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ES2052545T3 - (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas. - Google Patents

(n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas.

Info

Publication number
ES2052545T3
ES2052545T3 ES87200296T ES87200296T ES2052545T3 ES 2052545 T3 ES2052545 T3 ES 2052545T3 ES 87200296 T ES87200296 T ES 87200296T ES 87200296 T ES87200296 T ES 87200296T ES 2052545 T3 ES2052545 T3 ES 2052545T3
Authority
ES
Spain
Prior art keywords
piperazinyl
piperidinyl
substituted
aryl
methylazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87200296T
Other languages
English (en)
Inventor
Wijngaarden Ineke Van
Cornelis G Kruse
D Heyden Johannes A M V
Martinus T M Tulp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of ES2052545T3 publication Critical patent/ES2052545T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS (N-PIPERIDIL) METIL- Y (N-PIPERACINIL) METILAZOLES ARIL-SUSTITUIDOS QUE TIENEN PROPIEDADES FARMACOLOGICAS, EN ESPECIAL, ANTIPSICOTICOS. LOS COMPUESTOS PUEDEN PREPARARSE EN LA FORMA YA CONOCIDA PARA LA SINTESIS DE COMPUESTOS ANALOGOS Y PROCESARSE PARA OBTENER COMPOSICIONES DE ACUERDO CON METODOS CONOCIDOS.
ES87200296T 1986-02-27 1987-02-24 (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas. Expired - Lifetime ES2052545T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8600488 1986-02-27

Publications (1)

Publication Number Publication Date
ES2052545T3 true ES2052545T3 (es) 1994-07-16

Family

ID=19847632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87200296T Expired - Lifetime ES2052545T3 (es) 1986-02-27 1987-02-24 (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas.

Country Status (15)

Country Link
US (2) US4772604A (es)
EP (1) EP0241053B1 (es)
JP (1) JPH0798800B2 (es)
AT (1) ATE82281T1 (es)
AU (1) AU585131B2 (es)
CA (1) CA1279645C (es)
DE (1) DE3782525T2 (es)
DK (1) DK93087A (es)
ES (1) ES2052545T3 (es)
GR (1) GR3006689T3 (es)
IE (1) IE61724B1 (es)
IL (1) IL81669A (es)
NZ (1) NZ219380A (es)
PH (1) PH22783A (es)
ZA (1) ZA871335B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052545T3 (es) * 1986-02-27 1994-07-16 Duphar Int Res (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas.
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
GB9021453D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
US5159083A (en) * 1990-12-28 1992-10-27 Neurogen Corporation Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
IE914218A1 (en) * 1991-09-11 1993-03-24 Mcneilab Inc Novel 4-arylpiperazines and 4-arylpiperidines
US5569659A (en) * 1991-09-11 1996-10-29 Mcneilab, Inc. 4-arylpiperazines and 4-arylpiperidines
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5523299A (en) * 1992-08-06 1996-06-04 Smithkline Beecham Plc 5-(2-oxyphenyl)-pyrrole derivatives as dopamine D3 receptor antagonists
US5314885A (en) * 1992-09-11 1994-05-24 Mcneilab, Inc. Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
GB9307400D0 (en) * 1993-04-08 1993-06-02 Smithkline Beecham Plc Compounds
AU7186994A (en) * 1993-06-25 1995-01-17 Smithkline Beecham Plc Phenyrrole derivatives and their use as dopamine d3 antagonists
GB9315801D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9315800D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9320855D0 (en) * 1993-10-09 1993-12-01 Smithkline Beecham Plc Compounds
GB9325827D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Plc Compounds
GB9402197D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Compounds
GB9403199D0 (en) * 1994-02-19 1994-04-13 Smithkline Beecham Plc Compounds
WO1996016057A1 (en) * 1994-11-23 1996-05-30 Neurogen Corporation Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands
US5478934A (en) * 1994-11-23 1995-12-26 Yuan; Jun Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
GB9512129D0 (en) * 1995-06-15 1995-08-16 Smithkline Beecham Plc Compounds
EP0839144B1 (en) * 1995-07-13 2001-09-19 Knoll GmbH Piperazine derivatives as therapeutic agents
JP3989554B2 (ja) * 1996-03-29 2007-10-10 デユフアー・インターナシヨナル・リサーチ・ベー・ブイ ピペラジンおよびピペリジン化合物
WO1998028269A1 (en) 1996-12-23 1998-07-02 Du Pont Pharmaceuticals Company NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
TW486478B (en) * 1997-01-27 2002-05-11 Daiichi Seiyaku Co Pyrazole derivatives exhibiting anti-tumor effects and a pharmaceutical composition comprising the same
TW530054B (en) * 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
EP1637525B1 (en) 2000-07-04 2007-12-19 Kyoyu Agri Co., Ltd Benzoxazole compound, process for producing the same, and herbicides
DE60231507D1 (de) 2001-07-20 2010-07-01 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) * 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
ATE438401T1 (de) 2002-06-12 2009-08-15 Chemocentryx Inc 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
EP1720545B1 (en) * 2004-03-03 2014-10-29 ChemoCentryx, Inc. Bicyclic and bridged nitrogen heterocycles
BRPI0405418A (pt) * 2004-09-02 2006-05-02 Univ Rio De Janeiro uso de derivados n-fenilperazìnicos e composições farmacêuticas contendo os mesmos
TW200800946A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Substituted piperazines as metabotropic glutamate receptor antagonists
KR100654328B1 (ko) 2005-08-26 2006-12-08 한국과학기술연구원 피페라지닐알킬피라졸계 ｔ-타입 칼슘 채널 억제 화합물 및이의 제조방법
US9066903B2 (en) 2006-02-28 2015-06-30 The United States Of America As Represented By The Department Of Veterans Affairs Pharmacological treatment of Parkinson's disease
CN103570705B (zh) * 2012-07-18 2017-01-25 中国医学科学院医药生物技术研究所 取代的n‑((1＇,3＇‑杂唑‑4＇‑基)‑甲基)‑4‑苯甲酰基六氢吡啶类化合物及其用途
CA2932051A1 (en) * 2013-12-20 2015-06-25 Laboratorios Del Dr. Esteve, S.A. Piperazine derivatives having multimodal activity against pain
US9902711B2 (en) 2013-12-20 2018-02-27 Laboratorios Del Dr. Esteve S.A. Piperidine compounds having multimodal activity against pain

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407199A (en) * 1966-01-18 1968-10-22 Endo Lab Tertiaryamino ethyl or propyl pyrrol-2-yl ketones
DE2261351A1 (de) * 1972-12-15 1974-06-20 Merck Patent Gmbh Pyrazolderivate und verfahren zu ihrer herstellung
DE2526469A1 (de) * 1975-06-13 1976-12-30 Bayer Ag 1-substituierte pyrazolderivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4032526A (en) * 1975-10-02 1977-06-28 American Cyanamid Company 1,2-dimethyl-3 or 5-piperazinyl-pyrazolium salts
US4123529A (en) * 1976-04-23 1978-10-31 Lilly Industries Limited Phenylpiperazine derivatives
DE2747531A1 (de) * 1977-10-22 1979-04-26 Basf Ag Substituierte 3-aminopyrazole
FR2537133A1 (fr) * 1982-12-07 1984-06-08 Rhone Poulenc Sante Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent
AU577802B2 (en) * 1983-10-17 1988-10-06 Duphar International Research B.V. Blood-pressure lowering piperazine derivatives
US4562189A (en) * 1984-10-09 1985-12-31 American Cyanamid Company Pyrazolylpiperazines
DE3442860A1 (de) * 1984-11-24 1986-05-28 Kali-Chemie Pharma Gmbh, 3000 Hannover 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ES2052545T3 (es) * 1986-02-27 1994-07-16 Duphar Int Res (n-piperidinil)-metil- y (n-piperazinil)metilazoles sustituidos con arilo que tienen propiedades antipsicoticas.

Also Published As

Publication number Publication date
IL81669A0 (en) 1987-09-16
ZA871335B (en) 1987-09-30
US4772604A (en) 1988-09-20
GR3006689T3 (es) 1993-06-30
DE3782525T2 (de) 1993-05-27
JPH0798800B2 (ja) 1995-10-25
ATE82281T1 (de) 1992-11-15
EP0241053B1 (en) 1992-11-11
US4874770A (en) 1989-10-17
DK93087A (da) 1987-08-28
JPS62205058A (ja) 1987-09-09
AU585131B2 (en) 1989-06-08
DE3782525D1 (de) 1992-12-17
EP0241053A1 (en) 1987-10-14
PH22783A (en) 1988-12-12
AU6924787A (en) 1987-09-03
IE61724B1 (en) 1994-11-30
NZ219380A (en) 1990-06-26
CA1279645C (en) 1991-01-29
DK93087D0 (da) 1987-02-24
IL81669A (en) 1990-11-29
IE870466L (en) 1987-08-27

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