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ES2061977T3 - Compuestos analogos a bradiquinina, su sintesis y su uso en terapia. - Google Patents

Compuestos analogos a bradiquinina, su sintesis y su uso en terapia.

Info

Publication number
ES2061977T3
ES2061977T3 ES89303065T ES89303065T ES2061977T3 ES 2061977 T3 ES2061977 T3 ES 2061977T3 ES 89303065 T ES89303065 T ES 89303065T ES 89303065 T ES89303065 T ES 89303065T ES 2061977 T3 ES2061977 T3 ES 2061977T3
Authority
ES
Spain
Prior art keywords
bradiquinine
therapy
synthesis
analog compounds
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89303065T
Other languages
English (en)
Inventor
David H Coy
Jacques-Pierre Moreau
John E Taylor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Application granted granted Critical
Publication of ES2061977T3 publication Critical patent/ES2061977T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57572—Gastrin releasing peptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • C07K14/685—Alpha-melanotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBEN ANALOGOS DE BRADIQUININA QUE CONTIENEN UN ENLACE NO PEPTIDICO; ALGUNOS DE LOS ANALOGOS MUESTRAN ACTIVIDAD ANTAGONISTA LO QUE LOS HACE TERAPEUTICAMENTE UTILES, POR EJEMPLO, PARA MEJORAR EL HINCHAZON O EL PICOR INDUCIDO POR VASODILATACION; OTROS EXHIBEN ACTIVIDAD AGONISTA Y SON ADECUADOS, POR EJEMPLO, PARA EL TRATAMIENTO DE LA HIPERTENSION.
ES89303065T 1988-03-25 1989-03-28 Compuestos analogos a bradiquinina, su sintesis y su uso en terapia. Expired - Lifetime ES2061977T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17331188A 1988-03-25 1988-03-25

Publications (1)

Publication Number Publication Date
ES2061977T3 true ES2061977T3 (es) 1994-12-16

Family

ID=22631443

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89303065T Expired - Lifetime ES2061977T3 (es) 1988-03-25 1989-03-28 Compuestos analogos a bradiquinina, su sintesis y su uso en terapia.

Country Status (7)

Country Link
EP (1) EP0334685B1 (es)
AT (1) ATE100465T1 (es)
AU (1) AU3428089A (es)
CA (1) CA1335622C (es)
DE (1) DE68912376T2 (es)
ES (1) ES2061977T3 (es)
WO (1) WO1989009230A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
US5610142A (en) * 1992-10-08 1997-03-11 Scios Inc. Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids
US5541286A (en) * 1992-10-08 1996-07-30 Scios Nova Inc. Bradykinin antagonist pseudopeptide derivatives of olefinic aminoalkanoic acids
US5521158A (en) * 1992-10-08 1996-05-28 Scios Nova Inc. Pseudopeptide bradykinin receptor antagonists
US5686565A (en) * 1992-10-08 1997-11-11 Scios Inc. Bradykinin antagonist pseudopeptide derivatives of aminoalkanoic acids and related olefins
JPH11500100A (ja) * 1993-09-09 1999-01-06 サイオス ノバ インコーポレイテッド 偽ペプチドおよび非ペプチドブラジキニンレセプターアンタゴニスト
US5817756A (en) * 1993-09-09 1998-10-06 Scios Inc. Pseudo- and non-peptide bradykinin receptor antagonists
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3330857A (en) * 1963-07-01 1967-07-11 Pfizer & Co C N-carbazoylamino acid intermediates for polypeptides
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4803261A (en) * 1986-06-27 1989-02-07 The Administrators Of The Tulane Educational Fund Method for synthesizing a peptide containing a non-peptide

Also Published As

Publication number Publication date
AU3428089A (en) 1989-10-16
EP0334685A2 (en) 1989-09-27
DE68912376T2 (de) 1994-07-07
CA1335622C (en) 1995-05-16
EP0334685A3 (en) 1991-01-30
EP0334685B1 (en) 1994-01-19
ATE100465T1 (de) 1994-02-15
WO1989009230A1 (en) 1989-10-05
DE68912376D1 (de) 1994-03-03

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