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ES2173074T3 - Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico. - Google Patents

Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico.

Info

Publication number
ES2173074T3
ES2173074T3 ES90303093T ES90303093T ES2173074T3 ES 2173074 T3 ES2173074 T3 ES 2173074T3 ES 90303093 T ES90303093 T ES 90303093T ES 90303093 T ES90303093 T ES 90303093T ES 2173074 T3 ES2173074 T3 ES 2173074T3
Authority
ES
Spain
Prior art keywords
formula
disorders
group
xantina
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90303093T
Other languages
English (en)
Inventor
Harald Maschler
Barbara Ann Spicer
Harry Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Pharma GmbH and Co KG
Beecham Group PLC
Original Assignee
SmithKline Beecham Pharma GmbH and Co KG
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Pharma GmbH and Co KG, Beecham Group PLC filed Critical SmithKline Beecham Pharma GmbH and Co KG
Application granted granted Critical
Publication of ES2173074T3 publication Critical patent/ES2173074T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METODO PARA EL TRATAMIENTO DE DESORDENES CEREBROVASCULARES Y/O DESORDENES ASOCIADOS A LA SENILIDAD CEREBRAL Y/U OTROS DESORDENES, CONSISTENTE EN LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA Y NO TOXICA DE UN COMPUESTO DE LA FORMULA (I): O, SI FUERA APROPIADA, UNA SAL FARMACEUTICAMENTE ACEPTABLE, EN DONDE R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE ALQUILO O UNA MITAD DE LA FORMULA (A): -(CH2)M-A (A) EN DONDE M REPRESENTA CERO O EL ENTERO 1, 2 O 3; A REPRESENTA UN RADICAL DE HIDROCARBURO CICLICO SUSTITUIDO O SIN SUSTITUIR; Y R3 REPRESENTA UN ATOMO DE HALOGENO, UN GRUPO NITRO, O UN GRUPO -NR4R5 EN DONDE R4 Y R5 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO, ALQUILO O ALQUILOCARBONILO, O R4 Y R5 JUNTO AL NITROGENO AL QUE SE UNEN FORMANDO UN GRUPO HETEROCICLICO OPCIONALMENTE SUSTITUIDO; TAMBIEN SE REVELAN CIERTOS COMPUESTOS NUEVOS QUE SE ENCUENTRAN DENTRO DE LA FORMULA (I) Y COMPOSICIONES QUE COMPRENDEN DICHOS COMPUESTOS.
ES90303093T 1989-03-23 1990-03-22 Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico. Expired - Lifetime ES2173074T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898906792A GB8906792D0 (en) 1989-03-23 1989-03-23 Treatment and compounds

Publications (1)

Publication Number Publication Date
ES2173074T3 true ES2173074T3 (es) 2002-10-16

Family

ID=10653940

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90303093T Expired - Lifetime ES2173074T3 (es) 1989-03-23 1990-03-22 Derivados de xantina, procedimiento para su preparacion y su uso farmaceutico.

Country Status (27)

Country Link
US (4) US5734051A (es)
EP (2) EP1120417A3 (es)
JP (1) JP2510889B2 (es)
KR (1) KR0160768B1 (es)
CN (1) CN1031641C (es)
AT (1) ATE213498T1 (es)
AU (1) AU629315B2 (es)
CA (1) CA2012686C (es)
CZ (1) CZ391891A3 (es)
DE (1) DE69033915T2 (es)
DK (1) DK0389282T3 (es)
ES (1) ES2173074T3 (es)
FI (1) FI95033C (es)
GB (1) GB8906792D0 (es)
HK (1) HK1040392A1 (es)
HU (1) HU207081B (es)
IL (1) IL93832A (es)
MA (1) MA21800A1 (es)
MY (1) MY109737A (es)
NO (1) NO175592C (es)
NZ (1) NZ233021A (es)
PL (1) PL164811B1 (es)
PT (1) PT93527B (es)
SA (1) SA90100215B1 (es)
SK (1) SK391891A3 (es)
ZA (1) ZA902170B (es)
ZW (1) ZW3690A1 (es)

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ATE213498T1 (de) 2002-03-15
IL93832A0 (en) 1990-12-23
CZ391891A3 (en) 1993-11-17
ZA902170B (en) 1991-03-27
US5981535A (en) 1999-11-09
NO901300L (no) 1990-09-24
PL164811B1 (pl) 1994-10-31
HUT54155A (en) 1991-01-28
CA2012686A1 (en) 1990-09-23
NO901300D0 (no) 1990-03-21
NZ233021A (en) 1993-12-23
NO175592C (no) 1994-11-02
JPH02273676A (ja) 1990-11-08
EP1120417A2 (en) 2001-08-01
PT93527B (pt) 1996-08-30
HU207081B (en) 1993-03-01
HU901792D0 (en) 1990-06-28
US6180791B1 (en) 2001-01-30
JP2510889B2 (ja) 1996-06-26
DE69033915D1 (de) 2002-03-28
CA2012686C (en) 1999-12-07
SA90100215B1 (ar) 2001-10-07
AU5208390A (en) 1990-09-27
EP0389282A3 (en) 1992-07-01
FI95033B (fi) 1995-08-31
IL93832A (en) 1994-07-31
HK1040392A1 (en) 2002-06-07
CN1047502A (zh) 1990-12-05
MA21800A1 (fr) 1990-12-31
AU629315B2 (en) 1992-10-01
KR900013962A (ko) 1990-10-22
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NO175592B (no) 1994-07-25
US5734051A (en) 1998-03-31
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DK0389282T3 (da) 2002-06-03
FI901447A0 (fi) 1990-03-22
US6531600B1 (en) 2003-03-11
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DE69033915T2 (de) 2002-10-10
FI95033C (fi) 1995-12-11
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PT93527A (pt) 1990-11-07
MY109737A (en) 1997-05-31
CN1031641C (zh) 1996-04-24
EP1120417A3 (en) 2001-08-08

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