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ES2053714T3 - Proceso para la preparacion de 11-arilesteroides. - Google Patents

Proceso para la preparacion de 11-arilesteroides.

Info

Publication number
ES2053714T3
ES2053714T3 ES88202678T ES88202678T ES2053714T3 ES 2053714 T3 ES2053714 T3 ES 2053714T3 ES 88202678 T ES88202678 T ES 88202678T ES 88202678 T ES88202678 T ES 88202678T ES 2053714 T3 ES2053714 T3 ES 2053714T3
Authority
ES
Spain
Prior art keywords
group
hydroxyl
acyloxy
alkoxy
hydrocarbyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88202678T
Other languages
English (en)
Inventor
Jongh Hendrik Paul De
Vliet Nicolaas Pieter Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Application granted granted Critical
Publication of ES2053714T3 publication Critical patent/ES2053714T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Gyroscopes (AREA)
  • Fats And Perfumes (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS 11 - ARIL ESTEROIDES QUE CONTIENEN UNA FUERTE ACTIVIDAD ANTIPROGESTINA Y UNA ACTIVIDAD ANTIGLUCOCORTICOIDE DEBIL O NO EXISTENTE, A PROCESOS PARA SU PREPARACION Y A PREPARADOS FARMACEUTICOS QUE CONTIENEN ESTOS DERIVADOS COMO COMPONENTE ACTIVO. LOS CUITADOS ESTEROIDES SE CARACTERIZAN POR TENER LA FORMULA(I) EN LA QUE R1 ES UN GRUPO ARILO CON UN GRUPO (II) COMO SUSTITUYENTE (EN EL QUE X E Y SON CADA UNO SEPARADAMENTE H O UN GRUPO HIDROCARBILO DE 1 A 4 C O JUNTOS UN GRUPO HIDROCARBILO DE 2 A 6 C QUE FORMA UN ABILLO DE 3 A 7 MIEMBROS JUNTO CON EL ATOMO DE N), R2 ES H, OH, ARILOXI, ALCOXI O UN GRUPO HIDROCARBILO DE 1 A 8 C CON AL MENOS UN GRUPO OH, OXO, ACIDO, CIANO O HALOGENO, R3 ES OH, ACILOXI O ALCOXI O UN ACILO QUE PUEDE ESTAR SUSTITUIDO POR OH, ALCOXI, ACILOXI O HALOGENO, O R2 Y R3 JUNTOS FORMAN UN ANILLO CON LA CONDICION DE QUE SI R3 ES OH, R2 NO ES H NI OH, R4 ES UN GRUPO METILO O ETILO, LAS LINEAS DISCONTINUAS SIGNIFICAN ENLACES ALFA Y LAS FLECHAS ENLACES BETA.
ES88202678T 1987-12-12 1988-11-25 Proceso para la preparacion de 11-arilesteroides. Expired - Lifetime ES2053714T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8703008 1987-12-12

Publications (1)

Publication Number Publication Date
ES2053714T3 true ES2053714T3 (es) 1994-08-01

Family

ID=19851082

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88202678T Expired - Lifetime ES2053714T3 (es) 1987-12-12 1988-11-25 Proceso para la preparacion de 11-arilesteroides.

Country Status (16)

Country Link
US (1) US4921845A (es)
EP (1) EP0321010B1 (es)
JP (1) JP2768707B2 (es)
KR (1) KR970009592B1 (es)
CN (1) CN1019807B (es)
AT (1) ATE85342T1 (es)
AU (1) AU613433B2 (es)
CA (1) CA1301162C (es)
DE (1) DE3878198T2 (es)
DK (1) DK168444B1 (es)
ES (1) ES2053714T3 (es)
FI (1) FI89056C (es)
IE (1) IE61848B1 (es)
NZ (1) NZ227269A (es)
PT (1) PT89185B (es)
ZA (1) ZA888996B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0411733T3 (da) * 1989-08-04 1999-06-28 Schering Ag 11-beta-aryl-gona-4,9-dien-3-oner
FR2650748B1 (fr) * 1989-08-08 1991-11-08 Roussel Uclaf Nouveaux esters d'acides organiques avec des alcools derives de 19-nor steroides et leurs sels, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions les renfermant
DE4018168A1 (de) * 1990-06-01 1991-12-05 Schering Ag Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen
US5407928A (en) * 1990-08-15 1995-04-18 Schering Aktiengesellschaft 11β-aryl-gona-4,9-dien-3-ones
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
ZA953976B (en) * 1994-05-19 1996-01-19 Akzo Nobel Nv 11,21-bisphenyl-19-norpregnane derivatives
DE4434488A1 (de) 1994-09-14 1996-03-21 Schering Ag Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
IL115659A (en) * 1994-10-27 2000-06-01 Akzo Nobel Nv Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
ES2152671T3 (es) 1996-05-01 2001-02-01 Us Gov Health & Human Serv Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales.
US6900193B1 (en) * 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
US6020328A (en) * 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en) 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) * 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
FR2789393B1 (fr) * 1999-02-05 2001-10-12 Centre Nat Rech Scient Lactol steroidique
EP1272196B1 (en) * 2000-03-31 2006-08-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha,11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use
WO2004078709A2 (en) * 2003-02-28 2004-09-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services METHOD FOR PREPARING 17 α-ACETOXY-11β-(4-N,N-DIMETHYLAMINOPHENYL)-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES THEREOF, AND METHODS FOR THE PREPARATION OF SUCH INTERMEDIATES
US9283234B2 (en) 2006-10-24 2016-03-15 Repros Therapeutics Inc. Compositions and methods for suppressing endometrial proliferation
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
WO2011119194A1 (en) 2010-03-22 2011-09-29 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8231B (en) * 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
US4780461A (en) * 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
DE3347126A1 (de) * 1983-12-22 1985-07-11 Schering AG, 1000 Berlin und 4709 Bergkamen 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU580843B2 (en) * 1985-02-07 1989-02-02 Schering Aktiengesellschaft 11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
GB8513723D0 (en) * 1985-05-31 1985-07-03 Erba Farmitalia 11-beta substituted steroids

Also Published As

Publication number Publication date
FI89056C (fi) 1993-08-10
FI89056B (fi) 1993-04-30
US4921845A (en) 1990-05-01
JPH01211597A (ja) 1989-08-24
CN1019807B (zh) 1992-12-30
DE3878198D1 (de) 1993-03-18
AU2646988A (en) 1989-06-15
EP0321010A1 (en) 1989-06-21
IE61848B1 (en) 1994-11-30
KR890009968A (ko) 1989-08-05
KR970009592B1 (en) 1997-06-14
CA1301162C (en) 1992-05-19
AU613433B2 (en) 1991-08-01
IE883565L (en) 1989-06-12
FI885717A (fi) 1989-06-13
NZ227269A (en) 1990-06-26
ZA888996B (en) 1989-08-30
DE3878198T2 (de) 1993-06-24
DK688088D0 (da) 1988-12-09
PT89185B (pt) 1993-06-30
EP0321010B1 (en) 1993-02-03
FI885717A0 (fi) 1988-12-09
DK688088A (da) 1989-06-13
CN1034731A (zh) 1989-08-16
ATE85342T1 (de) 1993-02-15
JP2768707B2 (ja) 1998-06-25
PT89185A (pt) 1989-12-29
DK168444B1 (da) 1994-03-28

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