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ES2072536T3 - Derivados de tiazolidina que presentan actividad anti-hipertensiva y su uso en terapeutica. - Google Patents

Derivados de tiazolidina que presentan actividad anti-hipertensiva y su uso en terapeutica.

Info

Publication number
ES2072536T3
ES2072536T3 ES91300461T ES91300461T ES2072536T3 ES 2072536 T3 ES2072536 T3 ES 2072536T3 ES 91300461 T ES91300461 T ES 91300461T ES 91300461 T ES91300461 T ES 91300461T ES 2072536 T3 ES2072536 T3 ES 2072536T3
Authority
ES
Spain
Prior art keywords
therapeutics
thiazolidine derivatives
present anti
hypertensive activity
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91300461T
Other languages
English (en)
Inventor
Hiroyoshi Horikoshi
Toshihiko Fujiwara
Shinji Yoshioka
Hiroshi Nishino
Hiroyuki Koike
Takao Yoshioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2072536T3 publication Critical patent/ES2072536T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

FORMULA DEL DERIVADO DE TIAZOLIDINA. (EN LA CUAL: R ELEVADO A 1, R ELEVADO A 2, R ELEVADO A 4, R ELEVADO A 5 SON CADA UNA HIDROGENO O ALQUILO; Y R ELEVADO A 3 ES HIDROGENO, ACILO ALIFATICO, ALCOXICARBONILO, O ARILCARBONILO) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES SON AGENTES ANTI-HIPERTENSIVOS Y SON UTILES EN EL TRATAMIENTO DE HIPERTENSION RELACIONADO CON LA OBESIDAD Y PARA LA PREPARACION DE USOS PARA TAL TRATAMIENTO.
ES91300461T 1990-01-22 1991-01-22 Derivados de tiazolidina que presentan actividad anti-hipertensiva y su uso en terapeutica. Expired - Lifetime ES2072536T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1232190 1990-01-22

Publications (1)

Publication Number Publication Date
ES2072536T3 true ES2072536T3 (es) 1995-07-16

Family

ID=11802053

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91300461T Expired - Lifetime ES2072536T3 (es) 1990-01-22 1991-01-22 Derivados de tiazolidina que presentan actividad anti-hipertensiva y su uso en terapeutica.

Country Status (12)

Country Link
US (1) US5614542A (es)
EP (1) EP0439321B1 (es)
JP (1) JP2826379B2 (es)
KR (1) KR0163052B1 (es)
AT (1) ATE119773T1 (es)
AU (1) AU637182B2 (es)
CA (1) CA2034616A1 (es)
DE (1) DE69108067T2 (es)
DK (1) DK0439321T3 (es)
ES (1) ES2072536T3 (es)
FI (1) FI910303A (es)
HK (1) HK1006284A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175179A (en) * 1991-09-25 1992-12-29 Pfizer Inc. Method for treating hypertension
JP3081245B2 (ja) * 1993-09-15 2000-08-28 三共株式会社 Ｎｉｄｄｍの発症を阻止又は遅延するためのチアゾリジンジオン類の用途
CZ293016B6 (cs) * 1995-06-01 2004-01-14 Sankyo Company Limited Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
KR100579765B1 (ko) 1996-07-01 2006-12-28 닥터 레디스 레보러터리즈 리미티드 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
TW577875B (en) * 1997-01-31 2004-03-01 Shionogi & Co Pyrrolidine derivatives with inhibitory activity for phospholipase A2
WO1997041119A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
DK173350B1 (da) * 1985-02-26 2000-08-07 Sankyo Co Thiazolidinderivater, deres fremstilling og farmaceutisk paæparat indeholdende dem
US4873255A (en) * 1987-02-04 1989-10-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
US4933355A (en) * 1988-04-14 1990-06-12 Sankyo Company Limited Thiazole derivatives, their preparation and their use in the treatment of diabetes complications
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
US5053420A (en) * 1989-10-13 1991-10-01 Pershadsingh Harrihar A Thiazolidine derivatives for the treatment of hypertension

Also Published As

Publication number Publication date
US5614542A (en) 1997-03-25
JPH03251530A (ja) 1991-11-11
AU637182B2 (en) 1993-05-20
EP0439321A3 (en) 1992-04-01
FI910303A (fi) 1991-07-23
AU6948091A (en) 1991-07-25
EP0439321A2 (en) 1991-07-31
DK0439321T3 (da) 1995-07-24
HK1006284A1 (en) 1999-02-19
EP0439321B1 (en) 1995-03-15
KR910014119A (ko) 1991-08-31
CA2034616A1 (en) 1991-07-23
DE69108067T2 (de) 1995-11-02
JP2826379B2 (ja) 1998-11-18
ATE119773T1 (de) 1995-04-15
DE69108067D1 (de) 1995-04-20
FI910303A0 (fi) 1991-01-21
KR0163052B1 (ko) 1998-12-01

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