Nothing Special   »   [go: up one dir, main page]

ES2078911T3 - Fenil-heterociclos disustituidos en 3,4 y su utilizacion. - Google Patents

Fenil-heterociclos disustituidos en 3,4 y su utilizacion.

Info

Publication number
ES2078911T3
ES2078911T3 ES89730158T ES89730158T ES2078911T3 ES 2078911 T3 ES2078911 T3 ES 2078911T3 ES 89730158 T ES89730158 T ES 89730158T ES 89730158 T ES89730158 T ES 89730158T ES 2078911 T3 ES2078911 T3 ES 2078911T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
disstituted
heterocicles
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89730158T
Other languages
English (en)
Inventor
Andreas Dr Huth
Ralph Dr Schmiechen
Helmut Dr Wachtel
Herbert Hans Dr Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2078911T3 publication Critical patent/ES2078911T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCRIBE UN COMPUESTO DE FORMULA (I), SU ESTEROISOMERO, SU PRODUCCION Y SU APLICACION COMO MEDICAMENTO. SIENDO; R1 ALGUILO CON UNO A CUATRO CARBONOS; R3 HIDROGENO, ALQUILO CON UNO A CUATRO CARBONOS ACILO, ASILO; R4 Y R5 HIDROGENO O ALQUILO DE UNO A CUATRO CARBONOS; X OXIGENO, CH2 O NR1 E Y UN ANILLO AROMATICO O HETEROMATICO CONTENIENDO DOS HETERODONOS Y SUBSTITUIDO.
ES89730158T 1988-07-07 1989-07-06 Fenil-heterociclos disustituidos en 3,4 y su utilizacion. Expired - Lifetime ES2078911T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3823299A DE3823299A1 (de) 1988-07-07 1988-07-07 Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
ES2078911T3 true ES2078911T3 (es) 1996-01-01

Family

ID=6358323

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89730158T Expired - Lifetime ES2078911T3 (es) 1988-07-07 1989-07-06 Fenil-heterociclos disustituidos en 3,4 y su utilizacion.

Country Status (8)

Country Link
US (1) US5064854A (es)
EP (1) EP0350437B1 (es)
JP (1) JPH0285250A (es)
AT (1) ATE127451T1 (es)
CA (1) CA1338789C (es)
DE (2) DE3823299A1 (es)
ES (1) ES2078911T3 (es)
GR (1) GR3017916T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69127260T2 (de) * 1990-06-07 1997-12-04 Zeneca Ltd., London Therapeutische heterocyclische verbindungen
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1992007567A1 (en) * 1990-11-06 1992-05-14 Smithkline Beecham Corporation Imidazolidinone compounds
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
AU2869092A (en) * 1991-10-11 1993-05-03 Smithkline Beecham Corporation Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4213931A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
MX9800710A (es) 1995-07-26 1998-04-30 Pfizer Derivados de n-(aroil) glicina acido hidroxamico y compuestos relacionados.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1350582A (en) * 1970-07-24 1974-04-18 Ucb Sa Cerivatives of 2-pyrrolidinone
US4193926A (en) * 1974-03-20 1980-03-18 Schering Aktiengesellschaft 4-(Polyalkoxy phenyl)-2-pyrrolidones
US4119637A (en) * 1975-09-23 1978-10-10 A. H. Robins Company, Inc. 4-Hydroxymethyl-2-pyrrolidinones
DE2655369A1 (de) * 1976-12-03 1978-06-08 Schering Ag 5-(subst. phenyl)-oxazolidinone und deren schwefelanaloga sowie verfahren zu deren herstellung
AU518986B2 (en) * 1977-10-11 1981-10-29 Takeda Chemical Industries Ltd. Lactams
EP0021772B1 (en) * 1979-07-03 1985-01-02 JOHN WYETH & BROTHER LIMITED Method of preparing 2-oxo- and 2-unsubstituted-hexahydroazepine derivatives
US4558449A (en) * 1983-07-08 1985-12-10 At&T Bell Laboratories Semiconductor laser with coupled loss modulator for optical telecommunications
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant

Also Published As

Publication number Publication date
ATE127451T1 (de) 1995-09-15
US5064854A (en) 1991-11-12
DE58909420D1 (de) 1995-10-19
DE3823299A1 (de) 1990-01-11
EP0350437A1 (de) 1990-01-10
GR3017916T3 (en) 1996-01-31
EP0350437B1 (de) 1995-09-06
JPH0285250A (ja) 1990-03-26
CA1338789C (en) 1996-12-10

Similar Documents

Publication Publication Date Title
ES2070186T3 (es) Nuevos derivados de 2,4-diamino-pirimidina-3-oxido y su utilizacion en la prevencion de la caida de los cabellos.
FR2417500A1 (fr) Derives d'amino-acides cycliques dehydrogenes et leur utilisation therapeutique
ES2134926T3 (es) Derivados vinileno-azaindolicos y su procedimiento de preparacion.
ES2038623T3 (es) Procedimiento para preparar soluciones de oxazafosforinas con estabilidad mejorada.
ES2078911T3 (es) Fenil-heterociclos disustituidos en 3,4 y su utilizacion.
FI910924A0 (fi) Nya propanaminer, framstaellning av dessa och anvaendning av dessa foer terapeutiska aendamaol, i synnerhet som diarremediciner.
NO903430L (no) Fremgangsmaate for fremstilling av aminoketonderivater.
FI842112A0 (fi) Foerfarande foer framstaellning av- karbolin-3-karboxylsyraderivat.
FI800057A (fi) Foerfarande foer framstaellning av hexahydro-1,4-oxazepin
DE3666223D1 (en) Anticonvulsant agents
DE68921051D1 (de) Pyridin-3-percarboxylsäure monopersulfat.
ATE57T1 (de) 4,5-methano-bufadienolid-rhamnoside, verfahren zu deren herstellung und diese enthaltende arzneimittel.
ATE70050T1 (de) 1-benzoyl-2-oxo-5-alkoxy-pyrrolidin-derivate, ihre herstellung und verwendung als heilmittel und zubereitungen, die sie enthalten.
ES2061675T3 (es) Compuestos heterociclicos y su preparacion y uso.
DE59102829D1 (de) Ergolinderivate.
SE7909980L (sv) I-amino-indolin-derivat, deras framstellning och farmaceutiska kompositioner innehallande desamma

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 350437

Country of ref document: ES