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ES2173167T3 - Derivados de benzodiazepina. - Google Patents

Derivados de benzodiazepina.

Info

Publication number
ES2173167T3
ES2173167T3 ES95902983T ES95902983T ES2173167T3 ES 2173167 T3 ES2173167 T3 ES 2173167T3 ES 95902983 T ES95902983 T ES 95902983T ES 95902983 T ES95902983 T ES 95902983T ES 2173167 T3 ES2173167 T3 ES 2173167T3
Authority
ES
Spain
Prior art keywords
receptors
optionally substituted
cck
lower alkyl
conh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902983T
Other languages
English (en)
Inventor
Sanji Hagishita
Susumu Kamata
Kaoru Seno
Nobuhiro Haga
Yasunobu Ishihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2173167T3 publication Critical patent/ES2173167T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN DERIVADO DE BENZODIAZEPINA DE LA FORMULA (I): EN LA QUE R{SUB,1} ES UN ENLACE, -CH{SUB,2}-, -CH{SUB,2}O-, OCH{SUB,2}-, -SCH{SUB,2}- O UN GRUPO DE LA FORMULA: R{SUB,2} ES UN GRUPO ALQUILO INFERIOR, -COOR{SUB,5}, CONH(CH{SUB,2}){SUB,N}COOR{SUB,5}, -CONHSO{SUB,2}R{SUB,5}, SO{SUB,2}NHCOR{SUB,5} O UN GRUPO HETEROCICLICO OPCIONALMENTE SUSTITUIDO (R{SUB,5} ES UN ATOMO DE HIDROGENO, ALQUILO INFERIOR O BENCILO Y N ES UN ENTERO DE 1 A 5); R{SUB,3} ES UN ENLACE, -COO -CONH-; Y R{SUB,4} ES UN GRUPO HETEROCICLICO OPCIONALMENTE SUSTITUIDO, ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, CICLOALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, ARILO OPCIONALMENTE SUSTITUIDO, O UN GRUPO ALCOXICARBONILO INFERIOR, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, QUE PRESENTA UNA ALTA AFINIDAD A LOS RECEPTORES DE GASTRINA Y/O RECEPTORES DE CCKB PERO NO A LOS RECEPTORES DE CCK-A, Y ES UTIL PARA EL TRATAMIENTO DE LAS ENFERMEDADES ASOCIADAS CON LOS RECEPTORES DE GASTRINA Y/O LOS RECEPTORES DE CCK-B SIN INDUCIR LOS EFECTOSSECUNDARIOS ASOCIADOS A LOS RECEPTORES DE CCK-A.
ES95902983T 1993-12-28 1994-12-19 Derivados de benzodiazepina. Expired - Lifetime ES2173167T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP33616893 1993-12-28

Publications (1)

Publication Number Publication Date
ES2173167T3 true ES2173167T3 (es) 2002-10-16

Family

ID=18296379

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902983T Expired - Lifetime ES2173167T3 (es) 1993-12-28 1994-12-19 Derivados de benzodiazepina.

Country Status (12)

Country Link
US (1) US5776929A (es)
EP (1) EP0728748B1 (es)
JP (1) JP3621416B2 (es)
CN (1) CN1073089C (es)
AT (1) ATE214056T1 (es)
AU (1) AU684871B2 (es)
CA (1) CA2177960A1 (es)
DE (1) DE69430068T2 (es)
ES (1) ES2173167T3 (es)
PT (1) PT728748E (es)
TW (1) TW334428B (es)
WO (1) WO1995018110A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
ES2206754T3 (es) * 1996-12-10 2004-05-16 Zeria Pharmaceutical Co., Ltd. Derivados de 1,5 - benzodiazepina.
JP2000026434A (ja) * 1998-06-05 2000-01-25 Zeria Pharmaceut Co Ltd 新規１，５−ベンゾジアゼピン誘導体
GB0008179D0 (en) * 2000-04-05 2000-05-24 Glaxo Group Ltd Chemical process
CN1221538C (zh) 1999-12-02 2005-10-05 泽里新药工业株式会社 1,5－苯并二氮杂䓬衍生物的钙盐、该盐的制备方法及含有该盐的药物
EP2065046B1 (en) * 2007-11-30 2013-07-31 Kao Corporation Gip secretion inhibitor
JP5075254B2 (ja) 2011-01-07 2012-11-21 スノーデン株式会社 胃酸及びガストリンの産生を抑制する乳酸菌

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5408646A (en) * 1991-03-29 1995-04-18 International Business Machines Corp. Multipath torus switching apparatus
DK0558104T3 (da) * 1992-01-21 1999-04-26 Glaxo Wellcome Spa 1,5-Benzodiazepinderivater og deres anvendelse i lægemidler
GB9201181D0 (en) * 1992-01-21 1992-03-11 Glaxo Spa Chemical compounds
GB9307833D0 (en) * 1993-04-15 1993-06-02 Glaxo Inc Modulators of cholecystokinin and gastrin
CN1120845A (zh) * 1993-04-15 1996-04-17 格拉克索有限公司 具有cck和/或胃泌素拮抗活性的1，5-苯并二氮杂䓬衍生物
GB9308421D0 (en) * 1993-04-23 1993-06-09 Glaxo Spa Chemical compounds

Also Published As

Publication number Publication date
CN1143362A (zh) 1997-02-19
WO1995018110A1 (fr) 1995-07-06
AU1201195A (en) 1995-07-17
TW334428B (en) 1998-06-21
ATE214056T1 (de) 2002-03-15
CA2177960A1 (en) 1995-07-06
US5776929A (en) 1998-07-07
EP0728748B1 (en) 2002-03-06
EP0728748A4 (en) 1997-03-19
JP3621416B2 (ja) 2005-02-16
CN1073089C (zh) 2001-10-17
DE69430068D1 (de) 2002-04-11
DE69430068T2 (de) 2002-08-14
AU684871B2 (en) 1998-01-08
PT728748E (pt) 2002-06-28
EP0728748A1 (en) 1996-08-28

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