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ES2020655A6 - Compositions and in situ methods for forming films on body tissue. - Google Patents

Compositions and in situ methods for forming films on body tissue.

Info

Publication number
ES2020655A6
ES2020655A6 ES909001992A ES9001992A ES2020655A6 ES 2020655 A6 ES2020655 A6 ES 2020655A6 ES 909001992 A ES909001992 A ES 909001992A ES 9001992 A ES9001992 A ES 9001992A ES 2020655 A6 ES2020655 A6 ES 2020655A6
Authority
ES
Spain
Prior art keywords
compositions
films
situ
methods
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES909001992A
Other languages
Spanish (es)
Inventor
Edwin Pomerantz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zila Pharmaceuticals Inc
Original Assignee
Zila Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Pharmaceuticals Inc filed Critical Zila Pharmaceuticals Inc
Publication of ES2020655A6 publication Critical patent/ES2020655A6/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D101/00—Coating compositions based on cellulose, modified cellulose, or cellulose derivatives
    • C09D101/08—Cellulose derivatives
    • C09D101/26—Cellulose ethers
    • C09D101/28—Alkyl ethers
    • C09D101/284—Alkyl ethers with hydroxylated hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Paints Or Removers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Methods and compositions for in situ formation of protective films on body tissues. The compositions include hydroxypropyl cellulose and a weak carboxylic acid in a non-toxic volatile polar solvent, e.g., ethyl alcohol. The preferred carboxylic acids are salicylic acid, tannic acid, and mixtures thereof. A cross-linking agent, e.g., boric acid, incorporated in these compositions improves the physical properties of the film. Methods for in situ deposition of such films include the steps of drying the body tissue, applying the compositions and air drying the compositions to form the film in situ. The films also function as sustained-release matrices for topical medicines. The films themselves act as effective barriers to air, saliva and foods, and provide effective pain relief in the treatment of recurrent aphthous stomatitis.
ES909001992A 1988-05-02 1990-07-24 Compositions and in situ methods for forming films on body tissue. Expired - Fee Related ES2020655A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18903288A 1988-05-02 1988-05-02
PCT/US1989/003216 WO1990001046A1 (en) 1988-05-02 1989-07-24 Compositions and in situ methods for forming films on body tissue

Publications (1)

Publication Number Publication Date
ES2020655A6 true ES2020655A6 (en) 1991-08-16

Family

ID=22695630

Family Applications (1)

Application Number Title Priority Date Filing Date
ES909001992A Expired - Fee Related ES2020655A6 (en) 1988-05-02 1990-07-24 Compositions and in situ methods for forming films on body tissue.

Country Status (14)

Country Link
EP (1) EP0380647A4 (en)
JP (1) JP3000104B2 (en)
KR (1) KR940011240B1 (en)
CN (1) CN1038227C (en)
AU (2) AU2252388A (en)
BR (1) BR9002342A (en)
CA (1) CA1337396C (en)
ES (1) ES2020655A6 (en)
FI (1) FI901443A0 (en)
IE (1) IE902096A1 (en)
MX (1) MX21686A (en)
NO (1) NO180618C (en)
NZ (1) NZ232625A (en)
WO (2) WO1989010745A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989010745A1 (en) * 1988-05-02 1989-11-16 Pomerantz, Edwin Compositions and in situ methods for forming films on body tissue
GR1001331B (en) * 1990-07-18 1993-08-31 Zila Pharm Inc Compositions and in situ methods for forming films on body tissue
IL97930A (en) * 1991-04-23 1996-06-18 Perio Prod Ltd Sustained-release toothbleaching preparations containing a peroxy agent
WO1999004764A1 (en) * 1997-07-23 1999-02-04 Perio Products Ltd. Tannic acid-polymer compositions for controlled release of pharmaceutical agents, particularly in the oral cavity
US20030185761A1 (en) 1997-10-01 2003-10-02 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating pain
US20030077227A1 (en) 1997-10-01 2003-04-24 Dugger Harry A. Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
EP1029536B1 (en) 1997-10-01 2007-11-28 Novadel Pharma Inc. Buccal non-polar spray
US20040136914A1 (en) 1997-10-01 2004-07-15 Dugger Harry A. Buccal, polar and non-polar spray containing ondansetron
US7632517B2 (en) 1997-10-01 2009-12-15 Novadel Pharma Inc. Buccal, polar and non-polar spray containing zolpidem
FR2773068B1 (en) * 1997-12-29 2000-09-01 Oreal FILM-FORMING COSMETIC COMPOSITION BASED ON A CELLULOSE DERIVATIVE CONTAINING, AS A THICKENING AGENT, AN ALKALI METAL TETRABORATE
US6595940B1 (en) * 1998-12-23 2003-07-22 Closure Medical Corporation Applicator for dispensable liquids
US6283933B1 (en) 1998-12-23 2001-09-04 Closure Medical Corporation Applicator for dispensable liquids
US20020064542A1 (en) * 1999-06-29 2002-05-30 George Endel Deckner Tissue products utilizing water soluble films as carriers for antiviral compositions and process for making
CN1891300B (en) * 2005-07-06 2010-04-14 上海医药工业研究院 Benzocaine film-formed gel composition and its use
CN100446814C (en) * 2005-07-22 2008-12-31 上海医药工业研究院 Compound econazole nitrate film forming gel composition and its use
CN101138543B (en) * 2006-09-06 2012-01-04 上海医药工业研究院 Centella asiatica partial film forming gel composition and uses thereof
CN101190178B (en) * 2006-11-24 2010-05-12 上海医药工业研究院 Antiviral partial film forming gel composition
FR2976808B1 (en) * 2011-06-22 2013-06-28 Urgo Lab FILMOGENE COMPOSITION AND USE THEREOF FOR THE TREATMENT OF HERPES
EP2742931A1 (en) * 2012-12-13 2014-06-18 LTS LOHMANN Therapie-Systeme AG Topical drug for treating ulcers
CN104337939A (en) * 2013-08-05 2015-02-11 天津司威林医疗器械科技有限公司 Preparation method for traditional Chinese medicine hemostasis coating film material
CN104997723A (en) * 2014-04-16 2015-10-28 上海现代药物制剂工程研究中心有限公司 Film-forming gel composition and uses thereof, and pharmaceutical film-forming gel composition
CN105012960A (en) * 2014-04-16 2015-11-04 上海现代药物制剂工程研究中心有限公司 Film-forming gel composition, application and wound protecting material
KR101874770B1 (en) * 2018-01-02 2018-07-05 김진동 Apartment type plant
KR102072816B1 (en) * 2018-05-28 2020-02-03 서석호 Conveyor Belt Stand System to Support Impact Bar with Air Hole for moving Conveyor Belt
CN110201218A (en) * 2018-12-23 2019-09-06 山东泰开制药有限公司 Liquid adhesive bandage and preparation method thereof
US20220287981A1 (en) * 2019-08-16 2022-09-15 Amd Pharma Ltd. Adhesive drug delivery microparticles and a product comprising thereof
WO2021132199A1 (en) * 2019-12-26 2021-07-01 帝人ファーマ株式会社 Medical dressing

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US438129A (en) * 1890-10-07 Geoege henesy flint
NL31756C (en) * 1962-04-26
US3591680A (en) * 1969-11-17 1971-07-06 Smith Kline French Lab Concentrated antacid compositions and method of producing antacid activity
DE2905134A1 (en) * 1978-02-17 1979-08-23 Degussa NEW ACYLATED AMINOALKYL CYANOGUANIDINE WITH A HETEROCYCLIC REST
JPS5540604A (en) * 1978-09-14 1980-03-22 Mitsui Toatsu Chem Inc Improved local topicum
US4244948A (en) * 1979-05-07 1981-01-13 Allergan Pharmaceuticals, Inc. Medical use of esters of acetylsalicylic acid to treat acne
US4307075A (en) * 1979-09-13 1981-12-22 American Home Products Corporation Topical treatment of aphthous stomatitis
US4381296A (en) * 1980-06-23 1983-04-26 Tinnell James E Treatment for herpes virus
US4434181A (en) * 1981-12-07 1984-02-28 Fearing Manufacturing Co., Inc. Teat dip
JPS5927818A (en) * 1982-08-09 1984-02-14 Nippon Soda Co Ltd Artificial saliva
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
JPS6187603A (en) * 1984-06-09 1986-05-06 Earth Chem Corp Ltd Mite controlling agent
US4695464A (en) * 1984-10-09 1987-09-22 The Dow Chemical Company Sustained release dosage form based on highly plasticized cellulose ether gels
US4678516A (en) * 1984-10-09 1987-07-07 The Dow Chemical Company Sustained release dosage form based on highly plasticized cellulose ether gels
JPS6263513A (en) * 1985-09-13 1987-03-20 Nippon Shinyaku Co Ltd Film preparation
US4704285A (en) * 1985-11-18 1987-11-03 The Dow Chemical Company Sustained release compositions comprising hydroxypropyl cellulose ethers
JPS62270503A (en) * 1986-05-20 1987-11-24 Nippon Soda Co Ltd Sheet-or film-shaped disinfectant and production thereof
WO1989010745A1 (en) * 1988-05-02 1989-11-16 Pomerantz, Edwin Compositions and in situ methods for forming films on body tissue

Also Published As

Publication number Publication date
WO1990001046A1 (en) 1990-02-08
WO1989010745A1 (en) 1989-11-16
AU614179B2 (en) 1991-08-22
CN1038227C (en) 1998-05-06
FI901443A0 (en) 1990-03-22
NO180618C (en) 1997-05-21
JP3000104B2 (en) 2000-01-17
JPH03503052A (en) 1991-07-11
CN1048979A (en) 1991-02-06
AU2252388A (en) 1989-11-29
IE902096A1 (en) 1991-06-19
AU4053689A (en) 1990-02-19
BR9002342A (en) 1991-08-06
NZ232625A (en) 1991-08-27
EP0380647A1 (en) 1990-08-08
EP0380647A4 (en) 1991-07-24
MX21686A (en) 1994-01-31
NO180618B (en) 1997-02-10
KR900701251A (en) 1990-12-01
CA1337396C (en) 1995-10-24
NO901346L (en) 1990-03-23
NO901346D0 (en) 1990-03-23
KR940011240B1 (en) 1994-12-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060725