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EP2263796B1 - Récipient doté d'une solution de référence - Google Patents

Récipient doté d'une solution de référence Download PDF

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Publication number
EP2263796B1
EP2263796B1 EP10003312.5A EP10003312A EP2263796B1 EP 2263796 B1 EP2263796 B1 EP 2263796B1 EP 10003312 A EP10003312 A EP 10003312A EP 2263796 B1 EP2263796 B1 EP 2263796B1
Authority
EP
European Patent Office
Prior art keywords
container
wick
reference solution
puncturing
outlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP10003312.5A
Other languages
German (de)
English (en)
Other versions
EP2263796A1 (fr
Inventor
Wilhelm Leichner
Hans List
Herbert Harttig
Axel Ahl
Christa Sternberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diabetes Care GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diabetes Care GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diabetes Care GmbH filed Critical F Hoffmann La Roche AG
Priority to EP10003312.5A priority Critical patent/EP2263796B1/fr
Publication of EP2263796A1 publication Critical patent/EP2263796A1/fr
Application granted granted Critical
Publication of EP2263796B1 publication Critical patent/EP2263796B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/523—Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid

Definitions

  • the invention relates to a container with reference solution for clinical chemistry contained therein, for example, glucose solution, lactate solution, cholesterol solution or hemoglobin solution.
  • a container having the features specified in the preamble of claim 1 is known from DE 31 22 237 A1 known.
  • Such reference solutions are needed for testing or calibrating gauges used, for example, by diabetics to determine their blood sugar levels.
  • Manufacturers of measuring systems for the determination of analyte concentrations in body fluid samples therefore offer containers with reference solution in defined concentrations as part of such measuring systems.
  • Modern measuring instruments contain a lancing device for sample taking.
  • lancing elements can be used with a capillary channel, so that a body fluid sample can be automatically taken during a puncture.
  • a container which contains a sponge impregnated with reference solution and is closed with a membrane.
  • the meter is attached to the membrane and pierced with a lancing element.
  • the inclusion of reference solution thus takes place in an analogous manner as a sample holder, namely with a puncturing movement of the lancing element.
  • a constant goal in the development of measuring systems is to simplify the handling and to save costs.
  • the object of the invention is therefore to show a cost-effective way how it can be easier for users to supply meters with integrated lancing equipment without contamination with reference solution.
  • the invention further relates to a system for measuring an analyte concentration in a human or animal body fluid sample, comprising such a container and a measuring device which contains a pricking device for taking samples.
  • the invention also relates to a method for recording reference solution with a lancing element according to claim 10.
  • a wick By arranging a wick in a container with reference solution contained therein, it is possible both to reduce the manufacturing outlay and to make handling much easier for users. Namely, with a wick, reference solution can be made available at the outlet regardless of the level of the container, so that reference solution can be absorbed by a piercing element of a puncturing instrument which pierces the wick.
  • reference solution can be made available at the outlet regardless of the level of the container, so that reference solution can be absorbed by a piercing element of a puncturing instrument which pierces the wick.
  • large tolerances are accepted, so that the container is partially filled with air. Namely, it does not hurt if the interior of the container is partially filled with air. Capillary forces of the wick always ensure that the full length of the wick is saturated with reference solution.
  • a further advantage of a container according to the invention is, in particular, the fact that a sample holder with particularly high reliability is possible. This is attributed to the fact that the fibers of a wick extend substantially in the direction of the stitch movement performed by a lancing element for receiving reference solution. The lancing element is therefore surrounded on its entire immersed in the wick length of the held between the fibers of the wick by capillary forces reference solution. The active length of the lancing element for the sampling is therefore maximum. This is an important advantage over known containers in which sponges or similar porous bodies are arranged.
  • the wick may be loose in the container. However, it is preferred that the wick is attached to the container.
  • the wick may be materially bonded to a container wall.
  • the container has a container wall which surrounds the outlet and carries the closure part, wherein the container wall forms a stop for application to a puncturing device for a sampling.
  • the container wall forms a stop for application to a puncturing device for a sampling.
  • a stop can also be formed with substantially thinner walls, for example by arranging in the container a ring which surrounds the wick. During a sampling, the container wall which surrounds the outlet rests on the ring and is supported by it, so that the container wall can form a load-bearing stop, regardless of its strength.
  • the container withstands a contact force of at least 3 N when applying a puncturing device for a sampling, without reference solution being forced out of the outlet.
  • a user applies a force of 3 Newton to 9 Newton when applying a puncture device to a container with reference solution.
  • a container should also be able to withstand such a force, without thereby reference solution is pressed out when the container is open.
  • the fibers forming the wick are evenly distributed over its cross section. This measure has the advantage that a sampling can be carried out with the same reliability, regardless of where it is inserted at the end face of the wick.
  • the wick of a container according to the invention may be similar to the wick of a candle made of interwoven fibers. However, such an integration is not required.
  • a wick in particular, a fiber bundle can be used.
  • the fiber bundle like the bristles of a brush, can protrude from the outlet into the interior of the container.
  • the fiber bundle can be fixed in a channel, wherein the wick rests on a channel wall over a predominant part of its length, preferably substantially over its full length.
  • the channel may for example be formed by a tube which projects into the interior of the container. It is also possible that the channel wall is the inner wall of the container.
  • the closure part of a container according to the invention may be formed, for example, as a membrane. It is also possible to make the container resealable and to use as a closure part, for example, a screw cap. Preferably, however, the closure part is fastened to the container via a predetermined breaking point. In this way, the closure part can form a seal, the integrity of which ensures that the reference solution actually has the expected concentration and has not been adversely affected by harmful environmental influences.
  • the closure part may be integrally formed together with a container wall enclosing the outlet, preferably as an injection-molded part. It is particularly advantageous to attach the closure part to the container such that it can be rotated, for example by providing it with two wings. But it is also possible to form the closure part so that it is broken off by a kinking movement of the container.
  • the closure part is preferably smaller than the rest of the container. But it is also possible that the closure part is formed larger than the container and also has an interior, in which reference solution is located.
  • the container is defined by the fact that the wick is attached to it.
  • the container forms a stop on which a puncturing device rests when removing reference solution.
  • the outlet may be formed at a neck of the container, in particular by the container being shaped similar to a bottle. The part of the container which adjoins the neck from the outlet can advantageously form the stop.
  • a container according to the invention may, for example, also be designed as a tube which is closed at one end by a bottom and at the other end has the outlet from which the wick extends into the interior of the container.
  • a neck, on which the outlet is arranged may be formed as a predetermined breaking point between the container and a closure part.
  • the outlet it is also possible to form the outlet as a recess in a container wall, in which a puncturing device for removing reference solution is used.
  • a recess may in particular be formed to fit the shape of a puncturing device, so that the outlet and puncturing device, such as the lock and the key, match one another.
  • the outlet is formed in a container according to the invention as a container opening covered by the closure part, in which the wick is arranged.
  • the wick can block this opening, so that even with a possible overpressure in the interior of the container, there is little risk of reference solution spraying out of the container when the closure part is removed.
  • a pressure equalization channel closed off by the closure part may be provided in addition to the wick.
  • the wick can protrude slightly with the closure part something out of the container and thus out of the outlet.
  • the wick protrudes with the closure part removed at most on a length out of the container which is smaller than the width of the wick.
  • its width is the diameter.
  • the width of the wick is its greatest extent perpendicular to its longitudinal direction.
  • the wick is on the vast Part of its length between the outlet and a container bottom, in particular between the predetermined breaking point, via which the closure part is attached to the container, and arranged the container bottom.
  • the wick is arranged completely in the container.
  • a further advantageous embodiment of the invention provides that the wick is arranged in a channel.
  • the wick rests on a channel wall over a predominant part of its length. It is further preferred that the wick protrudes from the channel at most for a length which is smaller than its width.
  • the channel tapers to the removal point. The density of the wick increases from the interior of the container to the sampling point.
  • Another aspect of the present invention relates to a container with reference solution for clinical chemistry contained therein, wherein the container has an interior divided by a membrane into two chambers.
  • One of the two chambers contains the reference solution, while the other chamber is filled with air, wherein at least one container opening causes a pressure equalization between the air-filled chamber and the container environment.
  • the pressure in the chamber containing the reference solution deviates at most negligibly from the atmospheric air pressure of the container environment. Therefore, when puncturing the reference solution-containing chamber, there is no fear that a larger amount of reference solution will leak out and contaminate a meter.
  • the outlet of such a container can be closed with a membrane as a closure part, which is pierced to remove reference solutions with a lancing element.
  • a body soaked in reference solution in particular a wick, is arranged.
  • Such a wick as explained above, preferably extends from the outlet into the interior of the container, more precisely into the chamber containing the reference solution.
  • Another aspect of the present invention relates to a container having a reference solution for clinical chemistry contained therein, wherein the container contains a body soaked with reference solution and has a stopper for abutment with a puncture device for sampling.
  • the stop can absorb a pressure exerted by the application of a puncturing device without the pressure inside the container being increased to such an extent that reference solution is forced out of the container. By a stop thus the risk of contamination of the puncturing device is reduced.
  • the stop can easily be formed by the container walls.
  • an annular disc which surrounds the body soaked in reference solution can be arranged in the container.
  • Such an annular disc can support a container wall covering it, so that the wall section covering the annular disc can be used as a stop.
  • a container with a stop can also be designed as a blister, that is to say as a container with a bottom plate on which a film is fastened, so that a container interior is formed between the film and the bottom plate.
  • the stop can be formed by a surrounding the container interior region of the bottom plate. Pressure on the bottom plate in an area surrounding the container interior does not increase the pressure inside the container.
  • a container filled with reference solution forms a measuring system together with a measuring device containing a lancing device for sample collection.
  • the container may contain, for example, 100 .mu.l to 200 .mu.l reference solution
  • FIG. 1 shows a longitudinal section of a container 1 containing reference solution 2 in a clinical chemistry, for example, glucose solution.
  • the container is closed by a closure part 3.
  • the closure part 3 covers an outlet from which a wick 4 extends into the interior of the container 1.
  • the closure part 3 is removed from the container 1 and pierced with a lancing element in the thereby exposed outlet and thus in the wick 4.
  • a puncturing device is applied to a stop which is formed by a surrounding the wick 4 and thus also the outlet container wall.
  • the container walls are sufficiently stable to be able to withstand a force of at least 3 N, which is typically exerted by the pressing of a puncturing device to the stop, without reference solution 2 is pressed out of the container 1.
  • the wick 4 is formed by a fiber bundle which is arranged completely in the container 1.
  • One end of the fiber bundle 4 is arranged in the outlet, that is to say the container opening formed by removal of the closure part 3, and fastened there to the container 1.
  • the other end of the wick 4 is arranged in the interior of the container 1 contained in the reference solution 2 and immersed in the reference solution 2 when the container 1 is oriented so that its outlet points upwards.
  • the fibers of the wick 4 extend in the longitudinal direction thereof.
  • the wick 4 is attached to, more precisely inside, the container 1 by the wick 4 is arranged in a channel and rests on most of its length on the channel wall.
  • the wick 4 is attached to the channel wall, preferably by being welded to the channel wall.
  • the channel is formed in the illustrated embodiment as an extending into the interior of the container 1 tube.
  • the channel containing the wick 4 narrows towards the removal point, for example, in that the interior space of the channel is conical.
  • the closure part 3 is connected to the container 1 via a predetermined breaking point.
  • the predetermined breaking point can be designed, for example, as a circumferential constriction.
  • the closure part 3 is for turning off or kinked and therefore has two wings that facilitate the application of torque to a user.
  • FIG. 2 is a cross-sectional view too FIG. 1 shown along the section line AA.
  • FIG. 2 thus also shows a plan view of the outlet of the container 1 with removed closure part 3.
  • the wick 4 fills a in FIG. 1 from the closure part 3 covered container opening.
  • the fibers forming the wick 4 are evenly distributed over the cross section thereof.
  • wick 4 In addition to the wick 4 are one or more pressure equalization channels 5, which are also closed by the closure part 3. When the closure part 3 is removed from the container 1, gas can escape from the interior of the container 1 through the pressure compensation channel 5 or air can penetrate into the interior of the container 1, so that any over or underpressure present is reduced.
  • the wick 4 and its fibers extend in the direction of the pressure equalization channel. 5
  • FIG. 1 shows the wick 4 and the reference solution 2 contained interior of the container 1 is partially filled with air.
  • the wick 4 extends from the outlet so far into the interior of the container 1 that the wick 4 is immersed in the reference solution 2 when the outlet is directed upwards.
  • the wick 4 is therefore soaked with reference solution 2 over its entire length, so that reference solution 2 can be removed even with a very short lancing element, with which wick 4 arranged in the outlet is inserted.
  • the reference solution 2 may be mixed with a surfactant so that its surface tension is reduced.
  • the container 1 may have a bottom of foil 6.
  • the bottom 6 can be, for example, a plastic-coated metal foil, for example a plastic-coated aluminum foil.
  • the film 6 can be glued to the main part of the container 1 and printed with a batch information, such as the expiration date.
  • a main part of the container 1 for example, closed by the fact that the lower edges after filling of reference solution as in a tube connected to each other, for example, glued or welded.
  • FIG. 3 is a further embodiment of a container 1 with reference solution 2 contained therein in a cross section according to FIG. 2 shown.
  • the only difference from the preceding embodiment is in another form of pressure equalization channels 5 extending adjacent the wick 4.
  • FIG. 4 schematically shows the removal of reference solution by means of a piercing element 15 from the in FIG. 1
  • a puncturing device with its housing 14 is attached to the container 1, so that 4 reference solution 2 can be absorbed by a stitch in the wick.
  • the container 1 is oriented with its outlet oriented downwards, so that the stitch movement carried out by the puncturing element 15 is directed upward.
  • the container 1 can be oriented as desired for a sampling.
  • FIG. 5 shows a further embodiment of a container 1 with reference solution contained therein 2.
  • a closure member 3 is connected via a predetermined breaking point with a container.
  • the closure part 3 is larger than the container 1 containing the wick 4.
  • the closure part 3 also has an interior space contained in reference solution 2 and a bottom sealed with film 6.
  • FIG. 6 schematically shows how a lancing element 15 is inserted into the wick 4 for sampling.
  • the outlet is located at a neck of the container. This measure has the advantage that the container forms a stop for the device housing 14 attached to the container 1 during a sampling.
  • FIG. 7 shows a further embodiment of a container 1 with contained therein reference solution 2 for clinical chemistry, for example, glucose solution, lactate solution, cholesterol solution or hemoglobin solution.
  • the container 1 is composed of two nested wall elements 1a, 1b and has a divided by a membrane 11 into two chambers interior.
  • One of the two chambers contains reference solution 2, to which one surfactant may be admixed while the other chamber is filled with air.
  • Container openings with pressure compensation channels 5 leading through the wall element 1b effect a pressure equalization between the air-filled chamber and the container environment.
  • the reference solution 2 containing chamber may be partially or completely filled, so in addition to reference solution also contain air, which in FIG. 7 is indicated by an air bubble 16.
  • This chamber has an outlet which is closed by a closure part, namely a membrane 12. At the outlet, a body impregnated with reference solution 2, for example a sponge 13, is arranged.
  • a puncturing device 14 can be attached to the outlet closed by the membrane 12 and the membrane 12 can be pierced with a lancing element 15, which has a sample receiving device, for example a capillary channel. But it is also possible to remove the membrane 12 from the outlet before a sting.
  • the membrane 12 can be cited as a sealing film.
  • the membrane may be a metal foil, which is preferably coated with plastic.
  • the outlet of the container 1 is adapted to the shape of the puncturing device 14 to facilitate users to correctly attach the puncturing device 14 to the membrane 12 for removal of reference solution 2.
  • the membrane 12 may have a hydrophobic surface. In this way it can be prevented that after a perforation of the membrane 12 reference solution 2 exits from the container 1 by itself and causes contamination.
  • the two container parts 1a, 1b are preferably rigid-walled.
  • Such wall elements 1a, 1b can be produced inexpensively, for example, as injection-molded parts made of plastic.
  • the wall element 1a together with the membrane 11 forms a container containing the reference solution.
  • the container part 1b has the function of protecting the membrane 11 from damage.
  • the two wall elements 1a, 1b are preferably locked together. In this way, the production cost can be advantageously reduced.
  • a single opening with a pressure equalization channel 5 is sufficient per se.
  • a plurality of openings with pressure compensation channels 5 are preferred. If a user in handling the container 1 covers some of the openings 5 with pressure equalization channels 5, this is harmless, since even a single uncovered opening with a pressure equalization channel 5 allows sufficient pressure equalization.
  • FIG. 8 shows a further embodiment, which differs from the in FIG. 7 illustrated embodiment essentially only differs in that the porous body 13 has been replaced by a wick 4. To avoid repetition is in this context to the description in the FIGS. 1 to 4 referenced embodiments.
  • FIG. 9 a further embodiment is shown, which differs from that in the FIGS. 7 and 8th illustrated embodiments essentially differs in that a container wall a pointing to the diaphragm 11 mandrel 16th shows.
  • the wall elements 1a, 1b are movable relative to each other in this embodiment. By the two wall elements 1a, 1b are compressed, the wall element 1b is moved with the mandrel 17 to the membrane 11, so that the mandrel 17 pierces the membrane 11. This is in FIG. 10 shown.
  • the mandrel 16 attached to one of the two wall elements 1a, 1b pierces the membrane 11. It is preferred that the two wall elements 1a, 1b latch together when pressed together in an end position a used container 1, that is to say a container 1 with pierced membrane 11, is easily recognizable.
  • one of the two wall elements 1a, 1b may have a marking, for example a colored ring, which is concealed when the two wall elements 1a, 1b are pushed into one another.
  • FIGS. 11 and 12 is a further embodiment of a container 1 is shown with reference solution contained therein.
  • the illustrated container 1 has a relatively thin container wall, which consists for example of plastic film. So that the container wall can still form a stop for application to a puncturing device for sampling, an annular disc 7 is arranged in the container, which surrounds a container 4 soaked in reference solution, for example a wick or a sponge. For a sampling can be pressed with a puncturing device against a supported by the annular disc 7 section of the container wall, without thereby appreciably increases the fluid pressure inside the container.
  • the in the FIGS. 11 and 12 shown container may be, for example, a foil bag or a blister.
  • a blister is a package consisting of a bottom plate carrying a foil so that a container interior is formed between the foil and the bottom plate.
  • the top may be covered with a peel-off adhesive label 3, for example made of paper or foil.
  • a peel-off adhesive label for example made of paper or foil.
  • the container may have means for fixing on the fingertip, for example, an adhesive surface or a loop 8, as shown schematically in FIG FIG. 13 is shown. Since body fluid samples are usually taken with pricking equipment from the fingertip of a straight finger 9, with such an attachment, the user's usual movements can also be applied to the removal of reference solution.
  • the container can also be provided with a longer handle, as shown schematically in FIG. 14 is shown. Also in this way, the puncturing device for removing reference solution can be pressed against a voltage applied to the fingertip container.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Claims (10)

  1. Récipient muni d'une solution de référence contenue en son sein et destiné à la chimie clinique, dans lequel
    le récipient (1) présente une sortie recouverte par une partie fermeture (3) et au niveau de laquelle de la solution de référence (2) peut être prélevée par piquage d'un élément d'échantillonnage (15) dans une mèche (4), et
    le récipient (1) présente une paroi de récipient, qui entoure la mèche (4) et supporte la partie fermeture (3),
    dans lequel la mèche (4) imprégnée de solution de référence (2) est agencée dans le récipient (1), ladite mèche s'étendant vers l'intérieur à partir de la sortie jusque dans un espace intérieur du récipient (1) au sein duquel elle est agencée pour la plus grande partie de sa longueur, et la paroi de récipient forme une butée destinée à venir en place au niveau d'un appareil d'échantillonnage en vue d'un prélèvement d'échantillon,
    caractérisé en ce que
    les fibres de la mèche (4) s'étendent essentiellement dans le sens d'un mouvement de piquage qui est effectué en vue d'un prélèvement de solution de référence (2) par un élément d'échantillonnage (15) d'un appareil d'échantillonnage mis en place au niveau de la butée.
  2. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que le récipient (1) maintient une force de pression d'au moins 3 N lors de la mise en place d'un appareil d'échantillonnage en vue d'un prélèvement d'échantillon, sans que de la solution de référence soit expulsée hors de la sortie.
  3. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que la partie fermeture (3) est fixée sur le récipient (1) par l'intermédiaire d'une section de rupture intentionnellement prévue.
  4. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce qu'un canal d'équilibrage de pression (5), qui est fermé par la partie fermeture (3), s'étend à côté de la mèche (4).
  5. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que la mèche (4) est réalisée sous la forme d'un faisceau de fibres.
  6. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que la mèche (4) fait saillie hors du récipient (1), lorsque la pièce de fermeture (3) est retirée, au plus sur une longueur qui est inférieure à sa largeur.
  7. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce que la mèche (4) plonge dans la solution de référence (2) lorsque la sortie est orientée vers le haut.
  8. Récipient selon l'une quelconque des revendications précédentes, caractérisé en ce qu'une extrémité de la mèche (4) est agencée au niveau de la sortie.
  9. Système de mesure d'une concentration en analyte d'un échantillon de fluide corporel humain ou animal, comprenant un récipient selon l'une quelconque des revendications précédentes et un appareil de mesure qui contient un appareil d'échantillonnage destiné à un prélèvement d'échantillon.
  10. Procédé de prélèvement de solution de référence (2) pour la chimie clinique grâce à un élément d'échantillonnage (15), dans lequel la solution de référence (2) est stockée dans un récipient (1) et est prélevée dans une mèche (4) imprégnée de solution de référence (2) grâce à l'élément d'échantillonnage (15), ladite mèche étant agencée dans le récipient (1), caractérisé en ce que
    une partie fermeture (3) est retirée du récipient (1) et un appareil d'échantillonnage est mis en place au niveau d'une butée formée par le récipient (1), ladite butée subissant une pression exercée par la mise en place de l'appareil d'échantillonnage afin d'éviter que la solution de référence (2) soit expulsée du récipient (1).
EP10003312.5A 2009-06-20 2010-03-27 Récipient doté d'une solution de référence Not-in-force EP2263796B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP10003312.5A EP2263796B1 (fr) 2009-06-20 2010-03-27 Récipient doté d'une solution de référence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09008114 2009-06-20
EP10003312.5A EP2263796B1 (fr) 2009-06-20 2010-03-27 Récipient doté d'une solution de référence

Publications (2)

Publication Number Publication Date
EP2263796A1 EP2263796A1 (fr) 2010-12-22
EP2263796B1 true EP2263796B1 (fr) 2018-07-25

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EP10003312.5A Not-in-force EP2263796B1 (fr) 2009-06-20 2010-03-27 Récipient doté d'une solution de référence

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US (1) US9475050B2 (fr)
EP (1) EP2263796B1 (fr)

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US9475050B2 (en) 2016-10-25
US20110004077A1 (en) 2011-01-06
EP2263796A1 (fr) 2010-12-22

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