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ES2096653T3 - Composiciones de aerosol presurizado. - Google Patents

Composiciones de aerosol presurizado.

Info

Publication number
ES2096653T3
ES2096653T3 ES91912173T ES91912173T ES2096653T3 ES 2096653 T3 ES2096653 T3 ES 2096653T3 ES 91912173 T ES91912173 T ES 91912173T ES 91912173 T ES91912173 T ES 91912173T ES 2096653 T3 ES2096653 T3 ES 2096653T3
Authority
ES
Spain
Prior art keywords
compositions
pressurized aerosol
surfactant
medicinal product
polyetoxylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91912173T
Other languages
English (en)
Inventor
Asit Somani
Clive Booles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Ltd
Original Assignee
Fisons Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909014526A external-priority patent/GB9014526D0/en
Priority claimed from GB909014527A external-priority patent/GB9014527D0/en
Priority claimed from GB909023953A external-priority patent/GB9023953D0/en
Application filed by Fisons Ltd filed Critical Fisons Ltd
Application granted granted Critical
Publication of ES2096653T3 publication Critical patent/ES2096653T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fertilizers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

SE PRESENTAN COMPOSICIONES PARA AEROSOLES A PRESION QUE COMPRENDEN UN MEDICAMENTO, UN PROPELENTE DE HIDROFLUOROCARBONO Y UN SURFACTANTE POLIETOXILADO, LAS COMPOSICIONES NO CONTIENEN SUBSTANCIALMENTE OTRO DISOLVENTE QUE EL PROPELENTE, INCREMENTANDOSE LA SOLUBILIDAD DEL SURFACTANTE EN EL PROPELENTE. LAS COMPOSICIONES DE ACUERDO CON LA INVENCION TIENEN LA VENTAJA DE QUE LA SOLUBILIDAD DEL SURFACTANTE ES TAL QUE ASEGURA UNA BUENA DISPERSION DEL MEDICAMENTO Y UN FUNCIONAMIENTO SUAVE DE LA VALVULA DEL AEROSOL.
ES91912173T 1990-06-29 1991-06-25 Composiciones de aerosol presurizado. Expired - Lifetime ES2096653T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB909014526A GB9014526D0 (en) 1990-06-29 1990-06-29 Aerosol formulation
GB909014527A GB9014527D0 (en) 1990-06-29 1990-06-29 Aerosol formulation
GB909023953A GB9023953D0 (en) 1990-11-03 1990-11-03 Pharmaceutical composition

Publications (1)

Publication Number Publication Date
ES2096653T3 true ES2096653T3 (es) 1997-03-16

Family

ID=27265168

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91912173T Expired - Lifetime ES2096653T3 (es) 1990-06-29 1991-06-25 Composiciones de aerosol presurizado.

Country Status (21)

Country Link
US (1) US5846521A (es)
EP (1) EP0536235B1 (es)
JP (1) JP2854974B2 (es)
AT (1) ATE147973T1 (es)
AU (1) AU8055691A (es)
BR (1) BR9106595A (es)
CA (1) CA2085884C (es)
CZ (1) CZ392592A3 (es)
DE (1) DE69124374T2 (es)
DK (1) DK0536235T3 (es)
ES (1) ES2096653T3 (es)
FI (1) FI925852L (es)
GR (1) GR3023065T3 (es)
HU (1) HUT63554A (es)
IE (1) IE912220A1 (es)
MX (1) MX9100008A (es)
NO (1) NO924954L (es)
NZ (1) NZ238746A (es)
PT (1) PT98133A (es)
SK (1) SK392592A3 (es)
WO (1) WO1992000061A1 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766573A (en) 1988-12-06 1998-06-16 Riker Laboratories, Inc. Medicinal aerosol formulations
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
US5785952A (en) * 1990-11-09 1998-07-28 Glaxo Group Limited Aerosol medicament formulation having a surface coating of surfactant
ZA924164B (en) * 1991-06-10 1993-02-24 Schering Corp Non-chlorofluorocarbon aerosol formulations
US6503482B1 (en) 1991-06-10 2003-01-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant
US5916540A (en) 1994-10-24 1999-06-29 Glaxo Group Limited Aerosol formulations containing P134A and/or P227 and particulate medicament
CA2125666C (en) 1991-12-12 2002-07-16 Rachel Ann Akehurst Medicaments
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
US5376359A (en) * 1992-07-07 1994-12-27 Glaxo, Inc. Method of stabilizing aerosol formulations
MX9304585A (es) * 1992-07-31 1994-03-31 Glaxo Group Ltd Formulacion farmaceutica en aerosol, lata adecuada para liberar la formulacion e inhalador de dosis dosificada que comprende la lata.
CA2156408C (en) * 1993-03-17 2005-02-15 Daniel C. Duan Aerosol formulation containing a polyester dispersing aid
CA2156075C (en) * 1993-03-17 2004-06-22 Daniel C. Duan Aerosol formulation containing a dispersing aid
US5593661A (en) * 1993-03-29 1997-01-14 Henry; Richard A. Lidocaine aerosol anaesthetic
ES2193186T3 (es) * 1993-12-02 2003-11-01 Abbott Lab Composiciones medicamentosas en aerosol para la utilizacion con gases propulsores sin cfc.
US5502076A (en) * 1994-03-08 1996-03-26 Hoffmann-La Roche Inc. Dispersing agents for use with hydrofluoroalkane propellants
US5635159A (en) * 1994-08-26 1997-06-03 Abbott Laboratories Aerosol drug formulations containing polyglycolyzed glycerides
US5635161A (en) * 1995-06-07 1997-06-03 Abbott Laboratories Aerosol drug formulations containing vegetable oils
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
AU718967B2 (en) 1997-02-05 2000-05-04 Jagotec Ag Medical aerosol formulations
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
GB9805938D0 (en) 1998-03-19 1998-05-13 Glaxo Group Ltd Valve for aerosol container
GB9807232D0 (en) 1998-04-03 1998-06-03 Univ Cardiff Aerosol composition
US6451285B2 (en) 1998-06-19 2002-09-17 Baker Norton Pharmaceuticals, Inc. Suspension aerosol formulations containing formoterol fumarate and a fluoroalkane propellant
US6585958B1 (en) 1998-07-24 2003-07-01 Jago Research Ag Medicinal aerosol formulations
AU749697B2 (en) * 1998-08-04 2002-07-04 Jagotec Ag Medicinal aerosol formulations
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6451287B1 (en) 2000-05-26 2002-09-17 Smithkline Beecham Corporation Fluorinated copolymer surfactants and use thereof in aerosol compositions
JP2004509159A (ja) 2000-09-22 2004-03-25 グラクソ　グループ　リミテッド 新規なアルカン酸誘導体
JP2005504715A (ja) 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0125127D0 (en) 2001-10-19 2001-12-12 Glaxo Group Ltd Compounds
ES2415654T3 (es) 2001-11-20 2013-07-26 Civitas Therapeutics, Inc. Composiciones particuladas mejoradas para suministro pulmonar
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
AU2002367032B8 (en) * 2001-12-21 2008-10-23 3M Innovative Properties Company Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient
CA2474626A1 (en) 2002-02-13 2003-08-21 Glaxo Group Limited Carboxylic acid compounds for use as surfactants
GB0205327D0 (en) * 2002-03-06 2002-04-17 Glaxo Group Ltd compounds
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
AU2004264941B2 (en) 2003-08-11 2008-11-27 Glaxo Group Limited Pharmaceutical metered dose inhaler and methods relating thereto
CA2536876A1 (en) 2003-08-29 2005-03-17 Glaxo Group Limited Pharmaceutical metered dose inhaler and methods relating thereto
PT2425820E (pt) 2007-02-11 2015-08-04 Map Pharmaceuticals Inc Método de administração terapêutica de dhe para permitir o rápido alívio das enxaquecas ao mesmo tempo que minimiza o perfil de efeitos secundários
GB0712454D0 (en) 2007-06-27 2007-08-08 Generics Uk Ltd Pharmaceutical compositions
EP3174522A1 (en) 2014-07-29 2017-06-07 3M Innovative Properties Company Method of preparing a pharmaceutical composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7708731A (nl) * 1976-08-13 1978-02-15 Montedison Spa Werkwijze voor de bereiding van nieuwe drijf- middelsamenstellingen voor aerosolen.
CA1136547A (en) * 1979-03-08 1982-11-30 Song-Ling Lin Aerosol anesthetic compositions
GB8432063D0 (en) * 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
DE3872635T2 (de) * 1987-04-09 1992-12-17 Fisons Plc Pentamidin enthaltende pharmazeutische zusammensetzungen.
US5225183A (en) * 1988-12-06 1993-07-06 Riker Laboratories, Inc. Medicinal aerosol formulations
GB8828477D0 (en) * 1988-12-06 1989-01-05 Riker Laboratories Inc Medical aerosol formulations
GB8828544D0 (en) * 1988-12-07 1989-01-11 Ici Plc Chemical process
DE3905726A1 (de) * 1989-02-24 1990-08-30 Hoechst Ag Druckgaspackung und treibmittel fuer aerosole
GB8908250D0 (en) * 1989-04-12 1989-05-24 Fisons Plc Formulations
US5653962A (en) * 1991-12-12 1997-08-05 Glaxo Group Limited Aerosol formulations containing P134a and particulate medicaments
US5658549A (en) * 1991-12-12 1997-08-19 Glaxo Group Limited Aerosol formulations containing propellant 134a and fluticasone propionate

Also Published As

Publication number Publication date
DK0536235T3 (da) 1997-04-14
ATE147973T1 (de) 1997-02-15
US5846521A (en) 1998-12-08
NZ238746A (en) 1992-10-28
CA2085884C (en) 2001-12-04
BR9106595A (pt) 1993-04-20
HU9204098D0 (en) 1993-03-29
FI925852A7 (fi) 1992-12-23
WO1992000061A1 (en) 1992-01-09
DE69124374T2 (de) 1997-06-19
HUT63554A (en) 1993-09-28
PT98133A (pt) 1992-04-30
NO924954D0 (no) 1992-12-21
GR3023065T3 (en) 1997-07-30
AU8055691A (en) 1992-01-23
EP0536235A1 (en) 1993-04-14
FI925852A0 (fi) 1992-12-23
MX9100008A (es) 1992-02-03
IE912220A1 (en) 1992-01-01
CA2085884A1 (en) 1991-12-30
JPH05507712A (ja) 1993-11-04
JP2854974B2 (ja) 1999-02-10
FI925852L (fi) 1992-12-23
SK392592A3 (en) 1994-07-06
NO924954L (no) 1992-12-21
CZ392592A3 (en) 1993-05-12
DE69124374D1 (de) 1997-03-06
EP0536235B1 (en) 1997-01-22

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