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ES2001341A6 - Un procedimiento de producir un derivado de acido guanidinometilbenzoico. - Google Patents

Un procedimiento de producir un derivado de acido guanidinometilbenzoico.

Info

Publication number
ES2001341A6
ES2001341A6 ES8600664A ES8600664A ES2001341A6 ES 2001341 A6 ES2001341 A6 ES 2001341A6 ES 8600664 A ES8600664 A ES 8600664A ES 8600664 A ES8600664 A ES 8600664A ES 2001341 A6 ES2001341 A6 ES 2001341A6
Authority
ES
Spain
Prior art keywords
novel
acid derivatives
guanidinomethylbenzoic acid
guanidinomethylbenzoic
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600664A
Other languages
English (en)
Inventor
Toshio Satoh
Hitoshi Matsumoto
Hisao Kakegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MED CREAT KK
Original Assignee
MED CREAT KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MED CREAT KK filed Critical MED CREAT KK
Publication of ES2001341A6 publication Critical patent/ES2001341A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE PRODUCIR UN DERIVADO DE ACIDO GUANIDINOMETILBENZOICO, REPRESENTADO POR LA FORMULA O UNA SAL DEL MISMO, QUE COMPRENDE HACER REACCIONAR ACIDO 4-GUANIDINOMETILBENZOICO Y ANILINA Y, SI ES NECESARIO, CONVERTIR EL PRODUCTO LIBRE RESULTANTE EN UNA SAL DEL MISMO. LOS PRODUCTOS OBTENIDOS PUEDEN UTILIZARSE PARA EL TRATAMIENTO Y LA PREVENCION DE ULCERAS GASTROENTERICAS.
ES8600664A 1985-07-30 1986-07-29 Un procedimiento de producir un derivado de acido guanidinometilbenzoico. Expired ES2001341A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60166903A JPS6229566A (ja) 1985-07-30 1985-07-30 新規グアニジノメチル安息香酸誘導体

Publications (1)

Publication Number Publication Date
ES2001341A6 true ES2001341A6 (es) 1988-05-16

Family

ID=15839768

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600664A Expired ES2001341A6 (es) 1985-07-30 1986-07-29 Un procedimiento de producir un derivado de acido guanidinometilbenzoico.

Country Status (7)

Country Link
US (1) US4732916A (es)
EP (1) EP0218027B1 (es)
JP (1) JPS6229566A (es)
AT (1) ATE46501T1 (es)
DE (1) DE3665711D1 (es)
ES (1) ES2001341A6 (es)
PT (1) PT83104B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63126860A (ja) * 1986-11-17 1988-05-30 Nippon Haipotsukusu:Kk グアニジノメチル安息香酸誘導体
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
US4970318A (en) * 1988-05-24 1990-11-13 Pfizer Inc. Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
US4948901A (en) * 1988-05-24 1990-08-14 Pfizer Inc. Benzamide protease inhibitors
US4948891A (en) * 1988-05-24 1990-08-14 Pfizer Inc. Benzamide protease inhibitors
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
DE4305536A1 (de) * 1993-02-19 1994-08-25 Asche Ag Verwendung von Enzym-Inhibitoren zur Herstellung eines Arzneimittels
EP1195372A1 (en) * 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
DZ3415A1 (fr) 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
DE60216747T2 (de) * 2001-04-09 2007-10-04 Novartis Vaccines and Diagnostics, Inc., Emeryville Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten
CN1203055C (zh) * 2001-09-26 2005-05-25 朱德煦 治疗或预防细菌感染的方法和组合物
US20030195187A1 (en) * 2002-02-04 2003-10-16 Chiron Corporation Guanidino compounds
US20030207814A1 (en) * 2002-02-04 2003-11-06 Chiron Corporation Novel guanidinyl derivatives
US20030229025A1 (en) * 2002-02-25 2003-12-11 Chiron Corporation Intranasal administration of MC4-R agonists
ATE478867T1 (de) * 2002-05-23 2010-09-15 Novartis Vaccines & Diagnostic Substituierte quinazolinone verbindungen
CA2523015A1 (en) * 2003-05-23 2004-12-29 Chiron Corporation Guanidino-substituted quinazolinone compounds as mc4-r agonists
AU2004293012A1 (en) * 2003-11-19 2005-06-09 Rustum S. Boyce Quinazolinone compounds with reduced bioaccumulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479401A (en) * 1966-06-28 1969-11-18 Merck & Co Inc Guanidinoaryl and guanidinomethylaryl compounds
BE757956A (fr) * 1969-10-24 1971-04-23 Ici Ltd Composes antiviraux
SE460667B (sv) * 1979-09-20 1989-11-06 Nippon Chemiphar Co Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendning
JPS57197256A (en) * 1981-05-28 1982-12-03 Nippon Chemiphar Co Ltd Novel cyclohexanecarboxamide derivative and its preparation

Also Published As

Publication number Publication date
PT83104A (en) 1986-08-01
ATE46501T1 (de) 1989-10-15
PT83104B (en) 1987-12-23
EP0218027A1 (en) 1987-04-15
JPS6229566A (ja) 1987-02-07
US4732916A (en) 1988-03-22
EP0218027B1 (en) 1989-09-20
DE3665711D1 (de) 1989-10-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001