ES2079315B1 - Nuevas imidazopiridinas. - Google Patents
Nuevas imidazopiridinas.Info
- Publication number
- ES2079315B1 ES2079315B1 ES09400364A ES9400364A ES2079315B1 ES 2079315 B1 ES2079315 B1 ES 2079315B1 ES 09400364 A ES09400364 A ES 09400364A ES 9400364 A ES9400364 A ES 9400364A ES 2079315 B1 ES2079315 B1 ES 2079315B1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- imidazopiridines
- new
- cyclloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical class O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- XTQHKBHJIVJGKJ-UHFFFAOYSA-N sulfur monoxide Chemical class S=O XTQHKBHJIVJGKJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NUEVAS IMIDAZOPIRIDINAS. COMPUESTOS DE FORMULA I Y SUS SALES Y SOLVATOS, EN DONDE R1 SIGNIFICA C1-4 ALQUILO O C3-7 CICLOALQUILO; AR1 REPRESENTA FENILO O PIRIDINA QUE PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS; AR2 REPRESENTA C3-7 CICLOALQUILO, FENILO OPCIONALMENTE SUSTITUIDO O HETEROCICLO; LA AGRUPACION X-Y REPRESENTA C=C O BIEN CH-CH; Z REPRESENTA, ENTRE OTROS, -CO2H O -TETRAZOL-5-IL; W REPRESENTA HIDROGENO, CIANO, C1-4 ALQUILO, CONHR5, AR2, C1-4 ALQUILSULFONIL, C1-4 ALQUILSULFINIL, C1-4 ALQUILTIO, C1-4 ALCOXI, C1-4 ALQUILCARBONIL, HALOGENO, HALOMETILO, HIDROXIMETILO O C1-4 ALCOXIMETILO O BIEN PUEDE REPRESENTAR CUALQUIERA DE LOS SIGNIFICADOS DE Z; Y R5 REPRESENTA HIDROGENO, C1-4 ALQUILO, ARILO O ARIL-(C1-4)ALQUILO. DICHOS COMPUESTOS SON UTILES COMO ANTAGONISTAS DE LA ANGIOTENSINA II. LA PRESENTE INVENCION DESCRIBE TAMBIEN PROCEDIMIENTOS PARA SU OBTENCION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09400364A ES2079315B1 (es) | 1994-02-24 | 1994-02-24 | Nuevas imidazopiridinas. |
| NO950684A NO304378B1 (no) | 1994-02-24 | 1995-02-23 | Nye imidazopyridinderivater som er angiotensin II-antagonister, farmas°ytiske preparater som inneholder dem, og deres anvendelse til fremstilling av medikamenter |
| MX9501084A MX9501084A (es) | 1994-02-24 | 1995-02-23 | Nuevas imidazopiridinas con actividad antagonista de la angiotensina ii. |
| CA002143412A CA2143412A1 (en) | 1994-02-24 | 1995-02-23 | Imidazopyridine derivatives as angiotensin ii antagonists |
| US08/393,981 US5554624A (en) | 1994-02-24 | 1995-02-24 | Imidazopyridine derivatives as angiotensin II antagonists |
| KR1019950003690A KR950032190A (ko) | 1994-02-24 | 1995-02-24 | 안지오텐신 ii 길항제로서의 신규 이미다조피리딘 유도체 |
| EP95102658A EP0669333A1 (en) | 1994-02-24 | 1995-02-24 | New imidazopyridine derivatives as angiotensin II antagonists |
| JP7061678A JPH07267951A (ja) | 1994-02-24 | 1995-02-24 | アンジオテンシンｉｉ拮抗剤としての新規イミダゾピリジン誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09400364A ES2079315B1 (es) | 1994-02-24 | 1994-02-24 | Nuevas imidazopiridinas. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2079315A1 ES2079315A1 (es) | 1996-01-01 |
| ES2079315B1 true ES2079315B1 (es) | 1996-10-16 |
Family
ID=8285334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09400364A Expired - Fee Related ES2079315B1 (es) | 1994-02-24 | 1994-02-24 | Nuevas imidazopiridinas. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5554624A (es) |
| EP (1) | EP0669333A1 (es) |
| JP (1) | JPH07267951A (es) |
| KR (1) | KR950032190A (es) |
| CA (1) | CA2143412A1 (es) |
| ES (1) | ES2079315B1 (es) |
| MX (1) | MX9501084A (es) |
| NO (1) | NO304378B1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465484B1 (en) * | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| IL148127A0 (en) * | 1999-08-30 | 2002-09-12 | Aventis Pharma Gmbh | Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events |
| JPWO2005011736A1 (ja) * | 2003-07-30 | 2006-09-14 | 株式会社 東北テクノアーチ | アルツハイマー病の予防および／または治療剤 |
| CA2557276A1 (en) * | 2004-02-26 | 2005-09-09 | Kyowa Hakko Kogyo Co., Ltd. | Preventive and/or therapeutic agent for neutrophilic inflammatory diseases |
| EP1856053A1 (en) * | 2005-01-14 | 2007-11-21 | Millennium Pharmaceuticals, Inc. | Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity |
| US20090291942A1 (en) * | 2008-05-26 | 2009-11-26 | Ivan Cornella Taracido | Imidazo pyridine derivatives |
| WO2011138657A1 (en) * | 2010-05-04 | 2011-11-10 | Glenmark Pharmaceuticals S.A. | Aryl substituted olefinic compounds as pde10a inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| JPH05504969A (ja) * | 1990-02-13 | 1993-07-29 | メルク・エンド・カムパニー・インコーポレーテツド | 置換ベンジル要素を含有するアンギオテンシン２アンタゴニスト類 |
| US5240938A (en) * | 1991-02-13 | 1993-08-31 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring |
| DE4142366A1 (de) * | 1991-07-15 | 1993-06-24 | Thomae Gmbh Dr K | Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1994
- 1994-02-24 ES ES09400364A patent/ES2079315B1/es not_active Expired - Fee Related
-
1995
- 1995-02-23 CA CA002143412A patent/CA2143412A1/en not_active Abandoned
- 1995-02-23 NO NO950684A patent/NO304378B1/no not_active IP Right Cessation
- 1995-02-23 MX MX9501084A patent/MX9501084A/es not_active IP Right Cessation
- 1995-02-24 EP EP95102658A patent/EP0669333A1/en not_active Withdrawn
- 1995-02-24 US US08/393,981 patent/US5554624A/en not_active Expired - Fee Related
- 1995-02-24 JP JP7061678A patent/JPH07267951A/ja active Pending
- 1995-02-24 KR KR1019950003690A patent/KR950032190A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2143412A1 (en) | 1995-08-25 |
| NO950684D0 (no) | 1995-02-23 |
| NO304378B1 (no) | 1998-12-07 |
| EP0669333A1 (en) | 1995-08-30 |
| JPH07267951A (ja) | 1995-10-17 |
| US5554624A (en) | 1996-09-10 |
| KR950032190A (ko) | 1995-12-20 |
| NO950684L (no) | 1995-08-25 |
| MX9501084A (es) | 1997-10-31 |
| ES2079315A1 (es) | 1996-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2146552B1 (es) | Peptidos inhibidores de tgf/31 | |
| PA8583201A1 (es) | Nuevos compuestos de pirazol como inhibidores del factor de crecimiento transformante (tgf) | |
| CR10967A (es) | Formas polimorficas de 3-(4-amino-1-oxo-1,3 dihidro-isoindol-2-il) piperidina-2,6-diona (divisional exp. 8291) | |
| AR030893A1 (es) | Uso combinado de inhibidores de acetilcolinesterasa y agonistas inversos de gabaa para el tratamiento de trastornos cognitivos | |
| DK1098649T3 (da) | Fremgangsmåde til stabilisering af farmaceutiske sammensætninger med speciel anvendelse af antioxidant | |
| ATE269295T1 (de) | Btk inhibitoren und verfahren zur identifizierung und verwendung | |
| GT200600199A (es) | Diarilsulfonas sulfonamidas y su uso | |
| HUP0300340A2 (hu) | c-JUN N-terminális kinázok (JNK) és más protein kinázok inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| SV2008002828A (es) | Agentes para prevenir y tratar trastornos que involucran la modulacion de los receptores ryr ref. 19240-619-sv1 | |
| PA8557401A1 (es) | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares | |
| ECSP034492A (es) | Derivados de hidroxamato utiles como inhibidores de desacetilasa | |
| CY1115124T1 (el) | Υποκατεστημενες 3-κυανοκινολινες ως αναστολεις κινασων πρωτεϊνης τυροσινης | |
| ES2191183T3 (es) | Derivados 6,6- o 6,7-biciclicos que contienen pirido o pirimido sustituidos. | |
| CY1105618T1 (el) | Δικυκλικες ετεροαρωματικες ενωσεις ως αναστολεις της κινασης τυροσινης πρωτεϊνης | |
| EP1613348A4 (en) | PROCESS FOR MODULATING THE ANGIOGENESIS WITH APELIN COMPOSITIONS | |
| ES2143056T3 (es) | Derivados de 2-(2,4,6-trimetilfenil)-ciclopentan-1,3-dionas. | |
| UY29437A1 (es) | Nuevos antagonistas de cgrp | |
| AR024138A1 (es) | Inhibidores de la proliferacion celular | |
| TR199900090A2 (xx) | Benzos�lfon t�revleri | |
| ES2079315B1 (es) | Nuevas imidazopiridinas. | |
| ES2192031T3 (es) | Nuevas amidas aromaticas, su procedimiento de preparacion y su aplicacion como medicamentos. | |
| ES2421948T3 (es) | Compuestos y composiciones para suministrar agentes activos | |
| ATE308324T1 (de) | Zolpidem hemitartrat | |
| PA8508301A1 (es) | Inhibidores de la proteina c del procolageno | |
| ES2063063T3 (es) | 1,2,4-triazindionas substituidas, procedimientos para su obtencion y su empleo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19940224 Kind code of ref document: B1 Effective date: 19940224 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20180806 |