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ES2161874T3 - Composicion oftalmica con viscosidad reducida. - Google Patents

Composicion oftalmica con viscosidad reducida.

Info

Publication number
ES2161874T3
ES2161874T3 ES95914362T ES95914362T ES2161874T3 ES 2161874 T3 ES2161874 T3 ES 2161874T3 ES 95914362 T ES95914362 T ES 95914362T ES 95914362 T ES95914362 T ES 95914362T ES 2161874 T3 ES2161874 T3 ES 2161874T3
Authority
ES
Spain
Prior art keywords
amount
weight
compound
reduced viscosity
ophthalmic composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914362T
Other languages
English (en)
Inventor
Timo Reunamaki
Kari Lehmussaari
Eija Vartiainen
Olli Oksala
Sakari Alaranta
Esko Pohjala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2161874T3 publication Critical patent/ES2161874T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

COMPUESTO OFTALMICO EN FORMA DE SOLUCION ACUOSA TOPICA QUE CONSISTE ESENCIALMENTE EN: UN AGENTE ACTIVO OFTALMOLOGICAMENTE, UN POLIMERO HIDROFILICO SENSIBLE IONICAMENTE EN UNA CANTIDAD DE 0.004 A 1.5% EN PESO, AL MENOS UNA SAL SELECCIONADA DEL GRUPO DE SALES INORGANICAS Y AMORTIGUADORES EN UNA CANTIDAD TOTAL DE 0.01 A 2.0% EN PESO, UN AGENTE HUMECTANTE EN UNA CANTIDAD DE 0 A 3.0% EN PESO, UN PRESERVADOR EN CANTIDAD DE 0 A 0.02% EN PESO, AGUA, Y OPCIONALMENTE UN AGENTE REGULADOR DE PH EN CANTIDAD SUFICIENTE PARA OFRECER AL COMPUESTO UN PH COMPRENDIDO ENTRE 4.0 Y 8.0; SIENDO EL INDICE ENTRE LA SAL Y LOS COMPONENTES POLIMERICOS TAL QUE LA SOLUCION TENGA UNA VISCOSIDAD INFERIOR A 1000MPAS. EL COMPUESTO TIENE LA CANTIDAD SUFICIENTE DE POLIMEROS PARA PROPORCIONAR UNA ABSORCION CONTROLADA DEL MEDICAMENTO POR EL OJO, HABIENDO SIDO REDUCIDA SU VISCOSIDAD PARA FACILITAR SU USO.
ES95914362T 1994-03-31 1995-03-29 Composicion oftalmica con viscosidad reducida. Expired - Lifetime ES2161874T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9401108A SE9401108D0 (sv) 1994-03-31 1994-03-31 Ophthalmic composition I

Publications (1)

Publication Number Publication Date
ES2161874T3 true ES2161874T3 (es) 2001-12-16

Family

ID=20393511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914362T Expired - Lifetime ES2161874T3 (es) 1994-03-31 1995-03-29 Composicion oftalmica con viscosidad reducida.

Country Status (27)

Country Link
US (1) US5710182A (es)
EP (1) EP0752847B1 (es)
JP (1) JPH10503470A (es)
KR (1) KR100365914B1 (es)
CN (1) CN1112918C (es)
AT (1) ATE202921T1 (es)
AU (1) AU694497B2 (es)
BG (1) BG63145B1 (es)
BR (1) BR9507438A (es)
CA (1) CA2186734A1 (es)
CZ (1) CZ290987B6 (es)
DE (2) DE69521686T2 (es)
DK (1) DK0752847T3 (es)
EE (1) EE03661B1 (es)
ES (1) ES2161874T3 (es)
GR (1) GR3036763T3 (es)
HK (1) HK1013953A1 (es)
HU (1) HU223071B1 (es)
MX (1) MX9603918A (es)
NO (1) NO314434B1 (es)
PL (1) PL179433B1 (es)
PT (1) PT752847E (es)
RO (1) RO115409B1 (es)
RU (1) RU2139016C1 (es)
SE (1) SE9401108D0 (es)
SK (1) SK280492B6 (es)
WO (1) WO1995026711A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9718568D0 (en) 1997-09-03 1997-11-05 Chauvin Pharmaceuticals Limite Compositions
AU4808000A (en) 1999-04-28 2000-11-10 Situs Corporation Drug delivery system
US6852688B2 (en) 2000-03-10 2005-02-08 University Of Florida Compositions for treating diabetic retinopathy and methods of using same
CN1638734A (zh) * 2002-02-22 2005-07-13 参天制药株式会社 微粒结膜下给药的药物释放系统
US7128928B2 (en) * 2002-02-22 2006-10-31 Pharmacia Corporation Ophthalmic formulation with novel gum composition
JP2004196787A (ja) * 2002-12-04 2004-07-15 Santen Pharmaceut Co Ltd 結膜下デポによるドラッグデリバリーシステム
EP1568359A4 (en) * 2002-12-04 2011-05-18 Santen Pharmaceutical Co Ltd DRUG DELIVERY SYSTEM HAVING SUB-CONJUNCTIVAL DEPOSIT
US7947295B2 (en) * 2003-06-13 2011-05-24 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
CA2839847C (en) * 2003-06-13 2016-03-15 Masood A. Chowhan Ophthalmic compositions containing a synergistic combination of two polymers
WO2005018608A1 (ja) * 2003-08-20 2005-03-03 Santen Pharmaceutical Co., Ltd. 微粒子テノン嚢下投与ドラッグデリバリーシステム
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
DE102005035986B4 (de) * 2005-07-28 2009-10-15 Bausch & Lomb Incorporated Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat
EP2334686B1 (en) 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin analogues and syntheses therof
EP2383286A1 (en) 2010-04-30 2011-11-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of retinal degenerative diseases
JP2012180346A (ja) * 2011-02-10 2012-09-20 Santen Pharmaceut Co Ltd 親水性薬物の薬物移行性を改善した水性組成物
WO2013124477A1 (en) 2012-02-24 2013-08-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of retinal degenerative diseases
SG10201808151RA (en) 2013-12-24 2018-10-30 Harvard College Cortistatin analogues and syntheses and uses thereof
EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
WO2017004411A1 (en) 2015-07-01 2017-01-05 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
CN109475756A (zh) 2016-02-17 2019-03-15 儿童医疗中心有限公司 Ffa1(gpr40)作为神经血管生成疾病或病症的治疗标靶
MX2018016046A (es) 2016-06-27 2019-05-02 Achillion Pharmaceuticals Inc Quinazolina y compuestos indol para tratar trastornos medicos.
WO2018033854A1 (en) * 2016-08-15 2018-02-22 Santen Pharmaceutical Co., Ltd. Ophthalmic composition and a method for treating ocular hypertension and glaucoma
US9867810B1 (en) 2016-08-19 2018-01-16 Orasis Pharmaceuticals Ltd. Ophthalmic pharmaceutical compositions and uses relating thereto
KR102632860B1 (ko) 2017-03-01 2024-02-02 아칠리온 파르마세우티칼스 인코포레이티드 의학적 장애의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 약학적 화합물
PT3548000T (pt) * 2017-05-11 2021-12-10 Vyluma Inc Composiões farmacológicas com atropina
EP3773576A4 (en) 2018-03-26 2021-12-29 C4 Therapeutics, Inc. Cereblon binders for the degradation of ikaros
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
CN113365617A (zh) 2018-10-16 2021-09-07 乔治亚州立大学研究基金会股份有限公司 用于医学疾病治疗的一氧化碳前药
CA3165309A1 (en) 2020-03-05 2021-09-10 Christopher G. Nasveschuk Compounds for targeted degradation of brd9
EP4288049A1 (en) * 2021-02-04 2023-12-13 Sydnexis, Inc. Ophthalmic compositions for presbyopia
EP4088713A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
EP4088714A1 (en) 2021-05-10 2022-11-16 Warszawskie Zaklady Farmaceutyczne Polfa S.A. Ophthalmic pharmaceutical composition comprising atropine
CN113786380A (zh) * 2021-09-18 2021-12-14 华北制药股份有限公司 一种硝酸毛果芸香碱眼用凝胶及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056684B2 (ja) * 1977-11-07 1985-12-11 東興薬品工業株式会社 点眼剤
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
FR2678832B1 (fr) * 1991-07-10 1995-03-17 Europhta Sa Laboratoire Nouvelles compositions ophtalmiques a resorption amelioree et leurs procedes de preparation.

Also Published As

Publication number Publication date
SE9401108D0 (sv) 1994-03-31
DE69521686D1 (de) 2001-08-16
BG100915A (en) 1997-07-31
AU2138995A (en) 1995-10-23
CN1112918C (zh) 2003-07-02
HK1013953A1 (en) 1999-09-17
PT752847E (pt) 2001-12-28
JPH10503470A (ja) 1998-03-31
DE69521686T2 (de) 2002-04-25
NO964070L (no) 1996-11-28
RO115409B1 (ro) 2000-02-28
HU223071B1 (hu) 2004-03-01
PL316584A1 (en) 1997-01-20
NO314434B1 (no) 2003-03-24
NO964070D0 (no) 1996-09-27
HU9602691D0 (en) 1996-11-28
SK280492B6 (sk) 2000-03-13
DE752847T1 (de) 1997-09-04
RU2139016C1 (ru) 1999-10-10
AU694497B2 (en) 1998-07-23
US5710182A (en) 1998-01-20
EP0752847A1 (en) 1997-01-15
EE9600120A (et) 1997-04-15
CN1144477A (zh) 1997-03-05
DK0752847T3 (da) 2001-10-22
ATE202921T1 (de) 2001-07-15
PL179433B1 (pl) 2000-09-29
EP0752847B1 (en) 2001-07-11
WO1995026711A1 (en) 1995-10-12
BG63145B1 (bg) 2001-05-31
GR3036763T3 (en) 2001-12-31
CA2186734A1 (en) 1995-10-12
KR100365914B1 (ko) 2003-04-16
KR970702024A (ko) 1997-05-13
BR9507438A (pt) 1997-09-16
EE03661B1 (et) 2002-04-15
CZ290987B6 (cs) 2002-11-13
CZ286596A3 (en) 1997-04-16
MX9603918A (es) 1997-04-30
SK123996A3 (en) 1997-06-04
HUT75666A (en) 1997-05-28

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