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ES2062145T3 - 1,8-naftiridinas substituidas. - Google Patents

1,8-naftiridinas substituidas.

Info

Publication number
ES2062145T3
ES2062145T3 ES90105652T ES90105652T ES2062145T3 ES 2062145 T3 ES2062145 T3 ES 2062145T3 ES 90105652 T ES90105652 T ES 90105652T ES 90105652 T ES90105652 T ES 90105652T ES 2062145 T3 ES2062145 T3 ES 2062145T3
Authority
ES
Spain
Prior art keywords
substituted
naphtiridines
naphthyridines
appropriate
cyclisation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90105652T
Other languages
English (en)
Inventor
Walter Dr Hubsch
Rolf Dr Angerbauer
Peter Dr Fey
Thomas Dr Philipps
Hilmar Dr Bischoff
Dieter Dr Dr Petzinna
Delf Dr Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2062145T3 publication Critical patent/ES2062145T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

EL INVENTO SE REFIERE A UN 1,8-NAFTIRIDINA SUSTITUIDA, TRATA DE UN PROCEDIMIENTO PARA LA PRODUCCION DE 1,8-NAFTIRIDINA SUSTITUIDA QUE CONSISTE EN REDUCIR CETONAS, SAPONIFICAR, CICLIZAR E HIDROXILAR LOS PRODUCTOS OBTENIDOS EN LAS SUCESIVAS ETAPAS Y SEPARAR LOS ISOMEROS Y DESCRIBE LA APLICACION DE LA 1,8 NAFTIRIDINA SUSTITUIDA COMO MATERIA ACTIVA EN MEDICAMENTEOS.
ES90105652T 1989-04-06 1990-03-24 1,8-naftiridinas substituidas. Expired - Lifetime ES2062145T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3911064A DE3911064A1 (de) 1989-04-06 1989-04-06 Substituierte 1,8-naphthyridine

Publications (1)

Publication Number Publication Date
ES2062145T3 true ES2062145T3 (es) 1994-12-16

Family

ID=6377950

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90105652T Expired - Lifetime ES2062145T3 (es) 1989-04-06 1990-03-24 1,8-naftiridinas substituidas.

Country Status (14)

Country Link
US (1) US5034399A (es)
EP (1) EP0391185B1 (es)
JP (1) JPH02290876A (es)
KR (1) KR900016207A (es)
AT (1) ATE99310T1 (es)
AU (1) AU622010B2 (es)
CA (1) CA2013783A1 (es)
DE (2) DE3911064A1 (es)
DK (1) DK0391185T3 (es)
ES (1) ES2062145T3 (es)
HU (1) HUT53904A (es)
IL (1) IL93988A0 (es)
PT (1) PT93662A (es)
ZA (1) ZA902627B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4022414A1 (de) * 1990-07-13 1992-01-16 Bayer Ag Substituierte pyrrolo-pyridine
DE69229839T2 (de) * 1991-01-29 2000-02-10 Mitsubishi Heavy Ind Ltd Methode zur Herstellung von Methanol unter Verwendung der Wärme eines Kernkraftwerkes
DE4405712A1 (de) * 1994-02-23 1995-08-24 Basf Ag Substituierte Naphthyridine und deren Verwendung
DE19627431A1 (de) * 1996-07-08 1998-01-15 Bayer Ag Heterocyclisch kondensierte Pyridine
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
EP1472228B1 (en) * 2002-01-31 2009-03-25 Novartis AG Process for the manufacture of hmg-coa reductase inhibitors
EP1596860A4 (en) * 2003-02-14 2009-05-27 Smithkline Beecham Corp NEW CONNECTIONS
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
ATE479662T1 (de) * 2004-12-23 2010-09-15 Hui Yao Pyrimidinonverbindungen, ihre herstellung und ihre verwendung
US20100093738A1 (en) * 2006-10-06 2010-04-15 Basf Se Fungicidal Compounds and Fungicidal Compositions
EP3698797A1 (en) 2017-10-16 2020-08-26 Tsinghua University Mevalonic acid pathway inhibitor and pharmaceutical composition thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA988522A (en) * 1972-05-05 1976-05-04 Haydn W.R. Williams 1,8-naphthyridine compounds
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
WO1984002131A1 (en) * 1982-11-22 1984-06-07 Sandoz Ag Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
PH24782A (en) * 1985-10-24 1990-10-30 Sankyo Co Composition containing a penem or carbapenem antibiotic and the use of the same
EP0302303A3 (en) * 1987-07-22 1989-05-24 Schering Corporation Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
US4761419A (en) * 1987-12-07 1988-08-02 Warner-Lambert Company 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
DE3825611A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte annellierte pyrrole, verfahren sowie zwischenprodukte zu ihrer herstellung, und ihre verwendung in arzneimitteln, insbesondere als hmg-coa-reduktase-inhibitoren
AU634561B2 (en) * 1989-07-27 1993-02-25 Eli Lilly And Company Naphthyridine derivatives

Also Published As

Publication number Publication date
CA2013783A1 (en) 1990-10-06
DE3911064A1 (de) 1990-10-11
ZA902627B (en) 1991-01-30
HUT53904A (en) 1990-12-28
US5034399A (en) 1991-07-23
JPH02290876A (ja) 1990-11-30
AU5254290A (en) 1990-10-11
DK0391185T3 (da) 1994-04-11
EP0391185A1 (de) 1990-10-10
EP0391185B1 (de) 1993-12-29
IL93988A0 (en) 1991-01-31
ATE99310T1 (de) 1994-01-15
HU902098D0 (en) 1990-07-28
PT93662A (pt) 1990-11-20
DE59003994D1 (de) 1994-02-10
AU622010B2 (en) 1992-03-26
KR900016207A (ko) 1990-11-12

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