EP3778607C0 - Benzoxazepin oxazolidinone compounds and methods of use - Google Patents
Benzoxazepin oxazolidinone compounds and methods of useInfo
- Publication number
- EP3778607C0 EP3778607C0 EP20174298.8A EP20174298A EP3778607C0 EP 3778607 C0 EP3778607 C0 EP 3778607C0 EP 20174298 A EP20174298 A EP 20174298A EP 3778607 C0 EP3778607 C0 EP 3778607C0
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- oxazolidinone compounds
- benzoxazepin oxazolidinone
- benzoxazepin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- KVQCNKSKFIZOKW-UHFFFAOYSA-N O1C(NCC1)=O.O1N=CC=CC2=C1C=CC=C2 Chemical class O1C(NCC1)=O.O1N=CC=CC2=C1C=CC=C2 KVQCNKSKFIZOKW-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22204250.9A EP4212536A1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188029P | 2015-07-02 | 2015-07-02 | |
| PCT/EP2016/065455 WO2017001645A1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP19171677.8A EP3567045B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP16733600.7A EP3317284B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Related Parent Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19171677.8A Division-Into EP3567045B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP19171677.8A Division EP3567045B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP16733600.7A Division EP3317284B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP16065455 Previously-Filed-Application | 2016-07-01 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP22204250.9A Division EP4212536A1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP22204250.9A Division-Into EP4212536A1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP3778607A1 EP3778607A1 (en) | 2021-02-17 |
| EP3778607B1 EP3778607B1 (en) | 2023-08-30 |
| EP3778607C0 true EP3778607C0 (en) | 2023-08-30 |
Family
ID=56292756
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP16733600.7A Active EP3317284B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP20174298.8A Active EP3778607B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP19171677.8A Active EP3567045B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP22204250.9A Pending EP4212536A1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP16733600.7A Active EP3317284B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19171677.8A Active EP3567045B1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
| EP22204250.9A Pending EP4212536A1 (en) | 2015-07-02 | 2016-07-01 | Benzoxazepin oxazolidinone compounds and methods of use |
Country Status (33)
| Country | Link |
|---|---|
| US (6) | US9650393B2 (en) |
| EP (4) | EP3317284B1 (en) |
| JP (4) | JP6523490B2 (en) |
| KR (2) | KR102014326B1 (en) |
| CN (4) | CN112062778B (en) |
| AR (1) | AR105238A1 (en) |
| AU (2) | AU2016287463B2 (en) |
| CA (1) | CA2982708C (en) |
| CL (1) | CL2017003436A1 (en) |
| CO (1) | CO2017011038A2 (en) |
| CR (1) | CR20170563A (en) |
| DK (1) | DK3317284T3 (en) |
| ES (2) | ES2764497T3 (en) |
| HK (1) | HK1253003A1 (en) |
| HR (1) | HRP20192349T1 (en) |
| HU (1) | HUE046756T2 (en) |
| IL (3) | IL255200B (en) |
| LT (1) | LT3317284T (en) |
| MA (3) | MA42295B1 (en) |
| MX (2) | MX2017016344A (en) |
| MY (1) | MY195002A (en) |
| PE (2) | PE20211775A1 (en) |
| PH (2) | PH12017502425A1 (en) |
| PL (2) | PL3317284T3 (en) |
| PT (1) | PT3317284T (en) |
| RS (1) | RS59740B1 (en) |
| RU (1) | RU2730529C2 (en) |
| SG (1) | SG10201913980SA (en) |
| SI (1) | SI3317284T1 (en) |
| TW (4) | TWI698440B (en) |
| UA (1) | UA121678C2 (en) |
| WO (1) | WO2017001645A1 (en) |
| ZA (1) | ZA201808370B (en) |
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| CA3094197C (en) | 2015-07-02 | 2023-02-28 | F. Hoffmann-La Roche Ag | Bicyclic lactams and methods of use thereof |
| CN107995911B (en) | 2015-07-02 | 2020-08-04 | 豪夫迈·罗氏有限公司 | Benzoxazepine compounds and methods of use thereof |
| CN112062778B (en) | 2015-07-02 | 2024-04-19 | 豪夫迈·罗氏有限公司 | Benzoxazepine oxazolidinone compounds and methods of use thereof |
| CN108349996B (en) | 2015-09-08 | 2021-01-08 | 豪夫迈·罗氏有限公司 | Tricyclic PI3K inhibitor compounds and methods of use thereof |
| TW201815787A (en) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | Phosphatidylinositol 3-kinase inhibitors |
| TW201813963A (en) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | Phosphatidylinositol 3-kinase inhibitors |
| TW201825465A (en) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | Phosphatidylinositol 3-kinase inhibitors |
| CN109843886B (en) | 2016-10-17 | 2022-04-19 | 豪夫迈·罗氏有限公司 | Bicyclic pyridone lactams and methods of use thereof |
| CN110088111B (en) * | 2016-12-15 | 2021-08-03 | 豪夫迈·罗氏有限公司 | Preparation method of (S) -2- ((2- ((S) -4- (difluoromethyl) -2-oxooxazolidin-3-yl) -5, 6-dihydrobenzo [ f ] imidazo [1,2-d ] [1,4] oxazepin-9-yl) amino) propionamide |
| US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
| AU2018259089B2 (en) * | 2017-04-28 | 2022-05-12 | F. Hoffmann-La Roche Ag | Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo(ƒ)imidazo(1,2-d)(1,4)oxazepin-9-yl)amino)propanamide, and methods of production |
| EP3781571B1 (en) | 2018-04-20 | 2024-01-17 | F. Hoffmann-La Roche AG | N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs) |
| AU2019276514B2 (en) * | 2018-05-30 | 2023-12-14 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Inhibitor containing tricyclic derivative, preparation method therefor, and application thereof |
| MX2021000847A (en) * | 2018-07-23 | 2021-03-26 | Hoffmann La Roche | Methods of treating cancer with pi3k inhibitor, gdc-0077. |
| JP2022504388A (en) | 2018-10-08 | 2022-01-13 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Cancer treatment method using PI3K alpha inhibitor and metformin |
| CN109265408B (en) * | 2018-12-11 | 2020-09-01 | 上海皓元生物医药科技有限公司 | Synthesis method of difluoromethyl substituted oxan-2-ketone |
| TW202038957A (en) | 2018-12-21 | 2020-11-01 | 日商第一三共股份有限公司 | Combination of antibody-drug conjugate and kinase inhibitor |
| CN111995541A (en) * | 2019-05-27 | 2020-11-27 | 润佳（苏州）医药科技有限公司 | Compound containing stable heavy isotope amide functional group and application thereof |
| WO2021088845A1 (en) * | 2019-11-04 | 2021-05-14 | 贝达药业股份有限公司 | Imidazolidinone compound and preparation method and application thereof |
| CN112830935B (en) * | 2019-11-25 | 2023-12-22 | 上海翰森生物医药科技有限公司 | Crystal form containing tricyclic derivative free alkali and pharmaceutical composition thereof |
| US20230014383A1 (en) * | 2019-11-25 | 2023-01-19 | Shanghai Hansoh Biomedical Co., Ltd. | Three fused ring derivative-containing salt or crystal form and pharmaceutical composition thereof |
| WO2021113219A1 (en) | 2019-12-03 | 2021-06-10 | Genentech, Inc. | Combination therapies for treatment of breast cancer |
| IL303502A (en) | 2020-12-11 | 2023-08-01 | Genentech Inc | Combination therapies for treatment of her2 cancer |
| JP2024504811A (en) * | 2021-01-29 | 2024-02-01 | メッドシャイン ディスカバリー インコーポレイテッド | Tricyclic compounds and their uses |
| WO2022237871A1 (en) | 2021-05-13 | 2022-11-17 | 贝达药业股份有限公司 | Polymorph of imidazolidinone compound, preparation method therefor and use thereof |
| MX2023013919A (en) | 2021-05-28 | 2023-12-08 | Genentech Inc | Process for the preparation of benzoxazepin oxazolidinone compounds. |
| JP7537026B2 (en) | 2021-07-19 | 2024-08-20 | 京セラ株式会社 | COMMUNICATION METHOD, USER EQUIPMENT, NETWORK DEVICE, MOBILE COMMUNICATION SYSTEM, PROGRAM, AND CHIPSET |
| WO2023196329A1 (en) | 2022-04-06 | 2023-10-12 | Genentech, Inc. | Combination therapies comprising gdc-6036 and gdc-0077 for the treatment of cancer |
| CN117466913A (en) * | 2022-07-27 | 2024-01-30 | 南京明德新药研发有限公司 | Crystal forms of 5, 6-dihydrobenzo [ f ] imidazo [1,2-d ] [1,4] oxazepine compound and preparation method thereof |
| WO2024100236A1 (en) | 2022-11-11 | 2024-05-16 | Astrazeneca Ab | Combination therapies for the treatment of cancer |
| WO2024206147A1 (en) | 2023-03-24 | 2024-10-03 | Arvinas Operations, Inc. | Dosage regimens of estrogen receptor degraders |
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| CN112062778B (en) | 2015-07-02 | 2024-04-19 | 豪夫迈·罗氏有限公司 | Benzoxazepine oxazolidinone compounds and methods of use thereof |
| CN110088111B (en) | 2016-12-15 | 2021-08-03 | 豪夫迈·罗氏有限公司 | Preparation method of (S) -2- ((2- ((S) -4- (difluoromethyl) -2-oxooxazolidin-3-yl) -5, 6-dihydrobenzo [ f ] imidazo [1,2-d ] [1,4] oxazepin-9-yl) amino) propionamide |
| AU2018259089B2 (en) * | 2017-04-28 | 2022-05-12 | F. Hoffmann-La Roche Ag | Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo(ƒ)imidazo(1,2-d)(1,4)oxazepin-9-yl)amino)propanamide, and methods of production |
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| JP2022504388A (en) | 2018-10-08 | 2022-01-13 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Cancer treatment method using PI3K alpha inhibitor and metformin |
| WO2021113219A1 (en) | 2019-12-03 | 2021-06-10 | Genentech, Inc. | Combination therapies for treatment of breast cancer |
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2016
- 2016-07-01 CN CN202010779436.0A patent/CN112062778B/en active Active
- 2016-07-01 CN CN201680039251.8A patent/CN107873032B/en active Active
- 2016-07-01 HU HUE16733600A patent/HUE046756T2/en unknown
- 2016-07-01 CA CA2982708A patent/CA2982708C/en active Active
- 2016-07-01 CN CN202010786032.4A patent/CN112047960B/en active Active
- 2016-07-01 PT PT167336007T patent/PT3317284T/en unknown
- 2016-07-01 ES ES16733600T patent/ES2764497T3/en active Active
- 2016-07-01 AR ARP160102006A patent/AR105238A1/en active IP Right Grant
- 2016-07-01 TW TW108100214A patent/TWI698440B/en active
- 2016-07-01 MY MYPI2017705097A patent/MY195002A/en unknown
- 2016-07-01 AU AU2016287463A patent/AU2016287463B2/en active Active
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