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EP3962651A4 - Microfluidic devices and methods of making the same - Google Patents

Microfluidic devices and methods of making the same Download PDF

Info

Publication number
EP3962651A4
EP3962651A4 EP20799361.9A EP20799361A EP3962651A4 EP 3962651 A4 EP3962651 A4 EP 3962651A4 EP 20799361 A EP20799361 A EP 20799361A EP 3962651 A4 EP3962651 A4 EP 3962651A4
Authority
EP
European Patent Office
Prior art keywords
making
methods
same
microfluidic devices
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20799361.9A
Other languages
German (de)
French (fr)
Other versions
EP3962651A1 (en
Inventor
Richard J. Paolini, Jr.
David ZHITOMIRSKY
Timothy J. O'malley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuclera Ltd
Original Assignee
Nuclera Nucleics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuclera Nucleics Ltd filed Critical Nuclera Nucleics Ltd
Publication of EP3962651A1 publication Critical patent/EP3962651A1/en
Publication of EP3962651A4 publication Critical patent/EP3962651A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B17/00—Pumps characterised by combination with, or adaptation to, specific driving engines or motors
    • F04B17/03—Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B01L2200/022—Variable spacings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP20799361.9A 2019-04-30 2020-04-22 Microfluidic devices and methods of making the same Withdrawn EP3962651A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962840443P 2019-04-30 2019-04-30
PCT/US2020/029276 WO2020223077A1 (en) 2019-04-30 2020-04-22 Microfluidic devices and methods of making the same

Publications (2)

Publication Number Publication Date
EP3962651A1 EP3962651A1 (en) 2022-03-09
EP3962651A4 true EP3962651A4 (en) 2022-11-23

Family

ID=73017701

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20799361.9A Withdrawn EP3962651A4 (en) 2019-04-30 2020-04-22 Microfluidic devices and methods of making the same

Country Status (4)

Country Link
US (1) US20200347840A1 (en)
EP (1) EP3962651A4 (en)
TW (1) TWI794603B (en)
WO (1) WO2020223077A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554375B2 (en) * 2019-06-07 2023-01-17 Nuclera Nucleics Ltd. Microfluidic devices containing reversibly pinned droplet samples and methods
EP4061530A4 (en) 2019-11-20 2023-12-27 Nuclera Nucleics Ltd Spatially variable hydrophobic layers for digital microfluidics
CN114945426A (en) 2020-01-17 2022-08-26 核酸有限公司 Spatially variable dielectric layer for digital microfluidics
WO2021154627A1 (en) 2020-01-27 2021-08-05 E Ink Corporation Method for degassing liquid droplets by electrowetting actuation at higher temperatures
CN115175764A (en) 2020-02-18 2022-10-11 核酸有限公司 Adaptive gate drive for high frequency AC drive of EWoD array
TWI795730B (en) 2020-02-19 2023-03-11 英商核酸有限公司 Latched transistor driving for high frequency ac driving of ewod arrays
EP4142942A4 (en) 2020-04-27 2024-05-22 Nuclera Ltd Segmented top plate for variable driving and short protection for digital microfluidics
CN114534805B (en) * 2022-02-09 2024-08-06 上海天马微电子有限公司 Microfluidic device, driving method thereof and manufacturing method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040082A1 (en) * 2006-07-10 2009-03-25 Hitachi High-Technologies Corporation Liquid transfer device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8187864B2 (en) * 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US20140216559A1 (en) * 2013-02-07 2014-08-07 Advanced Liquid Logic, Inc. Droplet actuator with local variation in gap height to assist in droplet splitting and merging operations
CA2910125A1 (en) * 2013-04-26 2014-10-30 Jx Nippon Oil & Energy Corporation Substrate having rugged structure obtained from hydrophobic sol/gel material
US20150377831A1 (en) * 2014-06-27 2015-12-31 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods employing integrated nanostructured electrodeposited electrodes
US9623407B2 (en) * 2015-03-27 2017-04-18 International Business Machines Corporation Microfluidic device with longitudinal and transverse liquid barriers for transverse flow mixing
KR102426825B1 (en) * 2015-10-27 2022-07-28 버클리 라잇츠, 인크. Microfluidic Electrowetting Device Apparatus With Covalently Bound Hydrophobic Surfaces
US10543466B2 (en) * 2016-06-29 2020-01-28 Digital Biosystems High resolution temperature profile creation in a digital microfluidic device
JP7064007B2 (en) * 2017-10-18 2022-05-09 ヌークレラ ヌクリークス， リミテッド Digital microfluidic device including double substrate with thin film transistor and capacitance sensing

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2040082A1 (en) * 2006-07-10 2009-03-25 Hitachi High-Technologies Corporation Liquid transfer device

Also Published As

Publication number Publication date
TW202103785A (en) 2021-02-01
EP3962651A1 (en) 2022-03-09
TWI794603B (en) 2023-03-01
WO2020223077A1 (en) 2020-11-05
US20200347840A1 (en) 2020-11-05

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