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ES2183200T3 - Granulados aplicables por via oral de derivados de hexahidropirazina. - Google Patents

Granulados aplicables por via oral de derivados de hexahidropirazina.

Info

Publication number
ES2183200T3
ES2183200T3 ES97931773T ES97931773T ES2183200T3 ES 2183200 T3 ES2183200 T3 ES 2183200T3 ES 97931773 T ES97931773 T ES 97931773T ES 97931773 T ES97931773 T ES 97931773T ES 2183200 T3 ES2183200 T3 ES 2183200T3
Authority
ES
Spain
Prior art keywords
hexahydropirazine
granulates
derivatives
oral route
applicable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97931773T
Other languages
English (en)
Inventor
Jochen Kalbe
Terence Hopkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2183200T3 publication Critical patent/ES2183200T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION TRATA DE LA PREPARACION DE GRANULADOS QUE SE ADMINISTRAN POR VIA ORAL DE DERIVADOS DE HEXAHIDROPIRAZINA, MEDIANTE EL CUAL SE MEZCLA EL PRINCIPIO ACTIVO EN PRESENCIA DE DISOLVENTES APROPIADOS CON SOPORTES HIDROFOBICOS, OPCIONALMENTE EN PRESENCIA DE ADYUVANTES, Y LA MEZCLA OBTENIDA SE TRANSFORMA OPCIONALMENTE EN FORMAS LISTAS PARA UTILIZARSE.
ES97931773T 1996-07-17 1997-07-04 Granulados aplicables por via oral de derivados de hexahidropirazina. Expired - Lifetime ES2183200T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19628776A DE19628776A1 (de) 1996-07-17 1996-07-17 Oral applizierbare Granulate von Hexahydropyrazinderivaten

Publications (1)

Publication Number Publication Date
ES2183200T3 true ES2183200T3 (es) 2003-03-16

Family

ID=7800044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97931773T Expired - Lifetime ES2183200T3 (es) 1996-07-17 1997-07-04 Granulados aplicables por via oral de derivados de hexahidropirazina.

Country Status (17)

Country Link
US (1) US6503536B2 (es)
EP (1) EP0912167B1 (es)
JP (1) JP4202422B2 (es)
KR (1) KR100485149B1 (es)
CN (1) CN1225579A (es)
AT (1) ATE227565T1 (es)
AU (1) AU711705B2 (es)
BR (1) BR9710377B1 (es)
CA (1) CA2260889C (es)
DE (2) DE19628776A1 (es)
DK (1) DK0912167T3 (es)
ES (1) ES2183200T3 (es)
HU (1) HUP9903180A3 (es)
NO (1) NO325272B1 (es)
NZ (1) NZ333745A (es)
PT (1) PT912167E (es)
WO (1) WO1998003157A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0313402B1 (pt) * 2002-08-13 2018-01-30 Intervet International B.V. Composição farmacêutica veterinária comestível e deglutível na forma de um produto mastigável de dose única e processo para a sua preparação mascar macia, e, processos para produzir a composição
US20040180034A1 (en) * 2003-03-10 2004-09-16 Lyn Hughes Anthelmintic resinates and a method for their preparation
US7396819B2 (en) * 2003-08-08 2008-07-08 Virbac Corporation Anthelmintic formulations
DE10358525A1 (de) 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
WO2005094210A2 (en) * 2004-03-12 2005-10-13 The Hartz Mountain Corporation Multi-action anthelmintic formulations
DE102005011779A1 (de) * 2005-03-11 2006-09-14 Bayer Healthcare Ag Endoparasitizide Mittel
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
NZ719079A (en) 2012-02-06 2017-09-29 Merial Inc Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
ES2633611T5 (es) 2012-04-04 2023-09-26 Intervet Int Bv Composiciones farmacéuticas orales sólidas de compuestos de isoxazolina

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2362539C2 (de) 1973-12-17 1986-05-07 Merck Patent Gmbh, 6100 Darmstadt 2-Acyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinoline, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US4447414A (en) * 1982-12-21 1984-05-08 Cutter Laboratories, Inc. Carnivore anthelmintics
DE3472678D1 (de) 1983-07-18 1988-08-18 Beecham Group Plc Benzazepine and benzoxazepine derivatives
DE3623321A1 (de) * 1986-07-11 1988-01-21 Bayer Ag Verfahren zur kontinuierlichen herstellung von sphaerischen granulaten
FI101344B1 (fi) * 1988-03-31 1998-06-15 Tanabe Seiyaku Co Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseuttisesti aktiivista ainetta
CN1099973A (zh) * 1993-09-08 1995-03-15 四川省医学科学院寄生虫病防治研究所 兽用驱虫药物复方制剂
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations

Also Published As

Publication number Publication date
HUP9903180A3 (en) 2000-07-28
AU3541397A (en) 1998-02-10
DE59708723D1 (de) 2002-12-19
NO990157L (no) 1999-01-14
PT912167E (pt) 2003-03-31
CA2260889C (en) 2007-09-11
KR100485149B1 (ko) 2005-04-25
NO990157D0 (no) 1999-01-14
KR20000067862A (ko) 2000-11-25
WO1998003157A1 (de) 1998-01-29
JP2000515519A (ja) 2000-11-21
NO325272B1 (no) 2008-03-17
ATE227565T1 (de) 2002-11-15
US20010055598A1 (en) 2001-12-27
EP0912167A1 (de) 1999-05-06
AU711705B2 (en) 1999-10-21
BR9710377B1 (pt) 2011-10-18
DE19628776A1 (de) 1998-01-22
NZ333745A (en) 2000-10-27
HUP9903180A2 (hu) 2000-04-28
BR9710377A (pt) 1999-08-17
EP0912167B1 (de) 2002-11-13
CN1225579A (zh) 1999-08-11
JP4202422B2 (ja) 2008-12-24
DK0912167T3 (da) 2003-03-10
US6503536B2 (en) 2003-01-07
CA2260889A1 (en) 1998-01-29

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