EP2340245A4 - A novel betaine cocrystal of epalrestat - Google Patents

A novel betaine cocrystal of epalrestat

Info

Publication number: EP2340245A4
Authority: EP; European Patent Office
Prior art keywords: epalrestat; novel betaine; betaine cocrystal; cocrystal; novel
Prior art date: 2008-07-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP09801070A

Other languages

German (de)

French (fr)

Other versions

EP2340245A2 (en

Inventor

Isabel Kalofonos

Patrick G Stahly

William Martin-Doyle

Dimitris Kalofonos

Jeffrey S Stults

Travis L Houston

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bionevia Pharmaceuticals Inc

Original Assignee

Bionevia Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-25

Filing date

2009-07-24

Publication date

2011-09-28

2009-07-24 Application filed by Bionevia Pharmaceuticals Inc filed Critical Bionevia Pharmaceuticals Inc

2011-07-06 Publication of EP2340245A2 publication Critical patent/EP2340245A2/en

2011-09-28 Publication of EP2340245A4 publication Critical patent/EP2340245A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/25—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids with polyoxyalkylated alcohols, e.g. esters of polyethylene glycol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

EP09801070A 2008-07-25 2009-07-24 A novel betaine cocrystal of epalrestat Withdrawn EP2340245A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8361908P	2008-07-25	2008-07-25
PCT/US2009/051693 WO2010011926A2 (en)	2008-07-25	2009-07-24	A novel betaine cocrystal of epalrestat

Publications (2)

Publication Number	Publication Date
EP2340245A2 EP2340245A2 (en)	2011-07-06
EP2340245A4 true EP2340245A4 (en)	2011-09-28

Family

ID=41570882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP09801070A Withdrawn EP2340245A4 (en)	2008-07-25	2009-07-24	A novel betaine cocrystal of epalrestat

Country Status (3)

Country	Link
EP (1)	EP2340245A4 (en)
EA (1)	EA018905B1 (en)
WO (1)	WO2010011926A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8697735B2 (en)	2008-07-25	2014-04-15	Bionevia Pharmaceuticals, Inc.	Solid forms of epalrestat
ES2639019T3 (en)	2008-09-06	2017-10-25	Bionevia Pharmaceuticals Inc.	New co-crystal of epalrestat hill
PT2665477E (en)	2011-01-20	2016-01-12	Bionevia Pharmaceuticals Inc	Modified release compositions of epalrestat or a derivative thereof and methods for using the same
ITMI20120586A1 (en)	2012-04-11	2013-10-12	Milano Politecnico	CO-CRYSTALS OF 3-IODIOPROPINYL BUTYCARBAMMATE
CN113277962B (en) *	2021-06-01	2023-02-07	天津大学	Epalrestat-metformin salt hydrate and preparation method and application thereof
CN113336718B (en) *	2021-06-01	2023-02-28	天津大学	Epalrestat-metformin salt and preparation method and application thereof
CN115925650B (en) *	2022-12-13	2023-08-01	山东达因海洋生物制药股份有限公司	Epalrestat eutectic and preparation method and application thereof
CN115947699B (en) *	2023-01-16	2024-01-19	威海海洋职业学院	Epalrestat eutectic crystal taking nicotinamide as precursor and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004078161A1 (en) *	2003-02-28	2004-09-16	Transform Pharmaceuticals, Inc.	Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2007099680A (en) *	2005-10-04	2007-04-19	Konica Minolta Chemical Co Ltd	Method for producing epalrestat

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5740478A (en) *	1980-08-22	1982-03-06	Ono Pharmaceut Co Ltd	Rhodanine derivative, its preparation and aldose reductase inhibitor containing rhodanine derivative
EP1727520A2 (en) *	2003-12-09	2006-12-06	Medcrystalforms, Llc	Method of preparation of mixed phase co-crystals with active agents

2009
- 2009-07-24 EP EP09801070A patent/EP2340245A4/en not_active Withdrawn
- 2009-07-24 EA EA201100246A patent/EA018905B1/en not_active IP Right Cessation
- 2009-07-24 WO PCT/US2009/051693 patent/WO2010011926A2/en active Application Filing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004078161A1 (en) *	2003-02-28	2004-09-16	Transform Pharmaceuticals, Inc.	Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JP2007099680A (en) *	2005-10-04	2007-04-19	Konica Minolta Chemical Co Ltd	Method for producing epalrestat

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MATTHEW L. PETERSON ET AL: "Expanding the Scope of Crystal Form Evaluation in Pharmaceu tical Science", J PHARM PHARMACEUT SCI, 1 January 2006 (2006-01-01), pages 317 - 326, XP055020303, Retrieved from the Internet <URL:http://www.ualberta.ca/~csps/JPPS9_3/Peterson/676_Final.pdf> [retrieved on 20120224] *

Also Published As

Publication number	Publication date
WO2010011926A3 (en)	2010-05-27
EP2340245A2 (en)	2011-07-06
WO2010011926A2 (en)	2010-01-28
EA201100246A1 (en)	2011-10-31
EA018905B1 (en)	2013-11-29

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ZA201104319B (en)	2012-03-28	Crystalline forms of a 3-carboxypropyl-aminotetralin compound
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GB0813347D0 (en)	2008-08-27	A set of parts
PL2346485T3 (en)	2017-11-30	Use of betaine
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Legal Events

Date	Code	Title	Description
2011-06-03	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2011-07-06	17P	Request for examination filed	Effective date: 20110330
2011-07-06	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
2011-07-06	AX	Request for extension of the european patent	Extension state: AL BA RS
2011-09-28	A4	Supplementary search report drawn up and despatched	Effective date: 20110829
2011-09-28	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 3/10 20060101ALI20110823BHEP Ipc: A61K 31/20 20060101ALI20110823BHEP Ipc: A61K 31/25 20060101ALI20110823BHEP Ipc: C07D 277/36 20060101AFI20110823BHEP
2011-11-02	DAX	Request for extension of the european patent (deleted)
2013-04-17	17Q	First examination report despatched	Effective date: 20130319
2013-10-16	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2013-11-13	INTG	Intention to grant announced	Effective date: 20131017
2014-07-25	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2014-08-27	18D	Application deemed to be withdrawn	Effective date: 20140228