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ES2054811T3 - Derivados de tetrahidroisoquinolin-2-ilo como antagonistas de tromboxano a2. - Google Patents

Derivados de tetrahidroisoquinolin-2-ilo como antagonistas de tromboxano a2.

Info

Publication number
ES2054811T3
ES2054811T3 ES88306582T ES88306582T ES2054811T3 ES 2054811 T3 ES2054811 T3 ES 2054811T3 ES 88306582 T ES88306582 T ES 88306582T ES 88306582 T ES88306582 T ES 88306582T ES 2054811 T3 ES2054811 T3 ES 2054811T3
Authority
ES
Spain
Prior art keywords
group
alkyl
carbon atoms
ring
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88306582T
Other languages
English (en)
Inventor
Andrew Derrick Gribble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Application granted granted Critical
Publication of ES2054811T3 publication Critical patent/ES2054811T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA COMPUETOS DE FORMULA (I) Y SUS SALES, DONDE A ES UN GRUPO NR3SO2 O SO2NR3; RA ES UN GRUPO HIDROCARBONADO ACICLICO, QUE TIENE 1-4 ATOMOS DE CARBONO LINEALES; RB ES UN ENLACE O UN GRUPO HIDROCARBONADO ACICLICO, QUE TIENE DE 1-3 ATOMOS DE CARBONO LINEALES, PREVIENDO QUE EL NUMERO TOTAL DE ATOMOS DE CARBONO LINEALES EN RA Y RB JUNTOS NO EXCEDE DE 4 Y QUE EL ATOMO DE CARBONO EN RA QUE ES ADYECENTE AL ATOMO D NITROGENO DEL ANILLO DE ISOQUINOLINA ESTA SATURADO; EL GRUPO: (FIG. A) ES UN GRUPO MONOCICLICO, QUE TIENE ENTRE 3 Y 7 MIEMBROS EN EL ANILLO Y CONTIENE HASTA 3 HETEROATOMOS; Y ES CO2H O UN GRUPO HIDROLIZABLE A CO2H; R1 ES FENILO, OPCIONALMENTE SUSTITUIDO POR UNO O MAS SUSTITIYENTES ELEGIDOS DEL GRUPO QUE CONSTA DE HALOGENO, ALQUILO C1-C4, ACILO C1-C6, ALCOXI C1-C4, NITRO Y TRIFLUOROMETILO; R2 ES HIDROGENO O UNO O MAS SUSTITUYENTES ALQUILO C1-C4, LOCALIZADOS EN LAS POSICIONES 1, 3 Y 4 DEL ANILLO QUINOLEINICO; Y R3 ES HIDROGENO O ALQUILO C1-C6. TAMBIEN SE PROPORCIONAN COMPOSICIONES QUE CONTIENEN LOS COMPUESTOS DE FORMULA (I), UN PROCEDIMIENTO PARA SU PREPARACION, Y SU USO COMO ANTAGONISTAS DE TROMBOXANO A2.
ES88306582T 1987-07-22 1988-07-19 Derivados de tetrahidroisoquinolin-2-ilo como antagonistas de tromboxano a2. Expired - Lifetime ES2054811T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878717374A GB8717374D0 (en) 1987-07-22 1987-07-22 Pharmaceutically active compounds

Publications (1)

Publication Number Publication Date
ES2054811T3 true ES2054811T3 (es) 1994-08-16

Family

ID=10621127

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88306582T Expired - Lifetime ES2054811T3 (es) 1987-07-22 1988-07-19 Derivados de tetrahidroisoquinolin-2-ilo como antagonistas de tromboxano a2.

Country Status (11)

Country Link
US (1) US4866076A (es)
EP (1) EP0300725B1 (es)
JP (1) JPS6440461A (es)
AT (1) ATE107644T1 (es)
AU (1) AU608339B2 (es)
DE (1) DE3850308T2 (es)
DK (1) DK168010B1 (es)
ES (1) ES2054811T3 (es)
GB (1) GB8717374D0 (es)
PT (1) PT88062B (es)
ZA (1) ZA885241B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658134B2 (en) * 1989-12-28 1995-04-06 Virginia Commonwealth University Sigma receptor ligands and the use thereof
US6087346A (en) * 1993-06-23 2000-07-11 Cambridge Neuroscience, Inc. Sigma receptor ligands and the use thereof
US6025355A (en) * 1997-05-19 2000-02-15 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
US6756389B2 (en) 1996-08-09 2004-06-29 Cambridge Neuroscience, Inc. Pharmaceutically active compounds and methods of use
DE19934272A1 (de) * 1999-07-21 2001-01-25 Bayer Ag Neue antivirale Mittel
CA2408913A1 (en) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
TWI281914B (en) 2002-05-29 2007-06-01 Glaxo Group Ltd Compounds
DE20307130U1 (de) * 2003-04-30 2003-07-10 Techno-Grafica GmbH, 75236 Kämpfelbach Aschesammler für Raucher
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
MD20150043A2 (ro) 2012-10-02 2015-08-31 Epitherapeutics Aps Inhibitori ai histon-demetilazelor
TW201625535A (en) * 2014-03-31 2016-07-16 Epitherapeutics Aps Inhibitors of histone demethylases

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988339A (en) * 1974-02-08 1976-10-26 Smithkline Corporation Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase
US4242346A (en) * 1979-12-19 1980-12-30 Smithkline Corporation Bis-2N-alkylene tetrahydroisoquinoline compounds
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4321254A (en) * 1980-09-26 1982-03-23 Smithkline Corporation Antiallergic imidodisulfamides
US4350698A (en) * 1981-09-25 1982-09-21 Smithkline Corporation Antiallergic imidosulfamides
DE3139970A1 (de) * 1981-10-08 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US4536510A (en) * 1983-07-22 1985-08-20 Smith Kline Beckman Corporation Method of antagonizing the effects of thromboxane
GB8419658D0 (en) * 1984-08-01 1984-09-05 Wellcome Found Nitrogen containing heterocyclic compounds
EP0194548A3 (de) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3514696A1 (de) * 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
CA1278577C (en) * 1985-11-18 1991-01-02 Tatsuo Tsuri Bicyclic sulfonamide derivatives
EP0266949B1 (en) * 1986-10-28 1990-11-28 Smith Kline & French Laboratories Limited Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists
EP0277384A3 (en) * 1986-12-24 1990-05-23 Janssen Pharmaceutica N.V. 1h-imidazole-5-carboxylic acid derivatives

Also Published As

Publication number Publication date
DK400688D0 (da) 1988-07-18
EP0300725B1 (en) 1994-06-22
JPS6440461A (en) 1989-02-10
DK400688A (da) 1989-01-23
PT88062B (pt) 1995-03-01
ZA885241B (en) 1989-06-28
DE3850308D1 (de) 1994-07-28
GB8717374D0 (en) 1987-08-26
US4866076A (en) 1989-09-12
DK168010B1 (da) 1994-01-17
EP0300725A1 (en) 1989-01-25
ATE107644T1 (de) 1994-07-15
PT88062A (pt) 1989-06-30
DE3850308T2 (de) 1994-10-06
AU1913788A (en) 1989-01-27
AU608339B2 (en) 1991-03-28

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