| US7546431B2 (en) * | 2005-03-21 | 2009-06-09 | Emc Corporation | Distributed open writable snapshot copy facility using file migration policies |
| HUE030390T2 (en) | 2005-12-21 | 2017-05-29 | Janssen Pharmaceutica Nv | Triazolopyridazines as tyrosine kinase modulators |
| ATE537171T1 (de) * | 2005-12-27 | 2011-12-15 | Hoffmann La Roche | Aryl-isoxazol-4-yl-imidazoä1,5-aüpyridin-deriva e |
| ES2328185T3 (es) | 2006-05-31 | 2009-11-10 | F. Hoffmann-La Roche Ag | Derivados de aril-4-etinil-isoxazol. |
| US7683060B2 (en) | 2006-08-07 | 2010-03-23 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| ES2399071T3 (es) | 2006-10-16 | 2013-03-25 | Bionomics Limited | Nuevos compuestos ansiolíticos |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| NO346024B1 (no) | 2006-11-22 | 2022-01-03 | Incyte Holdings Corp | Imidazotriaziner og imidazopyrimidiner som kinaseinhibitorer |
| AU2008267894B2 (en) | 2007-06-22 | 2012-08-23 | F. Hoffmann-La Roche Ag | Isoxazole-imidazole derivatives |
| JP5301556B2 (ja) | 2007-12-04 | 2013-09-25 | エフ．ホフマン−ラ ロシュ アーゲー | イソオキサゾロ−ピラジン誘導体 |
| US7943619B2 (en) | 2007-12-04 | 2011-05-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyridazine derivatives |
| US7902201B2 (en) | 2007-12-04 | 2011-03-08 | Hoffmann-La Roche Inc. | Isoxazolo-pyrazine derivatives |
| US9216983B2 (en) | 2007-12-21 | 2015-12-22 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| DK2300455T3 (en) | 2008-05-21 | 2017-10-30 | Incyte Holdings Corp | SALTS OF 2-FLUORO-N-METHYL-4- [7- (QUINOLIN-6-YL-METHYL) - IMIDAZO [1,2-B] [1,2,4] TRIAZIN-2-YL] BENZAMIDE AND PROCEDURES WITH THE PREPARATION THEREOF |
| US8895550B2 (en) | 2008-08-19 | 2014-11-25 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
| TWI496779B (zh) | 2008-08-19 | 2015-08-21 | Array Biopharma Inc | 作為ｐｉｍ激酶抑制劑之三唑吡啶化合物 |
| US8557809B2 (en) | 2008-08-19 | 2013-10-15 | Array Biopharma Inc. | Triazolopyridine compounds as PIM kinase inhibitors |
| TW201033201A (en) | 2009-02-19 | 2010-09-16 | Hoffmann La Roche | Isoxazole-isoxazole and isoxazole-isothiazole derivatives |
| US8389550B2 (en) | 2009-02-25 | 2013-03-05 | Hoffmann-La Roche Inc. | Isoxazoles / O-pyridines with ethyl and ethenyl linker |
| US8222246B2 (en) | 2009-04-02 | 2012-07-17 | Hoffmann-La Roche Inc. | Substituted isoxazoles |
| US20100280019A1 (en) | 2009-04-30 | 2010-11-04 | Roland Jakob-Roetne | Isoxazoles |
| WO2010127974A1 (en) | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Isoxazole-thiazole derivatives as gaba a receptor inverse agonists for use in the treatment of cognitive disorders |
| AU2010244553A1 (en) | 2009-05-05 | 2011-12-01 | F. Hoffmann-La Roche Ag | Isoxazole-pyridine derivatives |
| WO2010127975A1 (en) | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Isoxazole-pyrazole derivatives |
| AU2010244545A1 (en) | 2009-05-05 | 2011-10-13 | F. Hoffmann-La Roche Ag | Isoxazole-pyridazine derivatives |
| BRPI1013766A2 (pt) | 2009-05-07 | 2016-04-05 | Hoffmann La Roche | "derivados de isoxazol-piridina como moduladores de gaba" |
| BR112012019302B1 (pt) | 2010-02-03 | 2022-06-21 | Incyte Holdings Corporation | Imidazo[1,2-b] [1,2,4]triazinas como inibidores de c-met, composição que as compreende e métodos in vitro de inibir a atividade de c-met cinase, de inibir a via de sinalização da hgf/c-met cinase em uma célula e de inibir a atividade proliferativa de uma célula |
| SI2678329T1 (sl) | 2011-02-25 | 2016-05-31 | Array Biopharma Inc. | Triazolopiridinske spojine kot inhibitorji kinaze pim |
| EP2681198A4 (en) | 2011-03-02 | 2014-09-03 | Bionomics Ltd | NEW LITTLE MOLECULES AS THERAPIES |
| CN103649086A (zh) | 2011-05-12 | 2014-03-19 | 生态学有限公司 | 制备萘啶的方法 |
| US8785435B2 (en) | 2011-10-20 | 2014-07-22 | Hoffmann-La Roche Inc. | Solid forms |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| CN106854207B (zh) | 2015-12-08 | 2019-10-29 | 上海赛默罗生物科技有限公司 | 呔嗪类衍生物、其制备方法、药物组合物和用途 |
| US11512089B2 (en) | 2018-03-12 | 2022-11-29 | Shanghai SIMR Biotechnology Co., Ltd | Substituted [1,2,4]triazolo[3,4-a]phthalazines as modulators of GABAA receptor activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1194310B (it) * | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
| US5955465A (en) * | 1996-03-22 | 1999-09-21 | Neurogen Corporation | 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones |
| GB9715977D0 (en) * | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| US6297235B1 (en) | 1997-08-28 | 2001-10-02 | Merck Sharp & Dohme Ltd. | Triazolopyridazine derivatives for treating anxiety and enhancing cognition |
| CA2315219A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| AU3371099A (en) | 1998-03-30 | 1999-10-18 | President And Fellows Of Harvard College | Regulation of glycosaminoglycan synthesis, methods and reagents related thereto |
| JP2002540203A (ja) * | 1999-03-29 | 2002-11-26 | ニューロゲン コーポレイション | Ｎｋ−３および／またはｇａｂａ（ａ）受容体リガンドとしての４−置換キノリン誘導体 |
| EP1228069B1 (en) | 1999-11-12 | 2003-04-02 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
-
2000
- 2000-11-10 EP EP00977138A patent/EP1228069B1/en not_active Expired - Lifetime
- 2000-11-10 DE DE60001983T patent/DE60001983T2/de not_active Expired - Fee Related
- 2000-11-10 AU AU14817/01A patent/AU1481701A/en not_active Abandoned
- 2000-11-10 BR BR0015420-2A patent/BR0015420A/pt not_active Application Discontinuation
- 2000-11-10 IL IL14955000A patent/IL149550A0/xx unknown
- 2000-11-10 KR KR1020027005947A patent/KR20020050262A/ko not_active Application Discontinuation
- 2000-11-10 JP JP2001536550A patent/JP2003513975A/ja not_active Withdrawn
- 2000-11-10 AT AT00977138T patent/ATE236158T1/de not_active IP Right Cessation
- 2000-11-10 ES ES00977138T patent/ES2195943T3/es not_active Expired - Lifetime
- 2000-11-10 MX MXPA02004735A patent/MXPA02004735A/es active IP Right Grant
- 2000-11-10 WO PCT/US2000/030905 patent/WO2001034603A2/en active IP Right Grant
- 2000-11-10 CA CA002388593A patent/CA2388593A1/en not_active Abandoned
- 2000-11-10 CN CN00815483A patent/CN1390217A/zh active Pending
- 2000-11-10 US US09/709,887 patent/US6511987B1/en not_active Expired - Fee Related
-
2002
- 2002-05-07 NO NO20022185A patent/NO20022185D0/no not_active Application Discontinuation
- 2002-05-08 ZA ZA200203653A patent/ZA200203653B/en unknown
-
2003
- 2003-01-28 US US10/352,519 patent/US7053093B2/en not_active Expired - Fee Related
-
2006
- 2006-05-30 US US11/442,812 patent/US7326709B2/en not_active Expired - Fee Related
-
2008
- 2008-02-04 US US12/025,490 patent/US20080146546A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200203653B (en) | 2003-04-10 |
| KR20020050262A (ko) | 2002-06-26 |
| EP1228069A2 (en) | 2002-08-07 |
| MXPA02004735A (es) | 2003-01-28 |
| CA2388593A1 (en) | 2001-05-17 |
| US7053093B2 (en) | 2006-05-30 |
| IL149550A0 (en) | 2002-11-10 |
| JP2003513975A (ja) | 2003-04-15 |
| WO2001034603A2 (en) | 2001-05-17 |
| US7326709B2 (en) | 2008-02-05 |
| DE60001983D1 (de) | 2003-05-08 |
| US20060217384A1 (en) | 2006-09-28 |
| AU1481701A (en) | 2001-06-06 |
| NO20022185L (no) | 2002-05-07 |
| US20030181455A1 (en) | 2003-09-25 |
| DE60001983T2 (de) | 2004-01-29 |
| BR0015420A (pt) | 2002-07-16 |
| ATE236158T1 (de) | 2003-04-15 |
| WO2001034603A3 (en) | 2002-01-10 |
| US20080146546A1 (en) | 2008-06-19 |
| CN1390217A (zh) | 2003-01-08 |
| NO20022185D0 (no) | 2002-05-07 |
| EP1228069B1 (en) | 2003-04-02 |
| US6511987B1 (en) | 2003-01-28 |
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