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ES2182317T3 - Produccion de compuestos de avermectina. - Google Patents

Produccion de compuestos de avermectina.

Info

Publication number
ES2182317T3
ES2182317T3 ES98924534T ES98924534T ES2182317T3 ES 2182317 T3 ES2182317 T3 ES 2182317T3 ES 98924534 T ES98924534 T ES 98924534T ES 98924534 T ES98924534 T ES 98924534T ES 2182317 T3 ES2182317 T3 ES 2182317T3
Authority
ES
Spain
Prior art keywords
compound
sub
sup
reacted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98924534T
Other languages
English (en)
Inventor
Masanori Honda
Hiroshi Kadoi
Hiromasa Morita
Isao Nagakura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Application granted granted Critical
Publication of ES2182317T3 publication Critical patent/ES2182317T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invención proporciona un procedimiento para preparar un compuesto de fórmula (I): en la que R{sup,1} es H o un grupo protector de hidroxiimino; R{sup,2} es H, alquilo C{sub,1-4} o alcoxi C{sub,1-4}; R{sup,3} es alquilo C{sub,1-8}, alquenilo C{sub,2-8} o cicloalquilo C{sub,3-8} y R{sup,4} es H, haluro, alquilo C{sub,1-4}, o alcoxi C{sub,1-4}. Dicho procedimiento comprende las etapas de: (a) se hace reaccionar un derivado de avermectina B2 con un agente oxidante para formar un compuesto 5-oxo; (b) se permite reaccionar el compuesto 5-oxo con un compuesto de fórmula R{sup,1}-O-NH{sub,2} en la que R{sup,1} es H o un grupo protector de hidroxiimino, para formar un compuesto 5-imino; (c) se hace reaccionar el compuesto 5-imino con un agente de tionocarbonización para formar un éster de 4",23-bistiocarbonilo; (d) se hace reaccionar el éster de 4",23-bistiocarbonilo con un agente de desoxigenación para formar un compuesto 4",23-didesoxi y (e) se hace reaccionar el compuesto 4",23-didesoxi conun ácido para formar un compuesto de fórmula (I).
ES98924534T 1997-07-23 1998-06-25 Produccion de compuestos de avermectina. Expired - Lifetime ES2182317T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9700916 1997-07-23

Publications (1)

Publication Number Publication Date
ES2182317T3 true ES2182317T3 (es) 2003-03-01

Family

ID=11004591

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98924534T Expired - Lifetime ES2182317T3 (es) 1997-07-23 1998-06-25 Produccion de compuestos de avermectina.

Country Status (22)

Country Link
EP (1) EP1001962B8 (es)
JP (1) JP3267634B2 (es)
KR (1) KR100339191B1 (es)
CN (1) CN1184227C (es)
AR (1) AR016522A1 (es)
AT (1) ATE227733T1 (es)
AU (1) AU725506B2 (es)
CA (1) CA2294928C (es)
CZ (1) CZ296326B6 (es)
DE (1) DE69809433T2 (es)
DK (1) DK1001962T3 (es)
ES (1) ES2182317T3 (es)
HK (1) HK1027110A1 (es)
HU (1) HUP0004631A3 (es)
ID (1) ID24327A (es)
IL (1) IL133558A0 (es)
PL (1) PL188159B1 (es)
PT (1) PT1001962E (es)
RU (1) RU2211221C2 (es)
TR (1) TR200000196T2 (es)
WO (1) WO1999005156A1 (es)
YU (1) YU71699A (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110191868A1 (en) 2008-04-10 2011-08-04 Massachusetts Institute Of Technology Methods for identification and use of agents targeting cancer stem cells
WO2014074805A1 (en) 2012-11-08 2014-05-15 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
WO2015168255A1 (en) 2014-04-29 2015-11-05 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
CN104430397B (zh) * 2014-11-06 2016-08-24 山东永泰化工有限公司 一种用于防治红蜘蛛的水分散粒剂
CN107021990B (zh) * 2017-06-14 2019-07-12 博瑞生物医药（苏州）股份有限公司 高纯度塞拉菌素的制备方法
CN107118247B (zh) * 2017-06-14 2019-07-26 博瑞生物医药（苏州）股份有限公司 塞拉菌素的制备方法
CN107188915B (zh) * 2017-07-19 2019-08-02 苏州正永生物医药有限公司 一种塞拉菌素中间体的制备方法
CN107723325B (zh) * 2017-11-28 2021-03-30 山东齐发药业有限公司 基于pH控制的多拉菌素发酵生产方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
EP0676236A1 (en) * 1994-04-05 1995-10-11 Pfizer Inc. Process for removal of allyl group or allyloxycarbonyl group

Also Published As

Publication number Publication date
JP3267634B2 (ja) 2002-03-18
IL133558A0 (en) 2001-04-30
CZ200097A3 (cs) 2000-05-17
AU725506B2 (en) 2000-10-12
WO1999005156A1 (en) 1999-02-04
JP2000513385A (ja) 2000-10-10
RU2211221C2 (ru) 2003-08-27
CZ296326B6 (cs) 2006-02-15
CN1265113A (zh) 2000-08-30
AR016522A1 (es) 2001-07-25
KR100339191B1 (ko) 2002-06-01
EP1001962A1 (en) 2000-05-24
DK1001962T3 (da) 2002-12-16
PL188159B1 (pl) 2004-12-31
CA2294928C (en) 2003-01-14
ID24327A (id) 2000-07-13
CA2294928A1 (en) 1999-02-04
DE69809433D1 (de) 2002-12-19
PL338354A1 (en) 2000-10-23
CN1184227C (zh) 2005-01-12
PT1001962E (pt) 2003-01-31
HUP0004631A3 (en) 2002-11-28
YU71699A (sh) 2002-06-19
ATE227733T1 (de) 2002-11-15
AU7671498A (en) 1999-02-16
KR20010014066A (ko) 2001-02-26
TR200000196T2 (tr) 2000-07-21
EP1001962B1 (en) 2002-11-13
HK1027110A1 (en) 2001-01-05
EP1001962B8 (en) 2003-03-05
DE69809433T2 (de) 2003-05-08
HUP0004631A2 (hu) 2001-05-28

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