EP3265486A4 - Antibody therapeutics that bind tim3 - Google Patents
Antibody therapeutics that bind tim3 Download PDFInfo
- Publication number
- EP3265486A4 EP3265486A4 EP16762246.3A EP16762246A EP3265486A4 EP 3265486 A4 EP3265486 A4 EP 3265486A4 EP 16762246 A EP16762246 A EP 16762246A EP 3265486 A4 EP3265486 A4 EP 3265486A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antibody therapeutics
- tim3
- bind
- bind tim3
- therapeutics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562129321P | 2015-03-06 | 2015-03-06 | |
| PCT/US2016/021005 WO2016144803A2 (en) | 2015-03-06 | 2016-03-04 | Antibody therapeutics that bind tim3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3265486A2 EP3265486A2 (en) | 2018-01-10 |
| EP3265486A4 true EP3265486A4 (en) | 2018-11-14 |
Family
ID=56849611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP16762246.3A Withdrawn EP3265486A4 (en) | 2015-03-06 | 2016-03-04 | Antibody therapeutics that bind tim3 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9873741B2 (en) |
| EP (1) | EP3265486A4 (en) |
| JP (1) | JP2018510151A (en) |
| KR (1) | KR20180008405A (en) |
| CN (1) | CN107922484A (en) |
| AR (1) | AR103867A1 (en) |
| AU (1) | AU2016229189A1 (en) |
| CA (1) | CA2978892A1 (en) |
| IL (1) | IL254260A0 (en) |
| MX (1) | MX2017011406A (en) |
| TW (1) | TW201639888A (en) |
| WO (1) | WO2016144803A2 (en) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2860170C (en) | 2010-12-22 | 2022-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
| EP3409278B8 (en) | 2011-07-21 | 2020-11-04 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| CA2925421C (en) | 2013-09-24 | 2023-08-29 | Medicenna Therapeutics, Inc. | Interleukin-2 fusion proteins and uses thereof |
| CA2946398A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
| US10259881B2 (en) * | 2015-02-22 | 2019-04-16 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind CD137 |
| WO2016144803A2 (en) * | 2015-03-06 | 2016-09-15 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind tim3 |
| PL3443009T3 (en) | 2016-04-12 | 2022-01-31 | Symphogen A/S | Anti-tim-3 antibodies and compositions |
| TW202244062A (en) | 2016-05-27 | 2022-11-16 | 美商艾吉納斯公司 | Anti-tim-3 antibodies and methods of use thereof |
| CN109715196A (en) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | For promoting the composition and method of immune cell function |
| US10077306B2 (en) | 2016-07-14 | 2018-09-18 | Bristol-Myers Squibb Company | Antibodies against TIM3 and uses thereof |
| EP3617232A1 (en) | 2016-08-17 | 2020-03-04 | Compugen Ltd. | Anti-tigit antibodies, anti-pvrig antibodies and combinations thereof |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| TWI665216B (en) * | 2016-12-29 | 2019-07-11 | 財團法人生物技術開發中心 | Anti-human tim-3 antibodies and methods of use thereof |
| US11345753B2 (en) | 2017-02-27 | 2022-05-31 | Jiangsu Hengrui Medicine Co., Ltd. | TIM-3 antibody, antigen binding fragment thereof, and medicinal uses thereof |
| EP4116328A1 (en) | 2017-04-05 | 2023-01-11 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Combination therapies targeting pd-1, tim-3, and lag-3 |
| AR111651A1 (en) | 2017-04-28 | 2019-08-07 | Novartis Ag | CONJUGATES OF ANTIBODIES THAT INCLUDE TOLL TYPE RECEIVER AGONISTS AND COMBINATION THERAPIES |
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| WO2018234862A1 (en) | 2017-06-19 | 2018-12-27 | Medicenna Therapeutics Inc. | Uses and methods for il-2 superagonists, agonists, and fusions thereof |
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| AU2018302283A1 (en) | 2017-07-20 | 2020-02-06 | Novartis Ag | Dosage regimens of anti-LAG-3 antibodies and uses thereof |
| JP2021500916A (en) | 2017-07-28 | 2021-01-14 | フェインズ セラピューティクス，インコーポレーテッド | Anti-TIM-3 antibody and its use |
| EP3676616A1 (en) | 2017-08-28 | 2020-07-08 | Bristol-Myers Squibb Company | Tim-3 antagonists for the treatment and diagnosis of cancers |
| JP7196160B2 (en) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Treatment Regimens for Cancers Insensitive to BCL-2 Inhibitors Using the MCL-1 Inhibitor Albocidib |
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| KR20200109339A (en) | 2018-01-16 | 2020-09-22 | 브리스톨-마이어스 스큅 컴퍼니 | How to treat cancer using antibodies to TIM3 |
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| CA3126391A1 (en) * | 2019-01-11 | 2020-07-16 | Minerva Biotechnologies Corporation | Anti-variable muc1* antibodies and uses thereof |
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| US20220144807A1 (en) | 2019-02-15 | 2022-05-12 | Novartis Ag | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
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| EP3977132A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
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| EP4031578A1 (en) | 2019-09-18 | 2022-07-27 | Novartis AG | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
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| BR112022011902A2 (en) | 2019-12-20 | 2022-09-06 | Novartis Ag | COMBINATION THERAPIES |
| AU2021207348A1 (en) | 2020-01-17 | 2022-08-11 | Novartis Ag | Combination comprising a TIM-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia |
| KR102536302B1 (en) * | 2020-02-25 | 2023-05-26 | 국립암센터 | Monoclonal antibody specifically binding to TIM-3 and uses thereof |
| AR122644A1 (en) | 2020-06-19 | 2022-09-28 | Onxeo | NEW CONJUGATED NUCLEIC ACID MOLECULES AND THEIR USES |
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| CN113214396B (en) * | 2020-07-31 | 2022-04-19 | 北京市神经外科研究所 | Single-chain antibody of anti-TIM 3 and application thereof in preparing medicine for treating tumor |
| EP4188549A1 (en) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| WO2022043557A1 (en) | 2020-08-31 | 2022-03-03 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
| MX2023002326A (en) | 2020-08-31 | 2023-03-21 | Bristol Myers Squibb Co | Cell localization signature and immunotherapy. |
| EP4204020A1 (en) | 2020-08-31 | 2023-07-05 | Advanced Accelerator Applications International S.A. | Method of treating psma-expressing cancers |
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| TW202237119A (en) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk-5 inhibitors and uses thereof |
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| US20220233689A1 (en) | 2020-12-28 | 2022-07-28 | Bristol-Myers Squibb Company | Methods of treating tumors |
| EP4083065A1 (en) | 2021-01-28 | 2022-11-02 | NantBio, Inc. | Anti-tim3 monoclonal antibodies and chimeric antigen receptors |
| EP4314068A1 (en) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
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| AR125874A1 (en) | 2021-05-18 | 2023-08-23 | Novartis Ag | COMBINATION THERAPIES |
| WO2023064958A1 (en) | 2021-10-15 | 2023-04-20 | Compugen Ltd. | Combination therapy with anti-pvrig antibodies formulations, anti-tigit antibodies, and anti-pd-1 antibodies |
| KR20240133795A (en) | 2021-12-16 | 2024-09-04 | 발레리오 테라퓨틱스 | Novel conjugated nucleic acid molecules and uses thereof |
| TW202345900A (en) * | 2022-03-14 | 2023-12-01 | 大陸商正大天晴藥業集團南京順欣製藥有限公司 | Pharmaceutical composition of anti-tim-3 antibody and hypomethylating agent |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063792A2 (en) * | 2002-01-30 | 2003-08-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods related to tim-3, a th1-specific cell surface molecule |
| US20120189617A1 (en) * | 2010-06-11 | 2012-07-26 | Kyushu University, National University Corporation | Anti-tim-3 antibody |
| WO2013006490A2 (en) * | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9814383D0 (en) * | 1998-07-02 | 1998-09-02 | Cambridge Antibody Tech | Improvements relating to antibodies |
| WO2006124269A2 (en) * | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
| WO2010117057A1 (en) * | 2009-04-10 | 2010-10-14 | 協和発酵キリン株式会社 | Method for treatment of blood tumor using anti-tim-3 antibody |
| CA2802344C (en) * | 2010-06-18 | 2023-06-13 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| BR112013001640A2 (en) | 2010-07-22 | 2020-08-04 | The Regents Of The University Of California | monoclonal antibody that binds to epha2 and cd44 epitopes, their use in cancer treatment and cancer cell detection, as well as composition, kit, nucleic acid and expression vector 5 |
| CN110294807B (en) * | 2014-10-27 | 2023-05-12 | 新加坡科技研究局 | anti-TIM-3 antibodies |
| EP3632935A1 (en) * | 2014-11-06 | 2020-04-08 | F. Hoffmann-La Roche AG | Anti-tim3 antibodies and methods of use |
| WO2016144803A2 (en) * | 2015-03-06 | 2016-09-15 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind tim3 |
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2016
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- 2016-03-04 EP EP16762246.3A patent/EP3265486A4/en not_active Withdrawn
- 2016-03-04 US US15/061,832 patent/US9873741B2/en active Active
- 2016-03-04 AR ARP160100591A patent/AR103867A1/en unknown
- 2016-03-04 CN CN201680023702.9A patent/CN107922484A/en active Pending
- 2016-03-04 MX MX2017011406A patent/MX2017011406A/en unknown
- 2016-03-04 JP JP2017546804A patent/JP2018510151A/en not_active Withdrawn
- 2016-03-04 AU AU2016229189A patent/AU2016229189A1/en not_active Abandoned
- 2016-03-04 CA CA2978892A patent/CA2978892A1/en not_active Abandoned
- 2016-03-04 TW TW105106781A patent/TW201639888A/en unknown
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- 2017-08-31 IL IL254260A patent/IL254260A0/en unknown
- 2017-12-14 US US15/842,161 patent/US10927171B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003063792A2 (en) * | 2002-01-30 | 2003-08-07 | The Brigham And Women's Hospital, Inc. | Compositions and methods related to tim-3, a th1-specific cell surface molecule |
| US20120189617A1 (en) * | 2010-06-11 | 2012-07-26 | Kyushu University, National University Corporation | Anti-tim-3 antibody |
| WO2013006490A2 (en) * | 2011-07-01 | 2013-01-10 | Cellerant Therapeutics, Inc. | Antibodies that specifically bind to tim3 |
Non-Patent Citations (5)
| Title |
|---|
| ANDERSON ANA C ET AL: "Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 318, no. 5853, 1 November 2007 (2007-11-01), pages 1141 - 1143, XP002490579, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1148536 * |
| BAGHDADI MUHAMMAD ET AL: "Blocking monoclonal antibodies of TIM proteins as orchestrators of anti-tumor immune response", MABS, vol. 6, no. 5, September 2014 (2014-09-01), pages 1124 - 1132, XP002782647 * |
| L. YANG ET AL: "Lack of TIM-3 Immunoregulation in Multiple Sclerosis", THE JOURNAL OF IMMUNOLOGY, vol. 180, no. 7, 19 March 2008 (2008-03-19), pages 4409 - 4414, XP055183939, ISSN: 0022-1767, DOI: 10.4049/jimmunol.180.7.4409 * |
| S. F. NGIOW ET AL: "Anti-TIM3 Antibody Promotes T Cell IFN-?-Mediated Antitumor Immunity and Suppresses Established Tumors", CANCER RESEARCH, vol. 71, no. 10, 23 March 2011 (2011-03-23), pages 3540 - 3551, XP055181433, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-0096 * |
| YOSHIKANE KIKUSHIGE ET AL: "TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 7, no. 6, 6 October 2010 (2010-10-06), pages 708 - 717, XP028211787, ISSN: 1934-5909, [retrieved on 20101117], DOI: 10.1016/J.STEM.2010.11.014 * |
Also Published As
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|---|---|
| JP2018510151A (en) | 2018-04-12 |
| CA2978892A1 (en) | 2016-09-15 |
| KR20180008405A (en) | 2018-01-24 |
| AU2016229189A1 (en) | 2017-09-21 |
| MX2017011406A (en) | 2018-06-19 |
| US10927171B2 (en) | 2021-02-23 |
| CN107922484A (en) | 2018-04-17 |
| EP3265486A2 (en) | 2018-01-10 |
| TW201639888A (en) | 2016-11-16 |
| WO2016144803A8 (en) | 2016-11-17 |
| WO2016144803A3 (en) | 2016-10-13 |
| US20160257758A1 (en) | 2016-09-08 |
| IL254260A0 (en) | 2017-10-31 |
| WO2016144803A2 (en) | 2016-09-15 |
| US20180251549A1 (en) | 2018-09-06 |
| AR103867A1 (en) | 2017-06-07 |
| US9873741B2 (en) | 2018-01-23 |
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