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EP2327721A3 - Genetic products which are differentially expressed in tumours and use thereof - Google Patents

Genetic products which are differentially expressed in tumours and use thereof Download PDF

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Publication number
EP2327721A3
EP2327721A3 EP10011193A EP10011193A EP2327721A3 EP 2327721 A3 EP2327721 A3 EP 2327721A3 EP 10011193 A EP10011193 A EP 10011193A EP 10011193 A EP10011193 A EP 10011193A EP 2327721 A3 EP2327721 A3 EP 2327721A3
Authority
EP
European Patent Office
Prior art keywords
tumours
differentially expressed
tumor
expressed
genetic products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10011193A
Other languages
German (de)
French (fr)
Other versions
EP2327721A2 (en
EP2327721B1 (en
Inventor
Özlem TÜRECI
Ugur Sahin
Michael Koslowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ganymed Pharmaceuticals GmbH
Original Assignee
Ganymed Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganymed Pharmaceuticals GmbH filed Critical Ganymed Pharmaceuticals GmbH
Publication of EP2327721A2 publication Critical patent/EP2327721A2/en
Publication of EP2327721A3 publication Critical patent/EP2327721A3/en
Application granted granted Critical
Publication of EP2327721B1 publication Critical patent/EP2327721B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Erfindungsgemäß wurden Tumor-assoziiert exprimierte Genprodukte und die dafür kodierenden Nukleinsäuren identifiziert. Die vorliegende Erfindung betrifft die Therapie und Diagnose von Erkrankungen, bei denen diese Tumor-assoziiert exprimierten Genprodukte aberrant exprimiert werden. Des weiteren betrifft die Erfindung Proteine, Polypeptide und Peptide, die Tumor-assoziiert exprimiert werden und die dafür kodierenden Nukleinsäuren.In accordance with the invention, tumor-associated expressed gene products and the nucleic acids coding therefor were identified. The present invention relates to the therapy and diagnosis of diseases in which these tumor-associated expressed gene products are aberrantly expressed. Furthermore, the invention relates to proteins, polypeptides and peptides which are expressed tumor-associated and the nucleic acids coding therefor.

EP10011193.9A 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof Expired - Lifetime EP2327721B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10341812A DE10341812A1 (en) 2003-09-10 2003-09-10 Differentially expressed in tumors gene products and their use
EP04765088A EP1664103A2 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP04765088.2 Division 2004-09-10
EP04765088A Division EP1664103A2 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof

Publications (3)

Publication Number Publication Date
EP2327721A2 EP2327721A2 (en) 2011-06-01
EP2327721A3 true EP2327721A3 (en) 2011-09-21
EP2327721B1 EP2327721B1 (en) 2017-12-27

Family

ID=34258548

Family Applications (7)

Application Number Title Priority Date Filing Date
EP04765088A Withdrawn EP1664103A2 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof
EP10011191A Withdrawn EP2336157A3 (en) 2003-09-10 2004-09-10 Gene products which are differentially expressed in tumours and use thereof
EP10011190A Withdrawn EP2336156A3 (en) 2003-09-10 2004-09-10 Gene products which are differentially expressed in tumours and use thereof
EP10011192A Withdrawn EP2314613A3 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof
EP10011194A Withdrawn EP2322544A3 (en) 2003-09-10 2004-09-10 Differential in tumour gene products and use of same
EP10011193.9A Expired - Lifetime EP2327721B1 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof
EP16176546.6A Expired - Lifetime EP3095791B1 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof

Family Applications Before (5)

Application Number Title Priority Date Filing Date
EP04765088A Withdrawn EP1664103A2 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof
EP10011191A Withdrawn EP2336157A3 (en) 2003-09-10 2004-09-10 Gene products which are differentially expressed in tumours and use thereof
EP10011190A Withdrawn EP2336156A3 (en) 2003-09-10 2004-09-10 Gene products which are differentially expressed in tumours and use thereof
EP10011192A Withdrawn EP2314613A3 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof
EP10011194A Withdrawn EP2322544A3 (en) 2003-09-10 2004-09-10 Differential in tumour gene products and use of same

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP16176546.6A Expired - Lifetime EP3095791B1 (en) 2003-09-10 2004-09-10 Genetic products which are differentially expressed in tumours and use thereof

Country Status (8)

Country Link
US (1) US8765389B2 (en)
EP (7) EP1664103A2 (en)
JP (3) JP5007123B2 (en)
AU (1) AU2004272270B2 (en)
CA (1) CA2538528C (en)
DE (1) DE10341812A1 (en)
ES (1) ES2663242T3 (en)
WO (1) WO2005026205A2 (en)

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EP1795596A1 (en) * 2005-12-08 2007-06-13 Ganymed Pharmaceuticals AG Composition and methods for therapy and diagnosis of cancer
EP1911851A1 (en) * 2006-10-12 2008-04-16 Ganymed Pharmaceuticals AG Compositions and methods for therapy and diagnosis of cancer and cancer metastasis
EP2060583A1 (en) 2007-10-23 2009-05-20 Ganymed Pharmaceuticals AG Identification of tumor-associated markers for diagnosis and therapy
EP2108701A1 (en) * 2008-04-10 2009-10-14 Ganymed Pharmaceuticals AG Methods involving MS4A12 and agents targeting MS4A12 for therapy, diagnosis and testing
JP5565723B2 (en) * 2009-04-07 2014-08-06 学校法人北里研究所 Anti-DCD monoclonal antibody
CN117756916A (en) * 2010-09-20 2024-03-26 生物技术细胞和基因治疗公司 Antigen-specific T cell receptor and T cell epitope
WO2013164787A1 (en) 2012-05-02 2013-11-07 Helse Stavanger As Assay methods for diagnosing and monitoring cancer
EP2777714A1 (en) 2013-03-15 2014-09-17 NBE-Therapeutics LLC Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
WO2015140567A1 (en) * 2014-03-21 2015-09-24 Immunocore Limited Tumor associated antigens derived from traip
PE20181535A1 (en) 2015-12-16 2018-09-26 Gritstone Oncology Inc IDENTIFICATION, MANUFACTURE AND USE OF NEOANTIGEN
WO2019075112A1 (en) 2017-10-10 2019-04-18 Gritstone Oncology, Inc. Neoantigen identification using hotspots
CN111630602A (en) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 Reducing presentation of conjugated epitopes by neoantigens
US11308700B2 (en) 2020-04-06 2022-04-19 Saudi Arabian Oil Company Augmented reality visualization of underground pipelines using geospatial databases and KM markers
WO2021251842A1 (en) * 2020-06-08 2021-12-16 Qatar Foundation For Education, Science And Community Development Targeting of lactate dehydrogenase c, methods of preparing same, and methods of using same in combination with anti-cancer treatments
BR112024001180A2 (en) 2021-07-29 2024-04-30 BioNTech SE COMPOSITIONS AND METHODS FOR TREATMENT OF MELANOMA

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Also Published As

Publication number Publication date
CA2538528A1 (en) 2005-03-24
JP2013009673A (en) 2013-01-17
JP5007123B2 (en) 2012-08-22
WO2005026205A3 (en) 2005-07-07
DE10341812A1 (en) 2005-04-07
EP2336157A3 (en) 2011-11-16
EP1664103A2 (en) 2006-06-07
EP3095791A1 (en) 2016-11-23
EP2327721A2 (en) 2011-06-01
AU2004272270B2 (en) 2011-07-21
US8765389B2 (en) 2014-07-01
WO2005026205A2 (en) 2005-03-24
EP3095791B1 (en) 2020-06-10
EP2336157A2 (en) 2011-06-22
EP2336156A3 (en) 2011-11-16
CA2538528C (en) 2020-03-10
EP2322544A2 (en) 2011-05-18
EP2327721B1 (en) 2017-12-27
AU2004272270A1 (en) 2005-03-24
EP2314613A2 (en) 2011-04-27
ES2663242T3 (en) 2018-04-11
EP2314613A3 (en) 2011-11-16
US20100203040A1 (en) 2010-08-12
JP2007526759A (en) 2007-09-20
EP2322544A3 (en) 2011-11-16
EP2336156A2 (en) 2011-06-22
JP2012050441A (en) 2012-03-15
JP5711698B2 (en) 2015-05-07

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